CN102210658A - Microcapsule soft capsule preparation with high alpha-linolenic acid content - Google Patents
Microcapsule soft capsule preparation with high alpha-linolenic acid content Download PDFInfo
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- CN102210658A CN102210658A CN2010101390355A CN201010139035A CN102210658A CN 102210658 A CN102210658 A CN 102210658A CN 2010101390355 A CN2010101390355 A CN 2010101390355A CN 201010139035 A CN201010139035 A CN 201010139035A CN 102210658 A CN102210658 A CN 102210658A
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- Prior art keywords
- microcapsule
- soft capsule
- vitamin
- linolenic acid
- capsule preparation
- Prior art date
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- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 title claims abstract description 64
- 239000003094 microcapsule Substances 0.000 title claims abstract description 64
- 238000002360 preparation method Methods 0.000 title claims abstract description 40
- 239000007901 soft capsule Substances 0.000 title claims abstract description 34
- 235000020661 alpha-linolenic acid Nutrition 0.000 title claims abstract description 33
- 229960004488 linolenic acid Drugs 0.000 title claims abstract description 31
- 235000016709 nutrition Nutrition 0.000 claims abstract description 36
- 239000000463 material Substances 0.000 claims abstract description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 35
- 238000002372 labelling Methods 0.000 claims description 30
- 239000000203 mixture Substances 0.000 claims description 29
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 24
- 229930003270 Vitamin B Natural products 0.000 claims description 22
- 235000019156 vitamin B Nutrition 0.000 claims description 22
- 239000011720 vitamin B Substances 0.000 claims description 22
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims description 20
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 20
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 18
- 238000000034 method Methods 0.000 claims description 17
- 108010010803 Gelatin Proteins 0.000 claims description 14
- 239000002775 capsule Substances 0.000 claims description 14
- 239000008273 gelatin Substances 0.000 claims description 14
- 229920000159 gelatin Polymers 0.000 claims description 14
- 235000019322 gelatine Nutrition 0.000 claims description 14
- 235000011852 gelatine desserts Nutrition 0.000 claims description 14
- 238000005507 spraying Methods 0.000 claims description 13
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims description 10
- 229960000304 folic acid Drugs 0.000 claims description 10
- 235000019152 folic acid Nutrition 0.000 claims description 10
- 239000011724 folic acid Substances 0.000 claims description 10
- 235000019359 magnesium stearate Nutrition 0.000 claims description 10
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 claims description 10
- 239000011746 zinc citrate Substances 0.000 claims description 10
- 229940068475 zinc citrate Drugs 0.000 claims description 10
- 235000006076 zinc citrate Nutrition 0.000 claims description 10
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 9
- 229930003268 Vitamin C Natural products 0.000 claims description 9
- 239000011248 coating agent Substances 0.000 claims description 9
- 238000000576 coating method Methods 0.000 claims description 9
- 239000000843 powder Substances 0.000 claims description 9
- 239000011718 vitamin C Substances 0.000 claims description 9
- 235000019154 vitamin C Nutrition 0.000 claims description 9
- 235000010489 acacia gum Nutrition 0.000 claims description 7
- 239000001785 acacia senegal l. willd gum Substances 0.000 claims description 7
- 230000001476 alcoholic effect Effects 0.000 claims description 7
- 238000004090 dissolution Methods 0.000 claims description 7
- 239000002245 particle Substances 0.000 claims description 7
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 6
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 6
- 239000001856 Ethyl cellulose Substances 0.000 claims description 6
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 6
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims description 6
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 claims description 6
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 6
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 claims description 6
- 235000013734 beta-carotene Nutrition 0.000 claims description 6
- 239000011648 beta-carotene Substances 0.000 claims description 6
- 229960002747 betacarotene Drugs 0.000 claims description 6
- 235000019325 ethyl cellulose Nutrition 0.000 claims description 6
- 229920001249 ethyl cellulose Polymers 0.000 claims description 6
- 238000009472 formulation Methods 0.000 claims description 6
- 235000010445 lecithin Nutrition 0.000 claims description 6
- 239000000787 lecithin Substances 0.000 claims description 6
- 229940067606 lecithin Drugs 0.000 claims description 6
- 235000019155 vitamin A Nutrition 0.000 claims description 6
- 239000011719 vitamin A Substances 0.000 claims description 6
- 229940045997 vitamin a Drugs 0.000 claims description 6
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 claims description 6
- 239000000084 colloidal system Substances 0.000 claims description 4
- 238000010438 heat treatment Methods 0.000 claims description 4
- 238000009413 insulation Methods 0.000 claims description 4
- 229940088594 vitamin Drugs 0.000 claims description 4
- 229930003231 vitamin Natural products 0.000 claims description 4
- 235000013343 vitamin Nutrition 0.000 claims description 4
- 239000011782 vitamin Substances 0.000 claims description 4
- 150000003722 vitamin derivatives Chemical class 0.000 claims description 4
- 239000012530 fluid Substances 0.000 claims description 3
- RBCOYOYDYNXAFA-UHFFFAOYSA-L (5-hydroxy-4,6-dimethylpyridin-3-yl)methyl phosphate Chemical compound CC1=NC=C(COP([O-])([O-])=O)C(C)=C1O RBCOYOYDYNXAFA-UHFFFAOYSA-L 0.000 claims description 2
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- JZRWCGZRTZMZEH-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 claims description 2
- 239000004615 ingredient Substances 0.000 abstract description 8
- 235000019640 taste Nutrition 0.000 abstract description 3
- 239000004480 active ingredient Substances 0.000 abstract description 2
- 230000007547 defect Effects 0.000 abstract 1
- 239000000796 flavoring agent Substances 0.000 abstract 1
- 235000019634 flavors Nutrition 0.000 abstract 1
- 235000015097 nutrients Nutrition 0.000 description 28
- 210000004556 brain Anatomy 0.000 description 5
- 238000007599 discharging Methods 0.000 description 5
- 239000000725 suspension Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 229910052500 inorganic mineral Inorganic materials 0.000 description 3
- 235000010755 mineral Nutrition 0.000 description 3
- 239000011707 mineral Substances 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 239000012876 carrier material Substances 0.000 description 2
- 238000012856 packing Methods 0.000 description 2
- 239000008188 pellet Substances 0.000 description 2
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
- 239000004925 Acrylic resin Substances 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 229920000623 Cellulose acetate phthalate Polymers 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- 229920000858 Cyclodextrin Polymers 0.000 description 1
- 238000012695 Interfacial polymerization Methods 0.000 description 1
- 244000124853 Perilla frutescens Species 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 230000005587 bubbling Effects 0.000 description 1
- -1 but Substances 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 229940081734 cellulose acetate phthalate Drugs 0.000 description 1
- 238000005354 coacervation Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000013270 controlled release Methods 0.000 description 1
- 239000007771 core particle Substances 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 239000007952 growth promoter Substances 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 230000021332 multicellular organism growth Effects 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 230000007830 nerve conduction Effects 0.000 description 1
- 239000002858 neurotransmitter agent Substances 0.000 description 1
- 235000021049 nutrient content Nutrition 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
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- Medicinal Preparation (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention provides a microcapsule soft capsule preparation with a high alpha-linolenic acid content. The active ingredients of the preparation comprise high-content alpha-linolenic acid as the main nutritional ingredient and other nutritional ingredients such as oil-soluble nutritional ingredients and water-soluble nutritional ingredients, wherein the water-soluble nutritional ingredients are prepared into microcapsules by an encapsulating material. The alpha-linolenic acid content of the microcapsule soft capsule preparation with a high alpha-linolenic acid content provided by the invention is 50-60%. The microcapsule soft capsule preparation provided by the invention overcomes the defects of the existing preparations, effectively improves the stability of the product, reserves the contents of various nutritional ingredients, improves the bioavailability, reduces the dosage, flavors disagreeable tastes and has a better taste.
Description
Technical field
The present invention relates to nutrient and healthcare products, be specifically related to a kind of nourishing the brain and improving intelligence nutrient and healthcare products, relate in particular to a kind of high-load alpha-linolenic acid microcapsule soft capsule preparation.
Background technology
Nutrient is to keeping the human body growth promoter and ensureing healthy significant.The nourishing the brain and improving intelligence nutrient and healthcare products have certain health-care effect to promoting human brain growth and intellectual development, have the hypermnesis function simultaneously, improve old people's quality of life.Therefore, be subjected to people's favor.Alpha-linolenic acid is one of synthetic basic material of neurocyte, and its can directly affect the nerves physicochemical property of cell increases the flowability of film, promotes and improve the release and the nerve conduction velocity of neurotransmitter.
Existing nourishing the brain and improving intelligence nutrient and healthcare products are formed jointly with high-load alpha-linolenic acid and nutrient.Wherein nutrient is mainly vitamin and minerals composition, but, water soluble ingredient wherein can not well be dispersed in the oil-soluble composition, simultaneously some vitamin easily and mineral react, influence the stability and the degree of absorbing of product, and some mineral can exert an influence also to the mouthfeel of product.Therefore, be necessary, propose reasonable solution, keep various nutrient contents, effectively improve product stability, improve bioavailability, simultaneously mouthfeel is improved at the problems referred to above.Microcapsule technology is meant the tiny capsules of utilizing natural or synthetic macromolecular material solid or liquid component to be rolled into diameter 1～500 μ m, behind the effective ingredient microencapsulation, can improve its stability, alleviate bad smell, the release of slow release or controlled release of active ingredients, be convenient to storage, the use of product, the stabilate activity helps to bring into play curative effect.At present, the research of non-water soluble substance technique for packing is ripe, and the relative research of the technique for packing of water-soluble substances is less.
Summary of the invention
Technical problem to be solved by this invention is to overcome above-mentioned weak point, and research design improves product stability and bioavailability, improves the nourishing the brain and improving intelligence nutrient and healthcare products of mouthfeel.
The present invention is according to contemporary pharmaceutical preparation forward position theory, and utilization micronizing, microencapsulation packaging technique make the microcapsule that contains the water solublity nutritional labeling.
The invention provides a kind of high-load alpha-linolenic acid microcapsule soft capsule preparation.(hard-cover NEW gold clever capsule difficult to understand).
High-load alpha-linolenic acid microcapsule soft capsule preparation of the present invention is made up of content and rubber; Described content is made up of high-load alpha-linolenic acid, oil-soluble nutritional labeling and water solublity nutritional labeling microcapsule as active component; Rubber is made by gelatin, glycerol and pure water.
Described high-load alpha-linolenic acid is to get through purification from the seed of labiate common perilla or Folium Perillae, and content 60%-70% can commercially availablely buy.
Described water solublity nutritional labeling is zinc citrate, vitamin B
1, vitamin B
2, vitamin B
6, in vitamin or the folic acid one or more.
Described oil-soluble nutritional labeling is one or more in lecithin, vitamin A or the beta-carotene.
Described water solublity nutritional labeling is made microcapsule with the capsule material.
Described capsule material is one or more mixture with magnesium stearate in gelatin, arabic gum, the ethyl cellulose.
Above-mentioned raw materials all can commercially availablely be buied.
The content of high-load alpha-linolenic acid microcapsule soft capsule preparation of the present invention per distribution ratio by weight consists of:
Composition weight %
Alpha-linolenic acid 85-95
Oil-soluble nutritional labeling 1.5-8
Water solublity nutritional labeling microcapsule 1.5-10
The rubber of high-load alpha-linolenic acid microcapsule soft capsule preparation of the present invention consists of by weight ratio:
9～12 parts in gelatin, 3～4 parts of glycerol, 8～12 parts of pure water.
The nutritional labeling of the content of the high-load alpha-linolenic acid microcapsule soft capsule preparation of the present invention preferred group of per distribution ratio by weight becomes:
Composition weight %
Alpha-linolenic acid 85-95
Zinc citrate 0.5-2
Vitamin B
10.2-1
Vitamin B
20.2-1
Vitamin B
60.2-1
Vitamin C 0.5-2
Folic acid 0.001-0.01
Lecithin 1.5-8
Vitamin A 0.005-0.05
Beta-carotene 0.01-0.1.
Another object of the present invention has provided the preparation method of above-mentioned a kind of high-load alpha-linolenic acid microcapsule soft capsule preparation, and this method comprises the following steps:
One, the water solublity nutritional labeling is made microcapsule with the capsule material:
(1) with water solublity nutritional labeling mix homogeneously, form mixture, then mixture is carried out micronizing, its particle diameter is controlled in the 15 μ m, so that better form microcapsule, also make content more even simultaneously;
(2) water intaking dissolubility nutritional labeling micropowders is suspended on the fluid bed for 5～10 parts, and other gets 1 part of capsule material with 1.5～2.5 parts of alcoholic solution mixed dissolutions, and adds 0.01～0.1 part of magnesium stearate, forms coating solution;
(3) utilization top spraying process, the coating solution of step (2) gained is passed through atomizer, be sprayed on the superfine powder that the step (1) that circulates obtains, under 55 ℃～75 ℃ condition, the capsule material is deposited in the surface, through circulation in 10-16 minute, form uniform wall film, make water solublity nutritional labeling microcapsule;
Two, preparation microcapsule soft capsule preparation
(1) get 85～95 parts of high-load alpha-linolenic acids, 1.5～8 parts of oil-soluble nutritional labelings, 1.5～10 parts of mixing of water solublity nutritional labeling microcapsule with the even matter of colloid mill, are formed the microcapsule formulation content;
(2) get 9～12 parts in gelatin, 3～4 parts of glycerol, 8～12 parts of 60-80 ℃ of heating of pure water are dissolved, and insulation is filtered, and gets the rubber solution for standby;
(3) above-mentioned microcapsule formulation content and rubber solution are pressed into the microcapsule soft capsule preparation with encapsulating machine.
The present invention is directed to the used capsule material of the microcapsule parcel of water-soluble substances and the preparation method of microcapsule screens:
The preparation method of microcapsule has all multi-methods such as coacervation, solvent-nonsolvent method, interfacial polymerization, spray drying method, air suspension, air suspension wherein, by professor D.E.Wurster of Univ Wisconsin-Madison USA invention, so again this method is called the Wurster method usually.Need place fluid bed by the embedding powder, bubbling air makes the capsule-core dispersion suspension in the carrying air, and the wall material that will dissolve or melt passes through atomizer then, be sprayed on the capsule-core particle that circulates, and be deposited in the surface, through the repeated multiple times circulation, form the moderate uniform wall film of thickness.The composition that needs embedding among the present invention is compound water-soluble nutrients, and the water solublity nutritional labeling of carrying out the microcapsule parcel is: the mixture of zinc citrate, vitamin C, vitamin B group, folic acid or these nutritional labelings.Determine that by preferred air suspension is relatively more suitable method, and select top spraying process wherein to coat, this method is evenly distributed at the process mesospore material that coats the nutrient powder, thereby has reduced the consumption of wall material, and embedding rate can be up to 98%～99%.
The capsule material or the carrier material of parcel have gelatin, arabic gum, alginate, chitosan, polyacrylic resin, polyvinyl alcohol, paraffin, cyclodextrin, cellulose acetate-phthalate, carboxymethyl cellulose salt, ethyl cellulose, methylcellulose etc.Category is more, selects preferred to vitamin C envelop rate and drug loading by the present invention, clearly selects for use carrier material to be: gelatin, arabic gum, ethyl cellulose or their mixture.The present invention has also used magnesium stearate microcapsule has been handled, and can prevent to produce in spray process glutinous the company, prepares the microcapsule of favorable dispersibility
The present invention can overcome the deficiency of existing preparation, effectively improves product stability, keeps various nutrient composition contents; Improve bioavailability, reduce taking dose; Correct disagreeable taste, mouthfeel is better.The alpha-linolenic acid content of preparation of the present invention is 50%-60%.
Microcapsule formulation with the present invention's preparation is compared with the preparation that does not use microcapsule technology, has significant advantage:
(1) through micronizing, the material form changes, and carries out the microcapsule embedding better;
(2) product stability improves, and can prevent its decomposition effectively, oxidation (variable color, rotten);
(3) bioavailability improves, and consumer's using dosage can reduce;
(4) can cover up bad smell, mouthfeel is improved
The specific embodiment
Embodiment 1
Water intaking dissolubility nutrient: zinc citrate 10Kg, vitamin B
15Kg, vitamin B
26Kg, vitamin B
64Kg, vitamin C 15g, folic acid 0.05Kg, mix homogeneously, ZMD-80 type superfine comminution at low temperature machine carries out micronizing, control discharging particle diameter in 15 μ m, get the superfine powder water-soluble nutrients be suspended in WBF-250 multifunctional fluidized bed on, in addition with 5Kg gelatin and 10Kg alcoholic solution mixed dissolution, and adding 0.1Kg magnesium stearate, form coating solution, top spraying, the film forming of under 60 ℃ temperature, spraying, evenly coat above-mentioned water-soluble nutrients, make microcapsule.
Embodiment 2
Water intaking dissolubility nutrient: zinc citrate 12Kg, vitamin B
16Kg, vitamin B
26Kg, vitamin B
66Kg, vitamin C 12Kg, folic acid 0.08Kg, mix homogeneously, ZMD-80 type superfine comminution at low temperature machine carries out micronizing, and control discharging particle diameter is in 15 μ m; Get the superfine powder water-soluble nutrients be suspended in WBF-250 multifunctional fluidized bed on, in addition with 6Kg arabic gum and 11Kg alcoholic solution mixed dissolution, and adding 0.08Kg magnesium stearate, form coating solution, the top spraying, the film forming of spraying under 65 ℃ temperature evenly coats water-soluble nutrients, makes microcapsule.
Embodiment 3
Water intaking dissolubility nutrient: zinc citrate 14Kg, vitamin B
16Kg, vitamin B
24Kg, vitamin B
64Kg, vitamin C 8Kg, folic acid 0.03Kg, mix homogeneously, ZMD-80 type superfine comminution at low temperature machine carries out micronizing, control discharging particle diameter in 15 μ m, get the superfine powder water-soluble nutrients be suspended in WBF-250 multifunctional fluidized bed on, in addition with 2Kg arabic gum and 3Kg gelatin usefulness 8Kg alcoholic solution mixed dissolution, and adding 0.07Kg magnesium stearate, form coating solution, top spraying, the film forming of under 65 ℃ temperature, spraying, evenly coat water-soluble nutrients, make microcapsule.
Embodiment 4
Water intaking dissolubility nutrient: zinc citrate 8Kg, vitamin B
13Kg, vitamin B
23Kg, vitamin B
68Kg, vitamin C 16Kg, folic acid 0.06Kg, mix homogeneously, ZMD-80 type superfine comminution at low temperature machine carries out micronizing, control discharging particle diameter in 15 μ m, get the superfine powder water-soluble nutrients be suspended in WBF-250 multifunctional fluidized bed on, in addition with 6Kg ethyl cellulose and 10Kg alcoholic solution mixed dissolution, and adding 0.09Kg magnesium stearate, form coating solution, top spraying, the film forming of under 70 ℃ temperature, spraying, evenly coat water-soluble nutrients, make microcapsule.
Embodiment 5
Water intaking dissolubility nutrient: zinc citrate 6Kg, vitamin B
18Kg, vitamin B
22Kg, vitamin B
66Kg, vitamin C 12Kg, folic acid 0.06Kg, mix homogeneously, ZMD-80 type superfine comminution at low temperature machine carries out micronizing, control discharging particle diameter in 15 μ m, get the superfine powder water-soluble nutrients be suspended in WBF-250 multifunctional fluidized bed on, in addition with 2Kg ethyl cellulose and 2.5Kg arabic gum usefulness 10Kg alcoholic solution mixed dissolution, and adding 100g magnesium stearate, form coating solution, top spraying, the film forming of under 70 ℃ temperature, spraying, evenly coat water-soluble nutrients, make microcapsule.
Embodiment 6
Get alpha-linolenic acid (commercial content 65%) 8.6Kg, lecithin 0.4Kg, vitamin A 0.001Kg, beta-carotene 0.004Kg, the water-soluble nutrients microcapsule 1Kg that embodiment 1 makes mixes, and the JMS-80 colloid mill is spared matter, forms soft capsule content; Get gelatin 2Kg, glycerol 0.7Kg, pure water 2Kg, (70 ℃) are dissolved in heating, insulation is filtered, rubber solution, adopt HSR-200 soft capsule pellet press to be pressed into into 3333 of the soft capsules of every 300mg.(detecting alpha-linolenic acid content 55%).
Embodiment 7
Get alpha-linolenic acid (commercial content 66%) 9Kg, lecithin 0.2Kg, vitamin A 0.002Kg, beta-carotene 0.006Kg, the water-soluble nutrients microcapsule 0.8Kg that embodiment 2 makes, the JMS-80 colloid mill is spared matter, forms soft capsule content; Get gelatin 1.8Kg, glycerol 0.6Kg, pure water 1.5Kg, (75 ℃) are dissolved in heating, insulation is filtered, rubber solution, adopt HSR-200 soft capsule pellet press to be pressed into 4000 of the soft capsules of every 250mg.(detecting alpha-linolenic acid content 59%).
Claims (8)
1. high-load alpha-linolenic acid microcapsule soft capsule preparation is characterized in that described soft capsule preparation is made up of content and rubber; Described content is made up of high-load alpha-linolenic acid, oil-soluble nutritional labeling and water solublity nutritional labeling microcapsule as active component; Rubber is made by gelatin, glycerol and pure water.
2. according to the described high-load alpha-linolenic acid of claim 1 microcapsule soft capsule preparation, the alpha-linolenic acid content that it is characterized in that preparation is 50%-60%.
3. according to the described microcapsule soft capsule preparation of claim 1, it is characterized in that described water solublity nutritional labeling is zinc citrate, vitamin B
1, vitamin B
2, vitamin B
6, in vitamin or the folic acid one or more.
4. according to the described microcapsule soft capsule preparation of claim 1, it is characterized in that described oil-soluble nutritional labeling is one or more in lecithin, vitamin A or the beta-carotene.
5. according to the described microcapsule soft capsule preparation of claim 1, it is characterized in that described water solublity nutritional labeling makes microcapsule with the capsule material; Described capsule material is one or more mixture with magnesium stearate in gelatin, arabic gum, the ethyl cellulose.
6. according to the described microcapsule soft capsule preparation of claim 1, the content that it is characterized in that described soft capsule preparation per distribution ratio by weight consists of:
Composition weight %
Alpha-linolenic acid 85-95
Oil-soluble nutritional labeling 1.5-8
Water solublity nutritional labeling microcapsule 1.5-10
The rubber of microcapsule soft capsule microcapsule formulation consists of by weight ratio:
9～12 parts in gelatin, 3～4 parts of glycerol, 8～12 parts of pure water.
7. according to the described microcapsule soft capsule preparation of claim 7, the content that it is characterized in that described microcapsule soft capsule preparation is consisting of of per distribution ratio by weight:
Composition weight %
Alpha-linolenic acid 85-95
Zinc citrate 0.5-2
Vitamin B
10.2-1
Vitamin B
20.2-1
Vitamin B
60.2-1
Vitamin C 0.5-2
Folic acid 0.001-0.01
Lecithin 1.5-8
Vitamin A 0.005-0.05
Beta-carotene 0.01-0.1.
8. the preparation method of high-load alpha-linolenic acid microcapsule soft capsule preparation according to claim 1 is characterized in that this method comprises the following steps:
One, the water solublity nutritional labeling is made microcapsule with the capsule material:
(1) with water solublity nutritional labeling mix homogeneously, form mixture, then mixture is carried out micronizing, its particle diameter is controlled in the 15 μ m, so that better form microcapsule, also make content more even simultaneously;
(2) water intaking dissolubility nutritional labeling micropowders is suspended on the fluid bed for 5～10 parts, and other gets 1 part of capsule material with 1.5～2.5 parts of alcoholic solution mixed dissolutions, and adds 0.01～0.1 part of magnesium stearate, forms coating solution;
(3) utilization top spraying process, the coating solution of step (2) gained is passed through atomizer, be sprayed on the superfine powder that the step (1) that circulates obtains, under 55 ℃～75 ℃ condition, the capsule material is deposited in the surface, through circulation in 10-16 minute, form uniform wall film, make water solublity nutritional labeling microcapsule;
Two, preparation microcapsule soft capsule preparation
(1) get 85～95 parts of high-load alpha-linolenic acids, 1.5～8 parts of oil-soluble nutritional labelings, 1.5～10 parts of mixing of water solublity nutritional labeling microcapsule with the even matter of colloid mill, are formed the microcapsule formulation content;
(2) get 9～12 parts in gelatin, 3～4 parts of glycerol, 8～12 parts of 60-80 ℃ of heating of pure water are dissolved, and insulation is filtered, and gets the rubber solution for standby;
(3) above-mentioned microcapsule formulation content and rubber solution are pressed into the microcapsule soft capsule preparation with encapsulating machine.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103238846A (en) * | 2013-05-31 | 2013-08-14 | 烟台燕园科玛生物技术开发有限公司 | Alpha-linolenic acid soft capsule |
| CN104982930A (en) * | 2015-06-24 | 2015-10-21 | 芦冰 | Novel linseed oil microcapsule powder and preparation method thereof |
| CN108851058A (en) * | 2018-07-13 | 2018-11-23 | 德瑞美医药生物技术盐城有限公司 | A kind of multivitamin minerals soft capsule and preparation method thereof rich in alpha-linolenic acid |
| CN108968070A (en) * | 2018-08-13 | 2018-12-11 | 河南城建学院 | A kind of linseed omega-3 unsaturated fatty acid health care product and its microcapsule preparation method |
| CN110721112A (en) * | 2018-07-17 | 2020-01-24 | 广东福爱喜环保技术发展有限公司 | Small molecule inclusion compound, preparation process thereof and washing and caring product using small molecule inclusion compound |
| CN111067106A (en) * | 2019-12-17 | 2020-04-28 | 南通励成生物工程有限公司 | Water-soluble zinc citrate and preparation method and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1072013A (en) * | 1991-10-27 | 1993-05-12 | 吴建国 | Electric shock type lance |
| CN1582947A (en) * | 2004-05-26 | 2005-02-23 | 内蒙古草原兴发股份有限公司 | Capsules of alpha-linolinic acid |
-
2010
- 2010-04-02 CN CN201010139035A patent/CN102210658B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1072013A (en) * | 1991-10-27 | 1993-05-12 | 吴建国 | Electric shock type lance |
| CN1582947A (en) * | 2004-05-26 | 2005-02-23 | 内蒙古草原兴发股份有限公司 | Capsules of alpha-linolinic acid |
Non-Patent Citations (1)
| Title |
|---|
| 《天津大学学报》 19960731 范国梁等 水溶性维生素微囊包裹研究 , * |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103238846A (en) * | 2013-05-31 | 2013-08-14 | 烟台燕园科玛生物技术开发有限公司 | Alpha-linolenic acid soft capsule |
| CN103238846B (en) * | 2013-05-31 | 2015-03-18 | 烟台燕园科玛生物技术开发有限公司 | Alpha-linolenic acid soft capsule |
| CN104982930A (en) * | 2015-06-24 | 2015-10-21 | 芦冰 | Novel linseed oil microcapsule powder and preparation method thereof |
| CN108851058A (en) * | 2018-07-13 | 2018-11-23 | 德瑞美医药生物技术盐城有限公司 | A kind of multivitamin minerals soft capsule and preparation method thereof rich in alpha-linolenic acid |
| CN110721112A (en) * | 2018-07-17 | 2020-01-24 | 广东福爱喜环保技术发展有限公司 | Small molecule inclusion compound, preparation process thereof and washing and caring product using small molecule inclusion compound |
| CN108968070A (en) * | 2018-08-13 | 2018-12-11 | 河南城建学院 | A kind of linseed omega-3 unsaturated fatty acid health care product and its microcapsule preparation method |
| CN111067106A (en) * | 2019-12-17 | 2020-04-28 | 南通励成生物工程有限公司 | Water-soluble zinc citrate and preparation method and application thereof |
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| CN102210658B (en) | 2012-10-17 |
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