CN102206355A - Silver nanoparticle-containing bacterial cellulose membrane and preparation method thereof - Google Patents
Silver nanoparticle-containing bacterial cellulose membrane and preparation method thereof Download PDFInfo
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- CN102206355A CN102206355A CN2011100759719A CN201110075971A CN102206355A CN 102206355 A CN102206355 A CN 102206355A CN 2011100759719 A CN2011100759719 A CN 2011100759719A CN 201110075971 A CN201110075971 A CN 201110075971A CN 102206355 A CN102206355 A CN 102206355A
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Abstract
The invention relates to a silver nanoparticle-containing bacterial cellulose membrane and a preparation method thereof. Silver nanoparticles in the bacterial cellulose membrane are attached to the microfiber surface of a three-dimensional network structure of the bacterial cellulose membrane, and the silver nanoparticles are in an amount which is 0.1 to 15 percent of the total weight of the cellulose membrane and have the particle size of between 8 and 50nm. The preparation method comprises the following steps of: soaking the bacterial cellulose membrane in silver salt solution at room temperature for 10 minutes to 5 hours and taking the soaked membrane out; cleaning the surface of the bacterial cellulose membrane by using distilled water; irradiating by an ultraviolet radiation method for 0.5 to 6 hours to obtain a silver nanoparticle-containing bacterial cellulose wet membrane; and performing dehydration treatment to obtain the silver nanoparticle-containing bacterial cellulose membrane. The bacterial cellulose membrane has high bacteria resistance, high air permeability, high water-holding capacity and controllable moisture content and is suitable to be used as a trauma medical dressing; and in the invention, a chemical reduction reagent is not required to be added, an environment-friendly and safe process condition is realized, and equipment is simple and pollution-free.
Description
Technical field
The invention belongs to the silver nanoparticle-containing field of compound material, particularly relate to bacteria cellulose film of a kind of silver nanoparticle-containing and preparation method thereof.
Background technology
Bacteria cellulose is a kind of by microorganism synthetic high-purity cellulose, and its primitive fiber diameter has only 40-60nm, is the meticulousst nano material of occurring in nature.The ultra-fine fibre network structure makes it have high-specific surface area, high water-holding power and excellent biological compatibility and biodegradability, is known as " the Nature is given human natural biological medical material ".Big quantity research and clinical trial show that the wound dressing of bacteria cellulose base has good curative effect for empyrosis and chronic ulcer disease.For example, utilize hygrometric state bacteria cellulose film treatment veins of lower extremity chronic ulcer, treatment cycle only needed for 14 weeks, and the bearing hydrocolloid dressing that is widely used in such wound then needed for 20 weeks.The dressing of bacteria cellulose base also has the short more effect of tangible wound for diabetic foot chronic ulcer and II/III degree burn, and treatment cycle is compared obvious shortening with traditional medicine carrying gauze dressing.The investigator generally believes, it is theoretical that the structure of bacteria cellulose base dressing and performance meet the medical treatment of modern wound healing, have wettability power strong, promote healing, ease the pain and reduce advantages such as changing number of times.
Yet bacteria cellulose itself does not have anti-microbial property, is difficult to tackle the wound of infectation of bacteria.Argent and compound thereof are present the most frequently used inorganic antiseptics, are particularly useful for treating empyrosis and chronic ulcer wound.Nano silver particles is because surface effects, and antibacterial ability is more than 200 times of micro nanometer silver particle, therefore, is " ideal " medical wound dressing that carrier loaded nano silver particles will be expected to obtain to have the efficient moisture-retention antibacterial with the bacteria cellulose of rich hydroxyl.Grandson east equality people is carrier with the bacteria cellulose, formaldehyde is that reductive agent adopts the synthetic Ag-carrying bacterial cellulose matrix material of liquid phase chemical reduction method, gained Nano silver grain median size all has the ideal anti-microbial property to intestinal bacteria, yeast and Candida albicans etc. about 45nm.People such as Marques are matrix with bacteria cellulose and common vegetable fibre respectively, adopt NaBH
4In-situ reducing AgNO
3Method synthesizing nano-silver simple substance on cellulose membrane, the result shows that the silver-colored charge capacity of bacteria cellulose fibre can reach more than 50 times of vegetable fibre, and to Ag
+Having more persistent controlled-release function, is a kind of good nanometer silver synthetic substrate.NaBH is adopted in above-mentioned research mostly
4, chemical reagent such as formaldehyde is reductive agent, these reagent have higher human toxicity usually, reaction finishes the back and is difficult to solve the residue problem of reagent in tunica fibrosa, especially is not suitable for being applied to the preparation of bio-medical material product.Therefore, press for the preparation method of the silver nanoparticle-containing bacteria cellulose material of a kind of green safety of exploitation.
Summary of the invention
Technical problem to be solved by this invention provides bacteria cellulose film of a kind of silver nanoparticle-containing and preparation method thereof, and this bacteria cellulose film anti-microbial property height, good permeability, water-holding power is strong, water ratio is controlled, and is suitable to wound medical dressing; Need not chemical reduction reagent and participate in, the processing condition green safety, equipment is simple, pollution-free.
The bacteria cellulose film of a kind of silver nanoparticle-containing of the present invention, wherein Nano silver grain is attached to the primitive fiber surface of bacteria cellulose film tridimensional network, and Nano silver grain content accounts for the 0.1-15% of gross weight, and particle diameter is 8-50nm; Its preparation method comprises:
Bacteria cellulose film is at room temperature immersed immersion taking-up after 10 minutes-5 hours in the silver salt solution that concentration of silver ions is 0.0001mol/L-0.5mol/L, clean the bacteria cellulose film surface with distilled water then, adopt uv irradiating method irradiation 0.5-6 hour afterwards, obtain the bacterial cellulose wet-coating of silver nanoparticle-containing, after processed, obtain the bacteria cellulose film of silver nanoparticle-containing.
Described bacteria cellulose film by acetobacter xylinum, produce a kind of in acetobacter, acetify bacillus, Acetobacter pasteurianus, glucose bacillus, Agrobacterium, root nodule bacterium, sarcina, pseudomonas cepacia, Pseudomonas cocovenenans, the campylobacter jejuni and obtain through fermentation.Behind the substratum of cellulose membrane through the distilled water wash surface adhesion, successively adopt the method for high temperature poach and high temperature soda boiling to carry out separation and purification.The condition of high temperature poach is: place 60-100 ℃ distilled water to handle 5-12 hour bacteria cellulose film; The condition of high temperature soda boiling is: place 60-100 ℃ aqueous sodium hydroxide solution to handle 5-12 hour bacteria cellulose film.It is neutral washing bacteria cellulose film to washings repeatedly with distilled water then.
Described silver salt is Silver Nitrate or silver citrate.
Described number of times with distilled water cleaning bacteria cellulose film surface is advisable with 2-3 time.
Described uv irradiating method, ultraviolet wavelength are 200nm-365nm.
Described dewatering comprises lyophilize, vacuum-drying, seasoning, centrifugally dewaters, heating, drying or machinery are pressed eliminating method.The water content of the bacteria cellulose film of the silver nanoparticle-containing after drying is handled is the 0-95% of wet film gross weight.
The content and the size of Nano silver grain are relevant in the bacteria cellulose film of described silver salt solution concentration and the silver nanoparticle-containing that finally obtains.Can control the content of the Nano silver grain in the final bacteria cellulose film by the concentration of silver ions of regulating silver salt solution.
Preparation method of the present invention is based on the week reduction of bacteria cellulose itself, under the condition by any chemical reduction reagent not, utilizes the synthetic Nano silver grain of method original position of uv irradiating.
Beneficial effect
(1) do not relate to any poisonous chemical reagent, green safety, pollution-free in the preparation process of the bacteria cellulose film of silver nanoparticle-containing of the present invention, especially meet the product requirement of bio-medical material;
(2) content of Nano silver grain of the present invention and particle diameter are controlled, specifically can be by changing the size of silver salt solution concentration, uv irradiating condition, treatment time control Nano silver grain;
(3) preparation process of the present invention is simple, easy to operate, pollution-free, belongs to green synthesis and production process;
(4) the bacteria cellulose film anti-microbial property of the silver nanoparticle-containing that obtains of the present invention is good, and good permeability, water-holding power is strong, water ratio is controlled, and is suitable to wound medical dressing.
Embodiment
Below in conjunction with specific embodiment, further set forth the present invention.Should be understood that these embodiment only to be used to the present invention is described and be not used in and limit the scope of the invention.Should be understood that in addition those skilled in the art can make various changes or modifications the present invention after the content of having read the present invention's instruction, these equivalent form of values fall within the application's appended claims institute restricted portion equally.
Embodiment 1
With acetobacter xylinum fermentative preparation bacteria cellulose film, successively carry out high temperature poach and high temperature soda boiling and be placed in the silver nitrate solution of 0.1mol/l and soaked 1 hour.Clean the bacteria cellulose film surface 2 times with distilled water then, and bacteria cellulose film is flat on following the irradiation 4 hours of ultraviolet lamp of 254nm.The bacteria cellulose film that obtains is carried out lyophilize to be handled and promptly to obtain the bacteria cellulose dry film of water content near 0% silver nanoparticle-containing.
Embodiment 2
To produce acetobacter fermentative preparation bacteria cellulose film, and successively carry out high temperature poach and high temperature soda boiling and be placed in the silver nitrate solution of 0.000lmol/l and soaked 5 hours.Clean the bacteria cellulose film surface with distilled water then, and bacteria cellulose film is flat on following the irradiation 0.5 hour of ultraviolet lamp of 365nm.Partial dehydration was carried out in the bacteria cellulose film vacuum-drying that obtains in 6 hours, promptly obtain water ratio and be the bacteria cellulose film of 10% silver nanoparticle-containing.
Embodiment 3
The acetify bacillus fermentation is prepared bacteria cellulose film, successively carry out high temperature poach and high temperature soda boiling and be placed in the silver nitrate solution of 0.2mol/l and soaked 4 hours.Clean the bacteria cellulose film surface with distilled water then, and bacteria cellulose film is flat on following the irradiation 6 hours of ultraviolet lamp of 254nm.With the centrifugal part moisture that removes of the bacteria cellulose film that obtains, promptly obtain the bacteria cellulose film that water ratio is 95% silver nanoparticle-containing.
Embodiment 4
With Acetobacter pasteurianus fermentative preparation bacteria cellulose film, successively carry out high temperature poach and high temperature soda boiling and be placed in the silver nitrate solution of 0.3mol/l and soaked 5 hours.Clean the bacteria cellulose film surface 3 times with distilled water then, and bacteria cellulose film is flat on following the irradiation 5 hours of ultraviolet lamp of 365nm.Partial dehydration was carried out in seasoning under the bacteria cellulose film room temperature that obtains in 6 hours, promptly obtain water ratio and be the bacteria cellulose film of 20% silver nanoparticle-containing.
Embodiment 5
With Agrobacterium fermentative preparation bacteria cellulose film, successively carry out high temperature poach and high temperature soda boiling and be placed in the silver nitrate solution of 0.4mol/l and soaked 10 minutes.Clean the bacteria cellulose film surface with distilled water then, and bacteria cellulose film is flat on following the irradiation 6 hours of ultraviolet lamp of 365nm.Place 60 ℃ of baking oven internal heating to carry out partial dehydration in dry 10 hours the bacteria cellulose film that obtains, promptly obtain water ratio and be the bacteria cellulose film of 5% silver nanoparticle-containing.
Embodiment 6
With Pseudomonas cocovenenans fermentative preparation bacteria cellulose film, successively carry out high temperature poach and high temperature soda boiling and be placed in the silver nitrate solution of 0.0001mol/l and soaked 5 hours.Clean the bacteria cellulose film surface with distilled water then, and bacteria cellulose film is flat on following the irradiation 5 hours of ultraviolet lamp of 200nm.The method of the bacteria cellulose film mechanical presses that obtains is carried out partial dehydration, promptly obtain water ratio and be the bacteria cellulose film of 60% silver nanoparticle-containing.
Embodiment 7
With campylobacter jejuni fermentative preparation bacteria cellulose film, successively carry out high temperature poach and high temperature soda boiling and be placed in the silver nitrate solution of 0.5mol/l and soaked 5 hours.Clean the bacteria cellulose film surface with distilled water then, and bacteria cellulose film is flat on following the irradiation 6 hours of ultraviolet lamp of 365nm.The bacteria cellulose film natural drying at room temperature that obtains is carried out partial dehydration in 10 hours, promptly obtain water ratio and be the bacteria cellulose film of 30% silver nanoparticle-containing.
Claims (6)
1. the bacteria cellulose film of a silver nanoparticle-containing, it is characterized in that: Nano silver grain is attached to the primitive fiber surface of bacteria cellulose film tridimensional network in this bacteria cellulose film, Nano silver grain content accounts for the 0.1-15% of gross weight, and particle diameter is 8-50nm; Its preparation method comprises:
Bacteria cellulose film is at room temperature immersed immersion taking-up after 10 minutes-5 hours in the silver salt solution that concentration of silver ions is 0.0001mol/L-0.5mol/L, clean the bacteria cellulose film surface with distilled water then, adopt uv irradiating method irradiation 0.5-6 hour afterwards, obtain the bacterial cellulose wet-coating of silver nanoparticle-containing, after processed, obtain the bacteria cellulose film of silver nanoparticle-containing.
2. the bacteria cellulose film of a kind of silver nanoparticle-containing according to claim 1 is characterized in that: described bacteria cellulose film by acetobacter xylinum, produce a kind of in acetobacter, acetify bacillus, Acetobacter pasteurianus, glucose bacillus, Agrobacterium, root nodule bacterium, sarcina, pseudomonas cepacia, Pseudomonas cocovenenans, the campylobacter jejuni and obtain through fermentation.
3. the bacteria cellulose film of a kind of silver nanoparticle-containing according to claim 1, it is characterized in that: described silver salt is Silver Nitrate or silver citrate.
4. the bacteria cellulose film of a kind of silver nanoparticle-containing according to claim 1, it is characterized in that: described uv irradiating method, ultraviolet wavelength are 200nm-365nm.
5. the bacteria cellulose film of a kind of silver nanoparticle-containing according to claim 1 is characterized in that: the method for described processed is lyophilize, vacuum-drying, seasoning, centrifugally dewater, heating, drying or machinery are pressed and removed.
6. the bacteria cellulose film of a kind of silver nanoparticle-containing according to claim 1, it is characterized in that: the water content of the bacteria cellulose film of described silver nanoparticle-containing after processed is the x% of wet film gross weight, wherein 0＜x≤95.
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Cited By (15)
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| CN102641517A (en) * | 2011-11-04 | 2012-08-22 | 周业平 | Amorphous hydrocolloid dressing |
| CN102727926A (en) * | 2011-12-12 | 2012-10-17 | 北京科技大学 | Preparation method of polysaccharide-nanometer bacterial cellulose composite wound dressing |
| CN102775643A (en) * | 2012-07-10 | 2012-11-14 | 东华大学 | Preparation method for nano-sliver/cellulose nanocrystalline composite particle |
| CN103566771A (en) * | 2013-11-18 | 2014-02-12 | 武汉艾科滤膜技术有限公司 | Drying method for microporous film |
| CN104153120A (en) * | 2014-06-26 | 2014-11-19 | 浙江理工大学 | Antibacterial medical dressing film carrying nano-silver and cellulose nanocrystalline hybrid materials and preparation method thereof |
| CN106267300A (en) * | 2015-05-14 | 2017-01-04 | 北京化工大学 | A kind of multifunctional material having bactericidal haemostatic and biochemical war agent protective concurrently and preparation method thereof |
| CN106620809A (en) * | 2017-01-18 | 2017-05-10 | 山东纳美德生物科技有限公司 | Preparation method of bacterial cellulose membrane-based antibacterial dressing |
| CN107699874A (en) * | 2017-09-15 | 2018-02-16 | 天津科技大学 | A kind of nano silver fibre element composite and its preparation method and application |
| CN108484953A (en) * | 2018-05-09 | 2018-09-04 | 台州骊威环保科技有限公司 | Antibacterial composite membrane of cellulose and its preparation method and application is made with pineapple leaves |
| CN108888799A (en) * | 2018-06-25 | 2018-11-27 | 东莞市联洲知识产权运营管理有限公司 | A kind of enhanced compound cellulose medical dressing and preparation method thereof with disinsectization performance |
| CN111171361A (en) * | 2020-03-12 | 2020-05-19 | 黄旭萍 | Bacterial cellulose composite membrane for medical dressing and preparation method thereof |
| CN111228302A (en) * | 2020-02-27 | 2020-06-05 | 青岛科技大学 | Antibacterial hydrogel and preparation method and application thereof |
| CN113575612A (en) * | 2021-07-19 | 2021-11-02 | 常州大学 | Antibacterial film with gold nanosheet loaded on bacterial cellulose and preparation method and application thereof |
| CN115612156A (en) * | 2022-09-14 | 2023-01-17 | 福建师范大学 | Ag NPs-BCM substrate, preparation method thereof and application thereof in cancer marker detection |
| CN116036344A (en) * | 2023-02-14 | 2023-05-02 | 中国人民解放军总医院第一医学中心 | Anti-infection dressing and preparation method thereof |
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Cited By (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102641517A (en) * | 2011-11-04 | 2012-08-22 | 周业平 | Amorphous hydrocolloid dressing |
| CN102641517B (en) * | 2011-11-04 | 2013-08-28 | 周业平 | Amorphous hydrocolloid dressing |
| CN102727926A (en) * | 2011-12-12 | 2012-10-17 | 北京科技大学 | Preparation method of polysaccharide-nanometer bacterial cellulose composite wound dressing |
| CN102727926B (en) * | 2011-12-12 | 2015-10-07 | 北京科技大学 | The preparation method of the composite wound dressing of a kind of polysaccharide and nanometer bacteria cellulose |
| CN102775643A (en) * | 2012-07-10 | 2012-11-14 | 东华大学 | Preparation method for nano-sliver/cellulose nanocrystalline composite particle |
| CN102775643B (en) * | 2012-07-10 | 2014-07-02 | 东华大学 | Preparation method for nano-sliver/cellulose nanocrystalline composite particle |
| CN103566771A (en) * | 2013-11-18 | 2014-02-12 | 武汉艾科滤膜技术有限公司 | Drying method for microporous film |
| CN104153120A (en) * | 2014-06-26 | 2014-11-19 | 浙江理工大学 | Antibacterial medical dressing film carrying nano-silver and cellulose nanocrystalline hybrid materials and preparation method thereof |
| CN106267300B (en) * | 2015-05-14 | 2020-09-15 | 北京化工大学 | Multifunctional material with sterilization and hemostasis performance and biochemical warfare agent protection performance and preparation method thereof |
| CN106267300A (en) * | 2015-05-14 | 2017-01-04 | 北京化工大学 | A kind of multifunctional material having bactericidal haemostatic and biochemical war agent protective concurrently and preparation method thereof |
| CN106620809A (en) * | 2017-01-18 | 2017-05-10 | 山东纳美德生物科技有限公司 | Preparation method of bacterial cellulose membrane-based antibacterial dressing |
| CN107699874A (en) * | 2017-09-15 | 2018-02-16 | 天津科技大学 | A kind of nano silver fibre element composite and its preparation method and application |
| CN108484953A (en) * | 2018-05-09 | 2018-09-04 | 台州骊威环保科技有限公司 | Antibacterial composite membrane of cellulose and its preparation method and application is made with pineapple leaves |
| CN108888799A (en) * | 2018-06-25 | 2018-11-27 | 东莞市联洲知识产权运营管理有限公司 | A kind of enhanced compound cellulose medical dressing and preparation method thereof with disinsectization performance |
| CN111228302A (en) * | 2020-02-27 | 2020-06-05 | 青岛科技大学 | Antibacterial hydrogel and preparation method and application thereof |
| CN111171361A (en) * | 2020-03-12 | 2020-05-19 | 黄旭萍 | Bacterial cellulose composite membrane for medical dressing and preparation method thereof |
| CN113575612A (en) * | 2021-07-19 | 2021-11-02 | 常州大学 | Antibacterial film with gold nanosheet loaded on bacterial cellulose and preparation method and application thereof |
| CN115612156A (en) * | 2022-09-14 | 2023-01-17 | 福建师范大学 | Ag NPs-BCM substrate, preparation method thereof and application thereof in cancer marker detection |
| CN115612156B (en) * | 2022-09-14 | 2024-03-01 | 福建师范大学 | Ag NPs-BCM substrate, preparation method thereof and application thereof in cancer marker detection |
| CN116036344A (en) * | 2023-02-14 | 2023-05-02 | 中国人民解放军总医院第一医学中心 | Anti-infection dressing and preparation method thereof |
| CN116036344B (en) * | 2023-02-14 | 2023-09-12 | 中国人民解放军总医院第一医学中心 | Anti-infection dressing and preparation method thereof |
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Application publication date: 20111005 |