CN102205109A - Chinese medicinal composition for treating rheumatism and application thereof - Google Patents
Chinese medicinal composition for treating rheumatism and application thereof Download PDFInfo
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- CN102205109A CN102205109A CN2011101412819A CN201110141281A CN102205109A CN 102205109 A CN102205109 A CN 102205109A CN 2011101412819 A CN2011101412819 A CN 2011101412819A CN 201110141281 A CN201110141281 A CN 201110141281A CN 102205109 A CN102205109 A CN 102205109A
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Abstract
The invention provides a Chinese medicinal composition for treating rheumatism and application thereof. The Chinese medicinal composition is mainly prepared from Chinese herbal medicines such as rhizoma acori calami flower, European verbena, shiraia, notoginseng root and the like according to a certain weight ratio. In the Chinese medicinal composition, the Chinese herbal medicines can be crushed into fine powder directly to be used as medicines, and also can be prepared into any one common formulation with an appropriate pharmaceutic adjuvant according to the conventional preparation process. The Chinese medicinal composition has the effects of dispelling wind and removing dampness, and clinical observation indicates that the Chinese medicinal composition has an extremely good curative effect on the treatment of the rheumatism.
Description
Invention field
The invention belongs to the field of Chinese medicines, relate to the rheumatismal Chinese medicine composition of a kind of treatment, relate in particular to and a kind ofly form Chinese medicine composition by pure Chinese herbal medicine such as Rhizoma Acori Graminei, Herba Verbenae and Radix Notoginseng.
Background technology
Rheumatism is clinically common a kind ofly to be changed to main systemic disease with the joint, it is a kind of disease of containing blood matter, its main pathological change has that the joint is oozed out, lymphocytic infiltration and synovium of joint hypertrophy, it is a kind of chronic inflammatory disease process of outbreak repeatedly, belong to autoimmune disease, may be relevant with multiple factors such as infection, heredity and disorder of immune mechanism, people's living habit.
Traditional Chinese medical theory thinks that " rheumatism " is " strongly fragrant " card, belongs to " arthralgia aggravated by cold " disease category.Be rheumatismal generation mainly by due to four kinds of viruses " dampness, wet water, toxenia, toadstool ", so " wind and cold is wet " evil steroid does not for a long time loose, directly go into internal organs " spleen kidney " in the invasion and attack body, the consequently generation of all diseases that descends of outer and joint swelling and pain, interior and biochemical function.The rheumatism disease mainly shows as: headache, shoulder pain, lumbago, arthralgia etc. and severe pain unbearably, very the person also has gargalesthesia, severe patient can cause osteodynia.So the inventor is on pathogeny and the symptom, with the Rhizoma Acori Graminei is monarch drug, the Herba Verbenae of expelling wind and removing dampness, Caulis Sargentodoxae, each medical material is ingenious combines for the Radix Notoginseng of promoting blood circulation to remove obstruction in the collateral, Flos Carthami etc., through clinical research confirmation, Chinese medicine composition of the present invention is imitated satisfactory at treatment rheumatism formula pustule on the face, have good social benefit and clinical value.
Summary of the invention
Purpose of the present invention aims to provide rheumatismal Chinese medicine composition of being used for the treatment of of a kind of determined curative effect.
The objective of the invention is to realize by following manner:
The inventor gropes to choose through clinical treatment, and each crude drug of the present composition is formed and consumption is in the following weight parts scope treatment rheumatism all to be had curative effect preferably:
Rhizoma Acori Calami is spent 5～7 parts of 30～40 parts, 40～60 parts of Herba Verbenae, 4～6 parts of Radix Notoginseng, 6～8 parts of Concretio silicea Bambusae seu schizostachyis, 5～7 parts in Herba Ephedrae, 5～7 parts of native wall worms, 7～9 parts of Radix Sophorae Flavescentiss, 4～6 parts of Caulis Sargentodoxae, 5～7 parts on Flos Carthami, 8～10 parts of logical muscle grass, 8～10 parts of Rhizoma Zingiberiss and Pericarpium Citri Reticulatae.
Each crude drug of the present composition is formed and consumption is in the following weight parts scope treatment rheumatism to be had best curative effect:
Rhizoma Acori Calami is spent 6 parts of 35 parts, 50 parts of Herba Verbenae, 5 parts of Radix Notoginseng, 7 parts of Concretio silicea Bambusae seu schizostachyis, 6 parts in Herba Ephedrae, 6 parts of native wall worms, 8 parts of Radix Sophorae Flavescentiss, 5 parts of Caulis Sargentodoxae, 6 parts on Flos Carthami, 9 parts of logical muscle grass, 9 parts of Rhizoma Zingiberiss and Pericarpium Citri Reticulatae.
The selected medical material of respectively distinguishing the flavor of of Chinese medicine composition of the present invention, Rhizoma Acori Calami is spent warm in nature, acrid in the mouth, hardship, can declare gas to pursue expectorant, the detoxifcation parasite killing is widely used in the numbness disease that treatment is caused by anemofrigid-damp arthralgia in clinical, Herba Verbenae bitter in the mouth cool in nature, return liver, spleen channel, the effect of have inducing diuresis to remove edema, detoxifying and invigorating blood circulation is the principal agent of removing heat from blood removing blood stasis, the two 5 usefulness, be all monarch drug, play the effect of the detoxifcation of a surname's gas, promoting blood circulation and detumescence altogether, thus the arthromyodynia of effectively anti-rheumatism treating.Selected Concretio silicea Bambusae seu schizostachyi is flat, lightly seasoned, the energy expelling wind and removing dampness, and the easypro warp of invigorating blood circulation, selected Radix Notoginseng, Flos Carthami, Caulis Sargentodoxae and native wall worm are the good medicine of blood circulation promoting and blood stasis dispelling, can work in coordination with the monarch drug expelling wind and removing dampness, also can strengthen the effect of its easypro warp of invigorating blood circulation.And Radix Sophorae Flavescentis bitter in the mouth cold in nature, energy principal drug assistance heat clearing and damp drying, wind dispelling insecticide are all ministerial drug with above-mentioned each medicine in we; Selected Herba Ephedrae acrid in the mouth warm in nature, little hardship, can diaphoresis cold expelling, inducing diuresis to remove edema is messenger drug with the logical muscle grass of invigorate blood circulation logical muscle, inducing diuresis to remove edema, altogether with helping all monarch-minister drug cold expelling diuretic, promoting blood circulation by removing wind.Selected Rhizoma Zingiberis, with the Pericarpium Citri Reticulatae toxin expelling that all can sterilize be adjuvant drug, help ladies and gentlemen, minister, adjuvant drug sterilization, Rhizoma Zingiberis can be strengthened the wet cold expelling effect of moving back of paralyses pain in addition.So all medicines share, and play the effect of heat-clearing and toxic substances removing, expelling wind and removing dampness, promoting blood circulation to remove obstruction in the collateral altogether, cure mainly the disease of each rheumatoid disease.
This Chinese medicine composition can be used for being prepared into the pharmaceutical preparation of treatment rheumatism.The present composition can be ground into each crude drug behind the fine powder directly oral as powder, also can adopt the conventional method of Chinese medicine preparation to be prepared into any conventional formulation, the active component that is about to the medicine of the present invention of gained adds various conventional adjuvant required when preparing different dosage form, as disintegrating agent, lubricant, binding agent etc., be prepared into any modern preparation that allows on the pharmaceutics with the method for Chinese medicinal of routine.
The oral effective daily dose of the present invention is 15～100g raw medicinal herbs, divides and takes for 2～3 times, if the oral warm water delivery service that needs.
Test example, Chinese medicine composition clinical observation of the present invention
The inventor accepted example surplus the rheumatisant 200 for medical treatment in ChangSha, Hunan Province county one community clinic during 2006 to 2010, with Chinese medicine composition composition powders of the present invention is medicine, and cooperation cupping therapy, obtain satisfactory effect, and treat 150 routine patients with the tripterygium glycosides sheet and contrast, now gather the treatment situation as follows:
Treatment is organized in 200 examples, male 124 examples, and women 76 examples, at 20～70 years old age, the mean age is 54 years old, the course of disease 6 months to 18 years, average 8 years; In matched group 150 examples, male 87 examples, women 63 examples, 25～72 years old age, 52 years old mean age, the course of disease 7 months to 16 years, average 7 years.Treat between preceding two groups sex, age and the course of disease and learn by statistics and handle difference and do not have significance, have comparability.
With reference to diagnostic criteria and tcm syndrome typing that Americanism damp disease association formulated in 1987 two groups of patients are treated respectively.The treatment group is taken present composition powder, warm water delivery service, and one day twice, each once wrapped for one time 1 sooner or later.Matched group is taken the tripterygium glycosides sheet, every day 3 times, each 2.Two groups was a course of treatment with 1 month all, treated continuously 1～3 month.Stopping using in the therapeutic process, other have the medicine of therapeutic effect to this disease, and join cupping therapy simultaneously.Observe clinical symptoms feature and record, observe untoward reaction simultaneously.Contrast and treatment front and back comparative result such as following table between group:
Symptom and sign improves the situation comparison sheet before and after two groups of patient treatments
Annotate: relatively preceding with the treatment of this group, * P＜0.05, * * P＜0.01; With comparison after the treatment of control group, △ P＜0.05
Uncomfortable 3 examples of digestive tract appear in the treatment group in therapeutic process, adverse reaction rate is 1.5%, and uncomfortable 18 examples of upper digestive tract, cardiopalmus 17 examples appear in matched group, dizzy 9 examples, adverse reaction rate is 29.3%, two group and compares, before and after the treatment, two groups of patient's symptom and signs all are greatly improved, but the curative effect of treatment group obviously is better than matched group, and adverse reaction rate is extremely low, and the two difference has significance.This shows that Chinese medicine composition of the present invention is not only evident in efficacy, and safe.
In sum, Chinese medicine composition of the present invention has stronger therapeutical effect to rheumatism.
The specific embodiment
Come further to set forth present composition and preparation method thereof by the following examples.
Embodiment 1, powder of the present invention
Take by weighing Rhizoma Acori Calami flower 1750g, Herba Verbenae 2500g, Radix Notoginseng 250g, Concretio silicea Bambusae seu schizostachyi 350g, Herba Ephedrae 300g, native wall worm 300g, Radix Sophorae Flavescentis 400g, Caulis Sargentodoxae 250g, Flos Carthami 300g, logical muscle grass 450g, Rhizoma Zingiberis 450g and Pericarpium Citri Reticulatae 300g, each flavor medical material except that spending, Rhizoma Acori Calami is ground into fine powder behind the clean segment that is cut into about 1cm again, the Rhizoma Acori Calami flower is cured into black powder, with two kinds of fine powder mix homogeneously, promptly get powder 1000 bags of the present invention.
Embodiment 2, tablet of the present invention
Take by weighing Rhizoma Acori Calami flower 2000g, Herba Verbenae 2000g, Radix Notoginseng 300g, Concretio silicea Bambusae seu schizostachyi 300g, Herba Ephedrae 250g, native wall worm 350g, Radix Sophorae Flavescentis 350g, Caulis Sargentodoxae 300g, Flos Carthami 250g, logical muscle grass 500g, Rhizoma Zingiberis 400g and Pericarpium Citri Reticulatae 250g, the Rhizoma Acori Calami flower cured to become to deceive powder standby, other medical materials of respectively distinguishing the flavor of are soaked after 2 hours and are decocted 2 times, each each 2 hours, merge extractive liquid,, filter, be condensed into dry extract adding Rhizoma Acori Calami and spend black powder, mix homogeneously, add suitable additive of tablet, be prepared into 1000 in tablet.
Embodiment 3, capsule of the present invention
Take by weighing Rhizoma Acori Calami flower 1500g, Herba Verbenae 3000g, Radix Notoginseng 200g, Concretio silicea Bambusae seu schizostachyi 400g, Herba Ephedrae 350g, native wall worm 250g, Radix Sophorae Flavescentis 450g, Caulis Sargentodoxae 200g, Flos Carthami 250g, logical muscle grass 400g, Rhizoma Zingiberis 500g and Pericarpium Citri Reticulatae 350g, the Rhizoma Acori Calami flower cured to become to deceive powder standby, other medical materials of respectively distinguishing the flavor of extract 2 times after 4 hours with 65% soak with ethanol, each 3 hours, filter, it is standby to reclaim alcohol, merging filtrate also is condensed into dry extract and adds Rhizoma Acori Calami and spend black powder, mix homogeneously, add suitable capsule adjuvant, be prepared into 1000 of capsules.
Embodiment 4, plaster of the present invention
Take by weighing Rhizoma Acori Calami flower 1750g, Herba Verbenae 2500g, Radix Notoginseng 210g, Concretio silicea Bambusae seu schizostachyi 370g, Herba Ephedrae 300g, native wall worm 275g, Radix Sophorae Flavescentis 400g, Caulis Sargentodoxae 250g, Flos Carthami 350g, logical muscle grass 450g, Rhizoma Zingiberis 480g and Pericarpium Citri Reticulatae 300g, the Rhizoma Acori Calami flower cured to become to deceive powder standby, other medical materials of respectively distinguishing the flavor of extracted 1.5 hours after 3 hours with soak with ethanol, filter, it is standby to reclaim alcohol; Filtrate is condensed into equivalent extract adding Rhizoma Acori Calami spends black powder, mix homogeneously adds suitable an amount of plaster adjuvant, is prepared into plaster 1000 according to conventional method and pastes.
Claims (4)
1. the Chinese medicine composition of an expelling wind and removing dampness is characterized in that being made up of each crude drug of following weight parts: Rhizoma Acori Calami is spent 5～7 parts of 30～40 parts, 40～60 parts of Herba Verbenae, 4～6 parts of Radix Notoginseng, 6～8 parts of Concretio silicea Bambusae seu schizostachyis, 5～7 parts in Herba Ephedrae, 5～7 parts of native wall worms, 7～9 parts of Radix Sophorae Flavescentiss, 4～6 parts of Caulis Sargentodoxae, 5～7 parts on Flos Carthami, 8～10 parts of logical muscle grass, 8～10 parts of Rhizoma Zingiberiss and Pericarpium Citri Reticulatae.
2. Chinese medicine composition according to claim 1 is characterized in that each raw material medicines in portions by weight of described Chinese medicine composition is respectively: Rhizoma Acori Calami is spent 6 parts of 35 parts, 50 parts of Herba Verbenae, 5 parts of Radix Notoginseng, 7 parts of Concretio silicea Bambusae seu schizostachyis, 6 parts in Herba Ephedrae, 6 parts of native wall worms, 8 parts of Radix Sophorae Flavescentiss, 5 parts of Caulis Sargentodoxae, 6 parts on Flos Carthami, 9 parts of logical muscle grass, 9 parts of Rhizoma Zingiberiss and Pericarpium Citri Reticulatae.
3. Chinese medicine composition according to claim 1 and 2 is characterized in that described Chinese medicine composition is any oral formulations that allows on the raw material of described each weight portion and the pharmaceutics that suitable pharmaceutic adjuvant is prepared into.
4. Chinese medicine composition according to claim 3 is characterized in that described Chinese medicine composition is used to be prepared into the pharmaceutical preparation of treatment rheumatism.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011101412819A CN102205109B (en) | 2011-05-30 | 2011-05-30 | Chinese medicinal composition for treating rheumatism and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN2011101412819A CN102205109B (en) | 2011-05-30 | 2011-05-30 | Chinese medicinal composition for treating rheumatism and application thereof |
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| CN102205109A true CN102205109A (en) | 2011-10-05 |
| CN102205109B CN102205109B (en) | 2012-05-23 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103432315A (en) * | 2013-09-17 | 2013-12-11 | 陈玉生 | Traditional Chinese medicinal composition for treating flu and reducing fever |
| CN103816314A (en) * | 2012-11-16 | 2014-05-28 | 楚乐然 | Traditional Chinese medicine for rheumatism |
-
2011
- 2011-05-30 CN CN2011101412819A patent/CN102205109B/en not_active Expired - Fee Related
Non-Patent Citations (2)
| Title |
|---|
| 《中医药学刊》 20050510 李可大 类风湿性关节炎疼痛的辨证论治旨要 850-851 1-4 第23卷, 第05期 2 * |
| 《吉林中医药》 20041220 韦麟 类风湿性关节炎的中医治疗近况 54-56 1-4 第24卷, 第12期 2 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103816314A (en) * | 2012-11-16 | 2014-05-28 | 楚乐然 | Traditional Chinese medicine for rheumatism |
| CN103432315A (en) * | 2013-09-17 | 2013-12-11 | 陈玉生 | Traditional Chinese medicinal composition for treating flu and reducing fever |
| CN103432315B (en) * | 2013-09-17 | 2015-01-21 | 陈玉生 | Traditional Chinese medicinal composition for treating flu and reducing fever |
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| Publication number | Publication date |
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| CN102205109B (en) | 2012-05-23 |
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