CN102204550B - Sterilization composite containing metalaxyl-M and application thereof - Google Patents
Sterilization composite containing metalaxyl-M and application thereof Download PDFInfo
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- CN102204550B CN102204550B CN 201110084969 CN201110084969A CN102204550B CN 102204550 B CN102204550 B CN 102204550B CN 201110084969 CN201110084969 CN 201110084969 CN 201110084969 A CN201110084969 A CN 201110084969A CN 102204550 B CN102204550 B CN 102204550B
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Abstract
The invention discloses a sterilization composite containing metalaxyl-M and application thereof. The sterilization composite containing metalaxyl-M comprises two active components A and B, the component A is metalaxyl-M and the component B is propineb or metiram. The composite is efficient, safe and environmentally-friendly, has synergy, can be used for increasing crop production and fruit quality and lowering cost and is beneficial to the postponement of the generation of drug resistance of harmful bacteria. The composite also can be used for preventing and controlling crop banded sclerotial blight, damping off, root rot, rice blast, exserohilum turcicum, bipolaris maydis, downy mildew, phytophthora blight, leaf spot, gray mold, alternaria leaf spot, anthracnose, ring spot, powdery mildew, Leptosphaeria maculans and late blight.
Description
Technical field
The present invention relates to a kind of bactericidal composition that contains Metalaxyl-M and uses thereof.
Background technology
At present, in the pest chemical control, pest pesticide resistance problem is very serious.The fungus-caused disease of Oomycete takes place generally often to cause heavy losses in agricultural production.Metalaxyl-M is widely used in the control of corps diseases as a kind of bactericide with significant protection, treatment and eradicant action, has good control efficiency.But existing research thinks that there is high resistance risk in Metalaxyl-M to greenhouse, greenhouse crops disease.There is the complex composition of synergistic effect to reduce resistance risk to a certain extent, avoids producing the speed of resistance and delaying drug resistance generation.
Propineb is a kind of protective fungicide, acts on the synthetic of fungal cell wall and protein, can suppress infecting and sprouting of spore, can suppress mycelial growth simultaneously, causes its distortion, death.And this medicine contains and is easy to the zinc element that absorbed by crop, the quality that is conducive to promote plant growth and improves fruit.Different with the bactericidal mechanism of Metalaxyl-M, no cross resistance.No matter be what crop to use Propineb, not only do not find people and animals' intoxication accident, also do not find the contaminated environment phenomenon, and the equal non agricultural chemical residuum of agricultural byproducts.
Summary of the invention
What the object of the present invention is to provide a kind of efficient, safety, environmental protection contains bactericidal composition of Metalaxyl-M and uses thereof.
Technical solution of the present invention is:
A kind of bactericidal composition that contains Metalaxyl-M is characterized in that: active ingredient is become to be grouped into for two kinds by A and B, and composition A is Metalaxyl-M, and composition B is Propineb or Carbatene.
The mass ratio of effective constituents A and B is 60: 1～1: 80.
The gross mass percentage composition of active ingredient in bactericidal composition is 1～90%.
The formulation of described microbicide compositions is water dispersible granules, aqua, wetting powder, suspending agent, missible oil, aqueous emulsion or granule.
A kind of application of bactericidal composition in the medicine of preparation control crop banded sclerotial blight, damping off, root rot, rice blast, corn northern and southern leaf blight, downy mildew, eqpidemic disease, leaf spot, gray mold, spot defoliation, anthracnose, ring spot, powdery mildew, balck shank, late blight that contains Metalaxyl-M.
Described crop is paddy rice, wheat, corn, vegetables, fruit tree, melon and fruit, tobacco or potato.
The present invention is efficient, safety, environmental protection, and composition has synergistic effect, can improve crop yield, improve fruit quality, reduce cost and be of value to and delay the drug-fast generation of germ.
The invention will be further described below in conjunction with embodiment.
Embodiment
Embodiment 1:
With Metalaxyl-M 4g, Propineb 32g, calcium dodecyl benzene sulfonate 6g, phenethyl phenol polyethenoxy ether 4g, dimethylbenzene adds to 100g, is mixed to homogeneous phase liquid, makes composition missible oil.
Embodiment 2:
With Metalaxyl-M 5g, Propineb 64g, sodium lignin sulfonate 8g, diffusant sodium methylene bis-naphthalene sulfonate 4g, White Carbon black adds to 100g, and mixture carries out air-flow to be pulverized, and makes wetting powder.
Embodiment 3:
With Metalaxyl-M 2g, Propineb 16g, phenethyl phenol formaldehyde resin APEO 3g, basic phenol mela mine-formaldehyde resin APEO 2g, antifreeze ethylene glycol, glycerine 5g, dispersant fatty alcohol polyoxy ethyl ether 5g, antisettling agent xanthans 1g, suitable quantity of water is mixed, through the homogenizer high speed shear, make aqueous emulsion.
Embodiment 4
With Metalaxyl-M 5g, Propineb 48g, dispersant fatty alcohol polyoxy ethyl ether 5g, polyoxyethylene nonylphenol ether 3g, starch 1.2g, sodium bicarbonate 1g, bentonite 12g, kaolin adds to 100, mixes, and makes the dispersibility granula through pulverizing granulation.
Biological example:
The synergistic function of the present composition can illustrate by following example, but the present invention only limits to this by no means.
Take by weighing an amount of reactive compound acetone solution, water is mixed with the solution of described concentration with each compound, mixes by described proportioning equal proportion, obtains described proportioning and concentration.
The EC of each medicament is obtained in linear regression analysis between probit value by inhibiting rate and the logarithm value of serial drug concentration
50, according to the interaction that the method for Wadley is calculated mixed agent, A, B represent two medicament components respectively, and a|, b are the ratios of each component content in mixture.Analyze the effect be mixed with the SR value.Wherein: SR=0.5～1.5, two kinds of medicaments addition that has been mixed then, SR≤0.5, two kinds of medicaments antagonism that has been mixed then, SR 〉=1.5, then two kinds of medicaments synergistic effect that has been mixed.
The computational methods of SR value are:
EC
50(theoretical value)=(a+b)/(a/EC
50a+ b/EC
50b)
SR=EC
50(theoretical value)/EC
50(real value)
1, to the effect of apple tree spot defoliation.
The mycelial growth rate method is adopted in test.The previously prepared inoculated by hypha block of picking is on the EPA of different drug concentrations culture medium flat plate, cultivated 7 days down at 25 ℃, check colony diameter, calculate the percentage that each chemicals treatment suppresses mycelial growth, the EC of each medicament is obtained in linear regression analysis between probit value by inhibiting rate and the logarithm value of serial drug concentration
50, the interaction of calculating mixed agent according to the method for Wadley.
The reactive compound that table 1 is independent
| Embodiment | Reactive compound | EC 50μ g/ml (theoretical value) | EC 50μ g/ml (observed value) | SR 50 |
| 1 | The I Metalaxyl-M | 1.3056 | ||
| 2 | The II Propineb | 1.1098 | ||
| 3 | The III Carbatene | 1.1209 |
Table 2 mixture of the present invention
SR 〉=1.5, showing after both are mixed has obvious synergistic effect.
2, to the effect of black shank.
The mycelial growth rate method is adopted in test.The previously prepared inoculated by hypha block of picking is on the EPA of different drug concentrations culture medium flat plate, cultivated 6 days down at 22 ℃, check colony diameter, calculate the percentage that each chemicals treatment suppresses mycelial growth, the EC of each medicament is obtained in linear regression analysis between probit value by inhibiting rate and the logarithm value of serial drug concentration
50, the interaction of calculating mixed agent according to the method for Wadley.
The reactive compound that table 3 is independent
| Embodiment | Reactive compound | EC 50μ g/ml (theoretical value) | EC 50μ g/ml (observed value) | SR 50 |
| 12 | The I Metalaxyl-M | 0.0200 | ||
| 13 | The II Propineb | 1.3261 | ||
| 14 | The III Carbatene | 1.6723 |
Table 4 mixture of the present invention
SR 〉=1.5, showing after both are mixed has obvious synergistic effect.
3, to the effect of potato late blight.
Phytophthora infestans separation from Shandong Province's potato leaf, purifying, evaluation obtain.Before measuring, on the rye culture medium flat plate, cultivated 10 days in advance under 18 ℃, beat cut-off footpath 5mm mycelia piece at colony edge and be used for mensuration.The previously prepared inoculated by hypha block of picking is on the culture medium flat plate of different drug concentrations, mycelia faces up, after cultivating 12 days under 18 ℃, check colony diameter, calculate the percentage that each chemicals treatment suppresses mycelial growth, the EC of each medicament is obtained in linear regression analysis between probit value by inhibiting rate and the logarithm value of serial drug concentration
50, the interaction of calculating mixed agent according to the method for Wadley.
The reactive compound that table 5 is independent
| Embodiment | Reactive compound | EC 50μ g/ml (theoretical value) | EC 50μ g/ml (observed value) | SR 50 |
| 23 | The I Metalaxyl-M | 0.0057 | ||
| 24 | The II Propineb | 0.6860 | ||
| 25 | The III Carbatene | 0.9641 |
Table 6 mixture of the present invention
SR 〉=1.5, showing after both are mixed has obvious synergistic effect.
4, to the effect of capsicum epidemic disease
The previously prepared capsicum epidemic disease mycelia of picking piece is inoculated on the EPA culture medium flat plate of different drug concentrations, mycelia faces up, cultivated 5 days down at 22 ℃, check colony diameter, calculate the percentage that each chemicals treatment suppresses mycelial growth, the EC of each medicament is obtained in linear regression analysis between probit value by inhibiting rate and the logarithm value of serial drug concentration
50, the interaction of calculating mixed agent according to the method for Wadley.
The reactive compound that table 7 is independent
| Embodiment | Reactive compound | EC 50μ g/ml (theoretical value) | EC 50μ g/ml (observed value) | SR 50 |
| 34 | The I Metalaxyl-M | 0.032 | ||
| 35 | The II Propineb | 1.7892 | ||
| 36 | The III Carbatene | 1.9638 |
Table 8 mixture of the present invention
SR 〉=1.5, showing after both are mixed has obvious synergistic effect.
5, to the cucumber downy mildew effect
The mycelial growth rate method is adopted in test.The previously prepared inoculated by hypha block of picking is on the culture medium flat plate of different drug concentrations, cultivated 3 days down at 25 ℃, check colony diameter, calculate the percentage that each chemicals treatment suppresses mycelial growth, the EC of each medicament is obtained in linear regression analysis between probit value by inhibiting rate and the logarithm value of serial drug concentration
50, the interaction of calculating mixed agent according to the method for Wadley.
The reactive compound that table 9 is independent
| Embodiment | Reactive compound | EC 50μ g/ml (theoretical value) | EC 50μ g/ml (observed value) | SR 50 |
| 45 | The I Metalaxyl-M | 3.6800 | ||
| 46 | The II Propineb | 3.7410 | ||
| 47 | The III Carbatene | 4.8743 |
Table 10 mixture of the present invention
SR 〉=1.5, showing after both are mixed has obvious synergistic effect.
6, the effect of rice seedling blight
Rice seedling blight bacterium separation, purifying and carry out tieback and identify and obtain from the withered seedling of browning experimental field.Before measuring, on the PSA culture medium flat plate, cultivate 30h under 25 ℃ in advance, beat cut-off footpath 5mm mycelia piece at colony edge and be used for mensuration.The mycelia piece that picking has prepared is dressed seed on the culture medium flat plate that contains different chemicals treatment, and mycelia faces up, and checks colony diameter after cultivating 8 days under 25 ℃.The EC of each medicament is obtained in linear regression analysis between probit value by inhibiting rate and the logarithm value of serial drug concentration
50, the interaction of calculating mixed agent according to the method for Wadley.
The reactive compound that table 11 is independent
| Embodiment | Reactive compound | EC 50μ g/ml (theoretical value) | EC 50μ g/ml (observed value) | SR 50 |
| 56 | The I Metalaxyl-M | 0.0383 | ||
| 57 | The II Propineb | 2.1487 | ||
| 58 | The III Carbatene | 2.4650 |
Table 12 mixture of the present invention
SR 〉=1.5, showing after both are mixed has obvious synergistic effect.
Application method: foliar spray, seed treatment, the dispenser of pouring root.
Claims (3)
1. bactericidal composition that contains Metalaxyl-M, it is characterized in that: active ingredient is become to be grouped into for two kinds by A and B, and composition A is Metalaxyl-M, and composition B is Propineb or Carbatene; The mass ratio of active ingredient Metalaxyl-M and Propineb is 1:2～1:16, and the mass ratio of Metalaxyl-M and Carbatene is 1:2～1:15.
2. the bactericidal composition that contains Metalaxyl-M according to claim 1, it is characterized in that: the gross mass percentage composition of active ingredient in bactericidal composition is 1～90%.
3. the bactericidal composition that contains Metalaxyl-M according to claim 1 and 2, it is characterized in that: the formulation of described microbicide compositions is water dispersible granules, aqua, wetting powder, suspending agent, missible oil, aqueous emulsion or granule.
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| CN 201110084969 CN102204550B (en) | 2011-04-06 | 2011-04-06 | Sterilization composite containing metalaxyl-M and application thereof |
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| CN102204550B true CN102204550B (en) | 2013-09-25 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110973145A (en) * | 2019-12-29 | 2020-04-10 | 江苏宝灵化工股份有限公司 | Sterilization composition of metalaxyl-M and mancozeb and application |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103270915B (en) * | 2012-08-22 | 2015-03-18 | 湖北省烟草科研所 | Method for preventing and treating tobacco bacterial wilt |
| CA2890635C (en) * | 2012-11-22 | 2022-12-06 | Basf Corporation | Synergistic pesticidal mixtures comprising bacillus subtilis mbi-600 |
| CN103782851A (en) * | 2014-02-26 | 2014-05-14 | 云南省烟草公司楚雄州公司 | Method for preventing tobacco black shank |
| CN103875690A (en) * | 2014-03-14 | 2014-06-25 | 曹荣成 | Propineb and metalaxyl-M compound bactericidal composition |
| CN104396962B (en) * | 2014-12-03 | 2015-12-30 | 北京燕化永乐生物科技股份有限公司 | Composition pesticide |
| CN105475394A (en) * | 2015-12-27 | 2016-04-13 | 胡凡营 | Biological bactericide containing propineb and metalaxyl-M |
| CN110973133A (en) * | 2019-12-30 | 2020-04-10 | 江苏宝灵化工股份有限公司 | metalaxyl-M and propineb compound sterilization composition and application thereof |
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| EP0230209A3 (en) * | 1985-12-16 | 1987-08-12 | Ciba-Geigy Ag | Microbicides |
| IT1196465B (en) * | 1986-07-07 | 1988-11-16 | Montedison Spa | FUNGICIDE MIXTURES |
| CH687169A5 (en) * | 1994-07-11 | 1996-10-15 | Ciba Geigy Ag | Microbicides. |
| CN101642120A (en) * | 2009-07-09 | 2010-02-10 | 深圳诺普信农化股份有限公司 | Pesticide composition containing dyson fungicides |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN110973145A (en) * | 2019-12-29 | 2020-04-10 | 江苏宝灵化工股份有限公司 | Sterilization composition of metalaxyl-M and mancozeb and application |
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