CN102204537A - Antibacterial composition containing fluopicolide and ethofenprox - Google Patents
Antibacterial composition containing fluopicolide and ethofenprox Download PDFInfo
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- CN102204537A CN102204537A CN2011101144919A CN201110114491A CN102204537A CN 102204537 A CN102204537 A CN 102204537A CN 2011101144919 A CN2011101144919 A CN 2011101144919A CN 201110114491 A CN201110114491 A CN 201110114491A CN 102204537 A CN102204537 A CN 102204537A
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- methyl
- kresoxim
- bacterium amine
- pyrrole bacterium
- fluorine pyrrole
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Abstract
The invention relates to a compound antibacterial agent. The active components of the compound antibacterial agent are fluopicolide and ethofenprox in a mass percentage ratio of (1-80):(80-1), and the compound agent contains 1 to 80 percent of the fluopicolide and ethofenprox. The compound antibacterial agent disclosed by the invention can be prepared into formulations including suspension, wettable powder, water dispersion granules, water emulsion, microemulsion and the like by methods known by the technicians in the field. The antibacterial composition can be used for preventing and controlling various diseases in crops, particularly diseases caused by fungi in oomycete, such as downy mildew, epidemic disease, late blight and damping off.
Description
Technical field:
The present invention relates to the composite bactericide that a kind of pesticide field has synergistic effect, its active ingredient is fluorine pyrrole bacterium amine and kresoxim-methyl.
Background technology:
Fluorine pyrrole bacterium amine, a kind of benzamide series bactericidal agent of Bayer crop science company development, its English Fluopicolide by name, chemical name is: 2,6-two chloro-N-[(3-chloro-5-trifluoromethyl-2-pyridine radicals) methyl] benzamide.Common Oomycete diseases such as downy mildew, eqpidemic disease, late blight, damping off are had outstanding preventive effect,, be specially adapted to high-quality, green vegetables production crop and Environmental security.This product has good system's conductivity and stronger thin layer penetration power, and each main form of pathogen is all had good inhibitory effect, can provide comprehensively and lasting protection for young leaves, stem, stem tuber, young fruit.Because medicament can be through the blade face fast Absorption, thus resistance of rainwater washing against, for vegetables diseases prevention in rainy season provides reliable guarantee.Its structural formula is:
Kresoxim-methyl, English name: Azoxystrobin, the chinesization formal name used at school is called: (E)-[2-[6-(2-cyano-benzene oxygen) pyrimidine-4-base oxygen] phenyl]-the 3-methoxy-methyl acrylate.Its structural formula is:
This product is first commercial methoxy acrylic bactericide that Syngenta Co.,Ltd succeeds in developing, efficiently, wide spectrum, nearly all mycota (Ascomycotina, Basidiomycotina, Mastigomycotina and Deuteromycotina) disease such as powdery mildew, rust, glume blight, net blotch, downy mildew, rice blast etc. are all had good activity.Can be used for cauline leaf spraying, seed treatment, also can carry out soil treatment, be mainly used in cereal, paddy rice, peanut, grape, potato, fruit tree, vegetables, coffee, lawn etc.
The downy mildew that is caused by the Oomycete fungal attack, eqpidemic disease are the multiple diseases of vegetables and other crops (grape, strawberry, potato etc.), have infectivity, infect soon, develop characteristics such as rapid, wayward.Often cause the underproduction significantly even cause total crop failure to crops.Especially with the large tracts of land of vegetable protecting field culture technique promote along with the increasing of China fruit tree and growing vegetables area this year, makes crop pest incidence and occurring degree that obvious enhancing all be arranged.The frequent frequency of utilization of bactericide that makes of disease constantly increases, and highdensity dispenser makes germ produce more and more serious pesticide resistance, thereby cause vicious circle, traditional bactericide such as carbendazim, aliette etc. can not effectively be controlled such disease.
Summary of the invention:
The objective of the invention is provides a kind of Synergistic bactericidal composition and application at the problems referred to above; said composition adopts fluorine pyrrole bacterium amine and kresoxim-methyl to carry out composite; play the effect of Synergistic; be used for preventing and treating the multiple diseases on the gourd, fruit and vegetable, applied widely, effective cost is low; especially has good control efficiency for downy mildew, eqpidemic disease; it is high and delay advantage such as germ resistance to have bactericidal activity, and has protection and therapeutic action concurrently, and has the effect of protecting the leaf volume increase for crops.
Bactericidal composition active ingredient of the present invention is fluorine pyrrole bacterium amine and kresoxim-methyl, is used to prevent and treat multiple fungus-caused disease, especially for the fungus-caused various diseases of Oomycete, as downy mildew, eqpidemic disease, late blight, damping off etc. special efficacy is arranged.
Bactericidal composition of the present invention is characterised in that the mass ratio of its active ingredient fluorine pyrrole bacterium amine and kresoxim-methyl is 1～80: 80～1.
Bactericidal composition of the present invention is characterised in that an active ingredient fluorine pyrrole bacterium amine is 1～30: 30～1 with the preferred mass ratio of kresoxim-methyl.
The gross mass content of fluorine pyrrole bacterium amine and kresoxim-methyl is 1～80% in the bactericidal composition of the present invention.
Bactericidal composition of the present invention adopts method known in those skilled in the art, and the preferred formulation that can be prepared into is formulations such as suspending agent, wetting powder, water dispersible granules, aqueous emulsion.
Technical solution of the present invention is as follows:
Technical scheme one under the present invention, affiliated bactericidal composition is a wetting powder:
The concrete procedure of processing of this bactericidal composition wetting powder is: press above-mentioned prescription with fluorine pyrrole bacterium amine and kresoxim-methyl and dispersant, wetting agent and filler mixing, in stirred tank, evenly stir, behind airslide disintegrating mill, mixing, promptly can be made into the wetting powder of the present composition.
Two of technical scheme of the present invention, described bactericidal composition are suspending agent, and the percentage by weight of component is:
The concrete production stage of this suspending agent is earlier other auxiliary agents to be mixed, mix through high speed shear, add fluorine pyrrole bacterium amine and kresoxim-methyl, abrading-ball is 2～3 hours in ball crusher, make a diameter all below 5 μ m, make the suspending agent preparation that contains the bactericidal composition of fluorine pyrrole bacterium amine and kresoxim-methyl of the present invention.
Three of technical scheme of the present invention, described bactericidal composition are aqueous emulsion, and the percentage by weight of component is:
The concrete production stage of this aqueous emulsion is: at first former medicine fluorine pyrrole bacterium amine is added with kresoxim-methyl, solvent and emulsifier, cosolvent and be in the same place, make and be dissolved into uniform oil phase; With part water, antifreeze, other insecticides adjuvant such as antimicrobial mixes into uniform water; When the reactor high speed stirs, oil phase is added water, slowly add water, open clipper and carry out high speed shear, and add remaining water, shear half an hour approximately, form the aqueous emulsion of oil-in-water type until reaching the phase inversion point.Promptly make the aqueous emulsion of the bactericidal composition that contains fluorine pyrrole bacterium amine and kresoxim-methyl.
Four of technical scheme of the present invention, described bactericidal composition are water dispersible granules, and the percentage by weight of component is:
The concrete procedure of processing of this bactericidal composition water dispersible granules is: by above-mentioned prescription fluorine pyrrole bacterium amine, kresoxim-methyl and dispersant, wetting agent, disintegrant and filler are mixed, pulverize with micro jet, through mediating, add then and carry out granulation, drying, screening in the fluidized bed prilling dryer after sample analysis makes the water dispersible granules that contains the bactericidal composition of fluorine pyrrole bacterium amine and kresoxim-methyl of the present invention.
Described emulsifier is selected from any one or more mixtures formed with arbitrary proportion in calcium dodecyl benzene sulfonate and aliphatic acid polyethenoxy ether, alkylphenol polyoxyethylene sulfosuccinate, styryl phenol APEO, polyoxyethylene nonylphenol ether, castor oil polyoxyethylene ether, aliphatic acid polyethenoxy base ester, the polyoxyethylene aliphatic alcohol ether.
Described solvent is any one or more mixed solvents formed with arbitrary proportion in dimethylbenzene or biodiesel, toluene, diesel oil, methyl alcohol, ethanol, n-butanol, isopropyl alcohol, turpentine oil, solvent naphtha, dimethyl formamide, dimethyl sulfoxide (DMSO), the water equal solvent.
Described dispersant is selected from one or more in polycarboxylate, lignosulfonates, alkylphenol polyoxyethylene formaldehyde condensation products sulphate, alkyl benzene sulfonate calcium salt, naphthalene sulfonic acid-formaldehyde condensation product sodium salt, alkylphenol polyoxyethylene, aliphatic amine polyoxyethylene ether, polyoxyethylene carboxylate, the fatty acid glyceride APEO.
Described wetting agent is selected from: lauryl sodium sulfate, calcium dodecyl benzene sulfonate, Nekal BX., among the wetting and penetrating agent F, alkylnaphthalene sulfonate, polyoxyethylene triphenylethylene phosphenylic acid salt, spaonin powder, silkworm excrement, soapberry powder one or more.
Described disintegrant is selected from: one or more in bentonite, urea, ammonium sulfate, aluminium chloride, citric acid, succinic acid, the sodium bicarbonate.
Described thickener is selected from: one or more in xanthans, CMC, hydroxyethylcellulose, methylcellulose, Magnesiumaluminumsilicate, the polyvinyl alcohol.
Described stabilizing agent is selected from: a kind of in sodium citrate, the resorcinol.
Described antifreezing agent is selected from: one or more in ethylene glycol, propane diols, the glycerine.
Described defoamer is selected from: silicone oil, silicone compound, C
10-20Saturated fat acid compounds, C
8-10In the aliphatic alcohols compound one or more.
Described filler is selected from: one or more in kaolin, diatomite, bentonite, attapulgite, white carbon, starch, the precipitated calcium carbonate.
Bactericidal composition of the present invention has obvious synergistic effect, can reduce the consumption of active ingredient, delays the generation of disease for the bactericide resistance.Have prevention and protective effect simultaneously concurrently,, therefore can produce good protective action crops because medicament has good system's conductivity.
Bactericidal composition of the present invention is applicable to by the germ various diseases of Oomycete, as: late blight morning, damping off and the black shank etc. of the downy mildew of melon and fruit, vegetables, eqpidemic disease, potato.
Embodiment:
For making technical solutions according to the invention more clear, be illustrated with specific embodiment, but the present invention is not limited only to these examples.
Different farm chemical ingredients being carried out composite, is to solve some single agent some in using modes comparatively effectively and efficiently at present.The agricultural of different types of structure is carried out composite can occur usually afterwards three kinds of type of action, i.e. antagonism, summation action and synergistic effect.
Bactericidal composition of the present invention has obvious synergistic effect, can reduce the consumption of active ingredient, delays the generation of disease for the bactericide resistance.Have prevention and protective effect simultaneously concurrently, kresoxim-methyl can produce tangible production-increasing function after dispenser.
Test 1: fluorine pyrrole bacterium amine and kresoxim-methyl are composite to be tested the cucumber downy mildew control efficiency
Indoor inhibitory effect assay method: adopt growth rate method to measure the inhibitory action of bactericidal composition to bacterium of downy mildew of cucumber.The cucumber cream mold of cultivating 4d from the PDA medium edge cut-off that falls directly is inoculated into respectively on the PDA culture medium flat plate that contains the variable concentrations bactericide for the mycelia piece of 5mm, 28 ℃ of following constant temperature culture, not contain the medicament flat board is blank, measure the colony diameter that each is handled behind the 4d, calculate the inhibition percentage of medicament mycelial growth.Carry out regression analysis by the logarithm of each treatment dosage and the probability value of mycelial growth inhibition rate, calculate various bactericide concentration (EC in the inhibition of cucumber downy mildew
50), calculate co-toxicity coefficient (CTC) according to the abundant method of Sun Yun again.
When CTC≤80, then the composition performance is for antagonism, and when 80＜CTC＜120, then the composition performance is for summation action, and when CTC 〉=120, then the composition performance is synergistic effect.
Actual measurement toxicity index (ATI)=(standard medicament EC
50)/reagent agent EC
50) * 100
The percentage composition of B in percentage composition+B medicament toxicity index * mixture of A in theoretical toxicity index (TTI)=A medicament toxicity index * mixture
Co-toxicity coefficient (CTC)=[mixture actual measurement toxicity index (the ATI)/theoretical toxicity index (TTI) of mixture] * 100
Each processing of table 1 is to the Toxicity Determination result of bacterium of downy mildew of cucumber
Measurement result shows that fluorine pyrrole bacterium amine and kresoxim-methyl are 1～10 in proportioning: in the time of between 10～1, have obvious synergistic effect, especially at fluorine pyrrole bacterium amine and kresoxim-methyl at 1: 5 o'clock, synergistic effect is especially obvious, co-toxicity coefficient reaches 273.2.
Test that 2 fluorine pyrrole bacterium amine and kresoxim-methyl are composite to be tested the tomato late blight control efficiency
The percentage mycelial inhibition assay method is adopted in test, measures fluorine pyrrole bacterium amine and the composite and single agent of the kresoxim-methyl control efficiency for tomato late blight.The medicine of different disposal is made into 5 variable concentrations gradients with sterile water, drawing 1ml soup (is contrast with the clear water) with suction pipe on aseptic workbench joins in the 8cm culture dish, add the about 50-60PDA medium in 9ml fusing back with syringe again, soup is evenly mixed with medium, be cooled to room temperature, the tomato late blight germ piece of inoculation diameter 5mm in culture dish is cultivated 5～7d in 25 ℃ of incubators then, after treating that culture dish is covered with in contrast, measure colony diameter with the right-angled intersection method.Triplicate is averaged, and calculates the percentage mycelial inhibition of medicament.
Percentage mycelial inhibition (%)=[(contrast colony diameter-processing colony diameter)/contrast colony diameter] * 100
Calculate concentration EC in the inhibition according to above publicity
50, calculate co-toxicity coefficient (CTC) according to the abundant method of Sun Yun again.
When CTC≤80, then the composition performance is for antagonism, and when 80＜CTC＜120, then the composition performance is for summation action, and when CTC 〉=120, then the composition performance is synergistic effect.
Actual measurement toxicity index (ATI)=(standard medicament EC
50)/reagent agent EC
50) * 100
The percentage composition of B in percentage composition+B medicament toxicity index * mixture of A in theoretical toxicity index (TTI)=A medicament toxicity index * mixture
Co-toxicity coefficient (CTC)=[mixture actual measurement toxicity index (the ATI)/theoretical toxicity index (TTI) of mixture] * 100
Table 2 different disposal is to tomato late blight Toxicity Determination result
Measurement result shows that measurement result shows that fluorine pyrrole bacterium amine and kresoxim-methyl are 1～10 in proportioning: in the time of between 10～1, has obvious synergistic effect for tomato late blight, especially at fluorine pyrrole bacterium amine and kresoxim-methyl at 1: 5 o'clock, synergistic effect is especially obvious, co-toxicity coefficient reaches 437.1.
In sum, the bactericidal composition that contains fluorine pyrrole bacterium amine and kresoxim-methyl of the present invention has obvious synergistic effect for the fungus-caused disease of Oomycete, has the great significance for popularization.
Claims (5)
1. bactericidal composition that contains fluorine pyrrole bacterium amine and kresoxim-methyl.
2. composite bactericide according to claim 1 is characterized in that: the mass ratio of fluorine pyrrole bacterium amine and kresoxim-methyl is 1 ~ 80:80 ~ 1.
3. composite bactericide according to claim 1 is characterized in that: fluorine pyrrole bacterium amine is 1 ~ 30:30 ~ 1 with the quality optimization ratio of kresoxim-methyl.
4. composite bactericide according to claim 1 is characterized in that: active ingredient fluorine pyrrole bacterium amine and the total mass ratio of kresoxim-methyl in composition are 1 ~ 80%.
5. according to the composite bactericide of claim 1 majority, it is characterized in that: adopt the known technical scheme of those skilled in the art can be prepared into formulations such as suspending agent, wetting powder, water dispersible granules, aqueous emulsion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011101144919A CN102204537A (en) | 2011-05-05 | 2011-05-05 | Antibacterial composition containing fluopicolide and ethofenprox |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011101144919A CN102204537A (en) | 2011-05-05 | 2011-05-05 | Antibacterial composition containing fluopicolide and ethofenprox |
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|---|---|
| CN102204537A true CN102204537A (en) | 2011-10-05 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011101144919A Pending CN102204537A (en) | 2011-05-05 | 2011-05-05 | Antibacterial composition containing fluopicolide and ethofenprox |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102369939A (en) * | 2011-10-28 | 2012-03-14 | 陕西美邦农药有限公司 | Bactericidal combination containing fluopicolide and thiocarbamate compound |
| CN103168781A (en) * | 2013-03-26 | 2013-06-26 | 河北省农林科学院植物保护研究所 | Compound sterilizing agent containing fluopicolide and fludioxonil and application of sterilizing agent |
| CN104381266A (en) * | 2014-09-25 | 2015-03-04 | 北京燕化永乐生物科技股份有限公司 | Sterilization composition |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010118946A2 (en) * | 2009-04-15 | 2010-10-21 | Syngenta Participations Ag | Fungicidal mixtures |
| CN101983565A (en) * | 2010-12-10 | 2011-03-09 | 青岛海利尔药业有限公司 | Sterilization composite containing fluopyram |
-
2011
- 2011-05-05 CN CN2011101144919A patent/CN102204537A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010118946A2 (en) * | 2009-04-15 | 2010-10-21 | Syngenta Participations Ag | Fungicidal mixtures |
| CN101983565A (en) * | 2010-12-10 | 2011-03-09 | 青岛海利尔药业有限公司 | Sterilization composite containing fluopyram |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102369939A (en) * | 2011-10-28 | 2012-03-14 | 陕西美邦农药有限公司 | Bactericidal combination containing fluopicolide and thiocarbamate compound |
| CN103168781A (en) * | 2013-03-26 | 2013-06-26 | 河北省农林科学院植物保护研究所 | Compound sterilizing agent containing fluopicolide and fludioxonil and application of sterilizing agent |
| CN104381266A (en) * | 2014-09-25 | 2015-03-04 | 北京燕化永乐生物科技股份有限公司 | Sterilization composition |
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Application publication date: 20111005 |