CN102188589A - Zengshengping oral liquid composition and preparation method thereof - Google Patents
Zengshengping oral liquid composition and preparation method thereof Download PDFInfo
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- CN102188589A CN102188589A CN201110106532XA CN201110106532A CN102188589A CN 102188589 A CN102188589 A CN 102188589A CN 201110106532X A CN201110106532X A CN 201110106532XA CN 201110106532 A CN201110106532 A CN 201110106532A CN 102188589 A CN102188589 A CN 102188589A
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Abstract
The invention relates to a Chinese medicinal preparation, in particular to a Zengshengping oral liquid composition and a preparation method thereof. The composition provided by the invention is prepared from the Chinese medicinal raw materials in the following formula: 210 to 630 grams of subprostrate sophora, 210 to 630 grams of dragonwort, 210 to 630 grams of herba sonchi arvensis, 105 to 315 grams of root bark of shaggy-fruited dittany, 210 to 630 grams of selfheal and 50 to 150 grams of airpotato yam rhizome. The preparation method of the composition comprises: adding water into subprostrate sophora, decocting the subprostrate sophora, filtering, concentrating filtrate and drying for later use; and adding water into the airpotato yam rhizome, herba sonchi arvensis, dragonwort and selfheal, decocting the airpotato yam rhizome, herba sonchi arvensis, dragonwort and selfheal, filtering to obtain decoction, adding the root bark of shaggy-fruited dittany into the medicine residual, adding water, decocting, combining decoction, filtering, concentrating filtrate under reduced pressure, adding subprostrate sophora dry paste powder, uniformly mixing and drying to prepare the oral liquid.
Description
Technical field:
The present invention relates to a kind of Chinese medicine preparation, particularly the Chinese medicine zengshengping tablet oral liquid compositions of treatment proliferative disease.
Background technology:
90109821.3 of Chinese patents are called the preparation technology that " preparation technology of canceration shutoff agent " zengshengping tablet " " described a kind of zengshengping tablet, become extractum through the extraction with aqueous solution effective ingredient, make different dosage form then and form.Through experiment of rat and dog and 2531 routine epithelium of esophagus severe hypertrophy patients' observation, the result shows that " zengshengping tablet " is a kind of tumor prevention agent of novel blocking-up carcinogenesis.Consisting of of each component of hypertrophy plain film that this patent is described: Rhizoma Dioscoreae Bulbiferae 3-6, Spica Prunellae 18-25, Rhizoma Bistortae 17-21, Herba Patriniae 17-23, Radix Sophorae Tonkinensis 18-24, Cortex Dictamni 8-12.
Other has following patent to describe the preparation technology of " zengshengping tablet " and the application of Xin:
At present, " hypertrophy plain film " goes on the market, and its indication comprises:
Heat-clearing and toxic substances removing, blood stasis-eliminating and stagnation-dissipating.Be applicable to esophagus and cardia epithelial proliferation, have singultus, feed dysphagia, xerostomia, bitter taste, knot shower in the heat-phlegm such as the dark stringy and rolling pulse of pharyngalgia dry stool tongue.
Prescription consists of: Radix Sophorae Tonkinensis 420g, Rhizoma Bistortae 420g, Sonchus brachyotus DC. 420g, Cortex Dictamni 210g, Spica Prunellae 420g, Rhizoma Dioscoreae Bulbiferae 100g.
Chinese crude drug that zengshengping tablet is got confirms that through the modern pharmacology drug effect what have the antimicrobial antiphlogistic effect is: Rhizoma Bistortae, Cortex Dictamni, Spica Prunellae, Herba Patriniae, Rhizoma Dioscoreae Bulbiferae; Have having of the anticancer effect of antitumor: Radix Sophorae Tonkinensis, Cortex Dictamni, Rhizoma Dioscoreae Bulbiferae; Has the adjusting immunization, the having of raise immunity: Radix Sophorae Tonkinensis, Cortex Dictamni, Spica Prunellae.
In the disclosed at present data, the preparation method of zengshengping tablet mainly adopts the part medicine to pulverize and uses, the part medicine uses with water extraction, because the medicine of pulverizing is in dissolubility, mouthfeel and stability go up defectiveness, therefore improved necessity arranged, and unexpected discovery of the present invention transformed the preparation technology of zengshengping tablet, obtains a kind of brand-new extractum, this extractum is aspect preparation process, stability aspect, particularly dissolubility, mouthfeel, aspects such as sedimentation, good effect is all arranged, and obtaining better effect aspect the treatment mammary gland tumor, below is content of the present invention simultaneously.
Summary of the invention:
The invention provides a kind of Chinese medicine oral liquid composition and method of making the same.
Extract oral fluid composition of the present invention, form by following prescription that the raw material of Chinese medicine medicine is prepared from:
Radix Sophorae Tonkinensis 210-630g, Rhizoma Bistortae 210-630g, Sonchus brachyotus DC. 210-630g, Cortex Dictamni 105-315g, Spica Prunellae 210-630g, Rhizoma Dioscoreae Bulbiferae 50-150g
Extract oral fluid composition of the present invention, it is composed as follows preferably to fill a prescription:
Radix Sophorae Tonkinensis 420g, Rhizoma Bistortae 420g, Sonchus brachyotus DC. 420g, Cortex Dictamni 210g, Spica Prunellae 420g, Rhizoma Dioscoreae Bulbiferae 100g
In more than forming, weight is calculated with crude drug, when producing, can increase or reduce according to corresponding proportion, as large-scale production can be unit with the kilogram, or be unit with the ton, small-scale production can be a unit with gram or milligram also, and weight can increase or reduce, but the constant rate of the raw medicinal herbs weight proportion between each composition.
The ratio of above weight proportion obtains through science screening, for especial patient, and as serious symptom or light disease, fat or modest patient, the proportioning of the amount of can corresponding adjustment forming increases or reduces being no more than 100%, and drug effect is constant.
Single medicinal material, especially ministerial drug and adjuvant drug in more than forming also can be replaced by the suitable Chinese medicine with identical property of medicine, and its drug effect of the Chinese medicine preparation after the replacement is constant.
Extract oral fluid composition of the present invention, its Chinese medicine crude drug is through processing as pharmaceutically active substance, be prepared into the extract oral fluid composition through the galenic pharmacy routine techniques, this extract oral fluid composition, wherein pharmaceutically active substance shared percentage by weight in preparation is 0.01-99.9%, and all the other are the medicine acceptable carrier.Pharmaceutically active substance exists with unit dosage form, and described unit dosage form is meant the unit of preparation, as every ml of oral liquid etc.
Chinese medicine preparation of the present invention is an oral liquid, determines usage and dosage according to patient's situation in use, but obeys every day three times, each 1-20ml.
Extract oral fluid composition of the present invention, its preparation method obtains through screening, and preferred manufacturing procedure is as follows:
Prescription:
Radix Sophorae Tonkinensis 420g, Rhizoma Bistortae 420g, Sonchus brachyotus DC. 420g, Cortex Dictamni 210g, Spica Prunellae 420g, Rhizoma Dioscoreae Bulbiferae 100g
Preparation:
Get Radix Sophorae Tonkinensis and decoct with water filtration, filtrate concentrates, and is standby.
Rhizoma Dioscoreae Bulbiferae, Sonchus brachyotus DC., Rhizoma Bistortae and Spica Prunellae decoct with water, the leaching medicinal liquid adds Cortex Dictamni in the medicinal residues, decoct with water, collecting decoction, filter, filtrate decompression is concentrated into the clear paste that relative density is 1.30-1.35 (50 ℃), and this clear paste and Radix Sophorae Tonkinensis concentrated solution merge, add water, add adjuvant such as correctives etc., mixing, add water, filter promptly to specified volume.
The most preferred preparation method of the present invention is as follows:
Prescription:
Radix Sophorae Tonkinensis 420g, Rhizoma Bistortae 420g, Sonchus brachyotus DC. 420g, Cortex Dictamni 210g, Spica Prunellae 420g, Rhizoma Dioscoreae Bulbiferae 100g
Preparation:
Get the decocting that Radix Sophorae Tonkinensis adds 8 times of amounts and boil 2 times, each 1.5 hours, collecting decoction filtered, and filtrate decompression is concentrated into the thick paste that relative density is 1.30-1.35 (50 ℃), and is standby.
The decocting that Rhizoma Dioscoreae Bulbiferae, Sonchus brachyotus DC., Rhizoma Bistortae and Spica Prunellae add 8 times of amounts boils secondary, and 1 hour for the first time, the leaching medicinal liquid, add Cortex Dictamni in the medicinal residues, add the water of 8 times of amounts, decocted 1 hour, collecting decoction, filter, filtrate decompression is concentrated into the clear paste that relative density is 1.30-1.35 (50 ℃), and this clear paste and Radix Sophorae Tonkinensis concentrated solution merge, add water, correctives such as sucrose etc., mixing add water to specified volume, filter promptly.
The used correctives of the present invention includes but are not limited to sucrose, mannitol, xylitol, steviol glycosides, lactose, fructose, sucrose, protein sugar, maltose alcohol, glycyrrhizin, Sodium Cyclamate, gelatin, aspartame, flavoring banana essence, flavoring pineapple essence, vanillin, fragrant citrus essence, flavoring orange essence, Herba Menthae essence, ginseng essence, citric acid, citric acid etc., can use use also capable of being combined separately.
The present invention can also add thickening agent, as potassium alginate, starch, pectin, agar, gelatin, Sargassum fat, carrageenin, dextrin, tragacanth gum, the plain derivant of polysaccharide etc.
Extract oral fluid composition of the present invention has following function to cure mainly:
Heat-clearing and toxic substances removing, blood stasis-eliminating and stagnation-dissipating.Be applicable to esophagus and cardia epithelial proliferation, have singultus, feed dysphagia, xerostomia, bitter taste, knot shower in the heat-phlegm such as the dark stringy and rolling pulse of pharyngalgia dry stool tongue.
Also can be used for treating following disease:
Precancerous lesions such as the esophageal carcinoma, carcinoma of gastric cardia, gastric cancer are as esophageal epithelial proliferation, atypical hyperplasia of gastric mucosa, gastric intestinal metaplasia, dysplasia, can significantly reduce the sickness rate of the esophageal carcinoma and gastric cancer, can alleviate put, the toxic and side effects of chemotherapy, prevent the recurrence and the transfer of cancerous cell.Oral leukoplakia and buccal cavity white spot, stomach chronic inflammatory disease accompanied by intestinal epithelial metaplasia, intraepithelial neoplasia.
Mammary gland tumor, described mammary gland tumor comprises: cyclomastopathy, breast tumor, galactocele, wherein, cyclomastopathy comprises common cyclomastopathy and the cyclomastopathy that is not true to type, breast tumor comprises mammary gland benign tumor and breast carcinoma.
Craft screening:
Sedimentation rate is investigated
Take by weighing each 10g of extractum that different extraction process by water obtain respectively, add the 200ml water dissolution respectively, cover completely, be positioned under the natural conditions, observed clarity once, and the results are shown in Table 1 in per 24 hours.
The test of table 1 different process sedimentation rate
A01 technology is
Get the decocting that Radix Sophorae Tonkinensis 420g adds 8 times of amounts and boil 2 times, each 1.5 hours, collecting decoction filtered, and filtrate decompression is concentrated into the thick paste that relative density is 1.30-1.35 (50 ℃), and drying under reduced pressure (60 ℃) becomes dried cream, pulverizes, and is standby.Get Cortex Dictamni 210g, Rhizoma Dioscoreae Bulbiferae 100g, Sonchus brachyotus DC., Rhizoma Bistortae and each 420g of Spica Prunellae, put in the container, 8 times of amounts add water, decocted 3 hours, the leaching medicinal liquid, medicinal residues add the water of 8 times of amounts, decoct leaching medicinal liquid waste 3 hours.Twice filtrate is merged, be evaporated to relative density and survey 1.20 to 1.30 extractum for 60 ℃.
A02 technology is
Get the decocting that Radix Sophorae Tonkinensis 420g adds 8 times of amounts and boil 2 times, each 1.5 hours, collecting decoction filtered, and filtrate decompression is concentrated into the thick paste that relative density is 1.30-1.35 (50 ℃), and drying under reduced pressure (60 ℃) becomes dried cream, pulverizes, and is standby.Get Cortex Dictamni 210g, Rhizoma Dioscoreae Bulbiferae 100g, Sonchus brachyotus DC., Rhizoma Bistortae and each 420g of Spica Prunellae, put in the container, 8 times of amounts add water, decocted 2 hours, the leaching medicinal liquid, medicinal residues add the water of 8 times of amounts, decoct leaching medicinal liquid waste 2 hours.Twice filtrate is merged, be evaporated to relative density and survey 1.20 to 1.30 extractum for 60 ℃.
A03 technology is
Get the decocting that Radix Sophorae Tonkinensis 420g adds 8 times of amounts and boil 2 times, each 1.5 hours, collecting decoction filtered, and filtrate decompression is concentrated into the thick paste that relative density is 1.30-1.35 (50 ℃), and drying under reduced pressure (60 ℃) becomes dried cream, pulverizes, and is standby.Get Cortex Dictamni 210g, Rhizoma Dioscoreae Bulbiferae 100g, Sonchus brachyotus DC., Rhizoma Bistortae and each 420g of Spica Prunellae, put in the container, 8 times of amounts add water, decocted 1 hour, leaching medicinal liquid, medicinal residues add the water of 8 times of amounts, decoct leaching medicinal liquid waste 1 hour.Twice filtrate is merged, be evaporated to relative density and survey 1.20 to 1.30 extractum for 60 ℃.
A04 technology is
Get the decocting that Radix Sophorae Tonkinensis 420g adds 8 times of amounts and boil 2 times, each 1.5 hours, collecting decoction filtered, and filtrate decompression is concentrated into the thick paste that relative density is 1.30-1.35 (50 ℃), and drying under reduced pressure (60 ℃) becomes dried cream, pulverizes, and is standby.Get each 420g of Rhizoma Dioscoreae Bulbiferae 100g, Sonchus brachyotus DC., Rhizoma Bistortae and Spica Prunellae, put in the container, 8 times of amounts add water, decocted 3 hours, the leaching medicinal liquid adds Cortex Dictamni 210g in the medicinal residues, add the water of 8 times of amounts, decocts leaching medicinal liquid waste 3 hours.Twice filtrate is merged, be evaporated to relative density and survey 1.20 to 1.30 extractum for 60 ℃.
A05 technology is
Get the decocting that Radix Sophorae Tonkinensis 420g adds 8 times of amounts and boil 2 times, each 1.5 hours, collecting decoction filtered, and filtrate decompression is concentrated into the thick paste that relative density is 1.30-1.35 (50 ℃), and drying under reduced pressure (60 ℃) becomes dried cream, pulverizes, and is standby.Get each 420g of Rhizoma Dioscoreae Bulbiferae 100g, Sonchus brachyotus DC., Rhizoma Bistortae and Spica Prunellae, put in the container, 8 times of amounts add water, decocted 2 hours, the leaching medicinal liquid adds Cortex Dictamni 210g in the medicinal residues, add the water of 8 times of amounts, decocts leaching medicinal liquid waste 2 hours.Twice filtrate is merged, be evaporated to relative density and survey 1.20 to 1.30 extractum for 60 ℃.
A06 technology is
Get the decocting that Radix Sophorae Tonkinensis 420g adds 8 times of amounts and boil 2 times, each 1.5 hours, collecting decoction filtered, and filtrate decompression is concentrated into the thick paste that relative density is 1.30-1.35 (50 ℃), and drying under reduced pressure (60 ℃) becomes dried cream, pulverizes, and is standby.Get each 420g of Rhizoma Dioscoreae Bulbiferae 100g, Sonchus brachyotus DC., Rhizoma Bistortae and Spica Prunellae, put in the container, 8 times of amounts add water, decocted 1 hour, the leaching medicinal liquid adds Cortex Dictamni 210g in the medicinal residues, add the water of 8 times of amounts, decocts leaching medicinal liquid waste 1 hour.Twice filtrate is merged, be evaporated to relative density and survey 1.20 to 1.30 extractum for 60 ℃.
A07 technology is
Get the decocting that Radix Sophorae Tonkinensis 420g adds 8 times of amounts and boil 2 times, each 1.5 hours, collecting decoction filtered, and filtrate decompression is concentrated into the thick paste that relative density is 1.30-1.35 (50 ℃), and drying under reduced pressure (60 ℃) becomes dried cream, pulverizes, and is standby.Get Cortex Dictamni 210g, Rhizoma Dioscoreae Bulbiferae 100g, Sonchus brachyotus DC., Rhizoma Bistortae and each 420g of Spica Prunellae, put in the container, 8 times of amounts add water, decocted leaching medicinal liquid, medicinal residues 2 hours, the water that adds 8 times of amounts decocted the leaching medicinal liquid 2 hours, medicinal residues, the water that adds 8 times of amounts decocted the leaching medicinal liquid 2 hours, three filtrates are merged, be evaporated to relative density and survey 1.20 to 1.30 extractum for 60 ℃.
A08 technology is
Get the decocting that Radix Sophorae Tonkinensis 420g adds 8 times of amounts and boil 2 times, each 1.5 hours, collecting decoction filtered, and filtrate decompression is concentrated into the thick paste that relative density is 1.30-1.35 (50 ℃), and drying under reduced pressure (60 ℃) becomes dried cream, pulverizes, and is standby.Get Cortex Dictamni 210g, Rhizoma Dioscoreae Bulbiferae 100g, Sonchus brachyotus DC., Rhizoma Bistortae and each 420g of Spica Prunellae, put in the container, 8 times of amounts add water, decocted leaching medicinal liquid, medicinal residues 1 hour, the water that adds 8 times of amounts decocted the leaching medicinal liquid 1 hour, medicinal residues, the water that adds 8 times of amounts decocted the leaching medicinal liquid 1 hour, three filtrates are merged, be evaporated to relative density and survey 1.20 to 1.30 extractum for 60 ℃.
A09 technology is
Get the decocting that Radix Sophorae Tonkinensis 420g adds 8 times of amounts and boil 2 times, each 1.5 hours, collecting decoction filtered, and filtrate decompression is concentrated into the thick paste that relative density is 1.30-1.35 (50 ℃), and drying under reduced pressure (60 ℃) becomes dried cream, pulverizes, and is standby.Get Cortex Dictamni 210g, Rhizoma Dioscoreae Bulbiferae 100g, Sonchus brachyotus DC., Rhizoma Bistortae and each 420g of Spica Prunellae, put in the container, 8 times of amounts add water, decocted leaching medicinal liquid, medicinal residues 1.5 hours, the water that adds 8 times of amounts decocted the leaching medicinal liquid 1.5 hours, medicinal residues, the water that adds 8 times of amounts decocted the leaching medicinal liquid 1.5 hours, three filtrates are merged, be evaporated to relative density and survey 1.20 to 1.30 extractum for 60 ℃.
By last table result as can be seen, the product stability of A06 prepared is best, does not have sedimentation in 120 hours.
Mouthfeel is investigated and is seen Table 2,3.
Table 2 different process extract powder mouthfeel is investigated
Mouthfeel was investigated after table 3 different process extract powder 10g added 10g sucrose
By last table result as can be seen, the not sedimentation of finished product of A06 prepared, no bitterness is fit to large-scale production.
The research of A06 antiinflammatory action: anti-chronic inflammatory disease test (rat cotton balls hypodermic implantation)
Be subjected to the reagent thing:
Title: zengshengping tablet extractum, the extractum of the method preparation of usefulness embodiment 1
Character: be tan powder; Feeble QI, mildly bitter flavor.
Animal:
The wistar rat, quality: 200-250g male and female half and half.Medical courses in general institute Experimental Animal Center provides.
Experimental technique and result:
Get 50 of rats, male and female half and half are divided into 5 groups at random, 10 every group.The 1st group is the blank group, gives the isometric(al) normal saline; The 2nd group of positive matched group (prednisone sheet 8mg/kg); 3rd, 4,5 groups is zengshengping tablet group (0.2g, 0.4g, 0.8g/kg crude drug).Under the shallow fiber crops of ether, the cropping sterilization.The sterile working, in hypogastric region medisection skin, it is subcutaneous that the sterilization cotton balls of heavy 50mg is implanted the both sides groin, and skin suture is sterilized then.Begin the ig administration from the preceding 3d that performs the operation, 2ml/100g, 1 time/day, continuous 10d.D11 puts to death rat, carefully peels off the granulation tissue of taking out cotton balls and parcel, weighs behind 60 ℃ of dry 12h, deducts the raw cotton ball weight and is granulation tissue weight, represents with the contained granulation tissue weight of 100g body weight (bilateral).Check through t.The results are shown in Table 4.
Table 4 zengshengping tablet is to the influence of rat chronic hypertrophy inflammation (X ± S)
Compare * P＜0.05 * * P＜0.01 with the blank group
Zengshengping tablet is to the therapeutic effect of cyclomastopathy
Use E
2The rabbit hyperplasia of mammary gland model of duplicating is observed the influence to morphological change:
1) red, swollen, big three does not all have the person to be +++.
2) swollen, the two does not all have the person to be greatly ++.
3) become merely big person into+.
4) the no change person be-.
Table 5 zengshengping tablet increases the influence of degree to mammary gland
In addition, granule of the present invention has also carried out multinomial relevant test, comprises following content:
1. inhibition test: result of the test result shows that zengshengping tablet does not have the obvious suppression effect to S-180, and tumour inhibiting rate is all less than 30%.Use as merging with CTX, though do not demonstrate synergism aspect tumour inhibiting rate, the application of zengshengping tablet can obviously alleviate the inhibitory action (P＜0.05) of CTX to host's body weight gain.
2. the mice net is knitted the influence of endothelial system phagocytic function: zengshengping tablet can obviously strengthen the mice net and knit the function that endothelial system is engulfed foreign body.
3. to the influence of mouse lymphocyte conversion reaction: zengshengping tablet group CPM value illustrates that all apparently higher than matched group (P＜0.05) zengshengping tablet can significantly promote the lymphocytic answering of T.
4. mouse boosting cell is produced the influence of IL-2: zengshengping tablet group mouse boosting cell produces the ability of IL-2. in 5 dilution measurement results of curve, all, show that zengshengping tablet can obviously improve the ability that mouse boosting cell produces IL-2 apparently higher than matched group (P＜0.05).
5. to the influence of mouse skin delayed hypersensitivity: the response strength of matched group and zengshengping tablet group relatively, both differences have the significance meaning
6. experiment in vitro proves, zengshengping tablet has significantly anti-causing dashes forward and the anti-promoting effect, and can obviously suppress the in-vitro multiplication of K562 cancerous cell.
7. zoopery proves, zengshengping tablet can obviously suppress the hypertrophy and the canceration of rat esophagus epithelium, mice model of forestomach epithelium, suslik oral mucous epithelia, rat nasopharyngeal epithelium and rat bladder epithelium that carcinogen brings out, and the transfer of tumor is had the obvious suppression effect.
8. pharmacological experiment proves, zengshengping tablet is to the phagocytic function of net matter endothelial system, LT respond, the vigor that kills and wounds of NK cell, the generation ability of splenocyte IL-2, the ability of skin delayed hypersensitivity and hemolysin level etc. all have significant potentiation.Illustrate that zengshengping tablet can obviously improve the cell and the humoral immune function of body, has the effect of BRM sample material.
9. in the clinical trial, zengshengping tablet is to esophagus, cardia stomach function regulating. precancerous lesion and the treatment of inflammation, total effective rate reaches 91.9%.To oral mucosa lichen planus patient's clinical observation, confirming has better therapeutic effect, and effective percentage reaches 90%, especially to the more remarkable treatment effect of rotten to the corn atrophic type.
The beneficial effect of relevant extract oral fluid composition of the present invention is as follows:
Several factors is depended in the selection of the extracting method of Effective Components of Chinese Herb, as raw material availability, and curative effect, the simplification of production process, stability etc.
Why prior art is used as medicine the Cortex Dictamni pulverizing, main because it is generally acknowledged that Cortex Dictamni decocts with water extraction, can extract the relatively more bitter ingredient of some alkaloidss, simultaneously also can extract compositions such as some starch, protein, tannin, and the easy moisture absorption of water extract, be not suitable for dosage forms such as oral liquid.
The present invention is in order to improve the resolvability of zengshengping tablet medicine, change existing medicining mode, Cortex Dictamni has been carried out the decocting extraction, the unexpected discovery carried Cortex Dictamni by fresh water (FW) of the present invention, do not cause the problem of the water extract moisture absorption, it can be prepared into the good oral administration of soluble preparation of the good mouthfeel of dissolubility simultaneously.
The specific embodiment:
Further specify the present invention by the following examples, but not as limitation of the present invention.
Embodiment 1
Radix Sophorae Tonkinensis 420g, Rhizoma Bistortae 420g, Sonchus brachyotus DC. 420g, Cortex Dictamni 210g, Spica Prunellae 420g, Rhizoma Dioscoreae Bulbiferae 100g
Preparation:
Get the decocting that Radix Sophorae Tonkinensis 420g adds 8 times of amounts and boil 2 times, each 1.5 hours, collecting decoction filtered, and filtrate decompression is concentrated into the thick paste that relative density is 1.30-1.35 (50 ℃), and drying under reduced pressure (60 ℃) becomes dried cream, pulverizes, and is standby.Get each 420g of Rhizoma Dioscoreae Bulbiferae 100g, Sonchus brachyotus DC., Rhizoma Bistortae and Spica Prunellae, put in the container, 8 times of amounts add water, decocted 1 hour, the leaching medicinal liquid adds Cortex Dictamni 210g in the medicinal residues, add the water of 8 times of amounts, decocts leaching medicinal liquid waste 1 hour.Twice filtrate is merged, be evaporated to relative density and survey 1.20 to 1.30 extractum for 60 ℃.Extractum is merged, add 800ml water, 200g sucrose, dissolving back add distilled water to 1000ml, after the filtration promptly.
Embodiment 2
Radix Sophorae Tonkinensis 210g, Rhizoma Bistortae 210g, Sonchus brachyotus DC. 210g, Cortex Dictamni 105g, Spica Prunellae 210g, Rhizoma Dioscoreae Bulbiferae 50g
Preparation:
Get the decocting that Radix Sophorae Tonkinensis adds 8 times of amounts and boil 2 times, each 1.5 hours, collecting decoction filtered, and filtrate decompression is concentrated into the thick paste that relative density is 1.30-1.35 (50 ℃), and drying under reduced pressure (60 ℃) becomes dried cream, pulverizes, and is standby.Get Rhizoma Dioscoreae Bulbiferae, Sonchus brachyotus DC., Rhizoma Bistortae and Spica Prunellae, put in the container, 8 times of amounts add water, decocted 1 hour, the leaching medicinal liquid adds Cortex Dictamni in the medicinal residues, add the water of 8 times of amounts, decocts leaching medicinal liquid waste 1 hour.Twice filtrate is merged, be evaporated to relative density and survey 1.20 to 1.30 extractum for 60 ℃.Extractum is merged, add 800ml water, 200g sucrose, dissolving back add distilled water to 1000ml, after the filtration promptly.
Embodiment 3
Radix Sophorae Tonkinensis 630g, Rhizoma Bistortae 630g, Sonchus brachyotus DC. 630g, Cortex Dictamni 315g, Spica Prunellae 630g, Rhizoma Dioscoreae Bulbiferae 150g
Preparation:
Get the decocting that Radix Sophorae Tonkinensis adds 8 times of amounts and boil 2 times, each 1.5 hours, collecting decoction filtered, and filtrate decompression is concentrated into the thick paste that relative density is 1.30-1.35 (50 ℃), and drying under reduced pressure (60 ℃) becomes dried cream, pulverizes, and is standby.Get Rhizoma Dioscoreae Bulbiferae, Sonchus brachyotus DC., Rhizoma Bistortae and Spica Prunellae, put in the container, 8 times of amounts add water, decocted 1 hour, the leaching medicinal liquid adds Cortex Dictamni in the medicinal residues, add the water of 8 times of amounts, decocts leaching medicinal liquid waste 1 hour.Twice filtrate is merged, be evaporated to relative density and survey 1.20 to 1.30 extractum for 60 ℃.Extractum is merged, add 800ml water, 200g sucrose, dissolving back add distilled water to 1000ml, after the filtration promptly.
Embodiment 4
Radix Sophorae Tonkinensis 420g, Rhizoma Bistortae 420g, Sonchus brachyotus DC. 420g, Cortex Dictamni 210g, Spica Prunellae 420g, Rhizoma Dioscoreae Bulbiferae 100g
Preparation:
Get the decocting that Radix Sophorae Tonkinensis 420g adds 8 times of amounts and boil 2 times, each 1.5 hours, collecting decoction filtered, and filtrate decompression is concentrated into the thick paste that relative density is 1.30-1.35 (50 ℃), and drying under reduced pressure (60 ℃) becomes dried cream, pulverizes, and is standby.Get each 420g of Rhizoma Dioscoreae Bulbiferae 100g, Sonchus brachyotus DC., Rhizoma Bistortae and Spica Prunellae, put in the container, 8 times of amounts add water, decocted 1 hour, the leaching medicinal liquid adds Cortex Dictamni 210g in the medicinal residues, add the water of 8 times of amounts, decocts leaching medicinal liquid waste 1 hour.Twice filtrate is merged, be evaporated to relative density and survey 1.20 to 1.30 extractum for 60 ℃.Extractum is merged, add 800ml water, 2g steviosin, dissolving back add distilled water to 1000ml, after the filtration promptly.
Embodiment 5
Radix Sophorae Tonkinensis 420g, Rhizoma Bistortae 420g, Sonchus brachyotus DC. 420g, Cortex Dictamni 210g, Spica Prunellae 420g, Rhizoma Dioscoreae Bulbiferae 100g
Preparation:
Get the decocting that Radix Sophorae Tonkinensis 420g adds 8 times of amounts and boil 2 times, each 1.5 hours, collecting decoction filtered, and filtrate decompression is concentrated into the thick paste that relative density is 1.30-1.35 (50 ℃), and drying under reduced pressure (60 ℃) becomes dried cream, pulverizes, and is standby.Get each 420g of Rhizoma Dioscoreae Bulbiferae 100g, Sonchus brachyotus DC., Rhizoma Bistortae and Spica Prunellae, put in the container, 8 times of amounts add water, decocted 1 hour, the leaching medicinal liquid adds Cortex Dictamni 210g in the medicinal residues, add the water of 8 times of amounts, decocts leaching medicinal liquid waste 1 hour.Twice filtrate is merged, be evaporated to relative density and survey 1.20 to 1.30 extractum for 60 ℃.Extractum is merged, add 800ml water, 2g protein sugar, dissolving back add distilled water to 1000ml, after the filtration promptly.
Embodiment 6
Radix Sophorae Tonkinensis 420g, Rhizoma Bistortae 420g, Sonchus brachyotus DC. 420g, Cortex Dictamni 210g, Spica Prunellae 420g, Rhizoma Dioscoreae Bulbiferae 100g
Preparation:
Get the decocting that Radix Sophorae Tonkinensis 420g adds 8 times of amounts and boil 2 times, each 1.5 hours, collecting decoction filtered, and filtrate decompression is concentrated into the thick paste that relative density is 1.30-1.35 (50 ℃), and drying under reduced pressure (60 ℃) becomes dried cream, pulverizes, and is standby.Get each 420g of Rhizoma Dioscoreae Bulbiferae 100g, Sonchus brachyotus DC., Rhizoma Bistortae and Spica Prunellae, put in the container, 8 times of amounts add water, decocted 1 hour, the leaching medicinal liquid adds Cortex Dictamni 210g in the medicinal residues, add the water of 8 times of amounts, decocts leaching medicinal liquid waste 1 hour.Twice filtrate is merged, be evaporated to relative density and survey 1.20 to 1.30 extractum for 60 ℃.Extractum is merged, add 800ml water, 2g cyclamate, 1g steviosin, dissolving back add distilled water to 1000ml, after the filtration promptly.
Claims (10)
1. an extract oral fluid composition for the treatment of mammary gland tumor is characterized in that, is prepared from by following raw material of Chinese medicine medicine:
Radix Sophorae Tonkinensis 210-630g, Rhizoma Bistortae 210-630g, Sonchus brachyotus DC. 210-630g, Cortex Dictamni 105-315g, Spica Prunellae 210-630g, Rhizoma Dioscoreae Bulbiferae 50-150g.
2. compositions as claimed in claim 1 is characterized in that, is prepared from by following raw material of Chinese medicine medicine:
Radix Sophorae Tonkinensis 420g, Rhizoma Bistortae 420g, Sonchus brachyotus DC. 420g, Cortex Dictamni 210g, Spica Prunellae 420g, Rhizoma Dioscoreae Bulbiferae 100g.
3. compositions as claimed in claim 1 is characterized in that preparation method is as follows:
Get Radix Sophorae Tonkinensis and decoct with water filtration, filtrate concentrates, and is standby;
Rhizoma Dioscoreae Bulbiferae, Sonchus brachyotus DC., Rhizoma Bistortae and Spica Prunellae decoct with water, the leaching medicinal liquid, add Cortex Dictamni in the medicinal residues, decoct with water, collecting decoction, filter, the clear paste that it is 1.30-1.35 that filtrate decompression is concentrated into 50 ℃ of surveys of relative density, this clear paste and Radix Sophorae Tonkinensis concentrated solution merge, and add auxiliary materials and mixing, add water to specified volume, filter promptly.
4. compositions as claimed in claim 1 is characterized in that preparation method is as follows:
Get the decocting that Radix Sophorae Tonkinensis adds 8 times of amounts and boil 2 times, each 1.5 hours, collecting decoction filtered, and the thick paste that it is 1.30-1.35 that filtrate decompression is concentrated into 50 ℃ of surveys of relative density is standby;
The decocting that Rhizoma Dioscoreae Bulbiferae, Sonchus brachyotus DC., Rhizoma Bistortae and Spica Prunellae add 8 times of amounts boils secondary, and 1 hour for the first time, the leaching medicinal liquid, add Cortex Dictamni in the medicinal residues, add the water of 8 times of amounts, decocted 1 hour, collecting decoction, filter, the clear paste that it is 1.30-1.35 that filtrate decompression is concentrated into 50 ℃ of surveys of relative density, this clear paste and Radix Sophorae Tonkinensis concentrated solution merge, add water, the correctives mixing adds water to specified volume, filters promptly.
5. compositions as claimed in claim 2 is characterized in that preparation method is as follows:
Get the decocting that Radix Sophorae Tonkinensis 420g adds 8 times of amounts and boil 2 times, each 1.5 hours, collecting decoction, filter, the thick paste that it is 1.30-1.35 that filtrate decompression is concentrated into 50 ℃ of surveys of relative density, 60 ℃ of drying under reduced pressure become dried cream, pulverize, standby, get Rhizoma Dioscoreae Bulbiferae 100g, Sonchus brachyotus DC., each 420g of Rhizoma Bistortae and Spica Prunellae, put in the container, 8 times of amounts add water, decocted the leaching medicinal liquid 1 hour, add Cortex Dictamni 210g in the medicinal residues, the water that adds 8 times of amounts decocted leaching medicinal liquid waste 1 hour, twice filtrate is merged, be evaporated to relative density and survey 1.20 to 1.30 extractum for 60 ℃, extractum is merged, add 800ml water, 200g sucrose, dissolving back adds distilled water to 1000ml, after the filtration promptly.
6. preparation of compositions method as claimed in claim 1 is characterized in that step is as follows: get Radix Sophorae Tonkinensis and decoct with water filtration, filtrate concentrates, and is standby;
Rhizoma Dioscoreae Bulbiferae, Sonchus brachyotus DC., Rhizoma Bistortae and Spica Prunellae decoct with water, the leaching medicinal liquid, add Cortex Dictamni in the medicinal residues, decoct with water, collecting decoction, filter, the clear paste that it is 1.30-1.35 that filtrate decompression is concentrated into 50 ℃ of surveys of relative density, this clear paste and Radix Sophorae Tonkinensis concentrated solution merge, and add auxiliary materials and mixing, add water to specified volume, filter promptly.
7. preparation method as claimed in claim 6 is characterized in that step is as follows: get the decocting that Radix Sophorae Tonkinensis adds 8 times of amounts and boil 2 times, each 1.5 hours, collecting decoction filtered, and the thick paste that it is 1.30-1.35 that filtrate decompression is concentrated into 50 ℃ of surveys of relative density is standby;
The decocting that Rhizoma Dioscoreae Bulbiferae, Sonchus brachyotus DC., Rhizoma Bistortae and Spica Prunellae add 8 times of amounts boils secondary, and 1 hour for the first time, the leaching medicinal liquid, add Cortex Dictamni in the medicinal residues, add the water of 8 times of amounts, decocted 1 hour, collecting decoction, filter, the clear paste that it is 1.30-1.35 that filtrate decompression is concentrated into 50 ℃ of surveys of relative density, this clear paste and Radix Sophorae Tonkinensis concentrated solution merge, add water, the correctives mixing adds water to specified volume, filters promptly.
8. preparation method as claimed in claim 6 is characterized in that step is as follows:
Get the decocting that Radix Sophorae Tonkinensis 420g adds 8 times of amounts and boil 2 times, each 1.5 hours, collecting decoction, filter, the thick paste that it is 1.30-1.35 that filtrate decompression is concentrated into 50 ℃ of surveys of relative density, 60 ℃ of drying under reduced pressure become dried cream, pulverize, standby, get Rhizoma Dioscoreae Bulbiferae 100g, Sonchus brachyotus DC., each 420g of Rhizoma Bistortae and Spica Prunellae, put in the container, 8 times of amounts add water, decocted the leaching medicinal liquid 1 hour, add Cortex Dictamni 210g in the medicinal residues, the water that adds 8 times of amounts decocted leaching medicinal liquid waste 1 hour, twice filtrate is merged, be evaporated to relative density and survey 1.20 to 1.30 extractum for 60 ℃, extractum is merged, add 800ml water, 200g sucrose, dissolving back adds distilled water to 1000ml, after the filtration promptly.
9. the application of compositions as claimed in claim 1 in the medicine of the following disease of preparation treatment, heat-clearing and toxic substances removing, blood stasis-eliminating and stagnation-dissipating are applicable to esophagus and cardia epithelial proliferation, has singultus, feed dysphagia, xerostomia, knot shower in the bitter taste, heat-phlegm such as the dark stringy and rolling pulse of pharyngalgia dry stool tongue; Precancerous lesions such as the esophageal carcinoma, carcinoma of gastric cardia, gastric cancer are as esophageal epithelial proliferation, atypical hyperplasia of gastric mucosa, gastric intestinal metaplasia, dysplasia, can significantly reduce the sickness rate of the esophageal carcinoma and gastric cancer, can alleviate put, the toxic and side effects of chemotherapy, prevent the recurrence and the transfer of cancerous cell, oral leukoplakia and buccal cavity white spot, stomach chronic inflammatory disease accompanied by intestinal epithelial metaplasia, intraepithelial neoplasia; Cyclomastopathy, breast tumor, galactocele, wherein, cyclomastopathy comprises common cyclomastopathy and the cyclomastopathy that is not true to type, breast tumor comprises mammary gland benign tumor and breast carcinoma.
10. application as claimed in claim 9 comprises the auxiliary treatment of tumor, and and other antitumor drug unite use.
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| CN101670034A (en) * | 2009-10-21 | 2010-03-17 | 天津普瑞森医药贸易有限公司 | Application of traditional Chinese drug Zengshengping to treating mammary gland tumor |
| CN101940696A (en) * | 2010-09-10 | 2011-01-12 | 天津康晨瑞信医药集团有限公司 | Method for preparing Chinese medicinal compound Zengshengping |
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| CN101670034A (en) * | 2009-10-21 | 2010-03-17 | 天津普瑞森医药贸易有限公司 | Application of traditional Chinese drug Zengshengping to treating mammary gland tumor |
| CN101966272A (en) * | 2009-10-21 | 2011-02-09 | 天津康晨瑞信医药集团有限公司 | Chinese medicinal composition for treating proliferative diseases |
| CN101940696A (en) * | 2010-09-10 | 2011-01-12 | 天津康晨瑞信医药集团有限公司 | Method for preparing Chinese medicinal compound Zengshengping |
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