CN102188524B

CN102188524B - Pharmaceutical for treating prostatitis and preparation method thereof

Info

Publication number: CN102188524B
Application number: CN 201110119791
Authority: CN
Inventors: 孙文杰
Original assignee: Individual
Current assignee: Individual
Priority date: 2011-05-10
Filing date: 2011-05-10
Publication date: 2013-09-11
Anticipated expiration: 2031-05-10
Also published as: CN102188524A

Abstract

The invention discloses a traditional Chinese medicine composition for treating chronic prostatitis and benign prostatic hyperplasia, which is prepared from cortex phellodendri, plantain seeds, semen vaccariae, red-rooted salvia roots and epimedium herb, is effective in clearing away heat and detoxicating, as well as activating blood circulation and removing blood stasis, and is used for treatingchronic prostatitis and benign prostatic hyperplasia. The traditional Chinese medicine composition is prepared by a proper method, can be prepared into granules, tablets or capsules and the like by being matched with medicinal auxiliary materials.

Description

-kind of prostatitic medicine for the treatment of and preparation method thereof

Technical field

The invention belongs to the field of Chinese medicines, relate to Chinese medicine formula medicine of a kind of oral administration treatment chronic prostatitis and prostatic hyperplasia and preparation method thereof.

Technical background

Prostatitis (CP) is a kind of very common disease, in the 20-50 male in year, sickness rate is about 25%, and chronic nonbacterial prostatitis accounts for 64%～90% of prostatitis patient, domestic number of the infected more than 8,000 ten thousand is one of modal andropathys.

The cause of disease and the pathogenesis of chronic prostatitis are not illustrated yet fully, at present the cause of disease and the pathogeny to CP has many views, mainly contains in infected by microbes, the prostate urine and backflows that to cause dysimmunity in " chemical prostatitis ", the disorder of pelvic cavity neuromuscular function, spiritual psychological factor, the prostata tissue, the prostatic fluid inner cell factor unusual etc.Cardinal symptom has: urine, the dysurea of the discomfort of urinating, burning sensation, frequent micturition, urgent micturition, dysurea etc., abnormal color of urine, muddiness, white, can cause pain and the sexual dysfunction of lumbosacral region, hip, perineal position, suprapubic region and abdominal part, show as hyposexuality etc.

The traditional Chinese medical science thinks that chronic prostatitis is the damp-heat accumulation part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, the turbid retardance of the stasis of blood, consumption is impairment of the kidney due to the essence etc., damp and hot be the mark of primary disease, suffer from a deficiency of the kidney into primary disease, qi depression to blood stasis is the pathomechanism that primary disease further develops.Treatment should be general provisions with " giving consideration to both the incidental and fundamental, dampness removing leads to stasis of blood tonify deficiency ", should eliminating damp-heat, disperse blood stasis and dredge collateral takes stopgap measures, and also wants the tonify deficiency strengthening the body resistance.

Summary of the invention: the object of the present invention is to provide a kind of simplify, compatibility is rational, curative effect is outstanding Chinese medicine composition, through a series of extraction, filtration, drying steps, granule, tablet or capsule be can make, chronic prostatitis and prostatic hyperplasia are used for the treatment of.

Content of the present invention

A kind of Chinese medicine formula medicine for the treatment of chronic prostatitis and prostatic hyperplasia, it is characterized in that it contains by descending the materials of weight proportions medicine to make: Cortex Phellodendri 2-30 part, Semen Plantaginis 2-20 part, Semen Vaccariae 2-30 part, Radix Salviae Miltiorrhizae 2-20 part, Herba Epimedii 1-10 part.

Further, the present invention is made by following materials of weight proportions medicine: Cortex Phellodendri 10-15 part, Semen Plantaginis 5-10 part, Semen Vaccariae 10-15 part, Radix Salviae Miltiorrhizae 5-10 part, Herba Epimedii 2-5 part.

Optimum weight formula proportion of the present invention is to be made by following materials of weight proportions medicine: 16 parts of Cortex Phellodendris, 8 parts of Semen Plantaginiss, 16 parts of Semen Vaccariae, 7 parts of Radix Salviae Miltiorrhizaes, 3 parts of Herba Epimedii.

Another object of the present invention provides above-mentioned weight proportion preparation of compositions method, it is characterized in that comprising following extraction step: take by weighing each medicine in the formulation weight ratio, add 5-15 times of water gaging, boiled 0.5-2 hour, and filtered, get supernatant, filtering residue adds 6-10 times of water gaging, boils 0.5-1.5 hour, filters, get supernatant, merge supernatant, concentrate, vacuum drying, be ground into fine powder, add proper pharmaceutical excipients, make granule, sheet or pharmaceutical capsules dosage form.

Above-mentioned weight proportion preparation of compositions also can prepare by the following method, it is characterized in that formula proportion takes by weighing each medicine by weight, add 5-15 and doubly measure ethanol, volume by volume concentration is: 40-80%, backflow 0.5-2 hour twice, filter, get supernatant, merge supernatant, decompression recycling ethanol also concentrates, vacuum drying, be ground into fine powder, add proper pharmaceutical excipients, make granule, tablet or capsule medicine dosage form.Cortex Phellodendri bitter cold in the side is gone into kidney and urinary bladder channel, has heat clearing and damp drying, the effect of nourishing YIN to lower pathogenic fire; The Semen Plantaginis clearing away heat and promoting diuresis, the kind puckery pouring of diuresis; The Semen Vaccariae blood circulation promoting and blood stasis dispelling, the collateral dredging regulating menstruation; The Radix Salviae Miltiorrhizae blood circulation promoting and blood stasis dispelling, collateral dredging and blood; The Herba Epimedii kidney invigorating and YANG supporting, expelling wind and removing dampness.Five medicines share the effect that can reach eliminating damp-heat, disperse blood stasis and dredge collateral, tonify deficiency strengthening the body resistance.

Experimentation:

60 male SD rats, about body weight 200 grams, lumbar injection 0.9% pentobarbital sodium is pressed 0.5ml/100g anesthesia, aseptic condition hypogastric region median incision, expose the prostate notopodium of bladder and seminal vesicle inboard, 10 rats of normal control group are in 0.2ml/ normal saline of prostate notopodium injection, and all the other 50 rats are injected 25% XIAOZHILING ZHUSHEYE in the prostate notopodium.0.2ml/ only, close abdomen.The 7th day 50 rats with modeling of postoperative are divided into 5 groups at random, every group 10, be model group, positive drug control group QIANLIE ANTONG (1g/kg), be subjected to reagent low dose group (1.5g/kg), be subjected to dosage in the reagent (3.0g/kg), be subjected to reagent high dose (6.0g/kg), gastric infusion (granule of making by optimum formula), once a day, successive administration is 30 days.

Table 1 is respectively organized TNF-a and IL-8 comparison in rat prostate coefficient, the prostata tissue

Compare ##p＜0.01 with matched group; Compare * p＜0.05 with model group; * p＜0.01.

Model group rat prostate coefficient increases, compare with matched group, difference has significance (p＜0.01), is subjected to each dosage group of reagent can reduce the prostate coefficient in various degree, compares with model group, difference has significance (p＜0.01 or P＜0.05), see Table 1, illustrate to be subjected to each dosage group of reagent can alleviate chronic prostatitis syndrome, alleviate edema, reduce prostatic weight, suppress prostatic hyperplasia.TNF-a and IL-8 level increase in the model group rat prostate tissue, compare with the normal control group, significant difference (p＜0.01) is arranged, be subjected to each dosage group of reagent can reduce TNF-a and IL-8 level in the prostata tissue, compare with model group, difference has significance (p＜0.01 or p＜0.05), sees Table 1.

TNF-a is the factor that causes systemic inflammatory response the earliest, can cause the vascular endothelial cell structural change, causes vascular endothelial cell damage, makes plasma protein and water infilter local organization in a large number, increases the weight of the local inflammation reaction.IL-8 hangs down the potent inflammation chemotactic factor of molecular mass relatively, behind inflammatory stimulus, produces by macrophage, endotheliocyte etc. are a large amount of, and further exacerbate inflammation reaction, TNF-a and IL-8 level are more high, and inflammatory reaction is more heavy.

Table 1 data declaration is subjected to each dosage group of reagent can obviously reduce TNF-a and IL-8 level in the prostata tissue, shows the inflammatory reaction that is subjected to reagent can alleviate chronic prostatitis, and is effective to chronic prostatitis and hypertrophy.

Clinical research

The granule made from prescription noted earlier, take the 8-10 gram every day, taking 2-4 week continuously, serves as the treatment index with the discomfort of urinating, burning sensation, frequent micturition, urgent micturition, dysurea etc., abnormal color of urine, muddiness, white urine, dysurea, and above sx is effective, above symptom complete obiteration is for curing, through hospital clinical 30 routine chronic prostatitis patient's checkings, effective 30 examples are cured 25 examples, total effective rate 100%, obvious effective rate 83.3%.

Claims

1. pharmaceutical composition for the treatment of chronic prostatitis and prostatic hyperplasia is characterized in that it is made by following materials of weight proportions medicine: Cortex Phellodendri 2-30 part, Semen Plantaginis 2-20 part, Semen Vaccariae 2-30 part, Radix Salviae Miltiorrhizae 2-20, Herba Epimedii 1-10 part.

2. according to the pharmaceutical composition of the described treatment chronic prostatitis of claim 1 and prostatic hyperplasia, it is characterized in that it is made by following materials of weight proportions medicine: Cortex Phellodendri 10-15 part, Semen Plantaginis 5-10 part, Semen Vaccariae 10-15 part, Radix Salviae Miltiorrhizae 5-10 part, Herba Epimedii 2-5 part.

3. according to the pharmaceutical composition of the described treatment chronic prostatitis of claim 1 and prostatic hyperplasia, it is characterized in that it is made by following materials of weight proportions medicine: 16 parts of Cortex Phellodendris, 8 parts of Semen Plantaginiss, 16 parts of Semen Vaccariae, 7 parts of Radix Salviae Miltiorrhizaes, 3 parts of Herba Epimedii.

4. according to the pharmaceutical composition of the described treatment chronic prostatitis of one of claim 1～3 and prostatic hyperplasia, it is characterized in that taking by weighing each medicine by formula proportion, add 5-15 times of water gaging, boiled 0.5-2 hour, and filtered, get supernatant, filtering residue adds 6-10 times of water gaging, boils 0.5-1.5 hour, filters, get supernatant, merge supernatant, concentrate, vacuum drying, be ground into fine powder, add proper pharmaceutical excipients, make granule, sheet or pharmaceutical capsules dosage form.

5. according to the pharmaceutical composition of the described treatment chronic prostatitis of one of claim 1～3 and prostatic hyperplasia, it is characterized in that taking by weighing each medicine by formula proportion, add 5-15 and doubly measure ethanol, volume by volume concentration is: 40-80%, backflow 0.5-2 hour twice, filters, and gets supernatant, merge supernatant, decompression recycling ethanol also concentrates, and vacuum drying is ground into fine powder, add proper pharmaceutical excipients, make granule, sheet or pharmaceutical capsules dosage form.