CN102178935A - Preparation for resisting radiation, enhancing body immunity and preventing and treating tumors - Google Patents
Preparation for resisting radiation, enhancing body immunity and preventing and treating tumors Download PDFInfo
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- CN102178935A CN102178935A CN2011100987607A CN201110098760A CN102178935A CN 102178935 A CN102178935 A CN 102178935A CN 2011100987607 A CN2011100987607 A CN 2011100987607A CN 201110098760 A CN201110098760 A CN 201110098760A CN 102178935 A CN102178935 A CN 102178935A
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Abstract
The invention provides a preparation for resisting radiation, enhancing body immunity and preventing and treating tumors, which takes marine fishskin collagen oligopeptide powder and ganoderma extract as main raw materials and is concretely prepared from the following components in parts by weight: 300-700 parts of marine fishbone collagen oligopeptide powder, 100-300 parts of ganoderma extract, 200-400 parts of medicinal auxiliary sucrose, 30-70 parts of essence and 0.5-2 parts of sucralose. The components are treated by the production processes of premixing, granulating, totally mixing and the like to obtain granules. The invention has the beneficial effects that biologically active peptide and polysaccharide contained in the preparation are used as a regulator and an activator for an immune function, can directly act on immune cells to promote proliferation and differentiation of the immune cells, have the functions of improving the immunity of the human body, improving the hypoxia resistance of the human body and eliminating free radicals, and simultaneously can effectively resist the injury of radiation to the human body and improve the radiation resistance of the human body.
Description
Technical field
The present invention relates to a kind of combination formula, radiation hazradial bundle is had defencive function, can prevent curing oncoma and strengthen body immunity.
Background technology
Body is to realize its immunologic function by a complicated immune system of being made up of immune organ, immunocyte and immune factor.The normalization of immune existence and function is the stable basic assurance of body's immunity, any part damaged or all can cause the incomplete or disorderly of immunologic function unusually wherein, thus body is reduced or the forfeiture immunologic function.Radiation is an oxidative damage to one of mechanism of body injury, and when radiation effects during in body, intravital large quantity of moisture of machine is broken down into hydroperoxyl radical and hydroxyl radical free radical.These two kinds of free radicals are as initiator, and a large amount of lipid peroxidation in the primosome causes damage to body biomembrane and biomacromolecule, very easily the generation of induced tumor.Immune system is the responsive system of radiation damage, and the immune organ that participation immunologic functions such as spleen, thymus are regulated is high radiosensitive cell mass, and radiation effects will make the body immune system function reduce in these cell masses.Along with social development, the use of mobile phone, TV, computer etc. more and more widely, the radiation that these electrical equipment brought has very big harm to human body, but is necessary to develop a kind of not only enhance immunity but also can radiation-resistant product.
Summary of the invention
The invention provides a kind of preparation that is used for radioprotective, enhance immunity, anti-curing oncoma, not only effective, and taking convenience.
The technical solution adopted in the present invention is: adopting marine fish collagen oligopeptide powder, Ganoderma extract is primary raw material, it is characterized in that it is by following quality proportioning: 100～300 parts of 300～700 parts of marine fishbone collagen oligopeptide powder, Ganoderma extract are made granule in conjunction with 0.5～2 part of 200～400 parts of adjuvant sucrose, 30～70 parts in essence, sucralose through premix, preparation of granules, total production technology such as mix.Wherein Ganoderma extract is made by decoction and alcohol sedimentation technique, and Ganoderma sporophore is pulverized, and adds the water extraction 2 times of 8 times of amounts, filters merging filtrate, add an amount of 95% ethanol again, constantly stir, make to contain the alcohol amount and reach 70%, more than the quiet 24h, treat that precipitation is complete, get supernatant, concentrate decompression recycling ethanol.Slowly add 70 ℃ of hot distilled waters of equivalent in above concentrated solution, and add 0.5% sodium benzoate, constantly stir, make its abundant mixed dissolution, put under 3～5 ℃ of temperature, leave standstill more than the 48h, treat precipitation fully, be filtered to clear and brightly, concentrating under reduced pressure obtains extractum.
Of the present invention part is mass parts, is mass units such as this area microgram commonly used, milligram, gram, kilogram.
A preparation suggestion of the present invention day clothes effective dose is 5～10g, and every day 1 time, warm boiled water gets final product.
The invention has the beneficial effects as follows: biologically active peptide that this product is contained and polysaccharide component are the regulator and the activator of immunologic function, can directly act on immunocyte, promote the propagation and the differentiation of immunocyte, has human body immunity improving power, improve body's hypoxia tolerance, eliminate free radical, can effectively resist the injury that radiation causes body simultaneously, improve the capability of resistance to radiation of body.Be applicable to radiating worker of contact and the cancer patient who carries out chemotherapy, radiotherapy, and carry out causing immunologic hypofunction after chemotherapy, the radiotherapy patient of degradation toxic and side effects and immunologic hypofunction person under leukocyte, the erythrocyte.
Compound basis:
Marine fish collagen oligopeptide powder is that meat, skin, the bone with marine fishes is raw material, adopts the product of the method production of biological enzymolysis, and marine fish collagen oligopeptide powder becomes the focus of research because of its special physiological properties and physicochemical characteristic.Since affirmation gelatin such as the big island of Japanese scholar in 1979 have hypotensive activity, there have been a lot of researchs to show that all collagen polypeptide has different physiological roles.Most antibiotic Toplink in ocean is constantly synthetic in hemocyte, is stored in the cytoplasmic granule with the form of mature peptide, and the back that is upset discharges, and participates in the immune defence of body.Marine collagen by himself excellence antioxidation, can play the effect that radiation hazradial bundle is had assistant protection function indirectly.
Polysaccharide is the active ingredient of extracting from Ganoderma, is generally acknowledged it is the important activity composition of Ganoderma, and the main pharmacological of ganoderan shows as antitumor and raise immunity.The realization of its immunological enhancement and immune restoration effect mainly depends on two aspects: (1) is to the direct acting result of immunocyte; (2) realization by body nerve-endocrine-immune mutual regulating action.Show that by immunity test ganoderan is the human body immunity improving function obviously, the natural killer cell activity that normal kunming mice peritoneal macrophage is reached lotus Lewis lung cancer and immunocompromised mice also has tangible activation.Ganoderan can strengthen mice specific humoral immunity function, antitumor, antiviral, and aspect such as immunomodulating play an important role.
The effect of each raw material is complemented each other in this product, makes this product have the good health care that radiation hazradial bundle is had assistant protection function and enhancing immunity.
The function of said preparation:
One, improves body's immunity, enhancing human body immunity power
The contained effective ingredient of this invention preparation can directly act on immunocyte, promotes the propagation and the differentiation of immunocyte, and the enhance immunity answering is kept normal immunoreation, thereby strengthens the resistance of human body.
Two, radioprotective, anti-curing oncoma
Biologically active peptide in this invention and polysaccharide have very high oxidation resistance, can suppress leukocyte count and the reduction of lymphocyte number conversion ratio, liver lipid peroxidation and pancreatic cell apoptosis that acute radiation causes, and radiation damage is had auxiliary protection function; Can effectively suppress simultaneously the cancerous cell pathological changes that causes because of radiation etc., the generation of prophylaxis of tumours.
The specific embodiment
Following examples are used to illustrate the present invention, but are not used for limiting the scope of the invention.
The invention will be further described below in conjunction with embodiment:
Embodiment 1: the preparation of a kind of radioprotective, enhancing body immunity and anti-curing oncoma, adopting marine fish collagen oligopeptide powder, Ganoderma extract is primary raw material, by following quality proportioning: marine fishbone collagen oligopeptide powder 500g, Ganoderma extract 150g, pharmaceutic adjuvant sucrose 300g, essence 50g, sucralose 1g make granule through premix, preparation of granules, total production technology such as mix, adorn every bag of 6g, every day 1 time, each one bag, use warm boiled water.
Embodiment 2: the preparation of a kind of radioprotective, enhancing body immunity and anti-curing oncoma, adopting marine fish collagen oligopeptide powder, Ganoderma extract is primary raw material, by following quality proportioning: marine fishbone collagen oligopeptide powder 650g, Ganoderma extract 100g, pharmaceutic adjuvant sucrose 200g, essence 48g, sucralose 2g make granule through premix, preparation of granules, total production technology such as mix, adorn every bag of 6g, every day 1 time, each one bag, use warm boiled water.
Embodiment 3: the preparation of a kind of radioprotective, enhancing body immunity and anti-curing oncoma, adopting marine fish collagen oligopeptide powder, Ganoderma extract is primary raw material, by following quality proportioning: marine fishbone collagen oligopeptide powder 400g, Ganoderma extract 300g, pharmaceutic adjuvant sucrose 250g, essence 55g, sucralose 1.5g make granule through premix, preparation of granules, total production technology such as mix, adorn every bag of 6g, every day 1 time, each one bag, use warm boiled water.
Embodiment 4: human feeding trial.Use the granule of the present invention of preparation among the embodiment 1, the effect of this product is tested.
The study subject standard: the crowd of simple hypoimmunity, the age is between 45～65 years old.
Experimental design and grouping: adopt two kinds of control design between self and group.By above-mentioned Standard Selection 100 routine experimenters, divide into groups according to the requirement of randomized, double-blind, be divided into test-meal group and matched group, consider influence result's principal element such as age, sex, diet etc. as far as possible, carry out harmony to check, with the comparability between the assurance group.Every group of experimenter's 50 examples.The test-meal group is taken this invention granule 1 time for each person every day, and each 1 bag, matched group is taken placebo, takes continuously 60 days.
The grouping situation sees Table 1.The preceding two groups of blood of test-meal, urine, just routine and hepatic and renal function, Chest X-rays, electrocardiogram, B ultrasonic etc. are checked all in normal range, the equal no significant difference of content (P＞0.05) of two groups of interior macrophages of subject age, sex, blood medium-sized lymphocyte and body has comparability.
Data relatively as table 1 test-meal was last
After the test-meal situation see Table 2, table 3.
Table 2 blood testing-lymphocyte
Table 3 body fluid chemical examination-macrophage
By table 2, table 3 as seen, took back 60 days, the content of lymphocyte and macrophage all obviously improves (P＜0.01) before and after the test-meal of test-meal group, and significantly better than matched group, two group differences are (P＜0.01) very significantly.
The result shows, examination clothes preparation of the present invention is after 60 days, self relatively reach before and after the test-meal of test-meal group after the test-meal between test-meal group and matched group group relatively, the content of the interior macrophage of blood medium-sized lymphocyte and body obviously increases (P＜0.01), so this invention has the effect of enhancing human body immunity power.
Embodiment 5: human feeding trial.Use the granule of the present invention of preparation among the embodiment 1, the effect of this product is tested.
The study subject standard: the crowd that raying is more, as the IT industry of frequent use computer, broadcast television industry, medical industry etc.
Experimental design and grouping: adopt two kinds of control design between self and group.By above-mentioned Standard Selection 60 routine experimenters, divide into groups according to the requirement of randomized, double-blind, be divided into test-meal group and matched group, consider influence result's principal element such as age, sex, diet etc. as far as possible, carry out harmony to check, with the comparability between the assurance group.Every group of experimenter's 30 examples.The test-meal group is taken this invention granule 1 time for each person every day, and each 1 bag, matched group is taken placebo, takes continuously 60 days.
The preceding two groups blood of test-meal, urine, just routine and hepatic and renal function, Chest X-rays, electrocardiogram, B ultrasonic etc. are checked all in normal range, and the content no significant difference (P＞0.05) of two groups of subject age, sex, blood leucocyte has comparability.Concrete condition sees Table 1.
Data relatively as table 1 test-meal was last
Situation sees Table 2 after the test-meal
Leukocytic variation after table 2 test-meal
As can be seen from Table 2, take preparation of the present invention after 60 days, leukocytic quantity showed increased in the test-meal group blood of human body, and significantly better than matched group, two group differences are (P＜0.01) significantly.So this invention preparation can make leukocytosis in the human body, has the effect that radiation hazradial bundle is had assistant protection function.
Prove that by two groups of human feeding trials this invention preparation has enhance immunity and radioprotective, prevents the function of curing oncoma, and do not find in test toxic and side effects.
Claims (7)
1. a radioprotective, enhancing body immunity reach the preparation of preventing curing oncoma, and it is characterized in that adopting marine fish collagen oligopeptide powder, Ganoderma extract is primary raw material, and sucrose, essence, sucralose are pharmaceutic adjuvant.
2. the preparation of the described a kind of radioprotective of root a tree name claim 1, enhancing body immunity and anti-curing oncoma is characterized in that it is the preparation of being made by following quality proportion raw material: 300～700 parts of marine fishbone collagen oligopeptide powder, 100～300 parts of Ganoderma extracts, 200～400 parts of pharmaceutic adjuvant sucrose, 30～70 parts in essence, 0.5～2 part of sucralose.
The described a kind of radioprotective of root a tree name claim 1, strengthen the preparation of body immunity and anti-curing oncoma, the preparation technology's flow process that it is characterized in that it comprises premix, preparation of granules, total mix etc.
4. the described a kind of radioprotective of root a tree name claim 1, enhancing body immunity reach the preparation of anti-curing oncoma, and the dosage form that it is characterized in that it is a granule.
5. the described a kind of radioprotective of root a tree name claim 1, enhancing body immunity reach the preparation of anti-curing oncoma, it is characterized in that it is applicable to radiating worker of contact and the cancer patient who carries out chemotherapy, radiotherapy, and carry out causing immunologic hypofunction after chemotherapy, the radiotherapy patient of degradation toxic and side effects and immunologic hypofunction person under leukocyte, the erythrocyte.
6. the preparation of the described a kind of radioprotective of root a tree name claim 1, enhancing body immunity and anti-curing oncoma is characterized in that its a day clothes effective dose is 5～10g, every day 1 time, warm boiled water.
7. the preparation of a kind of radioprotective according to claim 1, enhancing body immunity and anti-curing oncoma, wherein used essence can be any edible essence, as fragrant citrus essence, strawberry essence, Fructus Vins essence, apple essence, hami melon essence etc.
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| CN2011100987607A CN102178935B (en) | 2011-04-20 | 2011-04-20 | Preparation for resisting radiation, enhancing body immunity and preventing and treating tumors |
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| CN2011100987607A CN102178935B (en) | 2011-04-20 | 2011-04-20 | Preparation for resisting radiation, enhancing body immunity and preventing and treating tumors |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102885301A (en) * | 2012-09-19 | 2013-01-23 | 北京同仁堂健康药业股份有限公司 | Composition for enhancing immunity and preparation method thereof |
| CN107183730A (en) * | 2017-05-19 | 2017-09-22 | 江苏江大五棵松生物科技有限公司 | A kind of marine collagen soy peptide powder for strengthen immunity |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101966222A (en) * | 2010-09-26 | 2011-02-09 | 林晨伟 | Medicinal composition and preparation for strengthening bones and preparation method thereof |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101966222A (en) * | 2010-09-26 | 2011-02-09 | 林晨伟 | Medicinal composition and preparation for strengthening bones and preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102885301A (en) * | 2012-09-19 | 2013-01-23 | 北京同仁堂健康药业股份有限公司 | Composition for enhancing immunity and preparation method thereof |
| CN102885301B (en) * | 2012-09-19 | 2013-12-11 | 北京同仁堂健康药业股份有限公司 | Composition for enhancing immunity and preparation method thereof |
| CN107183730A (en) * | 2017-05-19 | 2017-09-22 | 江苏江大五棵松生物科技有限公司 | A kind of marine collagen soy peptide powder for strengthen immunity |
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