CN102178068B - Application method of feed additive - Google Patents
Application method of feed additive Download PDFInfo
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- CN102178068B CN102178068B CN2010102181817A CN201010218181A CN102178068B CN 102178068 B CN102178068 B CN 102178068B CN 2010102181817 A CN2010102181817 A CN 2010102181817A CN 201010218181 A CN201010218181 A CN 201010218181A CN 102178068 B CN102178068 B CN 102178068B
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Abstract
The invention provides an application method of a feed additive for lowering the incidence rate of urinary calculi in sheep. In the method, a hydrochlorothiazide tablet is taken as an additive and fed to the sheep based on addition amount of 3.0-6.0mg/kg per day, and a diuresis effect can be achieved within 10-30 days so that the incidence rate of the urinary calculi in the sheep is lowered to below 5%. By adopting the feed additive, the urine excretion amount of the sheep can be improved by over 35%. The selected hydrochlorothiazide tablet is a diuretic without toxic side effect; and the method for feeding the additive to the sheep is scientific and reasonable and easy for operation.
Description
Technical field
The present invention relates to the use of feed addictive, especially can reduce the incidence of disease, particularly reasonable disposition of sheep urinary calculus and use in good time, effect is splendid.
Background technology
In recent years, along with the increasing of cotton seed hulls proportion in the cattle and sheep feed, the phenomenon of urinary calculus had appearred suffering from because of feeding cotton seed hulls in cattle and sheep.The cotton seed hulls of feeding suffers from urinary calculus has become mass-sending property disease, and the incidence of disease is up to 25-40%.Therefore, some area is used for cotton seed hulls to cultivate mushroom or is used as fertilizer.This has not only caused heavy economic losses to animal husbandry production, has caused the serious waste of feed resource simultaneously.
The sheep uriasis is a kind of metabolic disease that forms calculus (urinary calculi) in urinary tract.Urinary calculus is found in.Renal plevis, vesicoureteral or urethra face that to examine feature be urination disorder or renal shutdown.This disease can cause cystorrhexis, uremia or because of urinary tract system diffuse necrosis, hemorrhage and dead, the main pathogenic factor of this disease is nonprotein nitrogen and the excessive generation of mucoprotein because of renal shutdown, and urine pH increases and increases with phosphate content and form calculus.
Sheep calculus multiform is formed in kidney and bladder, often betides urethra but block, and vesical calculus does not show symptom not influencing when urinating, and urethral calculus mostly occurs at ram glans part and " S " shape pars convoluta.If calculus incomplete obstruction urethra, then visible urination time prolongs, frequent micturition, and hypourocrinia is interrupted or drips shape and flows out, and has urine to discharge sometimes; If stomachache appears in the then rarely seen micturition of calculus total blockage, urethra and lose the discharge of urine.Main methods of treatment is an operative treatment, but this mode easily recurs, and needs special nursing, has reduced the production performance of sheep.
Design of the present invention is to find a kind of feed addictive that diuresis is arranged, and the urinary calculus incidence of disease of supporting human body is significantly reduced, and these affluent resources of cotton seed hulls are rationally utilized, and has important directive function.
Summary of the invention
The objective of the invention is to: the feed addictive that provides can improve the amount of urinating of sheep, thereby reduces the urinary calculus incidence of disease that sheep causes because of edible cotton seed hulls; The additive main component is a Hydrochioro, and sheet is white in color.
The object of the present invention is achieved like this: a kind of using method of feed addictive, with the hydrochlorothiazide tablets is additive, 10-30 days can reach the effect of diuresis by the body weight 3.0-6.0mg/kg addition sheep of feeding every day, and the sheep calculus incidence of disease is dropped to below 5%.
The using method of described feed addictive uses that the urinary excretion of sheep can improve more than 35% after this agent.
The using method of described feed addictive, selecting hydrochlorothiazide tablets for use is the commercially available prod.
Design mechanism of the present invention and action principle: the main pathogenesis of sheep urinary calculus is regarded as nonprotein nitrogen and the excessive generation of mucoprotein, urine pH increases with phosphate content and increases and the formation calculus, but basic reason is to contain the cotton byproduct of gossypol owing to feed, because gossypol has significant antidiuresis biological function, cause the sheep amount of urinating to reduce, cause the deposition of calcium phosphorus to form calculus.We find in test: when the cotton seed hulls addition reached 450g/ (d. only), the lamb hypourocrinia was become thin gradually.When interpolation contained the cotton seed hulls of 1400mg free gossypol, the sheep amount of urinating descended 46.7 percentage points than control group.Contained the mixed fodder of 12% cotton seed hulls in 1 month feeding, fatten and suffer from 1400 of urinary calculus, dead 600 in the sheep 3500 1 years old age.
The hydrochlorothiazide tablets that the present invention selects for use is a diuretics, and its chemical name is a 6-nitrogen-3,4-two chloro-2H-1,2,4-benzene well thiadiazine-7-sulfonamide-1,1-dioxide;
Molecular structural formula is as follows:
Wherein: N, H, O, S, Cl represent nitrogen, hydrogen, oxygen, sulphur and chlorine respectively
Molecular formula is: C
7H
8ClN
3O
4S
2
Hydrochioro mainly suppresses the distal convoluted tubule near-end to Na
+And Cl
-Heavily absorption, kidney increased the drainage of sodium chloride and produce diuresis, be to imitate diuretics in a kind of.
The hydrochlorothiazide tablets that the present invention selects for use is that diuretics has following characteristics: (1) can regulate body water-electrolyte metabolism and electrolyte balance.(2) diuresis, urine sodium, potassium, chlorine, phosphorus and magnesium plasma are drained and are increased.(3) the diuresis adjusting control agent sheep of feeding, the sheep urinary calculus incidence of disease obviously reduces.The sheep methodological science of feeding is reasonable, simple to operation, has no side effect.
Design direction of the present invention is to select suitable diuretics, increases the amount of urinating that sheep reduces because of the gossypol of searching for food, and the calculus structure that forms is washed away urethra, thereby reduce the urinary calculus incidence of disease, shows technological progress.
The specific embodiment
Embodiment 1
The dosage of feeding is: every day is by body weight 3.0mg/kg or 4.5mg/kg;
Randomly draw 40 10 monthly ages, the male sheep of the about 40kg of body weight is divided into 5 groups at random, and body weight, feed intake and the amount of urinating difference are not remarkable between each group.Testing 1 group is control group, do not feed antidiuresis and gossypol, test 2 groups by area, the South Sinkiang custom cotton seed hulls 800g that feeds that normally feeds, test 3 groups of every sheep by 3.0mg/kg days interpolation antidiuretics, test 4 groups of every sheep and added antidiuretic, test 5 groups of every sheep and add antidiuretic by 6.0mg/kg by 4.5mg/kg days.Raise 10 days phases in advance, formal 30 days phases, survey the amount of urinating and amount of drinking water every day.
Table 1 influence (kg/d) of antidiuretic of feeding to the sheep amount of drinking water
Table 2 influence (kg/d) of antidiuretic of feeding to the sheep amount of urinating
By last 1,2 table data as can be known, the sheep of 800g cotton seed hulls of only feeding, amount of drinking water is reduced to 1.25 kilograms for preceding 2.04 kilograms by test, has reduced by 38.72%; The amount of urinating is reduced to 293.08 grams by preceding 637.59 grams of test, has reduced by 54.03%, significant difference (P＜0.05).And the addition that has added the antidiuresis Hydrochioro is in every 4.5mg/kg. days the sheep, tests the normal sheep of 4 groups of amounts of drinking water and the most approaching cotton seed hulls of not feeding of the amount of urinating, and this dose effect the best is described.
Embodiment 2
The dosage of feeding is: every day is by body weight 4.5mg/kg;
Verify of the influence of Hydrochioro groundwater increment to the sheep urinary calculus incidence of disease:
Culturing the sub-district with Kashi great cause Kazak sheep is example, and the statistics fattening lamb was 1662 in 2008, and lithiasis morbidity several 392 is because of dead 77 of lithiasis, the incidence of disease 23.59%; After the great special project of Xinjiang autonomous region " meat cattle and sheep standardized production " project in 2009 is subsidized drug use, 4217 of fattening lambs, lithiasis morbidity several 211, because of 9 of the dead sheep of lithiasis, the incidence of disease only is 5%.
Claims (3)
1. the purposes of hydrochlorothiazide tablets in the feed addictive that make to reduce the sheep urinary calculus incidence of disease, it is characterized in that: be additive with the hydrochlorothiazide tablets, every day is by the body weight 3.0-6.0mg/kg addition sheep of feeding, can reach the effect of diuresis in 10-30 days, the sheep calculus incidence of disease is dropped to below 5%.
2. the purposes of hydrochlorothiazide tablets according to claim 1 in the feed addictive that make to reduce the sheep urinary calculus incidence of disease is characterized in that: use that the urinary excretion of sheep can improve more than 35% after this agent.
3. the purposes of hydrochlorothiazide tablets according to claim 1 in making the feed addictive that reduces the sheep urinary calculus incidence of disease, it is characterized in that: selecting hydrochlorothiazide tablets for use is the commercially available prod.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102181817A CN102178068B (en) | 2010-07-06 | 2010-07-06 | Application method of feed additive |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010102181817A CN102178068B (en) | 2010-07-06 | 2010-07-06 | Application method of feed additive |
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| Publication Number | Publication Date |
|---|---|
| CN102178068A CN102178068A (en) | 2011-09-14 |
| CN102178068B true CN102178068B (en) | 2013-07-31 |
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| CN2010102181817A Expired - Fee Related CN102178068B (en) | 2010-07-06 | 2010-07-06 | Application method of feed additive |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103564202B (en) * | 2012-08-06 | 2016-01-20 | 甘肃农业大学 | The formula of prevention and alleviation sheep urinary calculus |
| CN104397431A (en) * | 2014-12-10 | 2015-03-11 | 山东新希望六和集团有限公司 | Compound feeds for treating bovine urolithiasis and preparation method for compound feeds |
| CN109053805B (en) * | 2018-10-11 | 2020-12-18 | 广州市兴达动物药业有限公司 | Preparation method of thiazine feed additive |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1593421A (en) * | 2004-06-22 | 2005-03-16 | 南京农业大学 | Compound formulation for preventing and treating broiler ascites syndrome |
| EP1480622B1 (en) * | 2002-03-06 | 2008-12-24 | Universiteit Gent | Immediate release pharmaceutical granule compositions and a continuous process for making them |
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2010
- 2010-07-06 CN CN2010102181817A patent/CN102178068B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1480622B1 (en) * | 2002-03-06 | 2008-12-24 | Universiteit Gent | Immediate release pharmaceutical granule compositions and a continuous process for making them |
| CN1593421A (en) * | 2004-06-22 | 2005-03-16 | 南京农业大学 | Compound formulation for preventing and treating broiler ascites syndrome |
Non-Patent Citations (4)
| Title |
|---|
| 兽医药理知识系列讲座(六) 特异性解毒药的分类及临床应用;司红彬;《兽医导刊》;20090415(第04期);33 * |
| 司红彬.兽医药理知识系列讲座(六) 特异性解毒药的分类及临床应用.《兽医导刊》.2009,(第04期), |
| 尿石颗粒剂利尿和排石作用;曾晓春等;《江西中医学院学报》;20031230(第04期);59 * |
| 曾晓春等.尿石颗粒剂利尿和排石作用.《江西中医学院学报》.2003,(第04期), |
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| CN102178068A (en) | 2011-09-14 |
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Granted publication date: 20130731 Termination date: 20190706 |