CN102167713A - 一种氨基葡萄糖盐酸盐的制备方法 - Google Patents
一种氨基葡萄糖盐酸盐的制备方法 Download PDFInfo
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- CN102167713A CN102167713A CN2010102469307A CN201010246930A CN102167713A CN 102167713 A CN102167713 A CN 102167713A CN 2010102469307 A CN2010102469307 A CN 2010102469307A CN 201010246930 A CN201010246930 A CN 201010246930A CN 102167713 A CN102167713 A CN 102167713A
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- Prior art keywords
- glucosamine hydrochloride
- suction filtration
- citric acid
- waste residue
- mother liquor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- MSWZFWKMSRAUBD-UHFFFAOYSA-N 2-Amino-2-Deoxy-Hexose Chemical compound NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 title abstract description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 120
- 238000000034 method Methods 0.000 claims abstract description 63
- 239000002699 waste material Substances 0.000 claims abstract description 34
- 238000006460 hydrolysis reaction Methods 0.000 claims abstract description 21
- 230000007062 hydrolysis Effects 0.000 claims abstract description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 72
- CBOJBBMQJBVCMW-BTVCFUMJSA-N (2r,3r,4s,5r)-2-amino-3,4,5,6-tetrahydroxyhexanal;hydrochloride Chemical compound Cl.O=C[C@H](N)[C@@H](O)[C@H](O)[C@H](O)CO CBOJBBMQJBVCMW-BTVCFUMJSA-N 0.000 claims description 64
- 229960001911 glucosamine hydrochloride Drugs 0.000 claims description 64
- 238000000967 suction filtration Methods 0.000 claims description 63
- 239000000047 product Substances 0.000 claims description 58
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 50
- 239000012452 mother liquor Substances 0.000 claims description 45
- 238000005119 centrifugation Methods 0.000 claims description 36
- 230000008859 change Effects 0.000 claims description 36
- 239000008367 deionised water Substances 0.000 claims description 36
- 229910021641 deionized water Inorganic materials 0.000 claims description 36
- 239000012043 crude product Substances 0.000 claims description 29
- 238000001816 cooling Methods 0.000 claims description 27
- 238000002156 mixing Methods 0.000 claims description 27
- 238000007670 refining Methods 0.000 claims description 27
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 26
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical group [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 18
- 238000004821 distillation Methods 0.000 claims description 18
- 239000007788 liquid Substances 0.000 claims description 18
- 239000000463 material Substances 0.000 claims description 10
- 239000012141 concentrate Substances 0.000 claims description 9
- 238000001035 drying Methods 0.000 claims description 9
- 238000001704 evaporation Methods 0.000 claims description 9
- 230000008020 evaporation Effects 0.000 claims description 9
- 239000007787 solid Substances 0.000 claims description 9
- 239000008399 tap water Substances 0.000 claims description 9
- 235000020679 tap water Nutrition 0.000 claims description 9
- 238000010792 warming Methods 0.000 claims description 9
- 238000012262 fermentative production Methods 0.000 claims description 6
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 claims description 5
- 239000000908 ammonium hydroxide Substances 0.000 claims description 5
- 230000008569 process Effects 0.000 claims description 5
- 239000002253 acid Substances 0.000 claims 1
- 230000001476 alcoholic effect Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 abstract description 18
- 239000002994 raw material Substances 0.000 abstract description 8
- 238000005516 engineering process Methods 0.000 abstract description 6
- 238000003912 environmental pollution Methods 0.000 abstract description 4
- 229910001385 heavy metal Inorganic materials 0.000 abstract description 4
- 235000003563 vegetarian diet Nutrition 0.000 abstract description 4
- 238000000855 fermentation Methods 0.000 abstract 1
- 230000004151 fermentation Effects 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 238000005086 pumping Methods 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 7
- 229910052799 carbon Inorganic materials 0.000 description 7
- 239000002893 slag Substances 0.000 description 7
- 238000006243 chemical reaction Methods 0.000 description 4
- 229920002101 Chitin Polymers 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 230000001093 anti-cancer Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
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- 241000238557 Decapoda Species 0.000 description 2
- 101000748141 Homo sapiens Ubiquitin carboxyl-terminal hydrolase 32 Proteins 0.000 description 2
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- 235000008452 baby food Nutrition 0.000 description 2
- 201000011510 cancer Diseases 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 230000002950 deficient Effects 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 239000002778 food additive Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 239000002028 Biomass Substances 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- 206010020880 Hypertrophy Diseases 0.000 description 1
- 208000001953 Hypotension Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 238000005903 acid hydrolysis reaction Methods 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000002052 anaphylactic effect Effects 0.000 description 1
- 230000002605 anti-dotal effect Effects 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 238000003763 carbonization Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 235000019261 food antioxidant Nutrition 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 229960002442 glucosamine Drugs 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 208000021822 hypotensive Diseases 0.000 description 1
- 230000001077 hypotensive effect Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 239000000568 immunological adjuvant Substances 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 235000013615 non-nutritive sweetener Nutrition 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 230000001603 reducing effect Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 241000712461 unidentified influenza virus Species 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (4)
Priority Applications (1)
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CN 201010246930 CN102167713B (zh) | 2010-08-02 | 2010-08-02 | 一种氨基葡萄糖盐酸盐的制备方法 |
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CN 201010246930 CN102167713B (zh) | 2010-08-02 | 2010-08-02 | 一种氨基葡萄糖盐酸盐的制备方法 |
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CN102167713A true CN102167713A (zh) | 2011-08-31 |
CN102167713B CN102167713B (zh) | 2013-08-21 |
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Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103450289A (zh) * | 2013-08-27 | 2013-12-18 | 上海应用技术学院 | 一种d-氨基葡萄糖盐酸盐的制备方法 |
CN103570773A (zh) * | 2013-11-15 | 2014-02-12 | 安徽丰原发酵技术工程研究有限公司 | 一种制备氨基糖盐酸盐的方法 |
CN108220349A (zh) * | 2016-12-22 | 2018-06-29 | 中粮集团有限公司 | 用于高效联产柠檬酸和氨基葡萄糖的发酵培养基及使用其的发酵方法 |
CN110256506A (zh) * | 2019-07-19 | 2019-09-20 | 山东润德生物科技有限公司 | 一种制备氨基葡萄糖盐酸盐的方法 |
CN113562729A (zh) * | 2021-06-12 | 2021-10-29 | 王德桂 | 一种柠檬酸菌渣联产活性炭 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101503433A (zh) * | 2009-03-06 | 2009-08-12 | 石勇 | 一种植物源氨基葡萄糖盐酸盐的制备方法 |
CN101550169A (zh) * | 2008-04-02 | 2009-10-07 | 徐州海吉亚生物制品有限公司 | 一种从柠檬酸渣中水解分离氨基葡萄糖盐酸盐的生产工艺 |
CN101628921A (zh) * | 2009-07-30 | 2010-01-20 | 扬州日兴生物科技股份有限公司 | 一种植物来源d-氨基葡萄糖盐酸盐的制备方法 |
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2010
- 2010-08-02 CN CN 201010246930 patent/CN102167713B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101550169A (zh) * | 2008-04-02 | 2009-10-07 | 徐州海吉亚生物制品有限公司 | 一种从柠檬酸渣中水解分离氨基葡萄糖盐酸盐的生产工艺 |
CN101503433A (zh) * | 2009-03-06 | 2009-08-12 | 石勇 | 一种植物源氨基葡萄糖盐酸盐的制备方法 |
CN101628921A (zh) * | 2009-07-30 | 2010-01-20 | 扬州日兴生物科技股份有限公司 | 一种植物来源d-氨基葡萄糖盐酸盐的制备方法 |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103450289A (zh) * | 2013-08-27 | 2013-12-18 | 上海应用技术学院 | 一种d-氨基葡萄糖盐酸盐的制备方法 |
CN103570773A (zh) * | 2013-11-15 | 2014-02-12 | 安徽丰原发酵技术工程研究有限公司 | 一种制备氨基糖盐酸盐的方法 |
CN108220349A (zh) * | 2016-12-22 | 2018-06-29 | 中粮集团有限公司 | 用于高效联产柠檬酸和氨基葡萄糖的发酵培养基及使用其的发酵方法 |
CN110256506A (zh) * | 2019-07-19 | 2019-09-20 | 山东润德生物科技有限公司 | 一种制备氨基葡萄糖盐酸盐的方法 |
CN113562729A (zh) * | 2021-06-12 | 2021-10-29 | 王德桂 | 一种柠檬酸菌渣联产活性炭 |
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CN102167713B (zh) | 2013-08-21 |
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Free format text: FORMER OWNER: JIANGSU JIANDING BIOTECHNOLOGY CO., LTD. Effective date: 20150629 |
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Effective date of registration: 20150629 Address after: 226000 Jiangsu Province, Nantong City Chongchuan District Youth Road No. 15 commercial office building 6 floor Patentee after: Nantong Foreign Trade Medical Health Products Co., Ltd. Address before: 226000 Jiangsu Province, Nantong City Chongchuan District Youth Road No. 15 commercial office building 6 floor Patentee before: Nantong Foreign Trade Medical Health Products Co., Ltd. Patentee before: Jiangsu Jianding Biotechnology Co., Ltd. |
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Application publication date: 20110831 Assignee: Pucheng Zhengtong Biotechnology Co.,Ltd. Assignor: NANTONG FOREIGN TRADE MEDICAL HEALTH PRODUCTS Co.,Ltd. Contract record no.: X2021980001867 Denomination of invention: A preparation method of glucosamine hydrochloride Granted publication date: 20130821 License type: Exclusive License Record date: 20210319 |
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