CN102166279B - Chinese medicinal composition for improving ovarian response and application thereof - Google Patents
Chinese medicinal composition for improving ovarian response and application thereof Download PDFInfo
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- CN102166279B CN102166279B CN2011100981352A CN201110098135A CN102166279B CN 102166279 B CN102166279 B CN 102166279B CN 2011100981352 A CN2011100981352 A CN 2011100981352A CN 201110098135 A CN201110098135 A CN 201110098135A CN 102166279 B CN102166279 B CN 102166279B
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Abstract
The invention provides a Chinese medicinal composition for improving ovarian response, which comprises the following raw materials in part by weight: 100 to 300 parts of Chinese angelica, 200 to 500 parts of prepared rehmannia root, 150 to 450 parts of south dodder seed, 200 to 500 parts of glossy privet fruit, 150 to 450 parts of himalayan teasel root, 100 to 300 parts of root of red-rooted salvia and 100 to 300 parts of medicinal indianmulberry root. The Chinese medicinal composition is supported by the substantial classical theory of gynecology in Chinese medical science, has a reasonable component proportion, a few herbal medicines in a prescription, low cost, and a definite clinical curative effect, does not have toxic or side effect, is safe in administration, and can be used for improving the ovarian response in in-vitro fertilization-embryo transplantation, and quality is easy to control.
Description
Technical field
The invention belongs to Chinese medicine composition, relate to a kind of Chinese medicine composition that is used for improving vitro fertilization-embryo implanting ovary response property, can be used for improving the application in the medicine of vitro fertilization-embryo implanting ovary response property in preparation.
Background technology
The vitro fertilization-embryo implanting technology is the important means that solves the sterility and infertility problem.Ovary response property is the key factor that can the vitro fertilization-embryo implanting technology successfully become pregnant.Chinese medicine composition has clear superiority aspect the ovary response property in improving vitro fertilization-embryo implanting.
Chinese medicine thinks that kidney qi is contained, and menses is ripe, and makes the conception vessel circulation, and chong channel is arrogant, acts on the uterus, dashes and appoint, and makes it QI and blood and is in harmonious proportion, and the men and women joins in good time, and two essences are fought mutually, and then tire is pregnant is to become.If asthenia of renal qi undermines menses, Chong and Ren channel disorder is qi-blood disharmony, all can influence the pregnant formation of tire.Kidney storing essence, essence can be changed into QI, the growth of human body, growth and reproduction are being dominated in the prosperity and decline of essence in kidney, and dominant force kidney-menses-dash and appoint-coordination of uterus reproduction s function.If congenital deficiency of kidney-QI, or intemperate sexual intercourse, prolonged illness is impairment of the kidney, and kidney qi secretly consumes, and then dashes and appoints void to decline, and vessels of the uterus loses supports, and can not become pregnant by consolidating semen; If insufficiency of kidney-YANG, decline of the fire from the gate of life is dashed to appoint and is lost in warm, can not become pregnant by consolidating semen; If deficiency of kidney yin, the essence and blood loss, born of the same parents lose moist, even hyperactivity of fire caused by deficiency of YIN, sea of blood intrinsic heat, Chong and Ren channel disorder all can not become pregnant by consolidating semen, sends out to be infertility." Yizong Jinjian gynecological heart method gist ": the event of infertilitas feminis, dash also by hindering it.Through saying: woman two or seven and menarche, conception vessel is logical, and taichong channel is contained, and regular menstrual cycle is so can there be son.Dash the arteries and veins of appointing if the heresy of three the moon is hindered it, diease occurrences such as menoxenia, leucorrhea with red and white discharge, menometrorrhagia, metrorrhagia are then arranged here.Or because of stagnated blood amasss in born of the same parents, it is pregnant that fresh blood can not become, or because of the cold born of the same parents' heat of born of the same parents, can not become pregnant by consolidating semen, or contain abundant expectoration because of body, and adipose membrane is jammed among the born of the same parents and infertile.All ought sift its because of, by card medical treatment, self energy has son also." on the Shen Shi woman section summary volume ": this asks the full QI and blood that relies of son sufficient, and it is loss of fecundity that void declines.So Xue Li vegetarian cloud: examine men and women's chi pulse to being in ... Right this special its body void of speech and conception failture person are also.The conception failture person if body is not empty must have him sick.
Summary of the invention
The purpose of this invention is to provide a kind of Chinese medicine composition that improves ovary response property, mainly is a kind of Chinese medicine composition that is used for improving vitro fertilization-embryo implanting ovary response property, and the preparation of per 1000 dosage units of this Chinese medicine composition is formed (weight proportion) by following proportion raw material: Radix Angelicae Sinensis 100-300 part; Radix Rehmanniae Preparata 200-500 part; Semen Cuscutae 150-450 part, Fructus Ligustri Lucidi 200-500 part, Radix Dipsaci 150-450 part; Radix Salviae Miltiorrhizae 100-300 part, Radix Morindae Officinalis 100-300 part.The weight of above component is calculated with crude drug.Per 1 part can be 1g, also can be kilogram or ton, if use gram to be unit, this prescription composition can be made into 1000 doses of pharmaceutical preparatioies.Said 1000 doses of fingers, the final drug preparation of processing, as process granule 1000g etc.; Also can process big packing as granule; Like the 100-500 bag, specifically can be 100 bags, 125 bags, 200 bags, 250 bags, 500 bags etc., every bag can be used as taking dose one time.
More than form, can be made into the preparation of 50-1000 taking dose,, process 125 bags, take the 1-2 bag at every turn, can take 62.5-125 time altogether as as granule.
More than form to be by weight as proportioning; When producing, can or reduce according to the corresponding proportion increase; Like large-scale production can be unit with the kilogram, or is unit with the ton, and small-scale production can milligram be a unit also; Weight can increase or reduce, but the constant rate of the raw medicinal herbs weight proportion between each composition.
The Chinese medicine composition of said ratio adds suitable excipient as required and processes suitable medicinal any dosage form, and said preparation can be multiple suitable dosage forms such as capsule, granule, tablet, powder.
Another object of the present invention provides described Chinese medicine composition and is used for improving the application in the medicine of vitro fertilization-embryo implanting ovary response property in preparation.
Usefulness of the present invention is: (1) pharmaceutical composition of the present invention has solid TCM Gynecology classical theory support, reasonable mixture ratio of components; (2) pharmaceutical composition clinical efficacy of the present invention is definite, has no side effect, and takes safety, can in preparation is used for improving the Chinese medicine composition of vitro fertilization-embryo implanting ovary response property, use; (3) pharmaceutical composition flavour of a drug of the present invention are few, are easy to quality control, and are simultaneously with low cost.
The specific embodiment
The present invention is further described through specific embodiment.
Embodiment 1 granule preparation of the present invention
Pharmaceutical composition is formed: Radix Angelicae Sinensis 100g, Radix Rehmanniae Preparata 200g, Semen Cuscutae 150g, Fructus Ligustri Lucidi 200g, Radix Dipsaci 150g, Radix Salviae Miltiorrhizae 100g, Radix Morindae Officinalis 100g.
Method for preparing:
(1) above seven flavor medicine, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, Semen Cuscutae, Fructus Ligustri Lucidi, Radix Dipsaci, Radix Salviae Miltiorrhizae, Radix Morindae Officinalis adds 10 times of amount 70% alcohol reflux 1.0 hours, extracts secondary altogether, and merge extractive liquid, reclaims ethanol.60 ℃ are evaporated to relative density of medicine liquid 1.05 (30 ℃ of surveys), with 14000 rev/mins of centrifugal remove impurity of tube centrifuge.Centrifugal liquid and alcohol extraction combining medicine, 60 ℃ are evaporated to relative density of medicine liquid 1.15 (60 ℃ of surveys).Concentrated solution is with spray dryer (control hydrojet speed is 2000ml/min, 140 ℃ of intake air temperatures, 85 ℃ of air outlet temperature) preparation extract powder.
(2) add 0.75g dextrin and the mixing of 1g Icing Sugar amount by the 1g dried cream powder, granulate with 85% ethanol moistening, wet grain drying (50 ℃ of pathogenic wind-warm), granulate is processed 1000 doses of granules, promptly gets.
Embodiment 2 preparation tablets of the present invention
Pharmaceutical composition is formed: Radix Angelicae Sinensis 100g, Radix Rehmanniae Preparata 200g, Semen Cuscutae 150g, Fructus Ligustri Lucidi 200g, Radix Dipsaci 150g, Radix Salviae Miltiorrhizae 100g, Radix Morindae Officinalis 100g.
Method for preparing:
(1) above seven flavor medicine, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, Semen Cuscutae, Fructus Ligustri Lucidi, Radix Dipsaci, Radix Salviae Miltiorrhizae, Radix Morindae Officinalis adds 10 times of amount 70% alcohol reflux 1.0 hours, extracts secondary altogether, and merge extractive liquid, reclaims ethanol.60 ℃ are evaporated to relative density of medicine liquid 1.05 (30 ℃ of surveys), with 14000 rev/mins of centrifugal remove impurity of tube centrifuge.Centrifugal liquid and alcohol extraction combining medicine, 60 ℃ are evaporated to relative density of medicine liquid 1.15 (60 ℃ of surveys).Concentrated solution is with spray dryer (control hydrojet speed is 2000ml/min, 140 ℃ of intake air temperatures, 85 ℃ of air outlet temperature) preparation extract powder.
(2) add lactose 495g, protein sugar 45g, 90-95% ethanol 50ml by the 1g dried cream powder and process granule, dried granule adds tabletting behind the magnesium stearate 30g mixing, processes 1000 in tablet, promptly gets.
Embodiment 3 capsule preparations of the present invention
Pharmaceutical composition is formed: Radix Angelicae Sinensis 100g, Radix Rehmanniae Preparata 200g, Semen Cuscutae 150g, Fructus Ligustri Lucidi 200g, Radix Dipsaci 150g, Radix Salviae Miltiorrhizae 100g, Radix Morindae Officinalis 100g.
Method for preparing:
(1) above seven flavor medicine, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, Semen Cuscutae, Fructus Ligustri Lucidi, Radix Dipsaci, Radix Salviae Miltiorrhizae, Radix Morindae Officinalis adds 10 times of amount 70% alcohol reflux 1.0 hours, extracts secondary altogether, and merge extractive liquid, reclaims ethanol.60 ℃ are evaporated to relative density of medicine liquid 1.05 (30 ℃ of surveys), with 14000 rev/mins of centrifugal remove impurity of tube centrifuge.Centrifugal liquid and alcohol extraction combining medicine, 60 ℃ are evaporated to relative density of medicine liquid 1.15 (60 ℃ of surveys).Concentrated solution is with spray dryer (control hydrojet speed is 2000ml/min, 140 ℃ of intake air temperatures, 85 ℃ of air outlet temperature) preparation extract powder.
(2) above dry extract is broken into fine powder, incapsulates, process 1000 of capsules, promptly get.
Embodiment 4 granule preparations of the present invention
Pharmaceutical composition is formed: Radix Angelicae Sinensis 150g, Radix Rehmanniae Preparata 275g, Semen Cuscutae 225g, Fructus Ligustri Lucidi 275g, Radix Dipsaci 225g, Radix Salviae Miltiorrhizae 150g, Radix Morindae Officinalis 150g.
Method for preparing:
(1) above seven flavor medicine, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, Semen Cuscutae, Fructus Ligustri Lucidi, Radix Dipsaci, Radix Salviae Miltiorrhizae, Radix Morindae Officinalis adds 10 times of amount 70% alcohol reflux 1.0 hours, extracts secondary altogether, and merge extractive liquid, reclaims ethanol.60 ℃ are evaporated to relative density of medicine liquid 1.05 (30 ℃ of surveys), with 14000 rev/mins of centrifugal remove impurity of tube centrifuge.Centrifugal liquid and alcohol extraction combining medicine, 60 ℃ are evaporated to relative density of medicine liquid 1.15 (60 ℃ of surveys).Concentrated solution is with spray dryer (control hydrojet speed is 2000ml/min, 140 ℃ of intake air temperatures, 85 ℃ of air outlet temperature) preparation extract powder.
(2) add 0.75g dextrin and the mixing of 1g Icing Sugar amount by the 1g dried cream powder, granulate with 85% ethanol moistening, wet grain drying (50 ℃ of pathogenic wind-warm), granulate is processed 1000 doses of granules, promptly gets.
Embodiment 5 preparation tablets of the present invention
Pharmaceutical composition is formed: Radix Angelicae Sinensis 150g, Radix Rehmanniae Preparata 275g, Semen Cuscutae 225g, Fructus Ligustri Lucidi 275g, Radix Dipsaci 225g, Radix Salviae Miltiorrhizae 150g, Radix Morindae Officinalis 150g.
Method for preparing:
(1) above seven flavor medicine, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, Semen Cuscutae, Fructus Ligustri Lucidi, Radix Dipsaci, Radix Salviae Miltiorrhizae, Radix Morindae Officinalis adds 10 times of amount 70% alcohol reflux 1.0 hours, extracts secondary altogether, and merge extractive liquid, reclaims ethanol.60 ℃ are evaporated to relative density of medicine liquid 1.05 (30 ℃ of surveys), with 14000 rev/mins of centrifugal remove impurity of tube centrifuge.Centrifugal liquid and alcohol extraction combining medicine, 60 ℃ are evaporated to relative density of medicine liquid 1.15 (60 ℃ of surveys).Concentrated solution is with spray dryer (control hydrojet speed is 2000ml/min, 140 ℃ of intake air temperatures, 85 ℃ of air outlet temperature) preparation extract powder.
(2) add lactose 495g, protein sugar 45g, 90-95% ethanol 50ml by the 1g dried cream powder and process granule, dried granule adds tabletting behind the magnesium stearate 30g mixing, processes 1000 in tablet, promptly gets.
Embodiment 6 capsule preparations of the present invention
Pharmaceutical composition is formed: Radix Angelicae Sinensis 150g, Radix Rehmanniae Preparata 275g, Semen Cuscutae 225g, Fructus Ligustri Lucidi 275g, Radix Dipsaci 225g, Radix Salviae Miltiorrhizae 150g, Radix Morindae Officinalis 150g.
Method for preparing:
(1) above seven flavor medicine, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, Semen Cuscutae, Fructus Ligustri Lucidi, Radix Dipsaci, Radix Salviae Miltiorrhizae, Radix Morindae Officinalis adds 10 times of amount 70% alcohol reflux 1.0 hours, extracts secondary altogether, and merge extractive liquid, reclaims ethanol.60 ℃ are evaporated to relative density of medicine liquid 1.05 (30 ℃ of surveys), with 14000 rev/mins of centrifugal remove impurity of tube centrifuge.Centrifugal liquid and alcohol extraction combining medicine, 60 ℃ are evaporated to relative density of medicine liquid 1.15 (60 ℃ of surveys).Concentrated solution is with spray dryer (control hydrojet speed is 2000ml/min, 140 ℃ of intake air temperatures, 85 ℃ of air outlet temperature) preparation extract powder.
(2) above dry extract is broken into fine powder, incapsulates, process 1000 of capsules, promptly get.
Embodiment 7 granule preparations of the present invention
Pharmaceutical composition is formed: Radix Angelicae Sinensis 200g, Radix Rehmanniae Preparata 350g, Semen Cuscutae 300g, Fructus Ligustri Lucidi 350g, Radix Dipsaci 300g, Radix Salviae Miltiorrhizae 200g, Radix Morindae Officinalis 200g.
Method for preparing:
(1) above seven flavor medicine, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, Semen Cuscutae, Fructus Ligustri Lucidi, Radix Dipsaci, Radix Salviae Miltiorrhizae, Radix Morindae Officinalis adds 10 times of amount 70% alcohol reflux 1.0 hours, extracts secondary altogether, and merge extractive liquid, reclaims ethanol.60 ℃ are evaporated to relative density of medicine liquid 1.05 (30 ℃ of surveys), with 14000 rev/mins of centrifugal remove impurity of tube centrifuge.Centrifugal liquid and alcohol extraction combining medicine, 60 ℃ are evaporated to relative density of medicine liquid 1.15 (60 ℃ of surveys).Concentrated solution is with spray dryer (control hydrojet speed is 2000ml/min, 140 ℃ of intake air temperatures, 85 ℃ of air outlet temperature) preparation extract powder.
(2) add 0.75g dextrin and the mixing of 1g Icing Sugar amount by the 1g dried cream powder, granulate with 85% ethanol moistening, wet grain drying (50 ℃ of pathogenic wind-warm), granulate is processed 1000 doses of granules, promptly gets.
Embodiment 8 preparation tablets of the present invention
Pharmaceutical composition is formed: Radix Angelicae Sinensis 200g, Radix Rehmanniae Preparata 350g, Semen Cuscutae 300g, Fructus Ligustri Lucidi 350g, Radix Dipsaci 300g, Radix Salviae Miltiorrhizae 200g, Radix Morindae Officinalis 200g.
Method for preparing:
(1) above seven flavor medicine, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, Semen Cuscutae, Fructus Ligustri Lucidi, Radix Dipsaci, Radix Salviae Miltiorrhizae, Radix Morindae Officinalis adds 10 times of amount 70% alcohol reflux 1.0 hours, extracts secondary altogether, and merge extractive liquid, reclaims ethanol.60 ℃ are evaporated to relative density of medicine liquid 1.05 (30 ℃ of surveys), with 14000 rev/mins of centrifugal remove impurity of tube centrifuge.Centrifugal liquid and alcohol extraction combining medicine, 60 ℃ are evaporated to relative density of medicine liquid 1.15 (60 ℃ of surveys).Concentrated solution is with spray dryer (control hydrojet speed is 2000ml/min, 140 ℃ of intake air temperatures, 85 ℃ of air outlet temperature) preparation extract powder.
(2) add lactose 495g, protein sugar 45g, 90-95% ethanol 50ml by the 1g dried cream powder and process granule, dried granule adds tabletting behind the magnesium stearate 30g mixing, processes 1000 in tablet, promptly gets.
Embodiment 9 capsule preparations of the present invention
Pharmaceutical composition is formed: Radix Angelicae Sinensis 200g, Radix Rehmanniae Preparata 350g, Semen Cuscutae 300g, Fructus Ligustri Lucidi 350g, Radix Dipsaci 300g, Radix Salviae Miltiorrhizae 200g, Radix Morindae Officinalis 200g.
Method for preparing:
(1) above seven flavor medicine, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, Semen Cuscutae, Fructus Ligustri Lucidi, Radix Dipsaci, Radix Salviae Miltiorrhizae, Radix Morindae Officinalis adds 10 times of amount 70% alcohol reflux 1.0 hours, extracts secondary altogether, and merge extractive liquid, reclaims ethanol.60 ℃ are evaporated to relative density of medicine liquid 1.05 (30 ℃ of surveys), with 14000 rev/mins of centrifugal remove impurity of tube centrifuge.Centrifugal liquid and alcohol extraction combining medicine, 60 ℃ are evaporated to relative density of medicine liquid 1.15 (60 ℃ of surveys).Concentrated solution is with spray dryer (control hydrojet speed is 2000ml/min, 140 ℃ of intake air temperatures, 85 ℃ of air outlet temperature) preparation extract powder.
(2) above dry extract is broken into fine powder, incapsulates, process 1000 of capsules, promptly get.
Embodiment 10 granule preparations of the present invention
Pharmaceutical composition is formed: Radix Angelicae Sinensis 250g, Radix Rehmanniae Preparata 425g, Semen Cuscutae 375g, Fructus Ligustri Lucidi 425g, Radix Dipsaci 375g, Radix Salviae Miltiorrhizae 250g, Radix Morindae Officinalis 250g.
Method for preparing:
(1) above seven flavor medicine, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, Semen Cuscutae, Fructus Ligustri Lucidi, Radix Dipsaci, Radix Salviae Miltiorrhizae, Radix Morindae Officinalis adds 10 times of amount 70% alcohol reflux 1.0 hours, extracts secondary altogether, and merge extractive liquid, reclaims ethanol.60 ℃ are evaporated to relative density of medicine liquid 1.05 (30 ℃ of surveys), with 14000 rev/mins of centrifugal remove impurity of tube centrifuge.Centrifugal liquid and alcohol extraction combining medicine, 60 ℃ are evaporated to relative density of medicine liquid 1.15 (60 ℃ of surveys).Concentrated solution is with spray dryer (control hydrojet speed is 2000ml/min, 140 ℃ of intake air temperatures, 85 ℃ of air outlet temperature) preparation extract powder.
(2) add 0.75g dextrin and the mixing of 1g Icing Sugar amount by the 1g dried cream powder, granulate with 85% ethanol moistening, wet grain drying (50 ℃ of pathogenic wind-warm), granulate is processed 1000 doses of granules, promptly gets.
Embodiment 11 preparation tablets of the present invention
Pharmaceutical composition is formed: Radix Angelicae Sinensis 250g, Radix Rehmanniae Preparata 425g, Semen Cuscutae 375g, Fructus Ligustri Lucidi 425g, Radix Dipsaci 375g, Radix Salviae Miltiorrhizae 250g, Radix Morindae Officinalis 250g.
Method for preparing:
(1) above seven flavor medicine, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, Semen Cuscutae, Fructus Ligustri Lucidi, Radix Dipsaci, Radix Salviae Miltiorrhizae, Radix Morindae Officinalis adds 10 times of amount 70% alcohol reflux 1.0 hours, extracts secondary altogether, and merge extractive liquid, reclaims ethanol.60 ℃ are evaporated to relative density of medicine liquid 1.05 (30 ℃ of surveys), with 14000 rev/mins of centrifugal remove impurity of tube centrifuge.Centrifugal liquid and alcohol extraction combining medicine, 60 ℃ are evaporated to relative density of medicine liquid 1.15 (60 ℃ of surveys).Concentrated solution is with spray dryer (control hydrojet speed is 2000ml/min, 140 ℃ of intake air temperatures, 85 ℃ of air outlet temperature) preparation extract powder.
(2) add lactose 495g, protein sugar 45g, 90-95% ethanol 50ml by the 1g dried cream powder and process granule, dried granule adds tabletting behind the magnesium stearate 30g mixing, processes 1000 in tablet, promptly gets.
Embodiment 12 capsule preparations of the present invention
Pharmaceutical composition is formed: Radix Angelicae Sinensis 250g, Radix Rehmanniae Preparata 425g, Semen Cuscutae 375g, Fructus Ligustri Lucidi 425g, Radix Dipsaci 375g, Radix Salviae Miltiorrhizae 250g, Radix Morindae Officinalis 250g.
Method for preparing:
(1) above seven flavor medicine, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, Semen Cuscutae, Fructus Ligustri Lucidi, Radix Dipsaci, Radix Salviae Miltiorrhizae, Radix Morindae Officinalis adds 10 times of amount 70% alcohol reflux 1.0 hours, extracts secondary altogether, and merge extractive liquid, reclaims ethanol.60 ℃ are evaporated to relative density of medicine liquid 1.05 (30 ℃ of surveys), with 14000 rev/mins of centrifugal remove impurity of tube centrifuge.Centrifugal liquid and alcohol extraction combining medicine, 60 ℃ are evaporated to relative density of medicine liquid 1.15 (60 ℃ of surveys).Concentrated solution is with spray dryer (control hydrojet speed is 2000ml/min, 140 ℃ of intake air temperatures, 85 ℃ of air outlet temperature) preparation extract powder.
(2) above dry extract is broken into fine powder, incapsulates, process 1000 of capsules, promptly get.
Embodiment 13 granule preparations of the present invention
Pharmaceutical composition is formed: Radix Angelicae Sinensis 300g, Radix Rehmanniae Preparata 500g, Semen Cuscutae 450g, Fructus Ligustri Lucidi 500g, Radix Dipsaci 450g, Radix Salviae Miltiorrhizae 300g, Radix Morindae Officinalis 300g.
Method for preparing:
(1) above seven flavor medicine, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, Semen Cuscutae, Fructus Ligustri Lucidi, Radix Dipsaci, Radix Salviae Miltiorrhizae, Radix Morindae Officinalis adds 10 times of amount 70% alcohol reflux 1.0 hours, extracts secondary altogether, and merge extractive liquid, reclaims ethanol.60 ℃ are evaporated to relative density of medicine liquid 1.05 (30 ℃ of surveys), with 14000 rev/mins of centrifugal remove impurity of tube centrifuge.Centrifugal liquid and alcohol extraction combining medicine, 60 ℃ are evaporated to relative density of medicine liquid 1.15 (60 ℃ of surveys).Concentrated solution is with spray dryer (control hydrojet speed is 2000ml/min, 140 ℃ of intake air temperatures, 85 ℃ of air outlet temperature) preparation extract powder.
(2) add 0.75g dextrin and the mixing of 1g Icing Sugar amount by the 1g dried cream powder, granulate with 85% ethanol moistening, wet grain drying (50 ℃ of pathogenic wind-warm), granulate is processed 1000 doses of granules, promptly gets.
Embodiment 14 preparation tablets of the present invention
Pharmaceutical composition is formed: Radix Angelicae Sinensis 300g, Radix Rehmanniae Preparata 500g, Semen Cuscutae 450g, Fructus Ligustri Lucidi 500g, Radix Dipsaci 450g, Radix Salviae Miltiorrhizae 300g, Radix Morindae Officinalis 300g.
Method for preparing:
(1) above seven flavor medicine, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, Semen Cuscutae, Fructus Ligustri Lucidi, Radix Dipsaci, Radix Salviae Miltiorrhizae, Radix Morindae Officinalis adds 10 times of amount 70% alcohol reflux 1.0 hours, extracts secondary altogether, and merge extractive liquid, reclaims ethanol.60 ℃ are evaporated to relative density of medicine liquid 1.05 (30 ℃ of surveys), with 14000 rev/mins of centrifugal remove impurity of tube centrifuge.Centrifugal liquid and alcohol extraction combining medicine, 60 ℃ are evaporated to relative density of medicine liquid 1.15 (60 ℃ of surveys).Concentrated solution is with spray dryer (control hydrojet speed is 2000ml/min, 140 ℃ of intake air temperatures, 85 ℃ of air outlet temperature) preparation extract powder.
(2) add lactose 495g, protein sugar 45g, 90-95% ethanol 50ml by the 1g dried cream powder and process granule, dried granule adds tabletting behind the magnesium stearate 30g mixing, processes 1000 in tablet, promptly gets.
Embodiment 15 capsule preparations of the present invention
Pharmaceutical composition is formed: Radix Angelicae Sinensis 300g, Radix Rehmanniae Preparata 500g, Semen Cuscutae 450g, Fructus Ligustri Lucidi 500g, Radix Dipsaci 450g, Radix Salviae Miltiorrhizae 300g, Radix Morindae Officinalis 300g.
Method for preparing:
(1) above seven flavor medicine, Radix Angelicae Sinensis, Radix Rehmanniae Preparata, Semen Cuscutae, Fructus Ligustri Lucidi, Radix Dipsaci, Radix Salviae Miltiorrhizae, Radix Morindae Officinalis adds 10 times of amount 70% alcohol reflux 1.0 hours, extracts secondary altogether, and merge extractive liquid, reclaims ethanol.60 ℃ are evaporated to relative density of medicine liquid 1.05 (30 ℃ of surveys), with 14000 rev/mins of centrifugal remove impurity of tube centrifuge.Centrifugal liquid and alcohol extraction combining medicine, 60 ℃ are evaporated to relative density of medicine liquid 1.15 (60 ℃ of surveys).Concentrated solution is with spray dryer (control hydrojet speed is 2000ml/min, 140 ℃ of intake air temperatures, 85 ℃ of air outlet temperature) preparation extract powder.
(2) above dry extract is broken into fine powder, incapsulates, process 1000 of capsules, promptly get.
Embodiment 16
1. case is collected and is divided into groups:
Choose the patient of 52 examples because of tubal infertility row vitro fertilization-embryo implanting.Be divided into treatment group 26 example and matched group 26 examples at random.Each group there are no significant at aspects such as age, the infertile time limit, Body Mass Index, menstruation the 3rd day FSH, LH, E2 difference has comparability.
2. Therapeutic Method
All patients all adopt conventional rectangular case (GnRHa+rFSH) induced ovulation scheme.Treatment group patient IVF falling tone cycle menstruation rose and takes this pharmaceutical composition (form: Radix Angelicae Sinensis 20g, Radix Rehmanniae Preparata 35g, Semen Cuscutae 30g, Fructus Ligustri Lucidi 35g, Radix Dipsaci 30g, Radix Salviae Miltiorrhizae 20g, Radix Morindae Officinalis 20g) simultaneously on the 3rd day, was decocted in water for oral dose 1 dose of every day, every day 2 times, serve on 28 days.
3. observation of curative effect:
Relatively two groups of patients' promoting ovulation drug consumption, HCG day blood E2 value and FSH value, obtain ovum rate, rate of fertilization, embryo quality rate, implantation rate, pregnancy rate, cycle cancellation rate.
4. result: this pharmaceutical composition can significantly improve vitro fertilization-embryo implanting person's ovary response property,
| Group | Matched group (n=26) | Treatment group (n=26) |
| Cycle cancellation rate | 2（7.7%） | 1（3.8%） |
| The ovarian stimulation natural law | 10±2 | 9±2 |
| Gn dosage (IU) | 2587±933 | 2172±522 |
| HCG day blood E2 (pmol/L) | 13257±9212 | 12892±8085 |
| Obtain the ovum number | 12±8 | 15±6 |
| Rate of fertilization (%) | 61.1±23.0 | 66.1±20.6 |
| Spilting of an egg embryo number | 8±5 | 8±4 |
| The embryo quality number | 5±4 | 6±3 |
| Pregnancy rate (%) | 33.9 | 36. |
Treatment group and matched group compare, * p 0.05, significant difference is arranged.
Claims (3)
1. a Chinese medicine composition that improves ovary response property is characterized in that, this Chinese medicine composition is processed by following materials of weight proportions medicine: Radix Angelicae Sinensis 100-300 part; Radix Rehmanniae Preparata 200-500 part; Semen Cuscutae 150-450 part, Fructus Ligustri Lucidi 200-500 part, Radix Dipsaci 150-450 part; Radix Salviae Miltiorrhizae 100-300 part, Radix Morindae Officinalis 100-300 part.
2. a kind of Chinese medicine composition that improves ovary response property according to claim 1 is used for improving the application in the medicine of vitro fertilization-embryo implanting ovary response property in preparation.
3. application according to claim 2 is characterized in that, the dosage form of said medicine is capsule, granule, tablet or powder.
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| CN109528980B (en) * | 2019-01-18 | 2021-09-17 | 北京厚成医药科技有限公司 | Traditional Chinese medicine composition for treating ovarian reserve function decline disease and pharmaceutical application thereof |
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