CN102160848A - Spot removing patch and preparation method thereof - Google Patents
Spot removing patch and preparation method thereof Download PDFInfo
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- CN102160848A CN102160848A CN201010110859XA CN201010110859A CN102160848A CN 102160848 A CN102160848 A CN 102160848A CN 201010110859X A CN201010110859X A CN 201010110859XA CN 201010110859 A CN201010110859 A CN 201010110859A CN 102160848 A CN102160848 A CN 102160848A
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- speckle dispelling
- paster
- skin
- patch
- preparation
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Abstract
The invention discloses a spot removing patch made of a novel substrate material, and a preparation method thereof. The spot removing patch is mainly added with the following components: aloe oil, green tea oil, a vitamin C derivative and a liquorice extract. An adhesive prepared by combining a novel elastomer material of styrene-isoprene-styrene triblock copolymer (SIS), a thickening agent and a plasticizer is taken as a cosmetic substrate material. A preparation process for a novel external patch is a low-temperature online fusion molding technology. The spot removing patch prepared by the method can obviously improve facial blackspots, has the multiple effects of removing spots, whitening and moisturizing, can infiltrate skin surface and fade various blackspots, and fulfills the aim of removing newly generated blackspots.
Description
Technical field
The present invention relates to speckle dispelling paster of a kind of employing novel elastomer material-styrene isoprene styrene block copolymer (SIS) (SIS) host material and preparation method thereof, belong to the skin nursing products field.
Background technology
The speckle kind mainly contains following several:
Chloasma also claims chloasma hepaticum, and the volume of being distributed in, cheek, nose etc. are located more, present irregular patch, but is symmetrically distributed.The formation reason of chloasma is most relevant with endocrine, and Exposure to Sunlight and stress can increase the weight of the color of chloasma, present large stretch of faint yellow mottle.
Black speck claims butterfly spot again, concentrates on two cheeks mostly, appears to a butterfly.The formation reason of black speck has multiple factor.Long-term over-drastic ultraviolet radiation, the aging inflammation of skin, or long for a long time small pox, eczema, procreation that all can chafe bottom black cell produces too much melanin, finally forms black speck.
Freckle is distributed in the zone that daylight shines easily usually.As near the eyes, cheeks, forehead, bridge of the nose place.Generally be that heredity causes, the people that skin is white is easier freckle, and after adolescence and the Exposure to Sunlight in summer, skin speckle number can increase, and color can be deepened.
The solar dermatitis that sunburn is promptly medically alleged also claims the daylight erythema.Exposed skin has Powdered desquamation later, and cutaneous pigmentation occurs through being exposed to the sun symptoms such as erythema, edema take place.Sunburn is to be formed by daylight or other irradiate light, be skin to a kind of acute injury reaction that strong illumination causes, be a kind of light sensitive dermatoses.Sunburn present oval projections or level and smooth, be dark-brown speckle, appear at the forearm outside, the back of the hand, shank front side and face easily.
Though the speckle kind is many, as above-mentioned chloasma, black speck, freckle, sunburn etc., all things considered, beauty treatment and eliminating spot and antioxidation have very big relation.Constantly produce and eliminate oxygen-derived free radicals in people's the body, when oxidation resistance in the body descends, just have too much free radical and form.Healthy young skin can be regulated the generation of skin free radical, eliminates unnecessary free radical, makes the free radical in the skin reach balance.With advancing age or the change of body constitution, the enzymatic activity of removing oxygen-derived free radicals in the skin descends, and oxidation preventive content reduces, and the free radical in the skin will disequilibrium.Unsaturated fatty acid in the free-radical oxidation skin forms the lipoid brown pigment and accumulates under the skin, will produce sunburn, chloasma etc. at skin appearance.Therefore, having only to human body constantly provides the antioxidant that can eliminate free radical, and making has enough oxidation resistances in the body, to impel the lipofuscin oxidation Decomposition that forms brown patch, improve the vigor of lysosomal enzyme, quicken melanic degraded, can reach the purpose of supporting outward, eliminating mottle with interior.
The product of speckle dispelling class is tinkling of jades meeting the eye on every side in the present skin-care cosmetics.Particularly to scytitis, pigmentation, medicative skin-care cosmetics such as chloasma is also quite a lot of, and these skin-care cosmetics majorities are formed with synthetic emulsion of chemical addition agent or cream frost, though certain therapeutical effect is arranged, but also the skin to health plays damaging action, has quickened the aging of skin.The water solublity pad pasting treatment of minority is arranged for the speckle dispelling paster simultaneously, but effect and not obvious.
Purpose of the present invention is intended to overcome the deficiency of above-mentioned prior art, and provide a kind of definite ingredients, function definite, easily transdermal, can discharge lastingly, quality softness, whippy external speckle dispelling paster and its production and application.
Summary of the invention
Problem at prior art exists the purpose of this invention is to provide a kind of fat-soluble speckle dispelling paster that contains aloe, green tea oil, vitamin C derivatives.Aloe can effectively be removed oxygen-derived free radicals, suppresses melanin and generates; Can restraint of tyrosinase activity, act on each stage of melanin metabolic pathway, control, suppress, reduce melanic generation.Be rich in abundant catechin component in the green tea oil, very strong removing free radical and antioxidative ability are arranged, and tangible effect is arranged, have tangible beauty functions eliminating mottle.Vitamin C derivatives can suppress the final oxidizing process that forms of melanin, can also be as the exfoliation agent, and coming off of accelerometer hull melanin promotes that skin surface contains chromatophorous natural death, purifies skin, makes the colour of skin even, and be transparent glossy.
Another object of the present invention provides a kind of speckle dispelling paster, and it is the novel adhesive of adjuvant that its substrate adopts SIS, prepares a kind of host material that is suitable for human face skin, and the affinity of itself and skin is good, long-acting, and the transdermal performance is good.Because the special framework material of this kind substrate can reach the effect of preserving moisture, whitening, when pasting the skin-protecting function that reaches the basis, add the purpose that functional component reaches speckle dispelling for speckle dispelling.
Another object of the present invention provides a kind of host material of speckle dispelling paster, and this kind substrate is adapted to different fat-soluble functional component pasters.
Another object of the present invention provides a kind of preparation method, be applicable to the adding of liposoluble constituent, and functional component and adhesive are separated preparation, realize the online heat seeling coating of low temperature, the loss of the functional component in the paster is little, is adapted to the widespread production of cosmetics.
Another object of the present invention provides a kind of speckle dispelling paster, and it has speckle dispelling, the multi-efficiency of whitening, preserve moisture.The deep enough skin surface of energy is desalinated multiple spot, can reach the purpose of dispeling for newborn spot.
The specific embodiment
Further describe the present invention by the following examples, it should be understood that this embodiment only is used for the purpose of illustration.
Embodiment one:
The preparation of speckle dispelling paster: what this preparation technology adopted is the method that raw material medicinal liquid and host material prepare respectively.
The preparation of raw material medicinal liquid: take by weighing the 0.1-1% coolant agent earlier and be ground into fine powder, get 1-5% aloe, 0.5-2% green tea oil, 0.5-5% vitamin C derivatives, 0.5-2% Radix Glycyrrhizae extract, 1-10% azone, the senior Fructus Canarii albi wet goods of 1-10%, above-mentioned solution stirring, mixing.The confected materials medicinal liquid stirred 10-20 minute more repeatedly, and is standby.
The preparation of host material: by styrene isoprene styrene block copolymer (SIS) (SIS) 1-75%, plasticizer 1-65%, viscosifier 1-35%, the ratio of antioxidant 0.1-3.5%, at 100-200 ℃ of pyroreaction 0-5 hour, make the host material that is fit to human body skin.After the blob of viscose cooling, standby.
Preparation method: raw material medicinal liquid, host material are put into dosed administration medicinal cupping, glue pot respectively, by the online melt molding equipment of low temperature, the host material gradation is added fusion, in 50-100 ℃, add the raw material medicinal liquid, finish the coating of glue medicine uniform mixing in second at 0-30, to keep nutritional labeling to greatest extent.
Embodiment two: the biological mechanics determining of speckle dispelling paster
The sample that embodiment one is produced carries out biological mechanics determining, and with the initial bonding strength of determining to adapt to the delicate skin of the requirement of human face skin, particularly face, hold viscous force and peeling force requirement, it the results are shown in Table 1.
The The performance test results of table 1 speckle dispelling paster
| First viscous force (steel ball number) | Hold viscous force (S) | Peel strength (N/mm) | Maximum drug loading (%) |
| 3-5 | 1-8 | 0.001-0.015 | 20 |
Embodiment three:
Press the speckle dispelling paster of embodiment one method preparation, do following clinical trial:
The test crowd age:
50 middle aged women that meet selected crowd's standard 28-45 year with spot puzzlement.
Using method:
Remove packing, take out, remove protective layer, will paste the appointment spot position that is affixed on the experimenter gently.Can not press with finger, otherwise affect the treatment.
Be two months service time, is divided into two courses of treatment, and be one month each course of treatment.The course of treatment one: be every day twice, in, each uses once behind the late clean skin, acts on 45 minutes at every turn.The course of treatment two: for once a day, use behind the clean every night skin, act on 45 minutes.Observe and the record experimental phenomena.
Observation index: perusal
With speckle dispelling paster front and back, the Taking Pictures recording experimenter is with pasting the position, so that observe more detailed each.Note whether having allergy and irritation simultaneously.Describe experimenter's local response, comprise that erythema, edema degree and standards of grading see Table 2, skin irritation intensity standards of grading see Table 3.Observe general state, behavior, sign etc. simultaneously.
Table 2 skin allergy standards of grading
Table 3 skin irritation intensity standards of grading
Result of the test:
1, the result shows, 50 volunteers that choose are the women, 36.2 years old mean age, pastes the back with speckle dispelling and represents curative effect with produce effects, effective, improvement, invalid four grades.Wherein, 38% produce effects, 51% is effective, and 11% improves, and total effective rate reaches 100%.
2, skin allergy and skin irritation intensity score value are 0.
3, behind the use speckle dispelling paster, for spot remarkable result is arranged a course of treatment, and do not stay any cicatrix.Wart for projection can be desalinated mottle a course of treatment equally, reduces projection.
Claims (6)
1. an efficient speckle dispelling paster is characterized in that mainly being made up of aloe, green tea oil, vitamin C derivatives, Radix Glycyrrhizae extract.
2. according to the described speckle dispelling paster of claim 1, it can pass through difformity, acts on each different position of face respectively.
3. the speckle dispelling paster described in claim 1,2 is characterized in that, main cosmetic base adjuvant is SIS.Used speckle dispelling paster host material is the novel adhesive based on SIS, when making circumference of eyes reach speckle dispelling, has well and whitens, moisture-keeping function.
4. speckle dispelling paster described in claim 1,2,3 and cosmetic base material are adapted to different fat-soluble functional component pasters.
5. as claim 1,2,3,4 described speckle dispelling pasters, its preparation technology makes molten for respectively medicine being made the extractum shape with adhesive, is coated with rapid shaping in low temperature.
6. as claim 1,2,3,4,5 described speckle dispelling pasters, it has speckle dispelling, the multi-efficiency of whitening, preserve moisture, and sensitization is low simultaneously, and zest is little, and skin-friendly can be good.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010110859XA CN102160848A (en) | 2010-02-21 | 2010-02-21 | Spot removing patch and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010110859XA CN102160848A (en) | 2010-02-21 | 2010-02-21 | Spot removing patch and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102160848A true CN102160848A (en) | 2011-08-24 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201010110859XA Pending CN102160848A (en) | 2010-02-21 | 2010-02-21 | Spot removing patch and preparation method thereof |
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| CN (1) | CN102160848A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103961390A (en) * | 2014-05-20 | 2014-08-06 | 张秀平 | Macula removing lotion composition |
| CN105377263A (en) * | 2013-07-11 | 2016-03-02 | 株式会社爱茉莉太平洋 | Composition for antioxidation or skin whitening containing 21-O-angeloyltheasapogenol E3 ingredient derived from green tea seed |
| CN105407895A (en) * | 2013-07-11 | 2016-03-16 | 株式会社爱茉莉太平洋 | Antiaging skin preparation composition containing 21-O-angeloyltheasapogenol E3 ingredient derived from green tea seed |
| CN112641666A (en) * | 2019-10-10 | 2021-04-13 | 广州樱奈儿化妆品有限公司 | Whitening and freckle removing essence and preparation method thereof |
-
2010
- 2010-02-21 CN CN201010110859XA patent/CN102160848A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105377263A (en) * | 2013-07-11 | 2016-03-02 | 株式会社爱茉莉太平洋 | Composition for antioxidation or skin whitening containing 21-O-angeloyltheasapogenol E3 ingredient derived from green tea seed |
| CN105407895A (en) * | 2013-07-11 | 2016-03-16 | 株式会社爱茉莉太平洋 | Antiaging skin preparation composition containing 21-O-angeloyltheasapogenol E3 ingredient derived from green tea seed |
| CN105407895B (en) * | 2013-07-11 | 2019-03-12 | 株式会社爱茉莉太平洋 | Anti-aging Dermatologic preparation composition is used for containing the 21-O- Radix Angelicae Sinensis acyl theasapogenol E3 ingredient from green tea seed |
| CN105377263B (en) * | 2013-07-11 | 2020-05-29 | 株式会社爱茉莉太平洋 | Antioxidant or skin whitening composition containing 21-O-angeloyltheasapogenol E3 derived from green tea seed |
| CN103961390A (en) * | 2014-05-20 | 2014-08-06 | 张秀平 | Macula removing lotion composition |
| CN112641666A (en) * | 2019-10-10 | 2021-04-13 | 广州樱奈儿化妆品有限公司 | Whitening and freckle removing essence and preparation method thereof |
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Application publication date: 20110824 |