CN102159236A - 用于治疗或预防心力衰竭的神经调节蛋白或其亚序列的治疗性施剂 - Google Patents

用于治疗或预防心力衰竭的神经调节蛋白或其亚序列的治疗性施剂 Download PDF

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Publication number
CN102159236A
CN102159236A CN2009801360798A CN200980136079A CN102159236A CN 102159236 A CN102159236 A CN 102159236A CN 2009801360798 A CN2009801360798 A CN 2009801360798A CN 200980136079 A CN200980136079 A CN 200980136079A CN 102159236 A CN102159236 A CN 102159236A
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CN
China
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days
neuregulin
hours
nrg
egf
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Pending
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CN2009801360798A
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English (en)
Chinese (zh)
Inventor
A·卡加诺
A·甘谷利
J·艾希
T·帕利
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Acorda Therapeutics Inc
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Acorda Therapeutics Inc
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Priority to CN201710109733.2A priority Critical patent/CN107019794B/zh
Publication of CN102159236A publication Critical patent/CN102159236A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1883—Neuregulins, e.g.. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Cardiology (AREA)
  • Organic Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CN2009801360798A 2008-07-17 2009-07-17 用于治疗或预防心力衰竭的神经调节蛋白或其亚序列的治疗性施剂 Pending CN102159236A (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201710109733.2A CN107019794B (zh) 2008-07-17 2009-07-17 用于治疗或预防心力衰竭的神经调节蛋白或其亚序列的治疗性施剂

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13517108P 2008-07-17 2008-07-17
US61/135,171 2008-07-17
PCT/US2009/004130 WO2010030317A2 (en) 2008-07-17 2009-07-17 Therapeutic dosing of a neuregulin or a subsequence thereof for treatment or prophylaxis of heart failure

Related Child Applications (2)

Application Number Title Priority Date Filing Date
CN201710109733.2A Division CN107019794B (zh) 2008-07-17 2009-07-17 用于治疗或预防心力衰竭的神经调节蛋白或其亚序列的治疗性施剂
CN201510010273.9A Division CN104623633A (zh) 2008-07-17 2009-07-17 用于治疗或预防心力衰竭的神经调节蛋白或其亚序列的治疗性施剂

Publications (1)

Publication Number Publication Date
CN102159236A true CN102159236A (zh) 2011-08-17

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Family Applications (3)

Application Number Title Priority Date Filing Date
CN201510010273.9A Pending CN104623633A (zh) 2008-07-17 2009-07-17 用于治疗或预防心力衰竭的神经调节蛋白或其亚序列的治疗性施剂
CN2009801360798A Pending CN102159236A (zh) 2008-07-17 2009-07-17 用于治疗或预防心力衰竭的神经调节蛋白或其亚序列的治疗性施剂
CN201710109733.2A Expired - Fee Related CN107019794B (zh) 2008-07-17 2009-07-17 用于治疗或预防心力衰竭的神经调节蛋白或其亚序列的治疗性施剂

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CN201510010273.9A Pending CN104623633A (zh) 2008-07-17 2009-07-17 用于治疗或预防心力衰竭的神经调节蛋白或其亚序列的治疗性施剂

Family Applications After (1)

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CN201710109733.2A Expired - Fee Related CN107019794B (zh) 2008-07-17 2009-07-17 用于治疗或预防心力衰竭的神经调节蛋白或其亚序列的治疗性施剂

Country Status (13)

Country Link
US (5) US20110166068A1 (enExample)
EP (3) EP3338791B1 (enExample)
JP (5) JP5797112B2 (enExample)
CN (3) CN104623633A (enExample)
AU (3) AU2009292216B2 (enExample)
BR (1) BRPI0916442A2 (enExample)
CA (1) CA2731113A1 (enExample)
DK (2) DK3338791T3 (enExample)
ES (2) ES2664394T3 (enExample)
MX (2) MX2011000696A (enExample)
PL (2) PL3338791T3 (enExample)
RU (4) RU2536938C2 (enExample)
WO (1) WO2010030317A2 (enExample)

Cited By (2)

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Publication number Priority date Publication date Assignee Title
WO2016058493A1 (zh) * 2014-10-17 2016-04-21 上海泽生科技开发有限公司 神经调节蛋白用于预防、治疗或延迟射血分数保留的心力衰竭的方法和组合物
US11253573B2 (en) 2011-10-10 2022-02-22 Zensun (Shanghai) Science & Technology, Co., Ltd. Compositions and methods for treating heart failure

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DK3338791T3 (da) 2008-07-17 2019-12-16 Acorda Therapeutics Inc Terapeutisk dosering af en neuregulin i behandling eller profylaxis af hjertesvigt
EP3173091B1 (en) 2008-08-15 2020-07-22 Acorda Therapeutics, Inc. Compositions and methods for treatment during non-acute periods following cns neurological injury
JP5743898B2 (ja) 2008-11-28 2015-07-01 ゼンサン （シャンハイ） サイエンス アンド テクノロジー リミテッド ニューレグリンペプチド及びその使用
PL3235504T3 (pl) 2009-10-14 2020-03-31 Acorda Therapeutics, Inc. Zastosowanie neureguliny do leczenia uszkodzenia nerwu obwodowego
DK3278811T3 (da) * 2012-03-30 2021-03-01 Acorda Therapeutics Inc Anvendelse af ggf2 til behandling af neuropatisk smerte ved peripheral nerveskade
EP2964249A1 (en) 2013-03-06 2016-01-13 Acorda Therapeutics, Inc. Therapeutic dosing of a neuregulin or a fragment thereof for treatment or prophylaxis of heart failure
KR102357275B1 (ko) 2013-05-22 2022-02-03 젠순 (상하이) 사이언스 앤드 테크놀로지 캄파니 리미티드 심부전을 치료하기 위한 뉴레귤린의 연장 방출
CN104758922A (zh) 2014-01-03 2015-07-08 上海泽生科技开发有限公司 纽兰格林制剂的配方
MA42936A (fr) 2015-09-25 2018-08-01 Douglas B Sawyer Procédé de traitement de blessures cardiaques
EP3445386B1 (en) * 2016-04-19 2020-08-26 Leibniz-Institut für Alternsforschung - Fritz-Lipmann-Institut e.V. (FLI) Neuregulin for the treatment and/or prevention of tumors of the nervous system
CN110835368A (zh) * 2018-08-15 2020-02-25 上海泽生科技开发股份有限公司 神经调节蛋白多肽片段及其用途
AR121035A1 (es) 2019-04-01 2022-04-13 Lilly Co Eli Compuestos de neuregulina-4 y métodos de uso
AU2020348436A1 (en) * 2019-09-16 2022-04-07 Zensun (Shanghai) Science & Technology, Co., Ltd. Recombinant human neuregulin derivatives and use thereof
US20250241989A1 (en) * 2021-10-22 2025-07-31 The Research Institute At Nationwide Children's Hospital Neuregulin for Protection Against Respiratory Viral Infection and Post-Viral Disease

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Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11253573B2 (en) 2011-10-10 2022-02-22 Zensun (Shanghai) Science & Technology, Co., Ltd. Compositions and methods for treating heart failure
US12076370B2 (en) 2011-10-10 2024-09-03 Zensun (Shanghai) Science & Technology, Co., Ltd. Compositions and methods for treating heart failure
WO2016058493A1 (zh) * 2014-10-17 2016-04-21 上海泽生科技开发有限公司 神经调节蛋白用于预防、治疗或延迟射血分数保留的心力衰竭的方法和组合物
CN105561298A (zh) * 2014-10-17 2016-05-11 上海泽生科技开发有限公司 神经调节蛋白用于预防、治疗或延迟射血分数保留的心力衰竭的方法和组合物
CN108064164A (zh) * 2014-10-17 2018-05-22 上海泽生科技开发股份有限公司 神经调节蛋白用于预防、治疗或延迟射血分数保留的心力衰竭的方法和组合物
US10561709B2 (en) 2014-10-17 2020-02-18 Zensun (Shanghai) Science & Technology, Co., Ltd. Methods and compositions of neuregulins for preventing, treating or delaying preserved ejection fraction cardiac failure
AU2015333335B2 (en) * 2014-10-17 2021-08-05 Zensun (Shanghai) Science & Technology, Co., Ltd. Methods and compositions of neuregulins for preventing, treating or delaying preserved ejection fraction cardiac failure

Also Published As

Publication number Publication date
AU2017203528A1 (en) 2017-06-15
RU2719199C1 (ru) 2020-04-17
WO2010030317A2 (en) 2010-03-18
ES2664394T3 (es) 2018-04-19
BRPI0916442A2 (pt) 2018-06-19
CN107019794B (zh) 2021-03-12
JP6189879B2 (ja) 2017-08-30
JP5797112B2 (ja) 2015-10-21
US20180280477A1 (en) 2018-10-04
AU2015202877B2 (en) 2017-03-09
HK1256637A1 (en) 2019-09-27
MX2011000696A (es) 2011-07-29
AU2009292216B2 (en) 2015-03-05
RU2020111236A (ru) 2021-09-21
JP2019196370A (ja) 2019-11-14
US9198951B2 (en) 2015-12-01
US9956266B2 (en) 2018-05-01
JP2017200949A (ja) 2017-11-09
RU2536938C2 (ru) 2014-12-27
CN104623633A (zh) 2015-05-20
US11235031B2 (en) 2022-02-01
RU2020111236A3 (enExample) 2021-09-21
JP2015129137A (ja) 2015-07-16
US20160113999A1 (en) 2016-04-28
CN107019794A (zh) 2017-08-08
MX384378B (es) 2025-03-14
EP2320933A4 (en) 2013-02-27
ES2763184T3 (es) 2020-05-27
JP2011528353A (ja) 2011-11-17
RU2014141514A (ru) 2016-05-10
US20200009228A1 (en) 2020-01-09
EP3338791A1 (en) 2018-06-27
PL2320933T3 (pl) 2018-07-31
DK2320933T3 (en) 2018-04-16
EP3338791B1 (en) 2019-09-18
EP2320933B1 (en) 2017-12-27
CA2731113A1 (en) 2010-03-18
AU2015202877A1 (en) 2015-06-18
EP2320933A1 (en) 2011-05-18
US20130324466A1 (en) 2013-12-05
DK3338791T3 (da) 2019-12-16
EP3632459A1 (en) 2020-04-08
RU2698090C2 (ru) 2019-08-22
AU2009292216A1 (en) 2010-03-18
JP2022023208A (ja) 2022-02-07
PL3338791T3 (pl) 2020-04-30
RU2011105821A (ru) 2012-08-27
US20110166068A1 (en) 2011-07-07

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Application publication date: 20110817