JP5797112B2 - 心不全の治療または予防のためのニューレグリンまたはそのサブ配列の治療的投与方法 - Google Patents

心不全の治療または予防のためのニューレグリンまたはそのサブ配列の治療的投与方法 Download PDF

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JP5797112B2
JP5797112B2 JP2011518734A JP2011518734A JP5797112B2 JP 5797112 B2 JP5797112 B2 JP 5797112B2 JP 2011518734 A JP2011518734 A JP 2011518734A JP 2011518734 A JP2011518734 A JP 2011518734A JP 5797112 B2 JP5797112 B2 JP 5797112B2
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neuregulin
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JP2011528353A5 (enExample
JP2011528353A (ja
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アンソニー カッジャーノ
アンソニー カッジャーノ
アニンディタ ガングリー
アニンディタ ガングリー
ジェニファー イアチ
ジェニファー イアチ
トム パーリー
トム パーリー
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アコーダ セラピューティクス インコーポレイテッド
アコーダ セラピューティクス インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1883—Neuregulins, e.g.. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2011518734A 2008-07-17 2009-07-17 心不全の治療または予防のためのニューレグリンまたはそのサブ配列の治療的投与方法 Expired - Fee Related JP5797112B2 (ja)

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US13517108P 2008-07-17 2008-07-17
US61/135,171 2008-07-17
PCT/US2009/004130 WO2010030317A2 (en) 2008-07-17 2009-07-17 Therapeutic dosing of a neuregulin or a subsequence thereof for treatment or prophylaxis of heart failure

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JP2015013248A Division JP6189879B2 (ja) 2008-07-17 2015-01-27 心不全の治療または予防のためのニューレグリンまたはそのサブ配列の治療的投与方法

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JP2011528353A JP2011528353A (ja) 2011-11-17
JP2011528353A5 JP2011528353A5 (enExample) 2012-01-05
JP5797112B2 true JP5797112B2 (ja) 2015-10-21

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JP2011518734A Expired - Fee Related JP5797112B2 (ja) 2008-07-17 2009-07-17 心不全の治療または予防のためのニューレグリンまたはそのサブ配列の治療的投与方法
JP2015013248A Expired - Fee Related JP6189879B2 (ja) 2008-07-17 2015-01-27 心不全の治療または予防のためのニューレグリンまたはそのサブ配列の治療的投与方法
JP2017150365A Pending JP2017200949A (ja) 2008-07-17 2017-08-03 心不全の治療または予防のためのニューレグリンまたはそのサブ配列の治療的投与方法
JP2019124501A Pending JP2019196370A (ja) 2008-07-17 2019-07-03 心不全の治療または予防のためのニューレグリンまたはそのサブ配列の治療的投与方法
JP2021179961A Pending JP2022023208A (ja) 2008-07-17 2021-11-04 心不全の治療または予防のためのニューレグリンまたはそのサブ配列の治療的投与方法

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JP2015013248A Expired - Fee Related JP6189879B2 (ja) 2008-07-17 2015-01-27 心不全の治療または予防のためのニューレグリンまたはそのサブ配列の治療的投与方法
JP2017150365A Pending JP2017200949A (ja) 2008-07-17 2017-08-03 心不全の治療または予防のためのニューレグリンまたはそのサブ配列の治療的投与方法
JP2019124501A Pending JP2019196370A (ja) 2008-07-17 2019-07-03 心不全の治療または予防のためのニューレグリンまたはそのサブ配列の治療的投与方法
JP2021179961A Pending JP2022023208A (ja) 2008-07-17 2021-11-04 心不全の治療または予防のためのニューレグリンまたはそのサブ配列の治療的投与方法

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US (5) US20110166068A1 (enExample)
EP (3) EP3632459A1 (enExample)
JP (5) JP5797112B2 (enExample)
CN (3) CN104623633A (enExample)
AU (3) AU2009292216B2 (enExample)
BR (1) BRPI0916442A2 (enExample)
CA (1) CA2731113A1 (enExample)
DK (2) DK2320933T3 (enExample)
ES (2) ES2763184T3 (enExample)
MX (2) MX2011000696A (enExample)
PL (2) PL2320933T3 (enExample)
RU (4) RU2536938C2 (enExample)
WO (1) WO2010030317A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015129137A (ja) * 2008-07-17 2015-07-16 アコーダ セラピューティクス インコーポレイテッド 心不全の治療または予防のためのニューレグリンまたはそのサブ配列の治療的投与方法
JP2016516016A (ja) * 2013-03-06 2016-06-02 アコーダ セラピューティクス インコーポレイテッド 心不全の治療または予防のためのニューレグリンまたはその断片の治療的投与の方法

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3777878A1 (en) 2008-08-15 2021-02-17 Acorda Therapeutics, Inc. Compositions and methods for treatment during non-acute periods following cns neurological injury
EP2808339B1 (en) 2008-11-28 2017-02-15 Zensun (Shanghai) Science & Technology, Co., Ltd. Neuregulin peptides and their use
PL2488194T3 (pl) 2009-10-14 2016-11-30 Zastosowanie neureguliny do leczenia uszkodzenia nerwu jamistego
WO2013053076A1 (en) 2011-10-10 2013-04-18 Zensun （Shanghai）Science & Technology Limited Compositions and methods for treating heart failure
EP2830645B1 (en) * 2012-03-30 2017-08-30 Acorda Therapeutics, Inc. Neuregulin for use in treating peripheral nerve injury
BR112015029293A2 (pt) 2013-05-22 2018-04-24 Zensun Shanghai Science & Tech Ltd método e kit para prevenir, tratar ou retardar uma doença ou distúrbio cardiovascular em um mamífero
CN104758922A (zh) 2014-01-03 2015-07-08 上海泽生科技开发有限公司 纽兰格林制剂的配方
CN105561298A (zh) * 2014-10-17 2016-05-11 上海泽生科技开发有限公司 神经调节蛋白用于预防、治疗或延迟射血分数保留的心力衰竭的方法和组合物
US20180296642A1 (en) 2015-09-25 2018-10-18 Douglas B. Sawyer Methods for treating cardiac injury
CN108778315A (zh) * 2016-04-19 2018-11-09 莱布尼茨研究所-针对老化研究(弗里茨利普曼研究所) 用于治疗和/或预防神经系统肿瘤的神经调节素
CN110835368A (zh) * 2018-08-15 2020-02-25 上海泽生科技开发股份有限公司 神经调节蛋白多肽片段及其用途
AR121035A1 (es) 2019-04-01 2022-04-13 Lilly Co Eli Compuestos de neuregulina-4 y métodos de uso
KR20220066116A (ko) * 2019-09-16 2022-05-23 젠순 (상하이) 사이언스 앤드 테크놀로지 캄파니 리미티드 재조합 인간 뉴레귤린 유도체 및 그의 용도
US20250241989A1 (en) * 2021-10-22 2025-07-31 The Research Institute At Nationwide Children's Hospital Neuregulin for Protection Against Respiratory Viral Infection and Post-Viral Disease

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5716930A (en) 1991-04-10 1998-02-10 Ludwig Institute For Cancer Research Glial growth factors
US7115554B1 (en) * 1993-05-06 2006-10-03 Acorda Therapeutics, Inc. Methods of increasing myotube formation or survival or muscle cell mitogenesis differentiation or survival using neuregulin GGF III
US5530109A (en) 1991-04-10 1996-06-25 Ludwig Institute For Cancer Research DNA encoding glial mitogenic factors
US6087323A (en) 1992-04-03 2000-07-11 Cambridge Neuroscience, Inc. Use of neuregulins as modulators of cellular communication
US7037888B1 (en) 1992-04-03 2006-05-02 Acorda Therapeutics, Inc. Methods for treating muscle diseases and disorders
US5811098A (en) * 1992-11-24 1998-09-22 Bristol-Myers Squibb Company Antibodies to HER4, human receptor tyrosine kinase
US5912326A (en) 1995-09-08 1999-06-15 President And Fellows Of Harvard College Cerebellum-derived growth factors
US6136558A (en) * 1997-02-10 2000-10-24 Genentech, Inc. Heregulin variants
US6051401A (en) 1998-07-28 2000-04-18 Bayer Corporation Methods and constructs for protein expression
HK1040363B (en) 1998-09-25 2007-01-26 Cubist Pharmaceuticals Llc Use of daptomycin
AUPP785098A0 (en) * 1998-12-21 1999-01-21 Victor Chang Cardiac Research Institute, The Treatment of heart disease
US6635249B1 (en) 1999-04-23 2003-10-21 Cenes Pharmaceuticals, Inc. Methods for treating congestive heart failure
CN1138785C (zh) * 1999-06-04 2004-02-18 周明东 生长因子神经调节蛋白及其类似物的新应用
AU1916301A (en) 1999-11-12 2001-06-06 Children's Medical Center Corporation Methods for administration of therapeutic agents on an antiangiogenic schedule
EP2357004B1 (en) 2000-05-23 2016-10-12 CeNeS Pharmaceuticals, Inc. NRG-2 nucleic acid molecules, polypeptides and diagnostic and therapeutical methods
CU23157A1 (es) * 2001-01-03 2006-07-18 Ct Ingenieria Genetica Biotech COMPOSICION FARMACéUTICA PARA EL TRATAMIENTO DEL DANO TISULAR DEBIDO A FALTA DE IRRIGACION SANGUINEA ARTERIAL
AU2003210549A1 (en) 2002-01-18 2003-09-02 Chiron Corporation Combination il-2/anti-herz antibody therapy for cancers characterized by overexpression of the her2 receptor protein
WO2003099320A1 (en) * 2002-05-24 2003-12-04 Zensun (Shanghai) Sci-Tech.Ltd Neuregulin based methods and compositions for treating viral myocarditis and dilated cardiomyopathy
US20070032557A1 (en) * 2005-02-18 2007-02-08 Matti Kivikko Method for administering levosimendan
US20080279865A1 (en) 2005-03-23 2008-11-13 Pfizer, Inc., Pfizer Products, Inc. Therapy of Prostate Cancer With Ctla-4 Antibodies and Hormonal Therapy
CA2658326C (en) 2005-09-02 2013-04-23 Morehouse School Of Medicine Neuregulins for prevention and treatment of damage from acute assault on vascular and neuronal tissue
US20070213264A1 (en) * 2005-12-02 2007-09-13 Mingdong Zhou Neuregulin variants and methods of screening and using thereof
US20070190127A1 (en) 2005-12-30 2007-08-16 Mingdong Zhou Extended release of neuregulin for improved cardiac function
BRPI0908271A2 (pt) 2008-02-29 2017-06-13 Acorda Therapeutics Inc método para alcançar níveis plasmáticos desejados de fator de crescimento glial
EP3632459A1 (en) * 2008-07-17 2020-04-08 Acorda Therapeutics, Inc. Therapeutic dosing of a neuregulin or a subsequence thereof for treatment or prophylaxis of heart failure
PL2488194T3 (pl) 2009-10-14 2016-11-30 Zastosowanie neureguliny do leczenia uszkodzenia nerwu jamistego
EP2603221A4 (en) 2010-08-13 2014-02-26 Univ Georgetown GGF2 AND METHOD FOR ITS APPLICATION
EP2830645B1 (en) 2012-03-30 2017-08-30 Acorda Therapeutics, Inc. Neuregulin for use in treating peripheral nerve injury

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015129137A (ja) * 2008-07-17 2015-07-16 アコーダ セラピューティクス インコーポレイテッド 心不全の治療または予防のためのニューレグリンまたはそのサブ配列の治療的投与方法
US9956266B2 (en) 2008-07-17 2018-05-01 Acorda Therapeutics, Inc. Therapeutic dosing of a neuregulin or a subsequence thereof for treatment or prophylaxis of heart failure
US11235031B2 (en) 2008-07-17 2022-02-01 Acorda Therapeutics, Inc. Therapeutic dosing of a neuregulin or a subsequence thereof for treatment or prophylaxis of heart failure
JP2016516016A (ja) * 2013-03-06 2016-06-02 アコーダ セラピューティクス インコーポレイテッド 心不全の治療または予防のためのニューレグリンまたはその断片の治療的投与の方法

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EP3338791A1 (en) 2018-06-27
MX2011000696A (es) 2011-07-29
BRPI0916442A2 (pt) 2018-06-19
RU2014141514A (ru) 2016-05-10
CN107019794A (zh) 2017-08-08
RU2020111236A3 (enExample) 2021-09-21
RU2020111236A (ru) 2021-09-21
CA2731113A1 (en) 2010-03-18
US9198951B2 (en) 2015-12-01
EP2320933A1 (en) 2011-05-18
RU2536938C2 (ru) 2014-12-27
RU2698090C2 (ru) 2019-08-22
US20110166068A1 (en) 2011-07-07
CN104623633A (zh) 2015-05-20
HK1256637A1 (en) 2019-09-27
CN107019794B (zh) 2021-03-12
RU2719199C1 (ru) 2020-04-17
AU2017203528A1 (en) 2017-06-15
JP2015129137A (ja) 2015-07-16
DK3338791T3 (da) 2019-12-16
PL2320933T3 (pl) 2018-07-31
US9956266B2 (en) 2018-05-01
RU2011105821A (ru) 2012-08-27
EP3632459A1 (en) 2020-04-08
US20180280477A1 (en) 2018-10-04
PL3338791T3 (pl) 2020-04-30
ES2763184T3 (es) 2020-05-27
CN102159236A (zh) 2011-08-17
WO2010030317A2 (en) 2010-03-18
US20160113999A1 (en) 2016-04-28
EP2320933B1 (en) 2017-12-27
DK2320933T3 (en) 2018-04-16
US20130324466A1 (en) 2013-12-05
JP2011528353A (ja) 2011-11-17
JP6189879B2 (ja) 2017-08-30
EP3338791B1 (en) 2019-09-18
EP2320933A4 (en) 2013-02-27
AU2009292216B2 (en) 2015-03-05
US20200009228A1 (en) 2020-01-09
AU2009292216A1 (en) 2010-03-18
ES2664394T3 (es) 2018-04-19
JP2022023208A (ja) 2022-02-07
AU2015202877B2 (en) 2017-03-09
US11235031B2 (en) 2022-02-01
MX384378B (es) 2025-03-14
JP2017200949A (ja) 2017-11-09
AU2015202877A1 (en) 2015-06-18
JP2019196370A (ja) 2019-11-14

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