CN102149721A - 用于治疗疼痛的氨基膦衍生物 - Google Patents
用于治疗疼痛的氨基膦衍生物 Download PDFInfo
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- CN102149721A CN102149721A CN2009801355925A CN200980135592A CN102149721A CN 102149721 A CN102149721 A CN 102149721A CN 2009801355925 A CN2009801355925 A CN 2009801355925A CN 200980135592 A CN200980135592 A CN 200980135592A CN 102149721 A CN102149721 A CN 102149721A
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- benzyl
- alkyl
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Abstract
Description
溶解之后的时间 | 0hrs | 3hrs | 6hrs | 96hrs |
初始化合物% | 90.5% | 82.0% | 75.7% | 25.1% |
Claims (16)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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FR0855015A FR2934267B1 (fr) | 2008-07-23 | 2008-07-23 | Derives aminophosphiniques utiles dans le traitement de la douleur |
FR0855015 | 2008-07-23 | ||
PCT/EP2009/059394 WO2010010106A1 (fr) | 2008-07-23 | 2009-07-22 | Derives aminophosphiniques utiles dans le traitement de la douleur |
Publications (2)
Publication Number | Publication Date |
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CN102149721A true CN102149721A (zh) | 2011-08-10 |
CN102149721B CN102149721B (zh) | 2015-01-28 |
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CN200980135592.5A Active CN102149721B (zh) | 2008-07-23 | 2009-07-22 | 用于治疗疼痛的氨基膦衍生物 |
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US (2) | US8703747B2 (zh) |
EP (2) | EP2740736B1 (zh) |
JP (1) | JP5607045B2 (zh) |
KR (1) | KR101631726B1 (zh) |
CN (1) | CN102149721B (zh) |
AU (1) | AU2009273238A1 (zh) |
BR (1) | BRPI0916811B1 (zh) |
CA (1) | CA2731544C (zh) |
DK (2) | DK2326655T3 (zh) |
ES (2) | ES2561579T3 (zh) |
FR (1) | FR2934267B1 (zh) |
HK (1) | HK1160471A1 (zh) |
IL (1) | IL210760A (zh) |
MX (1) | MX2011000867A (zh) |
RU (1) | RU2011106300A (zh) |
WO (1) | WO2010010106A1 (zh) |
ZA (1) | ZA201101424B (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108289901A (zh) * | 2015-11-30 | 2018-07-17 | 领先药物公司 | 用于预防和治疗眼痛的氨基次膦酸衍生物 |
TWI771386B (zh) * | 2017-03-09 | 2022-07-21 | 法商領先藥物公司 | 用於預防及治療眼發炎的氨基膦衍生物 |
CN114787171A (zh) * | 2019-12-11 | 2022-07-22 | 领先药物公司 | ((2s)-3-([1,1’-联苯]-4-基)-2-((羟基((1r)-1-(((1-(异丁酰氧基)乙氧基)羰基)氨基)乙基)磷酰基)甲基)丙酰基)-l-丙氨酸的二钠盐的工业制备方法 |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2934267B1 (fr) * | 2008-07-23 | 2010-08-13 | Pharmaleads | Derives aminophosphiniques utiles dans le traitement de la douleur |
FR2997081B1 (fr) | 2012-10-23 | 2015-11-27 | Pharmaleads | Inhibiteurs mixtes de l'aminopeptidase n et de la neprilysine |
CN105503947B (zh) * | 2015-12-31 | 2018-07-24 | 遵义医学院 | 一种含氨基酸片段的膦酸酯衍生物的制备方法及抗肿瘤应用 |
FR3063635B1 (fr) * | 2017-03-09 | 2019-06-07 | Pharmaleads | Derives aminophosphiniques pour la prevention et le traitement de l'inflammation oculaire |
FR3077201B1 (fr) | 2018-01-26 | 2020-01-17 | Pharmaleads | Derives aminoacides contenant un groupement disulfanyle sous forme d'un inhibiteur de nep et d'apn pour la prevention et le traitement des douleurs relatives au nerf trijumeau |
TW202029962A (zh) * | 2018-10-26 | 2020-08-16 | 法商量子基因科技有限公司 | 胺肽酶a抑制劑及包含其的醫藥組合物 |
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---|---|---|---|---|
FR853092A (fr) | 1938-06-20 | 1940-03-09 | Dispositif d'éclairage arrière pour véhicules, notamment pour véhicules automobiles | |
FR2518088B1 (fr) * | 1981-12-16 | 1987-11-27 | Roques Bernard | Nouveaux derives d'aminoacides, et leur application therapeutique |
FR2605004B1 (fr) | 1986-09-25 | 1989-01-13 | Centre Nat Rech Scient | Nouveaux derives d'amino-acides, leur procede de preparation et composition pharmaceutiques les contenant |
FR2651229B1 (fr) | 1989-08-24 | 1991-12-13 | Inst Nat Sante Rech Med | Nouveaux derives d'amino-acides, leur procede de preparation et leur application therapeutique. |
IT1270260B (it) * | 1994-06-21 | 1997-04-29 | Zambon Spa | Derivati dell'acido fosfonico ad attivita' inibitrice delle metallopeptidasi |
US5476847A (en) * | 1994-06-29 | 1995-12-19 | Schering Corporation | Derivatives of phosphinic acid useful as endothelin converting enzyme inhibitors |
IT1276710B1 (it) * | 1995-06-14 | 1997-11-03 | Zambon Spa | Derivati dell'acido fosfinico ad attivita' inibitrice delle metallopeptidasi |
US5597936A (en) | 1995-06-16 | 1997-01-28 | The Procter & Gamble Company | Method for manufacturing cobalt catalysts |
JPH0987291A (ja) * | 1995-09-26 | 1997-03-31 | Wakamoto Pharmaceut Co Ltd | 新規なアラニン誘導体 |
FR2755135B1 (fr) * | 1996-10-25 | 2002-12-27 | Inst Nat Sante Rech Med | Nouveaux derives d'(alpha-aminophosphino)peptides, leur procede de preparation et les compositions qui les contiennent |
DE69832712T2 (de) * | 1997-09-08 | 2006-06-22 | Warner-Lambert Company Llc | Analgetische zusammensetzung enthaltend antiepileptische arzneistoffe und deren verwendungen |
FR2777780B1 (fr) * | 1998-04-22 | 2001-05-04 | Inst Nat Sante Rech Med | Derives d'(alpha-aminophosphino) peptides, leur procede de preparation et les compositions qui les contiennent |
US6113915A (en) * | 1999-10-12 | 2000-09-05 | Allergan Sales, Inc. | Methods for treating pain |
ES2369256T3 (es) | 2000-06-26 | 2011-11-28 | Helen Of Troy Limited | Sistema de lámpara recargable. |
FR2834989B1 (fr) * | 2002-01-18 | 2005-05-20 | Commissariat Energie Atomique | Derives de pseudo-peptides phosphiniques inhibant selectivement le site actif c-terminal de l'enzyme de conversion de l'angiotensine i(ace) |
WO2005073214A2 (en) * | 2004-01-23 | 2005-08-11 | Janssen Pharmaceutica, N.V. | Novel inhibitors of chymase |
WO2006050472A2 (en) * | 2004-11-03 | 2006-05-11 | Xenoport, Inc. | Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphonous and -phosphinic acids |
FR2882752B1 (fr) * | 2005-03-01 | 2007-05-04 | Servier Lab | Nouveaux derives d'aminoacides phosphiniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
FR2931151A1 (fr) * | 2008-05-13 | 2009-11-20 | Pharmaleads Soc Par Actions Si | Nouveaux derives d'amino-acides, leur procede de preparation et leur utilisation therapeutique |
FR2934267B1 (fr) * | 2008-07-23 | 2010-08-13 | Pharmaleads | Derives aminophosphiniques utiles dans le traitement de la douleur |
-
2008
- 2008-07-23 FR FR0855015A patent/FR2934267B1/fr active Active
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2009
- 2009-07-22 WO PCT/EP2009/059394 patent/WO2010010106A1/fr active Application Filing
- 2009-07-22 RU RU2011106300/04A patent/RU2011106300A/ru unknown
- 2009-07-22 JP JP2011519156A patent/JP5607045B2/ja active Active
- 2009-07-22 CN CN200980135592.5A patent/CN102149721B/zh active Active
- 2009-07-22 ES ES14157306.3T patent/ES2561579T3/es active Active
- 2009-07-22 CA CA2731544A patent/CA2731544C/fr active Active
- 2009-07-22 ES ES09780902.4T patent/ES2533851T3/es active Active
- 2009-07-22 BR BRPI0916811-7A patent/BRPI0916811B1/pt active IP Right Grant
- 2009-07-22 KR KR1020117004013A patent/KR101631726B1/ko active IP Right Grant
- 2009-07-22 US US13/055,096 patent/US8703747B2/en active Active
- 2009-07-22 AU AU2009273238A patent/AU2009273238A1/en not_active Abandoned
- 2009-07-22 EP EP14157306.3A patent/EP2740736B1/fr active Active
- 2009-07-22 MX MX2011000867A patent/MX2011000867A/es active IP Right Grant
- 2009-07-22 DK DK09780902.4T patent/DK2326655T3/en active
- 2009-07-22 EP EP09780902.4A patent/EP2326655B1/fr active Active
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108289901A (zh) * | 2015-11-30 | 2018-07-17 | 领先药物公司 | 用于预防和治疗眼痛的氨基次膦酸衍生物 |
TWI771386B (zh) * | 2017-03-09 | 2022-07-21 | 法商領先藥物公司 | 用於預防及治療眼發炎的氨基膦衍生物 |
CN114787171A (zh) * | 2019-12-11 | 2022-07-22 | 领先药物公司 | ((2s)-3-([1,1’-联苯]-4-基)-2-((羟基((1r)-1-(((1-(异丁酰氧基)乙氧基)羰基)氨基)乙基)磷酰基)甲基)丙酰基)-l-丙氨酸的二钠盐的工业制备方法 |
CN114787171B (zh) * | 2019-12-11 | 2024-05-14 | 智腾大中华区有限公司 | 一种化合物的工业制备方法 |
Also Published As
Publication number | Publication date |
---|---|
CA2731544C (fr) | 2017-08-22 |
US20140161839A1 (en) | 2014-06-12 |
WO2010010106A1 (fr) | 2010-01-28 |
IL210760A0 (en) | 2011-03-31 |
DK2740736T3 (en) | 2016-03-07 |
CA2731544A1 (fr) | 2010-01-28 |
MX2011000867A (es) | 2011-04-05 |
ZA201101424B (en) | 2011-10-26 |
DK2326655T3 (en) | 2015-04-13 |
RU2011106300A (ru) | 2012-08-27 |
FR2934267B1 (fr) | 2010-08-13 |
KR20110053336A (ko) | 2011-05-20 |
US20110124601A1 (en) | 2011-05-26 |
BRPI0916811B1 (pt) | 2022-02-01 |
CN102149721B (zh) | 2015-01-28 |
EP2326655A1 (fr) | 2011-06-01 |
BRPI0916811A2 (pt) | 2020-09-15 |
HK1160471A1 (zh) | 2012-08-17 |
ES2533851T3 (es) | 2015-04-15 |
EP2326655B1 (fr) | 2014-12-31 |
JP2011528692A (ja) | 2011-11-24 |
FR2934267A1 (fr) | 2010-01-29 |
US8703747B2 (en) | 2014-04-22 |
AU2009273238A1 (en) | 2010-01-28 |
IL210760A (en) | 2014-06-30 |
EP2740736B1 (fr) | 2015-12-09 |
EP2740736A1 (fr) | 2014-06-11 |
KR101631726B1 (ko) | 2016-06-17 |
US10131681B2 (en) | 2018-11-20 |
JP5607045B2 (ja) | 2014-10-15 |
ES2561579T3 (es) | 2016-02-29 |
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