CN102143757A - 嵌合利尿钠多肽和抑制心脏重构的方法 - Google Patents

嵌合利尿钠多肽和抑制心脏重构的方法 Download PDF

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Publication number
CN102143757A
CN102143757A CN2009801289321A CN200980128932A CN102143757A CN 102143757 A CN102143757 A CN 102143757A CN 2009801289321 A CN2009801289321 A CN 2009801289321A CN 200980128932 A CN200980128932 A CN 200980128932A CN 102143757 A CN102143757 A CN 102143757A
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CN
China
Prior art keywords
polypeptide
composition
amino acid
natriuretic
decreased
Prior art date
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Pending
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CN2009801289321A
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English (en)
Chinese (zh)
Inventor
J·C·伯内特
陈鸿豪
O·里斯
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Mayo Clinic in Florida
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Mayo Clinic in Florida
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Publication of CN102143757A publication Critical patent/CN102143757A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/2242—Atrial natriuretic factor complex: Atriopeptins, atrial natriuretic protein [ANP]; Cardionatrin, Cardiodilatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN2009801289321A 2008-06-06 2009-06-03 嵌合利尿钠多肽和抑制心脏重构的方法 Pending CN102143757A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5957608P 2008-06-06 2008-06-06
US61/059,576 2008-06-06
PCT/US2009/046095 WO2009149161A2 (en) 2008-06-06 2009-06-03 Chimeric natriuretic polypeptides and methods for inhibiting cardiac remodeling

Publications (1)

Publication Number Publication Date
CN102143757A true CN102143757A (zh) 2011-08-03

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ID=41398834

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2009801289321A Pending CN102143757A (zh) 2008-06-06 2009-06-03 嵌合利尿钠多肽和抑制心脏重构的方法

Country Status (8)

Country Link
US (1) US20110152194A1 (https=)
EP (1) EP2303305A4 (https=)
JP (1) JP2011522824A (https=)
KR (1) KR20110020903A (https=)
CN (1) CN102143757A (https=)
AU (1) AU2009256222A1 (https=)
CA (1) CA2727085A1 (https=)
WO (1) WO2009149161A2 (https=)

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CN109843912A (zh) * 2016-08-18 2019-06-04 新加坡国立大学 具有血管扩张功能和/或利尿功能的肽

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US8455438B2 (en) 2008-12-29 2013-06-04 Mayo Foundation For Medical Education And Research Natriuretic polypeptides for reducing or preventing restenosis
US20120108514A1 (en) 2009-07-09 2012-05-03 University Of Iowa Research Foundation Long acting atrial natriuretic peptide (la-anp) and methods for use thereof
WO2012088608A1 (en) 2010-12-27 2012-07-05 Enobia Canada Limited Partnership Compositions comprising natriuretic peptides and methods of use thereof
EP2678028A2 (en) * 2011-02-25 2014-01-01 Medtronic, Inc. Systems and methods for therapy of kidney disease and/or heart failure using chimeric natriuretic peptides
US20120277155A1 (en) * 2011-02-25 2012-11-01 Medtronic, Inc. Therapy for kidney disease and/or heart failure
CN103906761B (zh) 2011-08-30 2016-12-21 梅约医学教育与研究基金会 利钠多肽
EP2750697A4 (en) 2011-09-02 2015-03-25 Medtronic Inc CHIMERIC NATRIURETIC PEPTIDE COMPOSITIONS AND METHOD FOR THE PRODUCTION THEREOF
WO2013103896A1 (en) 2012-01-06 2013-07-11 Mayo Foundation For Medical Education And Research Treating cardiovascular or renal diseases
US10052366B2 (en) 2012-05-21 2018-08-21 Alexion Pharmaceuticsl, Inc. Compositions comprising alkaline phosphatase and/or natriuretic peptide and methods of use thereof
WO2016007873A1 (en) 2014-07-11 2016-01-14 The Regents Of The University Of Michigan Compositions and methods for treating craniosynostosis
MX389350B (es) 2014-12-05 2025-03-19 Alexion Pharma Inc Fosfatasas alcalinas recombinantes y usos de las mismas para el tratamiento de convulsiones.
JP6868561B2 (ja) 2015-01-28 2021-05-12 アレクシオン ファーマシューティカルズ， インコーポレイテッド アルカリホスファターゼ欠損を有する被験者を治療する方法
CN108350440A (zh) 2015-08-17 2018-07-31 阿雷克森制药公司 碱性磷酸酯的制造
JP6868617B2 (ja) 2015-09-28 2021-05-12 アレクシオン ファーマシューティカルズ， インコーポレイテッド 低ホスファターゼ血症の組織非特異的アルカリホスファターゼ（ｔｎｓａｌｐ）酵素補充療法に有効な投薬計画の特定
JP2018533571A (ja) 2015-10-30 2018-11-15 アレクシオン ファーマシューティカルズ， インコーポレイテッド 患者の頭蓋縫合早期癒合症を治療するための方法
WO2017155569A1 (en) 2016-03-08 2017-09-14 Alexion Pharmaceuticals, Inc. Methods for treating hypophosphatasia in children
JP7613826B2 (ja) 2016-04-01 2025-01-15 アレクシオン ファーマシューティカルズ， インコーポレイテッド アルカリホスファターゼによって筋力低下を治療すること
US10898549B2 (en) 2016-04-01 2021-01-26 Alexion Pharmaceuticals, Inc. Methods for treating hypophosphatasia in adolescents and adults
US10988744B2 (en) 2016-06-06 2021-04-27 Alexion Pharmaceuticals, Inc. Method of producing alkaline phosphatase
EP3500289B1 (en) 2016-08-18 2024-10-09 Alexion Pharmaceuticals, Inc. Asfotase alfa for use in treating tracheobronchomalacia
EP3600383A4 (en) 2017-03-31 2020-10-28 Alexion Pharmaceuticals, Inc. METHODS OF TREATMENT OF HYPOPHOSPHATASIA (HPP) IN ADULTS AND ADOLESCENTS
US11913039B2 (en) 2018-03-30 2024-02-27 Alexion Pharmaceuticals, Inc. Method for producing recombinant alkaline phosphatase
US12268733B2 (en) 2018-08-10 2025-04-08 Alexion Pharmaceuticals, Inc. Methods of treating neurofibromatosis type 1 and related conditions with alkaline phosphatase
CA3161266A1 (en) 2019-12-09 2021-06-17 Alexion Pharmaceuticals, Inc. Alkaline phosphatase polypeptides and methods of use thereof
EP4117692A4 (en) * 2020-03-13 2024-05-01 Mayo Foundation for Medical Education and Research ASSESSMENT AND TREATMENT OF ACUTE DECOMPENSATED HEART FAILURE
AU2021337652B2 (en) 2020-09-04 2025-01-30 Alexion Pharmaceuticals, Inc. Methods for treating bone mineralization disorders
BR112023016048A2 (pt) 2021-02-12 2023-11-14 Alexion Pharma Inc Polipeptídeos de fosfatase alcalina e métodos de uso dos mesmos
WO2024094747A1 (en) 2022-11-02 2024-05-10 Novo Nordisk A/S Cnp compounds
US12427185B2 (en) 2023-09-05 2025-09-30 E-Star Biotech, LLC Formulations of MANP and uses thereof

Citations (3)

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WO2001044284A2 (en) * 1999-12-17 2001-06-21 Mayo Foundation For Medical Education And Research Chimeric natriuretic peptides
US20060019890A1 (en) * 2004-01-15 2006-01-26 Kapoun Ann M Method for treating cardiac remodeling following myocardial injury
US20060025367A1 (en) * 1999-05-24 2006-02-02 Mayo Foundation For Medical Education And Research, A Minnesota Corporation Adenovirus vectors encoding brain natriuretic peptide

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US4757048A (en) * 1985-11-05 1988-07-12 Biotechnology Research Associates J.V. Synthetic analogs of atrial natriuretic peptides
US4935492A (en) * 1987-12-24 1990-06-19 California Biotechnology Inc. Cyclic analogs of atrial natriuretic peptides
US20070042957A1 (en) * 2005-08-19 2007-02-22 Mayo Foundation For Medical Education And Research Type v phosphodiesterase inhibitors and natriuretic polypeptides
US7803901B2 (en) * 2005-09-16 2010-09-28 Mayo Foundation For Medical Education And Research Polypeptides with natriuresis activity
CN101501067B (zh) * 2006-08-08 2013-01-16 梅约医学教育与研究基金会 利尿和利尿钠的多肽
US8283318B2 (en) * 2006-09-08 2012-10-09 Mayo Foundation For Medical Education And Research Aquaretic and natriuretic polypeptides lacking vasodilatory activity
CN101541957B (zh) * 2007-07-20 2013-08-14 梅约医学教育与研究基金会 利尿钠多肽
US8741842B2 (en) * 2008-07-02 2014-06-03 Mayo Foundation For Medical Education And Research Chimeric natriuretic polypeptides with unique pharmacologic profiles
US8642550B2 (en) * 2008-10-24 2014-02-04 Mayo Foundation For Medical Education And Research Chimeric natriuretic peptides without hypotensive inducing capability
US8455438B2 (en) * 2008-12-29 2013-06-04 Mayo Foundation For Medical Education And Research Natriuretic polypeptides for reducing or preventing restenosis
WO2010129655A2 (en) * 2009-05-05 2010-11-11 Mayo Foundation For Medical Education And Research Natriuretic polypeptides having mutations within their disulfide rings
US20120108514A1 (en) * 2009-07-09 2012-05-03 University Of Iowa Research Foundation Long acting atrial natriuretic peptide (la-anp) and methods for use thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060025367A1 (en) * 1999-05-24 2006-02-02 Mayo Foundation For Medical Education And Research, A Minnesota Corporation Adenovirus vectors encoding brain natriuretic peptide
WO2001044284A2 (en) * 1999-12-17 2001-06-21 Mayo Foundation For Medical Education And Research Chimeric natriuretic peptides
US20060019890A1 (en) * 2004-01-15 2006-01-26 Kapoun Ann M Method for treating cardiac remodeling following myocardial injury

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109843912A (zh) * 2016-08-18 2019-06-04 新加坡国立大学 具有血管扩张功能和/或利尿功能的肽
CN109843912B (zh) * 2016-08-18 2023-04-04 新加坡国立大学 具有血管扩张功能和/或利尿功能的肽

Also Published As

Publication number Publication date
WO2009149161A2 (en) 2009-12-10
EP2303305A4 (en) 2012-07-04
WO2009149161A9 (en) 2010-04-08
CA2727085A1 (en) 2009-12-10
US20110152194A1 (en) 2011-06-23
KR20110020903A (ko) 2011-03-03
AU2009256222A1 (en) 2009-12-10
EP2303305A2 (en) 2011-04-06
JP2011522824A (ja) 2011-08-04
WO2009149161A3 (en) 2010-06-10

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