CN102137862B - 作为nadph氧化酶抑制剂的吡唑并吡啶衍生物 - Google Patents

作为nadph氧化酶抑制剂的吡唑并吡啶衍生物 Download PDF

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Publication number
CN102137862B
CN102137862B CN200980133736.3A CN200980133736A CN102137862B CN 102137862 B CN102137862 B CN 102137862B CN 200980133736 A CN200980133736 A CN 200980133736A CN 102137862 B CN102137862 B CN 102137862B
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pyridine
pyrazolo
methyl
optionally substituted
alkyl
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CN102137862A (zh
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P·帕戈
M·奥查德
B·拉露
F·加吉尼
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Calliditas Therapeutics Suisse SA
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Genkyotex SA
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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CN200980133736.3A 2008-09-23 2009-09-22 作为nadph氧化酶抑制剂的吡唑并吡啶衍生物 Expired - Fee Related CN102137862B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP20080164849 EP2166009A1 (en) 2008-09-23 2008-09-23 Pyrazolo pyridine derivatives as nadph oxidase inhibitors
EP08164849.5 2008-09-23
PCT/IB2009/054155 WO2010035220A1 (en) 2008-09-23 2009-09-22 Pyrazolo pyridine derivatives as nadph oxidase inhibitors

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CN102137862A CN102137862A (zh) 2011-07-27
CN102137862B true CN102137862B (zh) 2014-07-02

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US (2) US8455486B2 (enExample)
EP (2) EP2166009A1 (enExample)
JP (1) JP5750372B2 (enExample)
KR (1) KR101716511B1 (enExample)
CN (1) CN102137862B (enExample)
AU (1) AU2009298007B2 (enExample)
BR (1) BRPI0919331A2 (enExample)
CA (1) CA2737538C (enExample)
ES (1) ES2561210T3 (enExample)
IL (1) IL211891B (enExample)
RU (1) RU2548022C2 (enExample)
WO (1) WO2010035220A1 (enExample)

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CN115666704B (zh) 2019-12-13 2025-09-26 比特比德科有限责任公司 用于将治疗剂递送至胃肠道的可摄取装置
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EP2166009A1 (en) 2010-03-24
IL211891B (en) 2018-01-31
US9006238B2 (en) 2015-04-14
AU2009298007A1 (en) 2010-04-01
CA2737538C (en) 2019-04-23
HK1159092A1 (en) 2012-07-27
US8455486B2 (en) 2013-06-04
JP5750372B2 (ja) 2015-07-22
US20130158027A1 (en) 2013-06-20
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CA2737538A1 (en) 2010-04-01
JP2012502980A (ja) 2012-02-02
BRPI0919331A2 (pt) 2015-12-29
EP2342203B1 (en) 2015-11-04
WO2010035220A1 (en) 2010-04-01
KR20110060901A (ko) 2011-06-08
EP2342203A1 (en) 2011-07-13
CN102137862A (zh) 2011-07-27
ES2561210T3 (es) 2016-02-25
AU2009298007B2 (en) 2014-02-06
US20110178082A1 (en) 2011-07-21

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