CN102133331B - Capsule with function of improving sleeping quality and preparation process - Google Patents
Capsule with function of improving sleeping quality and preparation process Download PDFInfo
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- CN102133331B CN102133331B CN201110061293.0A CN201110061293A CN102133331B CN 102133331 B CN102133331 B CN 102133331B CN 201110061293 A CN201110061293 A CN 201110061293A CN 102133331 B CN102133331 B CN 102133331B
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- 239000002775 capsule Substances 0.000 title claims abstract description 30
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 12
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 12
- 235000008434 ginseng Nutrition 0.000 claims abstract description 12
- 229920002472 Starch Polymers 0.000 claims abstract description 8
- 239000008107 starch Substances 0.000 claims abstract description 8
- 235000019698 starch Nutrition 0.000 claims abstract description 8
- 239000002994 raw material Substances 0.000 claims abstract description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 36
- 239000000843 powder Substances 0.000 claims description 19
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims description 18
- 239000003814 drug Substances 0.000 claims description 12
- 241000208340 Araliaceae Species 0.000 claims description 11
- 210000000582 semen Anatomy 0.000 claims description 11
- 238000005516 engineering process Methods 0.000 claims description 10
- 238000011049 filling Methods 0.000 claims description 10
- 238000000605 extraction Methods 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 9
- 239000011812 mixed powder Substances 0.000 claims description 8
- 239000000047 product Substances 0.000 claims description 8
- 238000007689 inspection Methods 0.000 claims description 7
- 239000012567 medical material Substances 0.000 claims description 7
- 238000012856 packing Methods 0.000 claims description 7
- 230000001954 sterilising effect Effects 0.000 claims description 7
- 229940079593 drug Drugs 0.000 claims description 6
- 238000000034 method Methods 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 5
- 239000000463 material Substances 0.000 claims description 5
- 239000004677 Nylon Substances 0.000 claims description 4
- 241000700605 Viruses Species 0.000 claims description 4
- 239000005030 aluminium foil Substances 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 239000000428 dust Substances 0.000 claims description 4
- 239000000706 filtrate Substances 0.000 claims description 4
- 235000013305 food Nutrition 0.000 claims description 4
- 238000010438 heat treatment Methods 0.000 claims description 4
- 239000012535 impurity Substances 0.000 claims description 4
- 229920001778 nylon Polymers 0.000 claims description 4
- 239000005022 packaging material Substances 0.000 claims description 4
- 239000004033 plastic Substances 0.000 claims description 4
- 238000003825 pressing Methods 0.000 claims description 4
- 230000008569 process Effects 0.000 claims description 4
- 230000005855 radiation Effects 0.000 claims description 4
- 238000010992 reflux Methods 0.000 claims description 4
- 238000001291 vacuum drying Methods 0.000 claims description 4
- 239000012141 concentrate Substances 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 238000011017 operating method Methods 0.000 claims description 3
- 238000010298 pulverizing process Methods 0.000 claims description 3
- 238000000746 purification Methods 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 8
- 244000131316 Panax pseudoginseng Species 0.000 abstract 1
- 241001080798 Polygala tenuifolia Species 0.000 abstract 1
- 244000197580 Poria cocos Species 0.000 abstract 1
- 235000008599 Poria cocos Nutrition 0.000 abstract 1
- 240000006079 Schisandra chinensis Species 0.000 abstract 1
- 235000008422 Schisandra chinensis Nutrition 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 230000006870 function Effects 0.000 description 8
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 4
- 230000006872 improvement Effects 0.000 description 3
- 206010022437 insomnia Diseases 0.000 description 3
- 229940125717 barbiturate Drugs 0.000 description 2
- 229940049706 benzodiazepine Drugs 0.000 description 1
- 150000001557 benzodiazepines Chemical class 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 230000036449 good health Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 235000008935 nutritious Nutrition 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000002618 waking effect Effects 0.000 description 1
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Abstract
The invention discloses a capsule with a function of improving sleeping quality and a preparation process. The capsule is prepared by the following raw materials by weight: 600g of spina date seed, 500g of schisandra chinensis, 200g of ginseng, 150g of radix Ophiopogonis, 150g of polygala tenuifolia, 30g of Poria cocos and 20g of starch, which are prepared into 1000 particles of capsules. For the capsule and the preparation process, the raw materials are easy to obtain, the preparation process is simple, the administration is convenient, the effect is good, and the function of improving the sleeping quality is achieved.
Description
Technical field
The present invention relates to field of health care products, refer more particularly to a kind of capsule and preparation technology who improves sleep function that have.
Background technology
People has time of 1/3rd to spend in sleep, and sleep is the important step of body recovery, integration and consolidating memory, can make the brain of a day and body tired and estimate repaired and have a rest, so sleep is very important.Yet, along with the quickening of social life rhythm, the increase of life stress, increasing people joins the main forces of insomnia.There is data to show, in more than the ten thousand people's investigation of Shanghai, Beijing, Deng Ji big city, Guangzhou, find to be subject to difficulty falling asleep, easily wake up, the puzzlement person of dreaminess, early awakening, the raw insomnia problem such as be difficult for falling asleep of waking up is up to 42.5%, and is mostly the white collar crowd who is engaged in the strong mental work such as IT, management.NIH has announced a statistical data, and approximately 7,000 ten thousand Americans are perplexed by sleeping problems.At present conventional peace medicament for the eyes has Benzodiazepines, barbiturates and other non-barbiturates clinically, the effect of its Cure for insomnia is obvious, but it is larger for liver, kidney impact, user easily produces the dependency to medicine, conventionally dosage need to be continued to increase and effect could be kept, therefore, be not to be applicable to the long medicine of taking, and also can produce very large toxic and side effects.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point of the prior art and a kind of raw material that rationally utilizes is provided, draw materials easily, processing technology is simple, and taking convenience is effective, and has capsule and the preparation technology who improves sleep function.
The present invention realizes in the following way:
There is the capsule and the preparation technology that improve sleep function, it is characterized in that: this capsule is to be made by following raw material:
Semen Ziziphi Spinosae 600g, Fructus Schisandrae Chinensis 500g, Radix Ginseng 200g, Radix Ophiopogonis 150g, Radix Polygalae 150g, Poria 30g, starch 20g, above dosage can be made the capsule of 1000.
This technique with the capsule that improves sleep function is:
One, the purification of crude drug, the process of preparing Chinese medicine: Chinese crude drug Semen Ziziphi Spinosae, Fructus Schisandrae Chinensis, Radix Ginseng, Radix Ophiopogonis, Radix Polygalae, Poria are selected, removed foreign body impurity, screen out dust, standby;
Two, the pulverizing of Poria: get dry Poria decoction pieces, be ground into powder with universal mill, cross 100 mesh sieves, adopt 60Co roentgenization to kill virus, radiation dose is that 5000 lattice are auspicious, and the time is 2 hours, puts in clean hermetic container and preserves, standby;
Three, extract, filter, concentrate, be dried:
(1), the extraction of medical material, filtration: get Semen Ziziphi Spinosae, Fructus Schisandrae Chinensis, Radix Ginseng, Radix Ophiopogonis, Radix Polygalae, insert in multi-function extractor, the 60% food stage soak with ethanol 30min that adds 6 times of medical materials, heating and refluxing extraction 2 times, at every turn each 1.5h, with filter material, be that 80 order nylon cloths filter, collect ethanol, in room temperature, place after 12h, get above-mentioned ethanol and carry out filter pressing with filter press, collect filtrate, obtain extracting solution;
(2), vacuum concentration: get said extracted liquid, put that in vacuum concentrator, to reclaim ethanol and be concentrated into relative density be 1.15-1.20 (60 ℃ of heat are surveyed), obtain extractum, standby;
(3), dry: above-mentioned extractum is put to vacuum drying oven inner drying, obtain dry extract, dry extract is pulverized, and crosses 100 mesh sieves and obtains fine powder, standby;
Four, mix: get above-mentioned fine powder, put in mixer with standby Poria sterilizing fine powder and starch, mix homogeneously, crosses 80 mesh sieves, obtains mixed-powder, standby;
Five, capsule-filling: adopt automatic capsule filling machine by above-mentioned mixed-powder fill capsule, every tune is heavily 0.40g;
Six, subpackage, packing, product inspection, warehouse-in: adopt automatic water blister machine subpackage, inner packaging material is the hard sheet of PVC and aluminium foil, carries out aluminium-plastic bubble plate packing, 12 of every plates; Product inspection, warehousing after passing.
In preparation process, the sterilizing of 60Co roentgenization, extract powder sieve, mixing and capsule-filling and subpackage all carry out under 100,000 grades of clean area conditions, and other operating procedure is in general clean area.
Described capsule has the effect that improves sleep.
The invention has the advantages that:
1, formula innovation, rationally.
2, production technology is simple.
3, there is the sleep function of improvement.
Accompanying drawing explanation
Fig. 1 process diagram of the present invention.
The specific embodiment
The specific embodiment of the invention is described in detail in detail:
As shown in Figure 1: a kind of have capsule and a preparation technology who improves sleep function, it is characterized in that: this capsule is to be made by following raw material:
Semen Ziziphi Spinosae 600g, Fructus Schisandrae Chinensis 500g, Radix Ginseng 200g, Radix Ophiopogonis 150g, Radix Polygalae 150g, Poria 30g, starch 20g, above dosage can be made the capsule of 1000.
This technique with the capsule that improves sleep function is:
One, the purification of crude drug, the process of preparing Chinese medicine: Chinese crude drug Semen Ziziphi Spinosae, Fructus Schisandrae Chinensis, Radix Ginseng, Radix Ophiopogonis, Radix Polygalae, Poria are selected, removed foreign body impurity, screen out dust, standby;
Two, the pulverizing of Poria: get dry Poria decoction pieces, be ground into powder with universal mill, cross 100 mesh sieves, adopt 60Co roentgenization to kill virus, radiation dose is that 5000 lattice are auspicious, and the time is 2 hours, puts in clean hermetic container and preserves, standby;
Three, extract, filter, concentrate, be dried:
(1), the extraction of medical material, filtration: get Semen Ziziphi Spinosae, Fructus Schisandrae Chinensis, Radix Ginseng, Radix Ophiopogonis, Radix Polygalae, insert in multi-function extractor, the 60% food stage soak with ethanol 30min that adds 6 times of medical materials, heating and refluxing extraction 2 times, at every turn each 1.5h, with filter material, be that 80 order nylon cloths filter, collect ethanol, in room temperature, place after 12h, get above-mentioned ethanol and carry out filter pressing with filter press, collect filtrate, obtain extracting solution;
(2), vacuum concentration: get said extracted liquid, put that in vacuum concentrator, to reclaim ethanol and be concentrated into relative density be 1.15-1.20 (60 ℃ of heat are surveyed), obtain extractum, standby;
(3), dry: above-mentioned extractum is put to vacuum drying oven inner drying, obtain dry extract, dry extract is pulverized, and crosses 100 mesh sieves and obtains fine powder, standby;
Four, mix: get above-mentioned fine powder, put in mixer with standby Poria sterilizing fine powder and starch, mix homogeneously, crosses 80 mesh sieves, obtains mixed-powder, standby;
Five, capsule-filling: adopt automatic capsule filling machine by above-mentioned mixed-powder fill capsule, every tune is heavily 0.40g;
Six, subpackage, packing, product inspection, warehouse-in: adopt automatic water blister machine subpackage, inner packaging material is the hard sheet of PVC and aluminium foil, carries out aluminium-plastic bubble plate packing, 12 of every plates; Product inspection, warehousing after passing.
In preparation process, the sterilizing of 60Co roentgenization, extract powder sieve, mixing and capsule-filling and subpackage all carry out under 100,000 grades of clean area conditions, and other operating procedure is in general clean area.
Described capsule has the effect that improves sleep.
Embodiment:
One, by relevant technologies requirement under the Semen Ziziphi Spinosae of 2000 editions one of < < Chinese Pharmacopoeia > >, Fructus Schisandrae Chinensis, Radix Ginseng, Radix Ophiopogonis, Radix Polygalae, Poria item, undertaken, from each taste tcm and herbal slice, select, remove foreign body impurity, screen out dust, standby;
Two, get dry Poria decoction pieces, with universal mill, be ground into powder, cross 100 mesh sieves, adopt 60Co roentgenization to kill virus, radiation dose is that 5000 lattice are auspicious, and the time is 2 hours, puts in clean hermetic container and preserves, standby;
Three, get Semen Ziziphi Spinosae 600g, Fructus Schisandrae Chinensis 500g, Radix Ginseng 200g, Radix Ophiopogonis 150g, Radix Polygalae 150g, insert in multi-function extractor, the 60% food stage soak with ethanol 30min that adds 6 times of medical materials, heating and refluxing extraction 2 times, at every turn each 1.5h, with filter material, be that 80 order nylon cloths filter, collect ethanol, in room temperature, place after 12h, get above-mentioned ethanol and carry out filter pressing with filter press, collect filtrate, obtain extracting solution; Get said extracted liquid, put that in vacuum concentrator, to reclaim ethanol and be concentrated into relative density be 1.15-1.20 (60 ℃ of heat are surveyed), obtain extractum, standby; Above-mentioned extractum is put to vacuum drying oven inner drying, obtain dry extract, dry extract is pulverized, and crosses 100 mesh sieves and obtains fine powder, standby;
Four, get above-mentioned fine powder, put in mixer with standby Poria sterilizing fine powder 30g and starch 20g, mix homogeneously, crosses 80 mesh sieves, obtains mixed-powder, standby;
Five, adopt automatic capsule filling machine by above-mentioned mixed-powder fill capsule, every tune is heavily 0.40g;
Six, adopt automatic water blister machine subpackage, inner packaging material is the hard sheet of PVC and aluminium foil, carries out aluminium-plastic bubble plate packing, 12 of every plates; Product inspection, warehousing after passing.
The main composition in the present invention with improvement sleep is Saponin class and flavonoid, fat-soluble compared with good water solubility, selects the rare alcohol liquid of 60% ethanol to extract the stripping extraction that takes into account both compositions, and water or alcohol 95 % extraction all do not reach the effect of extracting both separately.
The present invention has nutritious, and good health care effect has advantages of the sleep of improvement.
Claims (1)
1. there is a capsule that improves sleep function, it is characterized in that: this capsule is to be made by following raw material:
Semen Ziziphi Spinosae 600g, Fructus Schisandrae Chinensis 500g, Radix Ginseng 200g, Radix Ophiopogonis 150g, Radix Polygalae 150g, Poria 30g, starch 20g, above dosage is made the capsule of 1000; Wherein the preparation technology of this capsule is:
(1), the purification of crude drug, the process of preparing Chinese medicine: Chinese crude drug Semen Ziziphi Spinosae, Fructus Schisandrae Chinensis, Radix Ginseng, Radix Ophiopogonis, Radix Polygalae, Poria are selected, are removed foreign body impurity, screen out dust, standby;
(2), the pulverizing of Poria: get dry Poria decoction pieces, be ground into powder with universal mill, cross 100 mesh sieves, adopt 60Co roentgenization to kill virus, radiation dose is that 5000 lattice are auspicious, and the time is 2 hours, puts in clean hermetic container and preserves, standby;
(3), extract, filter, concentrate, be dried:
(1), the extraction of medical material, filtration: get Semen Ziziphi Spinosae, Fructus Schisandrae Chinensis, Radix Ginseng, Radix Ophiopogonis, Radix Polygalae, insert in multi-function extractor, the 60% food stage soak with ethanol 30min that adds 6 times of medical materials, heating and refluxing extraction 2 times, at every turn each 1.5h, with filter material, be that 80 order nylon cloths filter, collect ethanol, in room temperature, place after 12h, get above-mentioned ethanol and carry out filter pressing with filter press, collect filtrate, obtain extracting solution;
(2), vacuum concentration: get said extracted liquid, put that in vacuum concentrator, to reclaim ethanol and be concentrated into relative density under 60 ℃ of temperature surveys be 1.15-1.20, obtain extractum, standby;
(3), dry: above-mentioned extractum is put to vacuum drying oven inner drying, obtain dry extract, dry extract is pulverized, and crosses 100 mesh sieves and obtains fine powder, standby;
(4), mix: get above-mentioned fine powder, put in mixer with standby Poria sterilizing fine powder and starch, mix homogeneously, crosses 80 mesh sieves, obtains mixed-powder, standby;
(5), capsule-filling: adopt automatic capsule filling machine by above-mentioned mixed-powder fill capsule, every tune is heavily 0.40g;
(6), subpackage, packing, product inspection, warehouse-in: adopt automatic water blister machine subpackage, inner packaging material is the hard sheet of PVC and aluminium foil, carries out aluminium-plastic bubble plate packing, 12 of every plates; Product inspection, warehousing after passing;
Wherein in preparation process, the sterilizing of 60Co roentgenization, extract powder sieve, mixing and capsule-filling and subpackage all carry out under 100,000 grades of clean area conditions, and other operating procedure is being carried out in general clean area.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110061293.0A CN102133331B (en) | 2011-03-11 | 2011-03-11 | Capsule with function of improving sleeping quality and preparation process |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201110061293.0A CN102133331B (en) | 2011-03-11 | 2011-03-11 | Capsule with function of improving sleeping quality and preparation process |
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| CN102133331A CN102133331A (en) | 2011-07-27 |
| CN102133331B true CN102133331B (en) | 2014-03-26 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102940768B (en) * | 2012-09-03 | 2014-12-03 | 吉林一正药业集团有限公司 | Composition for improving sleep and preparation method and application thereof |
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| CN102600355A (en) * | 2012-04-07 | 2012-07-25 | 周国生 | Traditional Chinese medicine for treatment of syndrome of tension in examination |
| CN102657715A (en) * | 2012-05-17 | 2012-09-12 | 双飞人制药（中国）有限公司 | Drug combination with function of improving sleep |
| CN105011129A (en) * | 2014-04-29 | 2015-11-04 | 赛珂睿德生物医药科技(上海)有限公司 | Functional food with sleep improving effect |
| CN104013690A (en) * | 2014-06-20 | 2014-09-03 | 苏州法莫生物技术有限公司 | Traditional Chinese medicine for improving sleeping |
| CN104524104B (en) * | 2014-12-17 | 2019-02-22 | 云南人羞花化妆品有限公司 | A kind of Sanqi Shuishu Capsule and preparation method thereof |
| CN105832842A (en) * | 2016-05-30 | 2016-08-10 | 元和药业股份有限公司 | Ginseng and wild jujube health-care preparation and preparation method thereof |
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Address after: Xin Dian Zhen ban Zhong Lu Fuzhou Jinan District 350012 Fujian province No. 6 thaihot city square (a) No. 2 Building 16 layer 26 Office Patentee after: Fujian Kangshimei Biotechnology Co.,Ltd. Address before: Xin Dian Zhen ban Zhong Lu Fuzhou Jinan District 350012 Fujian province No. 6 thaihot city square (a) No. 2 Building 16 layer 26 Office Patentee before: Fujian Qian Feng Biotechnology Co.,Ltd. |
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