CN102133250A - Medicinal composition with effect of improving immunity - Google Patents
Medicinal composition with effect of improving immunity Download PDFInfo
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- CN102133250A CN102133250A CN2011100607542A CN201110060754A CN102133250A CN 102133250 A CN102133250 A CN 102133250A CN 2011100607542 A CN2011100607542 A CN 2011100607542A CN 201110060754 A CN201110060754 A CN 201110060754A CN 102133250 A CN102133250 A CN 102133250A
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Abstract
The invention belongs to the field of medicine or health care food, and discloses a medicinal composition with an effect of improving immunity. The medicinal composition is characterized by comprising 5 to 20 weight parts of American ginseng and/or dendrobium, 0.005 to 3 weight parts of vitamins and 0.05 to 3 weight parts of minerals. Pharmacological experiments show that: the medicinal composition has a good effect of improving the immunity.
Description
Technical field
The present invention relates to medicine or field of health care food, be specifically related to a kind of pharmaceutical composition that improves immunity that has
Background technology
So-called immunity briefly is exactly the ability that human body avoids various pathogenic microorganism infringements.Should be in the very long evolutionary process of the mankind, human always at various pathogenic microorganism with occurring in nature, comprise that virus, antibacterial, fungus etc. struggle.No matter scientific and technological progress is to what degree, no matter human advanced person's the medicine of how inventing, immunity of human body itself still will continue bringing into play important effect.How should we improve immunity since immunity of human body itself is so important? one of them is plain by normal channel extra-nutrition, balanced diet, and monophagia does not help to improve body immunity so most.And modern's rhythm of life is fast, and diet is single or too meticulous, will inevitably cause the shortage of nutrient substance in the diet, the shortage of particularly necessary minerals and vitamins.Believe that many people know, the C that is deficient in vitamin can cause vitamin C deficiency, and the A that is deficient in vitamin can cause nyctalopia, and the E that is deficient in vitamin can cause miscarriage, and being deficient in vitamin also directly to cause the decline of resistance of human body.Lack the decline that mineral causes the thin and weak and immunity of human body too.In nearest nutritional survey for the third time, find that China people's diet does not reach the standard of balanced diet as yet.Particularly the amount of essential minerals and vitamin does not reach human body requirements.This shows, merely be difficult to reach balanced diet truly in the middle of the diet, so an amount of minerals and vitamins that replenishes is undoubtedly of great advantage to keeping body immunity outside the food, suitably the Resource of more oral this class is to improving body immunity, diseases prevention, the disease-resistant benefit that truly has.
Summary of the invention
For these reasons, the applicant is the basis by clinical research for many years, with the modern medical theory is guidance, Radix Panacis Quinquefolii and/or Herba Dendrobii and vitamin and mineral are carried out compatibility, obtain the new immunity of the raising pharmaceutical composition that has, pharmacological testing shows, the effect that the new pharmaceutical composition of the present invention has better raising immunity.
The present invention is achieved through the following technical solutions.
A kind of pharmaceutical composition with raising immunity, pharmaceutical composition comprises sends out Radix Panacis Quinquefolii and/or Herba Dendrobii, and pharmaceutical composition also comprises vitamin and mineral, wherein Radix Panacis Quinquefolii and/or Herba Dendrobii 5-20 weight portion, vitamin 0.005-3 weight portion, mineral 0.05-3 weight portion.Radix Panacis Quinquefolii of the present invention can replace with Radix Panacis Quinquefolii extract or American ginseng total saponins, and wherein Radix Panacis Quinquefolii extract or American ginseng total saponins are the 0.1-2 weight portion.
Wherein vitamin is in vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E, folic acid, vitamin B12, vitamin D, vitamin K, biotin, Citrin, vitamin PP, vitamin(e) M, vitamin(e) T, vitamin U, biotin, water soluble vitamins, nicotiamide, the pantothenic acid one or more in the pharmaceutical composition.
Wherein the pharmaceutical composition mineral is one or more in calcium, ferrum, zinc, selenium, phosphorus, potassium, chlorine, magnesium, copper, manganese, iodine, chromium, molybdenum, nickel, stannum, silicon, vanadium, cobalt, sulfur, sodium, fluorine, the strontium.
Wherein pharmaceutical composition also comprises lycopene 0.01-0.5 weight portion, oligofructose 0.01-0.5 weight portion.
Wherein pharmaceutical composition also comprises in Radix Ophiopogonis, Radix Achyranthis Bidentatae, the Cortex Eucommiae, Fructus Lycii, Radix Codonopsis, Fructus Schisandrae Chinensis, Poria, Radix Et Caulis Acanthopanacis Senticosi and the Rhizoma Phragmitis one or more being arranged.
The wherein pharmaceutical preparation of preparation of pharmaceutical compositions or food.
Wherein the pharmaceutical preparation of preparation of pharmaceutical compositions or food are tablet, granule, pill, oral liquid or capsule.
The beverage of preparation of pharmaceutical compositions wherein.
Wherein preparation of pharmaceutical compositions becomes milk powder or milk powder.
Milk powder of the present invention is can be for selling and edible milk powder on the market.The standard that meets State Administration for Quality Supervision and Inspection and Quarantine's promulgation: CCGF 114.2-2008.
Pharmacological testing
1, improves immunity function experiment 1
Trial drug:
Test 1 group: Radix Panacis Quinquefolii.
Test 2 groups: pharmaceutical composition of the present invention: Radix Panacis Quinquefolii 5g, vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E and folic acid is 0.7g (each 0.1g) altogether, and calcium, ferrum, zinc and selenium is 2g (each 0.5g) altogether.
Test 3 groups: pharmaceutical composition of the present invention: Radix Panacis Quinquefolii 20g, vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E and folic acid is 0.009g (vitamin B1 0.001g, vitamin B2 0.003g altogether, all the other each 0.001g), calcium, ferrum, zinc and selenium is 0.1g (calcium, ferrum, each 0.03g of zinc, selenium 0.01g) altogether.
Test 4 groups: pharmaceutical composition of the present invention: Radix Panacis Quinquefolii 10g, vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E and folic acid is 3g (vitamin C 1.5g, vitamin E 0.5g, all the other each 0.2g altogether,), calcium, ferrum, zinc and selenium is 2.8g (each 0.7g) altogether.
Test 5 groups: pharmaceutical composition of the present invention: Radix Panacis Quinquefolii 5g, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E be 0.005g (each 0.001g) altogether, calcium, ferrum, zinc and selenium is 0.06g (calcium, ferrum, each 0.01g of zinc altogether, selenium 0.03g), lycopene 0.015g, oligofructose 0.02g.
Test 6 groups: pharmaceutical composition of the present invention: Radix Panacis Quinquefolii 15g, vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E and folic acid is 0.009g (vitamin B1 0.001g, vitamin B2 0.003g altogether, all the other each 0.001g), calcium, ferrum, zinc and selenium is 0.1g (calcium, ferrum, each 0.03g of zinc altogether, selenium 0.01g), lycopene 0.5g, oligofructose 0.5g
Experimental animal: the female white mice of Kunming kind, body weight 18-22g.
Test method: get the mice random packet: blank group, trial drug group, mice gastric infusion every day 1 time, each dosage is 3g/kg, the blank group waits the distilled water of capacity.Respectively animal being carried out every immune indexes behind the 30d continuously measures.
Mice delayed allergy (DTH) is measured: in irritating stomach the 26th day, inject 2% sheep red blood cell (SRBC) (SRBC) 0.2ml/ to mouse peritoneal and only carry out sensitization, after immunity the 4th day the left back toe ring of the every Mus subcutaneous injection 20%SRBC of portion (20 μ l/ only) attack.And 24h measures the same position of the left back sufficient intestinal of every Mus thickness before attacking and after attacking, and calculates and attacks forward and backward difference, carries out variance analysis.Result of the test sees Table 1.
Table 1 pair mouse DTH measurement result (24h)
Annotate: compare with matched group
*P＜0.01,
*P＜0.05; Compare △ P＜0.05 for 1 group with test; Compare #P＜0.05 for 2 groups with test.
2, improve immunity function experiment 2
Trial drug:
Test 1 group: pharmaceutical composition: vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E and folic acid is 0.7g (each 0.1g) altogether, and calcium, ferrum, zinc and selenium is 2g (each 0.5g) altogether.
Test 2 groups: pharmaceutical composition of the present invention: Herba Dendrobii 5g, vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E and folic acid is 0.7g (each 0.1g) altogether, and calcium, ferrum, zinc and selenium is 2g (each 0.5g) altogether.
Test 3 groups: pharmaceutical composition of the present invention: Herba Dendrobii 20g, vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E and folic acid is 0.009g (vitamin B1 0.001g, vitamin B2 0.003g altogether, all the other each 0.001g), calcium, ferrum, zinc and selenium is 0.1g (calcium, ferrum, each 0.03g of zinc, selenium 0.01g) altogether.
Test 4 groups: pharmaceutical composition of the present invention: Herba Dendrobii 12g, vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E and folic acid is 3g (vitamin C 1.5g, vitamin E 0.5g, all the other each 0.2g altogether,), calcium, ferrum, zinc and selenium is 2.8g (each 0.7g) altogether.
Test 5 groups: pharmaceutical composition of the present invention: Herba Dendrobii 8g, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E be 0.005g (each 0.001g) altogether, and calcium, ferrum, zinc and selenium is 0.06g (calcium, ferrum, each 0.01g of zinc, selenium 0.03g) altogether, lycopene 0.1g, oligofructose 0.02g.
Test 6 groups: pharmaceutical composition of the present invention: Herba Dendrobii 18g, vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E and folic acid is 0.009g (vitamin B1 0.001g, vitamin B2 0.003g altogether, all the other each 0.001g), calcium, ferrum, zinc and selenium is 0.1g (calcium, ferrum, each 0.03g of zinc altogether, selenium 0.01g), lycopene 0.03g, oligofructose 0.4g.
Test method: get the mice random packet: blank group, trial drug group, mice gastric infusion every day 1 time, testing 1 group of each dosage is 0.2g/kg, and testing 2 groups is 3g/kg to testing 6 groups of dosages, and the blank group waits the distilled water of capacity.Respectively animal being carried out every immune indexes behind the 30d continuously measures.
ConA inducing mouse splenocyte transformation experiment (mtt assay): to the aseptic spleen of getting of each group mice, the system splenocyte suspension, adjusting splenocyte concentration with RPMI 1640 complete culture solutions is 3x10
9Individual/L, carry out lymphproliferation response according to MTr method in the program, survey its absorbance (A) at 752-C ultraviolet-uisible spectrophotometer 570nm wavelength place at last, calculate ConA
+With ConA
-The absorbance value difference in each hole.Carry out variance analysis.Result of the test sees Table 2.
Table 2 pair mouse spleen lymphocyte conversion test is measurement result (24h) as a result
Annotate: compare with matched group
*P＜0.05; Compare △ P＜0.05 for 1 group with test; Compare #P＜0.05 for 2 groups with test.
3, improve immunity function experiment 3
Trial drug:
Test 1 group: Radix Panacis Quinquefolii.
Test 2 groups: pharmaceutical composition of the present invention: Radix Panacis Quinquefolii 8g, vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E and folic acid is 0.007g (each 0.001g) altogether, and calcium, ferrum, zinc and selenium is 0.05g (each 0.0125g) altogether.
Test 3 groups: pharmaceutical composition of the present invention: Radix Panacis Quinquefolii 18g, vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E and folic acid is 0.009g (vitamin B1 0.001g, vitamin B2 0.003g altogether, all the other each 0.001g), calcium, ferrum, zinc and selenium is 0.1g (calcium, ferrum, each 0.03g of zinc, selenium 0.01g) altogether.
Test 4 groups: pharmaceutical composition of the present invention: Radix Panacis Quinquefolii 16g, vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E and folic acid is 0.01g (vitamin C 0.0025g altogether, vitamin E 0.0025g, all the other each 0.001g,), calcium, ferrum, zinc and selenium is 0.4g (each 0.1g) altogether.
Test 5 groups: pharmaceutical composition of the present invention: Radix Panacis Quinquefolii 10g, vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E and folic acid is 0.009g (vitamin B1 0.001g, vitamin B2 0.003g altogether, all the other each 0.001g), calcium, ferrum, zinc and selenium is 0.1g (calcium, ferrum, each 0.03g of zinc altogether, selenium 0.01g), lycopene 0.03g, oligofructose 0.45g, Fructus Lycii 4g, Radix Codonopsis 6g.
Test 6 groups: pharmaceutical composition of the present invention: Radix Panacis Quinquefolii 10g, vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E and folic acid is 0.009g (vitamin B1 0.001g, vitamin B2 0.003g altogether, all the other each 0.001g), calcium, ferrum, zinc and selenium is 0.1g (calcium, ferrum, each 0.03g of zinc, selenium 0.01g) altogether, lycopene 0.2g, oligofructose 0.06g, Fructus Lycii 4g, Radix Ophiopogonis 8g, Radix Et Caulis Acanthopanacis Senticosi 5g.
Experimental animal: the female white mice of Kunming kind, body weight 18-22g.
Test method: get the mice random packet: blank group, trial drug group, mice gastric infusion every day 1 time, each dosage is 3g/kg, the blank group waits the distilled water of capacity.Respectively animal being carried out every immune indexes behind the 30d continuously measures.
Serum hemolysin is measured: in irritating stomach the 25th day to mouse peritoneal injection 2%SRBC (0.2ml/ only), after immunity, plucked the eyeball blood sampling on the 5th day, separation of serum is also measured at the clear hemolysin of the enterprising promoting the circulation of blood of Microhemagglutination plate: hatch 3h for 37 ℃, statistics hemagglutination degree calculates the corresponding antibodies product.Carry out variance analysis.Result of the test sees Table 3.
Table 3 pair mice serum hemolysin measurement result
Annotate: compare with matched group
*P＜0.01,
*P＜0.05; Compare △ P＜0.05 for 1 group with test; Compare #P＜0.05 for 4 groups with test.
4, improve immunity function experiment 4
Trial drug:
Test 1 group: Radix Panacis Quinquefolii 3g, Herba Dendrobii 5g.
Test 2 groups: pharmaceutical composition of the present invention: Radix Panacis Quinquefolii 3g, Herba Dendrobii 5g, vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E and folic acid is 0.007g (each 0.001g) altogether, and calcium, ferrum, zinc and selenium is 0.05g (each 0.0125g) altogether.
Test 3 groups: pharmaceutical composition of the present invention: Radix Panacis Quinquefolii 10g, Herba Dendrobii 8g, vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E and folic acid is 0.009g (vitamin B1 0.001g, vitamin B2 0.003g altogether, all the other each 0.001g), calcium, ferrum, zinc and selenium is 0.1g (calcium, ferrum, each 0.03g of zinc, selenium 0.01g) altogether.
Test 4 groups: pharmaceutical composition of the present invention: Radix Panacis Quinquefolii 3g, Herba Dendrobii 5g, vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E and folic acid is 0.01g (vitamin C 0.0025g altogether, vitamin E 0.0025g, all the other each 0.001g,), calcium, ferrum, zinc and selenium is 0.4g (each 0.1g) altogether.
Test 5 groups: pharmaceutical composition of the present invention: Radix Panacis Quinquefolii 9g, Herba Dendrobii 5g, vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E and folic acid is 0.009g (vitamin B1 0.001g, vitamin B2 0.003g altogether, all the other each 0.001g), calcium, ferrum, zinc and selenium is 0.1g (calcium, ferrum, each 0.03g of zinc, selenium 0.01g) altogether, lycopene 0.5g, oligofructose 0.2g, Radix Ophiopogonis, Radix Achyranthis Bidentatae, the Cortex Eucommiae, Fructus Lycii, each 3g of Radix Codonopsis.
Test 6 groups: pharmaceutical composition of the present invention: Radix Panacis Quinquefolii 9g, Herba Dendrobii 5g, vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E and folic acid is 0.009g (vitamin B1 0.001g, vitamin B2 0.003g altogether, all the other each 0.001g), calcium, ferrum, zinc and selenium is 0.1g (calcium, ferrum, each 0.03g of zinc, selenium 0.01g) altogether, lycopene 0.09g, oligofructose 0.35g, Fructus Schisandrae Chinensis 4g, Poria 6g and Rhizoma Phragmitis 5g.
Experimental animal: the female white mice of Kunming kind, body weight 18-22g.
Test method: get the mice random packet: blank group, trial drug group, mice gastric infusion every day 1 time, each dosage is 3g/kg, the blank group waits the distilled water of capacity.Respectively animal being carried out every immune indexes behind the 30d continuously measures.
Antibody-producting cell (PFc) detects: in to mouse peritoneal injection 2%SRBC0.2ml/ only irritating stomach the 25th day, putting to death in the 5th day after immunity, dissect and get spleen and prepare splenocyte suspension, is 5x10 with RPMI 1640 complete culture solutions adjustment splenocyte concentration
9Individual/L.The follow procedure method prepares the agarose slide, at CO
2Incubator (37 ℃, 5%CO
2) in add complement behind the incubation 1.5h, incubation 1.5h counts the hemolysis plaque number that forms on every thin agar layer slide again.Carry out variance analysis.Result of the test sees Table 4.
Table 4 pair mouse antibodies cellulation testing result
Annotate: compare with matched group
*P＜0.01,
*P＜0.05; Compare △ P＜0.05 for 1 group with test; Compare #P＜0.05 for 2 groups with test.
Conclusion (of pressure testing): above-mentioned test shows that pharmaceutical composition of the present invention has the effect of fine raising immunity.
Annotate: Chinese crude drug is pulverized in the aforementioned pharmaceutical compositions, and behind the water extraction, concentrate drying adds aforementioned pharmaceutical compositions.
Preparation embodiment
Embodiment 1
Pharmaceutical composition: Radix Panacis Quinquefolii 5g, vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E and folic acid is 0.007g (each 0.001g) altogether, and calcium, ferrum, zinc and selenium is 0.05g (each 0.0125g) altogether.
Aforementioned pharmaceutical compositions is prepared into food or pharmaceutical preparation; Its dosage form is tablet, granule, pill, oral liquid or capsule.
Aforementioned pharmaceutical compositions is prepared into beverage.
Aforementioned pharmaceutical compositions is prepared into milk powder or milk powder.
Embodiment 2
Pharmaceutical composition: Radix Panacis Quinquefolii 20g, vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E and folic acid is 0.009g (vitamin B1 0.001g, vitamin B2 0.003g altogether, all the other each 0.001g), calcium, ferrum, zinc and selenium is 0.1g (calcium, ferrum, each 0.03g of zinc, selenium 0.01g) altogether.
Aforementioned pharmaceutical compositions is prepared into food or pharmaceutical preparation; Its dosage form is tablet, granule, pill, oral liquid or capsule.
Aforementioned pharmaceutical compositions is prepared into beverage.
Aforementioned pharmaceutical compositions is prepared into milk powder or milk powder.
Embodiment 3
Pharmaceutical composition: Radix Panacis Quinquefolii 6g, Herba Dendrobii 2g, vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E and folic acid is 0.01g (vitamin C 0.0025g altogether, vitamin E 0.0025g, all the other each 0.001g), calcium, ferrum, zinc and selenium is 0.4g (each 0.1g) altogether.
Aforementioned pharmaceutical compositions is prepared into food or pharmaceutical preparation; Its dosage form is tablet, granule, pill, oral liquid or capsule.
Aforementioned pharmaceutical compositions is prepared into beverage.
Aforementioned pharmaceutical compositions is prepared into milk powder or milk powder.
Embodiment 4
Pharmaceutical composition: Radix Panacis Quinquefolii 1g, Herba Dendrobii 4g, vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E and folic acid is 0.009g (vitamin B1 0.001g, vitamin B2 0.003g altogether, all the other each 0.001g), calcium, ferrum, zinc and selenium is 0.1g (calcium, ferrum, each 0.03g of zinc, selenium 0.01g) altogether, lycopene 0.02g, oligofructose 0.01g, Radix Achyranthis Bidentatae, the Cortex Eucommiae, Fructus Lycii, Radix Codonopsis, each 5g of Fructus Schisandrae Chinensis.
Aforementioned pharmaceutical compositions is prepared into food or pharmaceutical preparation; Its dosage form is tablet, granule, pill, oral liquid or capsule.
Aforementioned pharmaceutical compositions is prepared into beverage.
Aforementioned pharmaceutical compositions is prepared into milk powder or milk powder.
Embodiment 5
Pharmaceutical composition: Radix Panacis Quinquefolii 15g, Herba Dendrobii 5g, vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E and folic acid is 0.009g (vitamin B1 0.001g, vitamin B2 0.003g altogether, all the other each 0.001g), calcium, ferrum, zinc and selenium is 0.1g (calcium, ferrum, each 0.03g of zinc, selenium 0.01g) altogether, lycopene 0.3g, oligofructose 0.1g, Fructus Lycii 5g, Radix Ophiopogonis 6g.
Aforementioned pharmaceutical compositions is prepared into food or pharmaceutical preparation; Its dosage form is tablet, granule, pill, oral liquid or capsule.
Aforementioned pharmaceutical compositions is prepared into beverage.
Aforementioned pharmaceutical compositions is prepared into milk powder or milk powder.
Embodiment 6
Pharmaceutical composition of the present invention: Herba Dendrobii 5g, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E be 0.005g (each 0.001g) altogether, and calcium, ferrum, zinc and selenium is 0.06g (calcium, ferrum, each 0.01g of zinc, selenium 0.03g) altogether, lycopene 0.01g, oligofructose 0.01g.
Aforementioned pharmaceutical compositions is prepared into food or pharmaceutical preparation; Its dosage form is tablet, granule, pill, oral liquid or capsule.
Aforementioned pharmaceutical compositions is prepared into beverage.
Aforementioned pharmaceutical compositions is prepared into milk powder or milk powder.
Embodiment 7
Pharmaceutical composition of the present invention: Herba Dendrobii 20g, vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E and folic acid is 0.009g (vitamin B1 0.001g, vitamin B2 0.003g altogether, all the other each 0.001g), calcium, ferrum, zinc and selenium is 0.1g (calcium, ferrum, each 0.03g of zinc altogether, selenium 0.01g), lycopene 0.5g, oligofructose 0.5g.
Aforementioned pharmaceutical compositions is prepared into food or pharmaceutical preparation; Its dosage form is tablet, granule, pill, oral liquid or capsule.
Aforementioned pharmaceutical compositions is prepared into beverage.
Aforementioned pharmaceutical compositions is prepared into milk powder or milk powder.
Embodiment 8
Pharmaceutical composition of the present invention: Herba Dendrobii 15g, vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E and folic acid is 0.009g (vitamin B1 0.001g, vitamin B2 0.003g altogether, all the other each 0.001g), calcium, ferrum, zinc and selenium is 0.1g (calcium, ferrum, each 0.03g of zinc altogether, selenium 0.01g), lycopene 0.2g, oligofructose 0.4g.
Aforementioned pharmaceutical compositions is prepared into food or pharmaceutical preparation; Its dosage form is tablet, granule, pill, oral liquid or capsule.
Aforementioned pharmaceutical compositions is prepared into beverage.
Aforementioned pharmaceutical compositions is prepared into milk powder or milk powder.
Embodiment 9
Pharmaceutical composition of the present invention: Radix Panacis Quinquefolii 2g, Herba Dendrobii 3g, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E be 0.005g (each 0.001g) altogether, calcium, ferrum, zinc and selenium is 0.06g (calcium, ferrum, each 0.01g of zinc altogether, selenium 0.03g), lycopene 0.01g, oligofructose 0.01g.
Aforementioned pharmaceutical compositions is prepared into food or pharmaceutical preparation; Its dosage form is tablet, granule, pill, oral liquid or capsule.
Aforementioned pharmaceutical compositions is prepared into beverage.
Aforementioned pharmaceutical compositions is prepared into milk powder or milk powder.
Embodiment 10
Pharmaceutical composition of the present invention: Radix Panacis Quinquefolii 8g, Herba Dendrobii 7g, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E be 0.005g (each 0.001g) altogether, calcium, ferrum, zinc and selenium is 0.06g (calcium, ferrum, each 0.01g of zinc altogether, selenium 0.03g), lycopene 0.1g, oligofructose 0.05g.
Aforementioned pharmaceutical compositions is prepared into food or pharmaceutical preparation; Its dosage form is tablet, granule, pill, oral liquid or capsule.
Aforementioned pharmaceutical compositions is prepared into beverage.
Aforementioned pharmaceutical compositions is prepared into milk powder or milk powder.
Milk powder of the present invention is can be for selling and edible milk powder on the market.The standard that meets State Administration for Quality Supervision and Inspection and Quarantine's promulgation: CCGF 114.2-2008.
Claims (9)
1. one kind has the pharmaceutical composition that improves immunity, it is characterized in that pharmaceutical composition comprises a Radix Panacis Quinquefolii and/or a Herba Dendrobii, pharmaceutical composition also comprises vitamin and mineral, wherein Radix Panacis Quinquefolii and/or Herba Dendrobii 5-20 weight portion, vitamin 0.005-3 weight portion, mineral 0.05-3 weight portion.
2. a kind of pharmaceutical composition that improves immunity that has according to claim 1, wherein vitamin is in vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E, folic acid, vitamin B12, vitamin D, vitamin K, biotin, Citrin, vitamin PP, vitamin(e) M, vitamin(e) T, vitamin U, biotin, water soluble vitamins, nicotiamide, the pantothenic acid one or more in the pharmaceutical composition.
3. a kind of pharmaceutical composition that improves immunity that has according to claim 1, wherein the pharmaceutical composition mineral is one or more in calcium, ferrum, zinc, selenium, phosphorus, potassium, chlorine, magnesium, copper, manganese, iodine, chromium, molybdenum, nickel, stannum, silicon, vanadium, cobalt, sulfur, sodium, fluorine, the strontium.
4. a kind of pharmaceutical composition that improves immunity that has according to claim 1, wherein pharmaceutical composition also comprises lycopene 0.01-0.5 weight portion, oligofructose 0.01-0.5 weight portion.
5. according to claim 1 or 4 described a kind of pharmaceutical compositions that improve immunity that have, wherein pharmaceutical composition also comprises in Radix Ophiopogonis, Radix Achyranthis Bidentatae, the Cortex Eucommiae, Fructus Lycii, Radix Codonopsis, Fructus Schisandrae Chinensis, Poria, Radix Et Caulis Acanthopanacis Senticosi and the Rhizoma Phragmitis one or more being arranged.
6. according to claim 1-5 each described a kind of the have pharmaceutical composition that improves immunity, the wherein pharmaceutical preparation of preparation of pharmaceutical compositions or food.
7. according to each described a kind of pharmaceutical composition that improves immunity that has of claim 1-5, wherein the pharmaceutical preparation of preparation of pharmaceutical compositions or food are tablet, granule, pill, oral liquid or capsule.
8. according to claim 1-5 each described a kind of the have pharmaceutical composition that improves immunity, wherein beverage of preparation of pharmaceutical compositions.
9. according to the described a kind of pharmaceutical composition that improves immunity that has of claim 1-5, wherein preparation of pharmaceutical compositions becomes milk powder or milk powder.
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| CN2011100607542A CN102133250B (en) | 2011-03-15 | 2011-03-15 | Medicinal composition with effect of improving immunity |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102318821A (en) * | 2011-08-23 | 2012-01-18 | 福格森（武汉）生物科技有限公司 | Special meal nutritional food applicable to males preparing to have baby |
| CN103211222A (en) * | 2013-05-03 | 2013-07-24 | 江南大学 | Composition with effect of relieving physical fatigue |
| CN103238827A (en) * | 2012-02-10 | 2013-08-14 | 王慎君 | Composite nutrient preparation formula |
| CN103564587A (en) * | 2013-11-05 | 2014-02-12 | 云南韵雅生物科技有限公司 | Natural fulvic acid compound health-care beverage as well as preparation method thereof |
| CN103638328A (en) * | 2013-12-11 | 2014-03-19 | 郭景龙 | Pharmaceutical composition containing dendrobium polysaccharides |
| CN104305229A (en) * | 2014-11-05 | 2015-01-28 | 广西壮族自治区农业科学院农产品加工研究所 | Dendrobe dietary fiber food and processing method thereof |
| CN104304491A (en) * | 2014-09-30 | 2015-01-28 | 江苏奇力康皮肤药业有限公司 | Traditional Chinese medicinal milk tablet and preparation method thereof |
| CN115517309A (en) * | 2022-02-10 | 2022-12-27 | 孙栋梁 | Three-ingredient health tea and preparation method thereof |
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| CN1457808A (en) * | 2002-05-14 | 2003-11-26 | 上海市中药研究所 | Iron scale dendrobium compound preposition and preparation and use |
| CN101305801A (en) * | 2008-06-17 | 2008-11-19 | 陶国闻 | Dendrobium nobile American ginseng capsule |
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| CN1457808A (en) * | 2002-05-14 | 2003-11-26 | 上海市中药研究所 | Iron scale dendrobium compound preposition and preparation and use |
| CN101305801A (en) * | 2008-06-17 | 2008-11-19 | 陶国闻 | Dendrobium nobile American ginseng capsule |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102318821A (en) * | 2011-08-23 | 2012-01-18 | 福格森（武汉）生物科技有限公司 | Special meal nutritional food applicable to males preparing to have baby |
| CN102318821B (en) * | 2011-08-23 | 2013-02-06 | 福格森（武汉）生物科技有限公司 | Special meal nutritional food applicable to males preparing childbearing |
| CN103238827A (en) * | 2012-02-10 | 2013-08-14 | 王慎君 | Composite nutrient preparation formula |
| CN103211222A (en) * | 2013-05-03 | 2013-07-24 | 江南大学 | Composition with effect of relieving physical fatigue |
| CN103564587A (en) * | 2013-11-05 | 2014-02-12 | 云南韵雅生物科技有限公司 | Natural fulvic acid compound health-care beverage as well as preparation method thereof |
| CN103638328A (en) * | 2013-12-11 | 2014-03-19 | 郭景龙 | Pharmaceutical composition containing dendrobium polysaccharides |
| CN104304491A (en) * | 2014-09-30 | 2015-01-28 | 江苏奇力康皮肤药业有限公司 | Traditional Chinese medicinal milk tablet and preparation method thereof |
| CN104305229A (en) * | 2014-11-05 | 2015-01-28 | 广西壮族自治区农业科学院农产品加工研究所 | Dendrobe dietary fiber food and processing method thereof |
| CN115517309A (en) * | 2022-02-10 | 2022-12-27 | 孙栋梁 | Three-ingredient health tea and preparation method thereof |
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