CN102133241B - Medicine composite with effect of improving immunity - Google Patents
Medicine composite with effect of improving immunity Download PDFInfo
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- CN102133241B CN102133241B CN201110060757A CN201110060757A CN102133241B CN 102133241 B CN102133241 B CN 102133241B CN 201110060757 A CN201110060757 A CN 201110060757A CN 201110060757 A CN201110060757 A CN 201110060757A CN 102133241 B CN102133241 B CN 102133241B
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Abstract
The invention discloses a medicine composite with an effect of improving immunity, belonging to the field of medicine or health-care food. The medicine is characterized in that the medicine composite comprises following materials according to portion by weight: 0.1-1 portion of ferment powder caterpillar fungus, 0.005-3 portions of vitamin and 0.05-3 portions of mineral substance, or the medicine composite comprises the following materials according to portion by weight: 0.1-1 portion of cordyceps polysaccharide, 0.005-3 portions of vitamin and 0.05-3 portions of mineral substance. Shown by pharmacology test, the medicine composite has good effect of improving immunity.
Description
Technical field
The present invention relates to medicine or field of health care food, be specifically related to a kind of pharmaceutical composition that improves immunity that has
Background technology
So-called immunity briefly is exactly the ability that human body avoids various pathogenic microorganism infringements.Should be in the very long evolutionary process of the mankind, human always at various pathogenic microorganism with occurring in nature, comprise that virus, antibacterial, fungus etc. struggle.No matter scientific and technological progress is to what degree, no matter human advanced person's the medicine of how inventing, immunity of human body itself still will continue bringing into play important effect.How should we improve immunity since immunity of human body itself is so important? One of them is plain through normal channel extra-nutrition, and balanced diet is not partiality for a limited variety of food, helps to improve body immunity so most.And modern's rhythm of life is fast, and diet is single or too meticulous, will inevitably cause the shortage of nutrient substance in the diet, the particularly necessary vitamin and the shortage of mineral.Believe that many people know, the C that is deficient in vitamin can cause vitamin C deficiency, and the A that is deficient in vitamin can cause nyctalopia, and the E that is deficient in vitamin can cause miscarriage, and being deficient in vitamin also directly to cause the decline of resistance of human body.Lack the decline that mineral causes the thin and weak and immunity of human body too.In nearest nutritional survey for the third time, find that China people's diet does not reach the standard of balanced diet as yet.Particularly the amount of essential minerals and vitamin does not reach human body requirements.This shows; In the middle of diet, be difficult to reach balanced diet truly merely; So an amount of minerals and vitamins that replenishes is undoubtedly of great advantage to keeping body immunity outside the food; Suitably the Resource of more oral this type is to improving body immunity, diseases prevention, the disease-resistant benefit that truly has.
Summary of the invention
For these reasons; The applicant is the basis through clinical research for many years; With the modern medical theory is guidance, and fermented Cordyceps powder or Cordyceps polysaccharide and vitamin and mineral are carried out compatibility, obtains the new immunity of the raising pharmaceutical composition that has; Pharmacological testing shows, the effect that the new pharmaceutical composition of the present invention has better raising immunity.
The present invention realizes through following technical proposals.
A kind of pharmaceutical composition with raising immunity; Pharmaceutical composition comprises fermented Cordyceps powder, vitamin and mineral; Perhaps Cordyceps polysaccharide, vitamin and mineral; Wherein fermented Cordyceps powder or Cordyceps polysaccharide 0.1-1 weight portion, vitamin 0.005-3 weight portion, mineral 0.05-3 weight portion.
Wherein vitamin is in vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E, folic acid, vitamin B12, vitamin D, vitamin K, biotin, Citrin, vitamin PP, vitamin(e) M, vitamin(e) T, vitamin U, biotin, water soluble vitamins, nicotiamide, the pantothenic acid one or more in the pharmaceutical composition.
Wherein the pharmaceutical composition mineral is one or more in calcium, ferrum, zinc, selenium, phosphorus, potassium, chlorine, magnesium, copper, manganese, iodine, chromium, molybdenum, nickel, stannum, silicon, vanadium, cobalt, sulfur, sodium, fluorine, the strontium.
Wherein pharmaceutical composition also comprises lycopene 0.01-0.5 weight portion, oligofructose 0.01-0.5 weight portion.
Wherein pharmaceutical composition also comprises in the Cortex Eucommiae, Fructus Lycii, Radix Ophiopogonis, Bulbus Fritillariae Cirrhosae, Folium Eriobotryae, Radix Panacis Quinquefolii, Herba Saussureae Involueratae, Ganoderma and the pollen one or more being arranged.
The wherein pharmaceutical preparation of preparation of pharmaceutical compositions or food.
Wherein the pharmaceutical preparation of preparation of pharmaceutical compositions or food are tablet, granule, pill, oral liquid or capsule.
The beverage of preparation of pharmaceutical compositions wherein.
Wherein preparation of pharmaceutical compositions becomes milk powder or milk powder.
Milk powder according to the invention is can supply on the market to sell and edible milk powder.The standard that meets State Administration for Quality Supervision and Inspection and Quarantine's promulgation: CCGF 114.2-2008.
Fermented Cordyceps powder according to the invention include but not limited to peacilomyce hepiahi, Hirsutella hepiali Chen et Shen or from natural cordyceps separate and other arbitrary strain fermentation and mycelium powder, can use its extract.
Cordyceps polysaccharide according to the invention includes but not limited to from the natural cs sporophore, extract, or from the artificial culture Cordyceps sporophore, extracts, or from the Cordyceps mycelium of fermentation culture or fermentation liquid, extracts.
Pharmacological testing
1, improves immunity function property experiment 1
Trial drug:
Test 1 group: pharmaceutical composition: vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E and folic acid is 0.7g (each 0.1g) altogether, and calcium, ferrum, zinc and selenium is 2g (each 0.5g) altogether.
Test 2 groups: pharmaceutical composition of the present invention: fermented Cordyceps powder 0.5g, vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E and folic acid is 0.7g (each 0.1g) altogether, and calcium, ferrum, zinc and selenium is 2g (each 0.5g) altogether.
Test 3 groups: pharmaceutical composition of the present invention: fermented Cordyceps powder 1g; Vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E and folic acid is 0.009g (vitamin B1 0.001g, vitamin B2 0.003g altogether; All the other each 0.001g); Calcium, ferrum, zinc and selenium is 0.1g (calcium, ferrum, each 0.03g of zinc, selenium 0.01g) altogether.
Test 4 groups: pharmaceutical composition of the present invention: fermented Cordyceps powder 0.1g; Vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E and folic acid is 3g (vitamin C 1.5g, vitamin E 0.5g, all the other each 0.2g altogether;), calcium, ferrum, zinc and selenium is 2.8g (each 0.7g) altogether.
Test 5 groups: pharmaceutical composition of the present invention: fermented Cordyceps powder 0.4g; Vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E be 0.005g (each 0.001g) altogether; Calcium, ferrum, zinc and selenium is 0.06g (calcium, ferrum, each 0.01g of zinc altogether; Selenium 0.03g), lycopene 0.015g, oligofructose 0.02g.
Test 6 groups: pharmaceutical composition of the present invention: fermented Cordyceps powder 0.8g; Vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E and folic acid is 0.009g (vitamin B1 0.001g, vitamin B2 0.003g altogether; All the other each 0.001g), calcium, ferrum, zinc and selenium are total to 0.1g (calcium, ferrum, each 0.03g of zinc, selenium 0.01g); Lycopene 0.5g, oligofructose 0.5g
Experimental animal: the female white mice of Kunming kind, body weight 18-22g.
Test method: get the mice random packet: blank group, trial drug group, mice gastric infusion every day 1 time, each dosage is 0.15g/kg, the blank group waits the distilled water of capacity.Respectively animal being carried out each item immune indexes behind the 30d continuously measures.
Mice delayed allergy (DTH) is measured: in irritating stomach the 26th day, inject 2% sheep red blood cell (SRBC) (SRBC) 0.2ml/ to mouse peritoneal and only carry out sensitization, after immunity the 4th day the left back toe ring of the every Mus subcutaneous injection 20%SRBC of portion (20 μ l/ only) attack.And before attacking, measure the same position of the left back sufficient intestinal of every Mus thickness with attack back 24h, and calculate and attack forward and backward difference, carry out variance analysis.Result of the test is seen table 1.
Table 1 pair mouse DTH is measured result (24h)
Annotate: compare with matched group
*P＜0.01,
*P＜0.05; Compare △ P＜0.05 for 1 group with test; Compare #P＜0.05 for 2 groups with test.
2, improve immunity function property experiment 2
Trial drug:
Test 1 group: pharmaceutical composition: Cordyceps polysaccharide.
Test 2 groups: pharmaceutical composition of the present invention: Cordyceps polysaccharide 0.1g, vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E and folic acid is 0.7g (each 0.1g) altogether, and calcium, ferrum, zinc and selenium is 2g (each 0.5g) altogether.
Test 3 groups: pharmaceutical composition of the present invention: Cordyceps polysaccharide 1g; Vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E and folic acid is 0.009g (vitamin B1 0.001g, vitamin B2 0.003g altogether; All the other each 0.001g); Calcium, ferrum, zinc and selenium is 0.1g (calcium, ferrum, each 0.03g of zinc, selenium 0.01g) altogether.
Test 4 groups: pharmaceutical composition of the present invention: Cordyceps polysaccharide 0.5g; Vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E and folic acid is 3g (vitamin C 1.5g, vitamin E 0.5g, all the other each 0.2g altogether;), calcium, ferrum, zinc and selenium is 2.8g (each 0.7g) altogether.
Test 5 groups: pharmaceutical composition of the present invention: Cordyceps polysaccharide 0.2g; Vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E be 0.005g (each 0.001g) altogether; Calcium, ferrum, zinc and selenium is 0.06g (calcium, ferrum, each 0.01g of zinc altogether; Selenium 0.03g), lycopene 0.1g, oligofructose 0.02g.
Test 6 groups: pharmaceutical composition of the present invention: Cordyceps polysaccharide 0.5g; Vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E and folic acid is 0.009g (vitamin B1 0.001g, vitamin B2 0.003g altogether; All the other each 0.001g), calcium, ferrum, zinc and selenium are total to 0.1g (calcium, ferrum, each 0.03g of zinc, selenium 0.01g); Lycopene 0.03g, oligofructose 0.4g.
Test method: get the mice random packet: blank group, trial drug group, mice gastric infusion every day 1 time, each dosage is 0.15g/kg, the blank group waits the distilled water of capacity.Respectively animal being carried out each item immune indexes behind the 30d continuously measures.
ConA inducing mouse splenocyte transformation experiment (mtt assay): to the aseptic spleen of getting of each group mice, the system splenocyte suspension uses RPMI 1640 complete culture solutions adjustment splenocyte concentration to be 3x10
9Individual/L, carry out lymphproliferation response according to MTr method in the program, survey its absorbance (A) in 752-C ultraviolet-uisible spectrophotometer 570nm wavelength at last, calculate ConA
+With ConA
-The absorbance value difference in each hole.Carry out variance analysis.Result of the test is seen table 2.
Table 2 couple mouse spleen lymphocyte conversion test result measures result (24h)
Annotate: compare with matched group
*P＜0.05; Compare △ P＜0.05 for 1 group with test; Compare #P＜0.05 for 3 groups with test.
3, improve immunity function property experiment 3
Trial drug:
Test 1 group: fermented Cordyceps powder.
Test 2 groups: pharmaceutical composition of the present invention: fermented Cordyceps powder 0.3g, vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E and folic acid is 0.007g (each 0.001g) altogether, and calcium, ferrum, zinc and selenium is 0.05g (each 0.0125g) altogether.
Test 3 groups: pharmaceutical composition of the present invention: fermented Cordyceps powder 0.9g; Vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E and folic acid is 0.009g (vitamin B1 0.001g, vitamin B2 0.003g altogether; All the other each 0.001g); Calcium, ferrum, zinc and selenium is 0.1g (calcium, ferrum, each 0.03g of zinc, selenium 0.01g) altogether.
Test 4 groups: pharmaceutical composition of the present invention: fermented Cordyceps powder 0.6g; Vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E and folic acid is 0.01g (vitamin C 0.0025g altogether; Vitamin E 0.0025g; All the other each 0.001g), calcium, ferrum, zinc and selenium is 0.4g (each 0.1g) altogether.
Test 5 groups: pharmaceutical composition of the present invention: fermented Cordyceps powder 0.7g; Vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E and folic acid is 0.009g (vitamin B1 0.001g, vitamin B2 0.003g, all the other each 0.001g) altogether, and calcium, ferrum, zinc and selenium is 0.1g (calcium, ferrum, each 0.03g of zinc altogether; Selenium 0.01g); Lycopene 0.02g, oligofructose 0.45g, Fructus Lycii 4g.
Test 6 groups: pharmaceutical composition of the present invention: fermented Cordyceps powder 0.7g, vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E and folic acid is 0.009g (vitamin B1 0.001g, vitamin B2 0.003g, all the other each 0.001g) altogether; Calcium, ferrum, zinc and selenium is 0.1g (calcium, ferrum, each 0.03g of zinc altogether; Selenium 0.01g), lycopene 0.4g, oligofructose 0.05g; Fructus Lycii 4g, Radix Ophiopogonis 8g.
Experimental animal: the female white mice of Kunming kind, body weight 18-22g.
Test method: get the mice random packet: blank group, trial drug group, mice gastric infusion every day 1 time, each dosage is 0.2g/kg, the blank group waits the distilled water of capacity.Respectively animal being carried out each item immune indexes behind the 30d continuously measures.
Serum hemolysin is measured: in irritating stomach the 25th day to mouse peritoneal injection 2%SRBC (0.2ml/ only); After immunity, plucked the eyeball blood sampling on the 5th day; Separation of serum is also measured at the clear hemolysin of the enterprising promoting the circulation of blood of Microhemagglutination plate: hatch 3h for 37 ℃, statistics hemagglutination degree calculates the corresponding antibodies product.Carry out variance analysis.Result of the test is seen table 3.
Table 3 pair mice serum hemolysin is measured the result
Annotate: compare with matched group
*P＜0.01,
*P＜0.05; Compare △ P＜0.05 for 1 group with test; Compare #P＜0.05 for 4 groups with test.
4, improve immunity function property experiment 4
Trial drug:
Test 1 group: Cordyceps polysaccharide.
Test 2 groups: pharmaceutical composition of the present invention: Cordyceps polysaccharide 0.2g, vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E and folic acid is 0.007g (each 0.001g) altogether, and calcium, ferrum, zinc and selenium is 0.05g (each 0.0125g) altogether.
Test 3 groups: pharmaceutical composition of the present invention: Cordyceps polysaccharide 0.95g; Vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E and folic acid is 0.009g (vitamin B1 0.001g, vitamin B2 0.003g altogether; All the other each 0.001g); Calcium, ferrum, zinc and selenium is 0.1g (calcium, ferrum, each 0.03g of zinc, selenium 0.01g) altogether.
Test 4 groups: pharmaceutical composition of the present invention: Cordyceps polysaccharide 0.7g; Vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E and folic acid is 0.01g (vitamin C 0.0025g altogether; Vitamin E 0.0025g; All the other each 0.001g), calcium, ferrum, zinc and selenium is 0.4g (each 0.1g) altogether.
Test 5 groups: pharmaceutical composition of the present invention: Cordyceps polysaccharide 0.4g, vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E and folic acid is 0.009g (vitamin B1 0.001g, vitamin B2 0.003g, all the other each 0.001g) altogether; Calcium, ferrum, zinc and selenium is 0.1g (calcium, ferrum, each 0.03g of zinc altogether; Selenium 0.01g), lycopene 0.2g, oligofructose 0.2g; Radix Panacis Quinquefolii 2g, Herba Saussureae Involueratae 0.5g.
Test 6 groups: pharmaceutical composition of the present invention: Cordyceps polysaccharide 0.4g, vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E and folic acid is 0.009g (vitamin B1 0.001g, vitamin B2 0.003g, all the other each 0.001g) altogether; Calcium, ferrum, zinc and selenium is 0.1g (calcium, ferrum, each 0.03g of zinc, selenium 0.01g) altogether, lycopene 0.5g; Oligofructose 0.09g; Radix Panacis Quinquefolii 1g, Herba Saussureae Involueratae 1g, Ganoderma 1g.
Experimental animal: the female white mice of Kunming kind, body weight 18-22g.
Test method: get the mice random packet: blank group, trial drug group, mice gastric infusion every day 1 time, each dosage is 0.2g/kg, the blank group waits the distilled water of capacity.Respectively animal being carried out each item immune indexes behind the 30d continuously measures.
Antibody-producting cell (PFc) detects: in to mouse peritoneal injection 2%SRBC0.2ml/ only irritating stomach the 25th day, after immunity, put to death in the 5th day, dissect and get spleen and prepare splenocyte suspension, uses RPMI 1640 complete culture solutions to adjust splenocyte concentration and be 5x10
9Individual/L.The follow procedure method prepares the agarose slide, at CO
2Incubator (37 ℃, 5%CO
2) in add complement behind the incubation 1.5h, incubation 1.5h counts the hemolysis plaque number that forms on every thin agar layer slide again.Carry out variance analysis.Result of the test is seen table 4.
Table 4 pair mouse antibodies cellulation testing result
Annotate: compare with matched group
*P＜0.01,
*P＜0.05; Compare △ P＜0.05 for 1 group with test; Compare #P＜0.05 for 2 groups with test.
Conclusion (of pressure testing): above-mentioned test shows that pharmaceutical composition of the present invention has the effect of fine raising immunity.
Annotate: Chinese crude drug is pulverized in the aforementioned pharmaceutical compositions, and behind the water extraction, concentrate drying adds aforementioned pharmaceutical compositions.
Preparation embodiment
Embodiment 1
Pharmaceutical composition: fermented Cordyceps powder 1g, vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E and folic acid is 0.007g (each 0.001g) altogether, and calcium, ferrum, zinc and selenium is 0.05g (each 0.0125g) altogether.
Aforementioned pharmaceutical compositions is prepared into food or pharmaceutical preparation; Its dosage form is tablet, granule, pill, oral liquid or capsule.
Aforementioned pharmaceutical compositions is prepared into beverage.
Aforementioned pharmaceutical compositions is prepared into milk powder or milk powder.
Embodiment 2
Pharmaceutical composition: fermented Cordyceps powder 0.1g; Vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E and folic acid is 0.009g (vitamin B1 0.001g, vitamin B2 0.003g altogether; All the other each 0.001g); Calcium, ferrum, zinc and selenium is 0.1g (calcium, ferrum, each 0.03g of zinc, selenium 0.01g) altogether.
Aforementioned pharmaceutical compositions is prepared into food or pharmaceutical preparation; Its dosage form is tablet, granule, pill, oral liquid or capsule.
Aforementioned pharmaceutical compositions is prepared into beverage.
Aforementioned pharmaceutical compositions is prepared into milk powder or milk powder.
Embodiment 3
Pharmaceutical composition: fermented Cordyceps powder 0.45g; Vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E and folic acid is 0.01g (vitamin C 0.0025g, vitamin E 0.0025g, all the other each 0.001g altogether;), calcium, ferrum, zinc and selenium is 0.4g (each 0.1g) altogether.
Aforementioned pharmaceutical compositions is prepared into food or pharmaceutical preparation; Its dosage form is tablet, granule, pill, oral liquid or capsule.
Aforementioned pharmaceutical compositions is prepared into beverage.
Aforementioned pharmaceutical compositions is prepared into milk powder or milk powder.
Embodiment 4
Pharmaceutical composition: Cordyceps polysaccharide 1g; Vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E and folic acid is 0.009g (vitamin B1 0.001g, vitamin B2 0.003g, all the other each 0.001g) altogether, and calcium, ferrum, zinc and selenium is 0.1g (calcium, ferrum, each 0.03g of zinc altogether; Selenium 0.01g); Lycopene 0.01g, oligofructose 0.01g, Radix Astragali 5g.
Aforementioned pharmaceutical compositions is prepared into food or pharmaceutical preparation; Its dosage form is tablet, granule, pill, oral liquid or capsule.
Aforementioned pharmaceutical compositions is prepared into beverage.
Aforementioned pharmaceutical compositions is prepared into milk powder or milk powder.
Embodiment 5
Pharmaceutical composition: Cordyceps polysaccharide 0.1g; Vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E and folic acid is 0.009g (vitamin B1 0.001g, vitamin B2 0.003g, all the other each 0.001g) altogether, and calcium, ferrum, zinc and selenium is 0.1g (calcium, ferrum, each 0.03g of zinc altogether; Selenium 0.01g); Lycopene 0.5g, oligofructose 0.03g, Fructus Lycii 5g, Radix Ophiopogonis 6g, Bulbus Fritillariae Cirrhosae 3g.
Aforementioned pharmaceutical compositions is prepared into food or pharmaceutical preparation; Its dosage form is tablet, granule, pill, oral liquid or capsule.
Aforementioned pharmaceutical compositions is prepared into beverage.
Aforementioned pharmaceutical compositions is prepared into milk powder or milk powder.
Embodiment 6
Pharmaceutical composition of the present invention: Cordyceps polysaccharide 0.9g;, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E 0.005g (each 0.001g) altogether, calcium, ferrum, zinc and selenium is 0.06g (calcium, ferrum, each 0.01g of zinc, selenium 0.03g) altogether; Lycopene 0.01g, oligofructose 0.01g.
Aforementioned pharmaceutical compositions is prepared into food or pharmaceutical preparation; Its dosage form is tablet, granule, pill, oral liquid or capsule.
Aforementioned pharmaceutical compositions is prepared into beverage.
Aforementioned pharmaceutical compositions is prepared into milk powder or milk powder.
Embodiment 7
Pharmaceutical composition of the present invention: Cordyceps polysaccharide 0.2g; Vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E and folic acid is 0.009g (vitamin B1 0.001g, vitamin B2 0.003g altogether; All the other each 0.001g), calcium, ferrum, zinc and selenium are total to 0.1g (calcium, ferrum, each 0.03g of zinc, selenium 0.01g); Lycopene 0.5g, oligofructose 0.5g.
Aforementioned pharmaceutical compositions is prepared into food or pharmaceutical preparation; Its dosage form is tablet, granule, pill, oral liquid or capsule.
Aforementioned pharmaceutical compositions is prepared into beverage.
Aforementioned pharmaceutical compositions is prepared into milk powder or milk powder.
Milk powder according to the invention is can supply on the market to sell and edible milk powder.The standard that meets State Administration for Quality Supervision and Inspection and Quarantine's promulgation: CCGF 114.2-2008.
Claims (6)
1. one kind has the pharmaceutical composition that improves immunity; It is characterized in that pharmaceutical composition consists of: fermented Cordyceps powder or Cordyceps polysaccharide 0.1-1 weight portion; Vitamin 0.005-3 weight portion; Mineral 0.05-3 weight portion, lycopene 0.01-0.5 weight portion, oligofructose 0.01-0.5 weight portion; Wherein vitamin is one or more in vitamin A, vitamin B1, vitamin B2, vitamin B6, vitamin C, vitamin E, folic acid, vitamin B12, vitamin D, vitamin K, biotin, Citrin, vitamin PP, vitamin(e) M, vitamin(e) T, vitamin U, biotin, water soluble vitamins, nicotiamide, the pantothenic acid; Its mineral is one or more in calcium, ferrum, zinc, selenium, phosphorus, potassium, chlorine, magnesium, copper, manganese, iodine, chromium, molybdenum, nickel, stannum, silicon, vanadium, cobalt, sulfur, sodium, fluorine, the strontium.
2. according to the said a kind of pharmaceutical preparation of claim 1 with the preparation of pharmaceutical compositions that improves immunity.
3. according to the said a kind of food of claim 1 with the preparation of pharmaceutical compositions that improves immunity
4. a kind of preparation of pharmaceutical compositions with raising immunity according to claim 1 becomes tablet, granule, pill, oral liquid or capsule.
5. a kind of one-tenth beverage according to claim 1 with the preparation of pharmaceutical compositions that improves immunity.
6. a kind of preparation of pharmaceutical compositions with raising immunity according to claim 1 becomes milk powder or milk powder.
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| CN201110060757A CN102133241B (en) | 2011-03-15 | 2011-03-15 | Medicine composite with effect of improving immunity |
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| CN201110060757A CN102133241B (en) | 2011-03-15 | 2011-03-15 | Medicine composite with effect of improving immunity |
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| CN102133241B true CN102133241B (en) | 2012-10-10 |
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Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102309006A (en) * | 2011-09-01 | 2012-01-11 | 郭景龙 | Food with health care effect |
| CN102342522B (en) * | 2011-09-01 | 2013-10-23 | 郭景龙 | Health food |
| CN103918966B (en) * | 2013-01-15 | 2015-09-02 | 北京同仁堂健康药业股份有限公司 | A kind of composition containing haematococcus pluvialis |
| CN103211222A (en) * | 2013-05-03 | 2013-07-24 | 江南大学 | Composition with effect of relieving physical fatigue |
| CN105878365A (en) * | 2014-12-24 | 2016-08-24 | 王星和 | Anticancer drug and preparation method thereof |
| CN109645476A (en) * | 2019-02-14 | 2019-04-19 | 王书敏 | A kind of cordyceps sinensis calcium Tableted compositions and preparation method thereof |
| CN112890199B (en) * | 2021-02-27 | 2022-05-31 | 中国农业科学院油料作物研究所 | Composition for stably and efficiently regulating immunologic function and preparation and application thereof |
| CN113577240B (en) * | 2021-09-02 | 2024-01-30 | 翔宇药业股份有限公司 | Pharmaceutical composition, preparation method and application thereof |
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| CN1840634A (en) * | 2006-01-20 | 2006-10-04 | 陈颖敏 | Chinese caterpillar fungus wine and its preparing process |
| CN101273775A (en) * | 2007-03-28 | 2008-10-01 | 天津天狮生物发展有限公司 | Cordyceps mycelium capsules and producing process thereof |
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2011
- 2011-03-15 CN CN201110060757A patent/CN102133241B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1840634A (en) * | 2006-01-20 | 2006-10-04 | 陈颖敏 | Chinese caterpillar fungus wine and its preparing process |
| CN101273775A (en) * | 2007-03-28 | 2008-10-01 | 天津天狮生物发展有限公司 | Cordyceps mycelium capsules and producing process thereof |
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