CN102128800B - Method and device for online detection in traditional Chinese medicine extracting process - Google Patents
Method and device for online detection in traditional Chinese medicine extracting process Download PDFInfo
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Abstract
The invention relates to a method and device for online detection in a traditional Chinese medicine extracting process, in particularly to a device and method for online detection in the process of extracting with water and alcohol of different concentrations in the Chinese patent medicine extraction production and the plant extraction production. The device comprises an extract inlet, an extract outlet, a tangential microporous filter, an adjustable diverter, a detector, a centrifugal machine and the like. The method comprises the following steps: connecting an extraction tank with the device to form an extraction tank external circulation passage; when the extract passes through the microporous, filtering to acquire a filtrate; after the filtrate passes through the adjustable diverter filter, feeding the filtrate into the detector to perform absorption spectrum measurement; and returning the measured filtrate to the circulation passage, so that the filtrate can be moved into the extraction tank again. By using the device and method provided by the invention, the online detection of the traditional Chinese medicine extraction process can be implemented, and the whole detection process can be finished in a sealed pipeline and be detected on line in real time, thereby supplying a basis to the automatic control of traditional Chinese medicine extraction.
Description
Technical field
The present invention relates to online test method and device in a kind of traditional Chinese medicine extraction process, be specifically related to liquid flux and extract a kind of online test method and device in the Chinese medicine process.
Background technology
Traditional Chinese medicine extraction is the process of " depositing its elite, discarding dross ", also is the key point of herbal pharmaceutical.The Chinese medicine conventional method of extraction has decocting method, infusion process, percolation etc.; Along with development of technology; Some new technologies, new method aspect extraction process, have been introduced in recent years; Like supercritical fluid extraction, ultrasonic extraction, Enzymatic Extraction, Microwave Extraction method, charged extraction method, semi-bionic extraction etc., the application of these technology and equipment thereof has improved herbal pharmaceutical engineering and equipment widely, has promoted the development of Chinese medicine industry.But the extraction process process of Chinese medicine still has some shortcomings.
The technological parameter of Chinese medicine laboratory study gained and the technological parameter of industrial-scale production are difficult to reach basically identical.Present laboratory process research is major equipment with glass flask, Rotary Evaporators etc., and the technological parameter that provides therefrom is too simple; And the leaching process of the used extractor of commercial production, type of heating are different with the laboratory process process, thereby breadboard technical study can not provide necessary support for production.
Online test method is deficient in the industrial processes, the production run poor controllability.Because the complicacy of Chinese medicine; Under the situation that traditional Chinese medicine ingredients is difficult to confirm at present,, can only rely on effective control to its extrinsic parameter for the successful extraction of pharmaceutically active ingredient in guaranteeing; To guarantee the extraction of effective constituent, guaranteed the uniqueness and the stability of traditional Chinese medicine extraction in the certain limit.The extrinsic parameter of at present the Chinese medicine leaching process being controlled has temperature, pressure, relative density, flow etc.The content that effectively becomes in the extract is measured after then need extracting and accomplishing, and can not in time reflect extraction effect; It is not strong to extract in the production run automatic control simultaneously, and production run is discontinuous, and the direct labor exists difference to the control of on-site parameters, causes the production run poor controllability.
Domestic application for a patent for invention number provides a kind of Chinese medicine production technology product quality indicator online test method for the patent of invention of 02137234.B; This method adopts near infrared spectrometer and industrial control computer to carry out online detection; Utilization PLS and neural net method carry out the quality index of online in real time analyses and prediction Chinese medicine production run, and data analysis is provided.The quality control index value that the extract that at first obtains the intermediate steps of technological process is demarcated appearance and the demarcation appearance near infrared spectrum that records and demarcated appearance; Then set up the quality control index value of demarcation appearance and the forecast model that is associated of near infrared spectrum; Measure the near infrared spectrum that intermediate steps receives sample, utilize forecast model to carry out the online detection of quality thereafter.This patent is applicable to different Chinese medicine workshops.
The present invention then is the liquid vehicle leaching process to Chinese medicine, adopts suitable absorption spectrum to carry out online detection, calculates simply, and real-time is good, and is with strong points.
Summary of the invention
The objective of the invention is to overcome existing Chinese medicine and produce the shortcoming in the leaching process, a kind of method of problem of effective its index parameter of solution leaching process herb liquid The real time measure is provided.Emphasis solves extract by drawing the cyclic process that behind detecting device, imports extractor and the filtration of extract, the key issues such as mensuration of absorption spectrum in the extractor.
Of the present invention through following technical scheme realization:
Online test method in a kind of traditional Chinese medicine extraction process is that the quality control index of Chinese medicine extract is implemented online detection, it is characterized in that said method comprises the steps:
(i), at first obtain the supplemental characteristic such as absorption spectrum and temperature, viscosity, pH value, relative density of the extract of laboratory optimised process process steps;
To produce extractor (ii), then and be connected with on-line measuring device, and form the jar outer circulation path of extract, said on-line measuring device includes the extract import; Be communicated with hydro-extractor behind the extract import process A valve; Hydro-extractor is communicated with filtration unit after through the rising conveyance conduit, is provided with micro porous filtration core in tangential in the filtration unit, and the outlet of micro porous filtration core tangential is communicated with the scalable part flow arrangement after through the filtrating conveyance conduit; Scalable part flow arrangement communication with detection device; The micro porous filtration core is filtrated to detector flow through the conducting of scalable part flow arrangement on a small quantity, and detecting device is provided with flow cell, and detecting device connects computer data processing system; Detecting device forms a closed circuit at the back through the A valve that detects the import of liquid delivery pipe connection extract, is communicated with extracting liquid outlet behind the outlet process B valve of filtration unit;
Liquid outlet with extractor when (iii), extracting is connected with the extract import; The liquid inlet of extractor is connected with extracting liquid outlet; Open hydro-extractor and make extract get into the extractor outer circulation, through the micro porous filtration core extract is carried out the tangential and filter, filtrating is regulated through the scalable part flow arrangement; A small amount of filtrating is flowed to the detecting device direction; Filtrate flow goes into to carry out in the flow cell absorption spectrum measurement, measures temperature, viscosity, pH value, the relative density of extract, and the filtrating after detecting is conveyed in jar outer circulation by detecting the liquid delivery pipe once more;
(iv), be canonical reference with breadboard absorption spectrum and parameter, compare with absorption spectrum, the parameter of extract, carry out the online detection of extract quality.
Further; The method for distilling of said extract; It is characterized in that being selected from following arbitrary method: cold-maceration, temperature are soaked method, circumfluence method, ultrasonic extraction, Microwave Extraction method etc.; Extraction solvent can be selected for use: liquid fluxs such as water, ethanol, acetone, extract the optional usefulness of flow container: multi-function extractor, dynamic extraction pot, two dynamic extraction pots etc.
Further, described absorption spectrum and parameter, the characteristic of absorption spectrum is: be the basis with the Spectrum Absorption Principle, through the absorption spectrum that various spectral measurement instruments record, comprise ultra-violet absorption spectrum, visible absorption spectrum, fluorescent absorption spectrum etc.; Parameter comprises: extrinsic parameters such as the viscosity of extract, pH value, temperature, relative density.
On-line measuring device in a kind of traditional Chinese medicine extraction process includes the extract import, is communicated with hydro-extractor behind the extract import process A valve; Hydro-extractor is communicated with filtration unit after through the rising conveyance conduit; Be provided with micro porous filtration core in tangential in the filtration unit, be provided with micro porous filtration core in tangential in the filtration unit, the micro porous filtration core carries out the tangential to extract and filters; The outlet of micro porous filtration core tangential, tangential is passed through to be communicated with the scalable part flow arrangement behind the filtrating conveyance conduit; The scalable part flow arrangement flows to the detecting device direction through passing through a small amount of filtrating of D valve regulated after the shunt conduit, and detecting device forms a closed circuit at the back through the A valve that detects the import of liquid delivery pipe connection extract, and detecting device is provided with extract reference cell and flow cell; Detecting device connects computer data processing system, is communicated with extracting liquid outlet behind the outlet process B valve of filtration unit.
Further; Said tangential micro porous filtration core is equipped with the removable filter core; The extract flow direction is vertical with filtering direction, and the filter opening size of filter core is 0.1mm～0.01mm, and the material of filter core can be that membrane filtration acceptable material is stated in the Chinese medicine production technical field such as pottery, titanium alloy.
Further, said scalable part flow arrangement is by having acidproof alkali salt and ethanol etc., heatproof, advantages of high strength, and the acceptable material is processed in the Chinese medicine production technical field, can regulate bypass flow, the control split ratio, and adjustable split ratio can reach 1: 1000.
Further, said detecting device is made up of the absorption spectrum detector; Or measure extrinsic parameter such as meter by absorption spectrum detector and viscosity meter, pH meter, relative density and measure count one or more and forming through serial or parallel connection; Be used for measuring the various correlation parameters of extract.
Further, said absorption spectrum detector is characterized in that: with the spectral absorption principle, and the analysis and detecting instrument of reflection spectral absorption characteristics.Detecting device is made up of flow cell, extract reference cell, light path etc., and connects computing machine, can pass through the data acquisition of computer program control detection device, and the information of gathering is handled; Comprise: the ultra-violet absorption spectrum appearance, see optical absorption spectra appearance, fluorescent absorption spectrometer, outer absorption spectrometer, near-infrared absorption spectrum appearance, Atomic Absorption Spectrometer etc.
Further, said filtration unit is provided with inductor, and inductor connects the parameter display, is provided with between A valve and the hydro-extractor to detect liquid delivery pipe, filtrating conveyance conduit.
Further, said detecting device is provided with the extract reference cell, and detecting device connects computer data processing system, scalable part flow arrangement and the conducting of filtrating conveyance conduit, and the filtrating conveyance conduit is communicated with the flushing pipe inlet through the C valve.
Technical scheme by the invention described above provides can be found out; Online test method and device in a kind of traditional Chinese medicine extraction process of the present invention; Be to utilize hydro-extractor that the extract in the extractor is entered the mouth through behind the tangential flow filtration device by on-line measuring device; Be conveyed into the extractor from the on-line measuring device outlet, form the jar outer circulation of extract; Simultaneously, the tangential filtrating absorption spectrum detecting device of after the shunting of scalable part flow arrangement, flowing through carries out the dynamic real-time absorption spectrum and detects, and the solution after it detects flows into again and gets into extractor in jar outer circulation.But utilize the parameters such as temperature, viscosity, pH value and absorption spectrum of the inventive method and device Detection and Extraction liquid; Extract is carried out online detection; Through the reference data that the standard extract is done reference or provided with laboratory process research, the leaching process of extractor capable of on-line.
Online testing process of the present invention is carried out in closed conduct, and process is continuous, carries out online detection in real time, is applicable to the liquid flux to be the traditional Chinese medicine extraction of extract solvent, and the robotization control for the traditional Chinese medicine extraction process simultaneously provides the basis.
Description of drawings
Shown in Figure 1 is the structural representation of embodiment of the invention on-line measuring device.
Dependency structure mainly comprises following parts (or device) among the figure: extract import 1; A valve 2; Hydro-extractor 3; Rising conveyance conduit 4; Filtration unit 5; Parameter display 6; Inductor 7; Micro porous filtration core 8; B valve 9; Extracting liquid outlet 10; Filtrating conveyance conduit 11; Scalable part flow arrangement 12; Shunt conduit 13; D valve 14; Extract reference cell 15; Detecting device 16; Detect liquid delivery pipe 17; Computer data processing system 18; Flushing pipe inlet 19; C valve 20; Flow cell 21.
Embodiment
For further understanding characteristic of the present invention, technological means and the specific purposes that reached, function, resolve advantage of the present invention and spirit, by detailed description of the present invention further being understood below in conjunction with accompanying drawing and embodiment.
The present invention relates in Chinese medicine production leaching process, the quality control index of extract implemented online detection.This method comprises at first obtains the absorption spectrum of optimum extraction process extract in the laboratory process research process.Then produce in the leaching process,, form the circulation path of extract together through liquid outlet, inlet and the on-line measuring device provided by the invention of traditional Chinese medicine extraction jar at Chinese medicine; Or by as two outlets of extract in the described dynamic extraction pot of utility application (patent No.: 200720058787.2), with the be formed by connecting circulation path of extract of on-line measuring device provided by the invention.Extract is in cyclic process; Filter and the filtered fluid that obtains through the tangential direction of flow direction; Make an amount of filtrate flow through detecting device 16 by scalable part flow arrangement 12 again; Directly measuring the absorption spectrum of filtrating, serves as with reference to carrying out the online detection of quality with the absorption spectrum of laboratory optimised process extract.
Traditional Chinese medicine extraction production run of the present invention relates to liquid flux carries out traditional Chinese medicine extraction production.
The absorption spectrum of testing laboratory of the present invention optimum extraction process extract is meant by the requirement of study of tcm new drug guide; The rate of transform with middle pharmaceutically active ingredient is an index; Handle through experimental study and statistical method, and investigate the optimal parameter of confirming extracting technique of Chinese medicine; And extract according to the optimal parameter of extraction process, the analysis and detecting instrument equipment that utilization can be measured absorption spectrum is measured many batches of extracts and the standard absorption spectrum that obtains.
It is principle that absorption spectroanalysis detecting instrument equipment of the present invention relates to the spectral absorption, the analysis and detecting instrument of reflection spectral absorption characteristics.
It is the traditional Chinese medicine extraction flow container of extraction solvent that on-line measuring device of the present invention can connect liquid fluxs such as multi-function extractor, two dynamic extraction pots.
On-line measuring device of the present invention mainly comprises:
Extract import 1, extracting liquid outlet 10: respectively with extractor in extracting liquid outlet, inlet be connected, make extractor and this on-line measuring device form the circulation path of extract outside extractor.
The filtration unit 5 of extract: dismountable micro porous filtration core 8 is housed, carries out micro porous filtration, make filtered fluid not have insoluble particle and keep clarification, can not stop up path through detecting device, damage detecting device in the flow tangential direction of transmission direction of extract; Be connected with temperature, viscosity inductor 7, can measure temperature, the viscosity of the extract of stream process.Micro porous filtration core 8 filter core materials can be membrane filtration acceptable materials in the Chinese medicine production technical field such as pottery, titanium alloy.
Scalable part flow arrangement 12: the filtrating that will pass through micro porous filtration core 8 is shunted, and regulates the flow of filtrate flow through detecting device.
Detecting device 16: form by flow cell 21, extract reference cell 15, light path etc., and connect computing machine, can carry out data processing to the information of gathering.The absorption spectrum detecting device can be the detecting device that comprises reflection spectral absorption characteristics such as ultraviolet-visible absorption, fluorescent absorption, atomic absorption.Be equipped with extrinsic parameters such as viscosity that other pick-up unit also can detect filtrating, pH value.
Hydro-extractor 3: the power that is provided at extract circulation in the line detector.
Structure devices is shown in accompanying drawing 1; System is the structural representation of the present invention's on-line measuring device; The present invention includes extract import 1, and extract import 1 back is provided with an A valve 2, and extract import 1 is communicated with hydro-extractor 3 through A valve 2 backs; Be provided with shunt conduit between A valve 2 and the hydro-extractor 3 successively and detect liquid delivery pipe 17, filtrating conveyance conduit 11; Filtrating conveyance conduit 11 is provided with scalable part flow arrangement 12, and scalable part flow arrangement 12 is conducted with filtrating conveyance conduit 11, and filtrating conveyance conduit 11 is communicated with flushing pipe inlet 19 through C valve 20; Flushing pipe inlet 19 is communicated with filtrating conveyance conduit 11 through C valve 20; Be communicated to filtration unit 5 through the scalable part flow arrangement 12 on the filtrating conveyance conduit 11 again, hydro-extractor 3 is provided with tangential micro porous filtration core 8 through the import of rising conveyance conduit 4 back connection filtration units 5 in the filtration unit 5.
Micro porous filtration core 8 carries out the tangential to extract and filters; The outlet of tangential micro porous filtration core 8 tangentials is communicated with scalable part flow arrangement 12 through filtrating conveyance conduit 11 backs; Scalable part flow arrangement 12 passes through D valve 14 through shunt conduit 13 backs; Regulating filtrates on a small quantity flows to detecting device 16 directions, and detecting device 16 forms a closed circuit at the back through the A valve 2 that detects the 17 connection extract imports 1 of liquid delivery pipe.
Detecting device 16 is provided with extract reference cell 15 and flow cell 21; Detecting device 16 connects computer data processing system 18; The outlet of filtration unit 5 is communicated with extracting liquid outlet 10 through B valve 9 backs, and filtration unit 5 is provided with inductor 7, and inductor 7 connects parameter display 6.
Embodiment one
During compound danshen dripping pills extracts; An amount of medicinal material is got according to the ratio of the red sage root, pseudo-ginseng in the compound in the laboratory; Extracted 1.5 hours according to the boiling of 8 times of amounts of preparation technology's method; Extracting liquid filtering is settled to certain volume, measures content of Danshensu in the extract by the quality standard method, and measures absorbance, viscosity and the pH value etc. of extract at 203nm, 281nm place.
Produce in the leaching process, feed intake, add 8 times of water gagings, heating and extracting in multi-function extractor in the prescription ratio.Liquid outlet with extractor during extraction is connected with on-line measuring device extract of the present invention import 1; The liquid inlet of extractor is connected with the extracting liquid outlet of this device 10; Open A valve 2, B valve 9, close C valve 20, open hydro-extractor 3 and make extract get into the extractor outer circulation.Open inductor 7, measure temperature, viscosity, the pH value of extract; Tangential micro porous filtration core 8 adopts the titanium alloy material; The extract tangential filters; Filtrating is regulated a small amount of filtrating through scalable part flow arrangement 12 and is flowed to detecting device 16 directions, opens D valve 14, and filtrate flow is gone in the flow cell 21; Measure its ultraviolet absorption value at 203nm, 281nm place, the filtrating after detecting is conveyed in jar outer circulation by detecting liquid delivery pipe 17 once more.The extract of getting an amount of laboratory gained places the extract reference cell 15 of detecting device 16, measures its ultraviolet absorption value at 203nm, 281nm place, and the absorption value of contrast extract is implemented online measuring ability.In the leaching process; The ultraviolet absorption value of measuring in the detecting device at 203nm, 281nm place will move closer to the absorption value of experimental determination; When extraction time near 1.5 hours, the absorption value of online detection reaches breadboard absorption value and keeps relative stability, and can judge that extract reaches breadboard extraction effect; Prompting is extracted fully, connect this moment parameters such as viscosity that the parameter display 6 of inductor 7 shows, pH value also with the parameter basically identical of laboratory extract.At this moment can stop multi-functional extraction; Be closed in line detector inlet A valve 2, open C valve 20, introduce an amount of clean water the on-line measuring device pipeline is cleaned; Cleaning fluid is also imported to extract in the flow container and is merged with extract, and extract carries out next step technological operation.
Embodiment two
In the red sage root alcohol extract process of Fufang Danshen Pian; The red rooted salvia of prescription ratio is got in the laboratory; Add 8 times of amount 95% alcohol reflux 1.5 hours, extracting liquid filtering is settled to certain volume; Measure the content of tanshinone IIA in the extract by the quality standard method, and measure the parameters such as viscosity, pH value of extract.
Produce in the leaching process, feed intake, add 8 times of amount 95% ethanol, in two dynamic high-efficiency extractors, heat Dynamic Extraction in the prescription ratio.Two liquid outlets up and down with two dynamic high-efficiency extractors during extraction are connected with on-line measuring device extract extract of the present invention import 1, extracting liquid outlet 10 respectively through suitable pipeline; Open A valve 2, B valve 9; Close C valve 20, open hydro-extractor 3 and make extract get into the extractor outer circulation.Open inductor 7, measure temperature, viscosity, the pH value of extract; Hydro-extractor 3 is communicated with filtrating conveyance conduit 11 through micro porous filtration core 8; Micro porous filtration core 8 adopts the ceramic material filter membrane, and the extract tangential filters, and filtrating is regulated a small amount of filtrating through scalable part flow arrangement 12 and flowed to detecting device 16 directions; Open D valve 14; Filtrate flow is gone into flow cell 21, measures its ultraviolet absorption value at the 270nm place, and the filtrating after detecting is conveyed in jar outer circulation by detecting liquid delivery pipe 17 once more.The extract of getting an amount of laboratory gained places the extract reference cell 15 of detecting device, measures its ultraviolet absorption value at the 270nm place, and the absorption value of contrast extract is implemented online measuring ability.
In two Dynamic Extraction processes, can make the last fluid of extractor be connected, descend fluid to be connected with the extract import 1 of online detection through control valve with the extracting liquid outlet 10 of online detection; The following fluid of extractor is connected with the extract import 1 of online detection, goes up fluid and be connected with the extracting liquid outlet 10 of online detection.
When extraction time near 1.5 hours; In the detecting device 16 in flow cell 21 and the extract reference cell 15 the extract absorption value near consistent and keep relative stability; Can judge that extract reaches breadboard extraction effect; Prompting is extracted fully, parameters such as the viscosity that this moment, parameter display 6 showed, pH value also with the parameter basically identical of laboratory extract.At this moment can stop two Dynamic Extraction; Be closed in line detector inlet A valve 2, open C valve 20, introduce an amount of cleaning 95% ethanol the on-line measuring device pipeline is cleaned; Cleaning fluid is incorporated extract in the extraction flow container into, and extract carries out next step technological operation.
Online test method of the present invention and device aim at and satisfy modern Chinese herbal medicine and extract online detection, control automatically and design, and it installs and also satisfies the GMP authentication requesting.It is the online detection of the extraction process of extraction solvent that the present invention also is applicable in the technical fields such as food, chemical industry with the liquid flux.
Claims (9)
1. the online test method in the traditional Chinese medicine extraction process is that the quality control index of Chinese medicine extract is implemented online detection, it is characterized in that said method comprises the steps:
(i), at first obtain absorption spectrum and temperature, viscosity, pH value, the relative density data of the extract of laboratory optimised process process steps;
(ii), will produce extractor then is connected with on-line measuring device; Form the jar outer circulation path of extract; Said on-line measuring device includes extract import (1); Extract import (1) is communicated with hydro-extractor (3) through A valve (2) back, and hydro-extractor (3) is communicated with filtration unit (5) through rising conveyance conduit (4) back, is provided with tangential micro porous filtration core (8) in the filtration unit (5); Micro porous filtration core (8) flows to detecting device (16) through a small amount of filtrating of scalable part flow arrangement (12) conducting; Detecting device (16) is provided with flow cell (21), and detecting device (16) forms a closed circuit through detecting liquid delivery pipe (17) connection extract import (1) pipeline, and the outlet of filtration unit (5) is communicated with extracting liquid outlet (10) through B valve (9) back;
Liquid outlet with extractor when (iii), extracting is connected with extract import (1); The liquid inlet of extractor is connected with extracting liquid outlet (10); Open hydro-extractor (3) and make extract get into the extractor outer circulation, through micro porous filtration core (8) extract is carried out the tangential and filter, filtrating is regulated through scalable part flow arrangement (12); A small amount of filtrating is flowed to detecting device (16) direction; Filtrate flow goes into to carry out in the flow cell (21) the absorption spectrum measurement, measures temperature, viscosity, pH value, the relative density of extract, and the filtrating after detecting is conveyed in jar outer circulation by detecting liquid delivery pipe (17) once more;
(iv), be canonical reference with breadboard absorption spectrum and parameter, compare with absorption spectrum, temperature, viscosity, pH value, the relative density of extract, carry out the online detection of extract quality.
2. the online test method in a kind of traditional Chinese medicine extraction process according to claim 1 is characterized in that: the method for distilling of said extract is that cold-maceration, temperature are soaked method, circumfluence method, ultrasonic extraction, Microwave Extraction method; Extraction solvent is selected water, ethanol, acetone for use; The extraction flow container is selected for use: multi-function extractor, dynamic extraction pot, two dynamic extraction pot.
3. the online test method in a kind of traditional Chinese medicine extraction process according to claim 1 is characterized in that: said absorption spectrum is ultra-violet absorption spectrum, visible absorption spectrum, fluorescent absorption spectrum.
4. the on-line measuring device in the traditional Chinese medicine extraction process; Include: extract import (1); It is characterized in that: said extract import (1) is communicated with hydro-extractor (3) through A valve (2) back; Hydro-extractor (3) is communicated with filtration unit (5) through rising conveyance conduit (4) back, is provided with tangential micro porous filtration core (8) in the filtration unit (5), is provided with tangential micro porous filtration core (8) in the filtration unit (5); Micro porous filtration core (8) carries out the tangential to extract and filters; Tangential micro porous filtration core (8) tangential exports through being communicated with scalable part flow arrangement (12) behind the filtrating conveyance conduit (11), flows to detecting device (16) direction through a small amount of filtrating of D valve (14) adjusting in scalable part flow arrangement (12) process shunt conduit (13) back, and detecting device (16) forms a closed circuit through A valve (2) back of detecting liquid delivery pipe (17) connection extract import (1); Detecting device (16) is provided with flow cell (21), and the outlet of filtration unit (5) is communicated with extracting liquid outlet (10) through B valve (9) back.
5. the on-line measuring device in a kind of traditional Chinese medicine extraction process according to claim 4; It is characterized in that: said tangential micro porous filtration core (8) is equipped with the removable filter core; The extract flow direction is vertical with filtering direction; The filter opening size of filter core is 0.1mm～0.01mm, and the material of filter core is pottery, titanium alloy.
6. the on-line measuring device in a kind of traditional Chinese medicine extraction process according to claim 4; It is characterized in that: said scalable part flow arrangement (12) has acidproof alkali salt and ethanol, heatproof, advantages of high strength; Can regulate bypass flow, the control split ratio, adjustable split ratio can reach 1: 1000.
7. the on-line measuring device in a kind of traditional Chinese medicine extraction process according to claim 4 is characterized in that: said detecting device (16) is measured the one or more of meter by absorption spectrum detector and viscosity meter, pH meter, relative density and is formed through serial or parallel connection.
8. the on-line measuring device in a kind of traditional Chinese medicine extraction process according to claim 4; It is characterized in that: said filtration unit (5) is provided with inductor (7); Inductor (7) connects parameter display (6), is provided with between A valve (2) and the hydro-extractor (3) to detect liquid delivery pipe (17), filtrating conveyance conduit (11).
9. the on-line measuring device in a kind of traditional Chinese medicine extraction process according to claim 4; It is characterized in that: said detecting device (16) is provided with extract reference cell (15); Detecting device (16) connects computer data processing system (18); Scalable part flow arrangement (12) and the conducting of filtrating conveyance conduit (11), filtrating conveyance conduit (11) is communicated with flushing pipe inlet (19) through C valve (20).
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| CN1403822A (en) * | 2002-09-26 | 2003-03-19 | 浙江大学 | In-situ detection of product quality index in Chinese medicine production process |
| CN1596867A (en) * | 2003-09-17 | 2005-03-23 | 清华大学 | On-line extraction device and its application |
| CN201043939Y (en) * | 2007-04-29 | 2008-04-02 | 上海现代中医药技术发展有限公司 | Sampling system used for on-line spectrum analysis during Chinese medicine extraction course |
| CN101249042A (en) * | 2008-04-07 | 2008-08-27 | 北京中医药大学 | Chinese medicine liquid formulation automatic production line |
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