CN102200507B - Preprocessing system for near-infrared online detection and application thereof - Google Patents
Preprocessing system for near-infrared online detection and application thereof Download PDFInfo
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Abstract
The invention provides a preprocessing system for near-infrared online detection, which is composed of a filter, a back-up filter, a variable-frequency centrifugal pump, a temperature control device, a buffering device, a flowmeter, a near-infrared spectrum acquisition device, an automatic sampling device, a liquid inlet and a liquid outlet. The preprocessing system provided by the invention can run automatically, continuously and reliably, and can be switched for use under the condition of not affecting the function of the whole system, therefore, the automatic positive and negative washing can be realized simultaneously, the samples of acquired spectrums can be acquired in a targeted mode, and the cleaning and beauty of the whole system can be maintained. By using the preprocessing system provided by the invention, the problem of difficulty in detection caused by more insoluble solid particles, unstable flow, easily-produced bubbles and large temperature fluctuation in the process of near-infrared online detection is solved, so that the acquired near-infrared spectrum is stable, reliable, and good in repeatability, thereby improving the accuracy of results of near-infrared on-line detection, promoting the development and application of the near-infrared spectral analysis technology in pharmaceutical production processes, and then truly realizing on-line quality control.
Description
Technical field
The invention belongs to the near infrared online detection technical field, be specifically related to a kind of near infrared online detection pretreatment system and application thereof.
Background technology
Near-infrared spectral analysis technology is a kind of novel online measuring technique, has that spectra collection is convenient, analysis time is short, do not destroy sample, do not consume reagent, the advantage such as free from environmental pollution, has a wide range of applications in fields such as food, oil, chemical industry.Near-infrared spectral analysis technology can detect by many indexs that mathematical modeling is finished complex system, so it is fit to be applied to the real-time analysis of Chinese Traditional Medicine very much, such as extraction of traditional Chinese medicine, concentration process, alcohol precipitation process, column chromatography process etc.But because Chinese medicine is produced the singularity of object, many such as insoluble solid particle in the liquid, easily produce a large amount of bubbles etc., directly affect near infrared spectra collection, cause the frequent generation of exceptional spectrum, can't guarantee the stability of spectra collection and accuracy and the reliability of institute's established model.
In traditional Chinese medicine quality control and production application field, near infrared spectrum is applied to the existing Patents document of mensuration of index components as a kind of online measuring technique, such as patent (CN02137234.9, CN200710022408.9, CN200810050095.2 and CN200410090617.3) etc.But before traditional Chinese medicine liquid enters the spectra collection device, liquid is carried out multiple pre-service, then still have no relevant report.The conventional on-line measuring device that uses in the commercial production at present includes only flow cell, fibre-optical probe etc., the liquid of online detection is not taked filtration de-bubble and the measures such as temperature and flow regulation of specialty.The bubble of eliminating testing liquid can improve the reliability of near infrared spectra collection, avoids producing unusual, mistake spectrum.Adjustment not only is conducive to reduce bubble, and can reduce temperature variation to the impact of near infrared spectrum absorbance.Flow regulation then can prevent the near infrared spectrum baseline wander.Above function is that pretreatment system should possess and present on-line detecting system does not have.
Summary of the invention
The purpose of this invention is to provide a kind of near infrared online detection pretreatment system, to solve the problems such as repeatability, stability and poor reliability of the spectra collection that near-infrared spectral analysis technology is applied to produce in the pharmacy procedure, promote the promotion and application of near infrared online detection technology.This system can be continuously in real time to testing liquid filter, constant temperature, froth breaking, speed governing, make it reach the near infrared online detection requirement.In addition, this system also has automatic sampling and automatically cleans dirt eliminating function, can be when gathering testing liquid spectrum, and automatic collection sample, and the realization system is cleaned automatically after the near infrared online detection process finishes, to guarantee normally carrying out of online testing process next time.
A kind of near infrared online detection pretreatment system provided by the invention is comprised of filtrator, reserve filter, frequency conversion centrifugal pump, temperature control device, snubber assembly, flowmeter, near infrared spectra collection device, automatic sampling device, inlet, liquid outlet; Filtrator is by filtrator fluid pneumatic on-off valve, reserve filter is by reserve filter fluid pneumatic on-off valve, the common connection links to each other with the main line of temperature control device after filtrator switches Pneumatic three-way valve, the frequency conversion centrifugal pump links to each other with the inlet pneumatic on-off valve, be divided into afterwards two-way, one the tunnel links to each other with the liquid outlet pneumatic on-off valve, the liquid outlet pneumatic on-off valve is connected with liquid outlet, another road links to each other with reserve filter with filtrator respectively with reserve filter feed liquor pneumatic on-off valve by filtrator feed liquor pneumatic on-off valve, the temperature control interlayer of temperature control device connects the temperature control medium inlet by temperature control medium flow pneumatic control valve, the main line other end of temperature control device links to each other with snubber assembly, the snubber assembly top is provided with exhausr port, the bottom links to each other with flowmeter by the testing liquid flow control valve, and the other end of flowmeter links to each other with the near infrared spectra collection device.The other end of near infrared spectra collection device is divided into three the tunnel, the sampling pneumatic on-off valve of leading up to links to each other with automatic sampling device, another road links to each other with the waste liquid mouth by flowing to the switching Pneumatic three-way valve, as blowoff line, Third Road switches Pneumatic three-way valve connection liquid outlet pneumatic on-off valve through flowing to, inlet and liquid outlet butt up against respectively production equipment the corresponding interface, the cleaning fluid pneumatic on-off valve connects purified water, the cleaning fluid pneumatic on-off valve is divided into two-way, the filtrator forward of leading up to cleans the feed liquor pneumatic on-off valve and links to each other with filtrator with filtrator reverse cleaning feed liquor pneumatic on-off valve, another road is cleaned the fluid pneumatic on-off valve by reserve filter reverse cleaning feed liquor pneumatic on-off valve and reserve filter forward and is linked to each other with reserve filter, filtrator is connected the upper end and is cleaned the fluid pneumatic on-off valve by the filtrator forward respectively and is connected the fluid pneumatic on-off valve with the reserve filter forward and is connected with the waste liquid mouth with reserve filter, filtrator is connected the lower end and is passed through respectively filtrator reverse cleaning fluid pneumatic on-off valve and be connected with the waste liquid mouth with reserve filter reverse cleaning fluid pneumatic on-off valve with reserve filter.
Automatic control system is comprised of on-the-spot PLC control station.
Another object of the present invention provides the application of described near infrared online detection pretreatment system in the drug production process line Quality Control.
After testing liquid enters a kind of near infrared online detection pretreatment system provided by the invention, remove solid impurity particle and first one-step defoaming by filtration unit first, then entering temperature control device makes testing liquid keep constant temperature, enter again snubber assembly and further reduce bubble and local turbulence, regulate finally by the inflow-rate of water turbine regulation device that flow velocity is laggard to be entered the spectrum harvester and carry out spectra collection.If need to collect sample, a liquid part that then flows out the spectra collection device enters automatic sampling device and carries out sample collection, is used for foundation or the model modification of near-infrared model, and all the other liquid return production equipment by the fluid pipeline; If do not need collected specimens, then liquid does not all turn back to production equipment by automatic sampling device.Whole system cooperate to be produced by automation control system or the requirement of scientific research, automatically, continuously, reliably operation.There are touch screen operation interface and PLC electrical control cabinet in system.
Described filtration unit can switch use in the situation that does not affect the whole system function, realize simultaneously automatically positive back flush.
Described automatic sampling system can be collected the sample that is gathered spectrum pointedly.
Described detergent line and waste liquid pipeline can be kept the cleaning of whole system and attractive in appearance.
The invention solves that insoluble solid particle in the near infrared online detection process is many, instability of flow, easily produce the large and detection difficult problem that causes of bubble, temperature fluctuation, make the near infrared spectrum that collects stable, reliable, favorable reproducibility, improve the result's of near infrared online detection accuracy, promote development and the application of near-infrared spectral analysis technology in drug production process, really realize line Quality Control.
Description of drawings
Fig. 1 is structural representation of the present invention.
Fig. 2 is 3 tons of extractor structural representations.
Fig. 3 is the solid content near infrared online detection result of the radix paeoniae rubrathe medicinal material leaching process of routine.
Fig. 4 is the Paeoniflorin concentration near infrared online detection result of the radix paeoniae rubrathe medicinal material leaching process of routine.
Fig. 5 is the concentration of benzoic acid near infrared online detection result of the radix paeoniae rubrathe medicinal material leaching process of routine.
Fig. 6 is the solid content near infrared online detection result of radix paeoniae rubrathe medicinal material leaching process behind application the present invention.
Fig. 7 is the Paeoniflorin concentration near infrared online detection result of radix paeoniae rubrathe medicinal material leaching process behind application the present invention.
Fig. 8 is the concentration of benzoic acid near infrared online detection result of radix paeoniae rubrathe medicinal material leaching process behind application the present invention.
Fig. 9 is the forulic acid concentration near infrared online detection result of Ligusticum wallichii, the red sage root and the Radix Angelicae Sinensis three flavor medicinal material mixing leaching process of routine.
Figure 10 is the solid content near infrared online detection result of Ligusticum wallichii, the red sage root and the Radix Angelicae Sinensis three flavor medicinal material mixing leaching process of routine.
Figure 11 is the forulic acid concentration near infrared online detection result of Ligusticum wallichii, the red sage root and Radix Angelicae Sinensis three flavor medicinal material mixing leaching process behind application the present invention.
Figure 12 is the solid content near infrared online detection result of Ligusticum wallichii, the red sage root and Radix Angelicae Sinensis three flavor medicinal material mixing leaching process behind application the present invention.
Embodiment
The present invention is further described in conjunction with the accompanying drawings and embodiments.
Embodiment 1
Referring to Fig. 1, the invention provides a kind of near infrared online detection pretreatment system, by filtrator 1, reserve filter 2, frequency conversion centrifugal pump 3, temperature control device 4, snubber assembly 5, flowmeter 6, near infrared spectra collection device 7, automatic sampling device 8, inlet 9, liquid outlet 10 forms, filtrator 1 is by filtrator fluid pneumatic on-off valve 15, reserve filter 2 is by reserve filter fluid pneumatic on-off valve 21, the common connection links to each other with the main line of temperature control device 4 after filtrator switches Pneumatic three-way valve 24, frequency conversion centrifugal pump 3 links to each other with inlet pneumatic on-off valve 26, liquid is divided into two-way afterwards, one the tunnel links to each other with liquid outlet pneumatic on-off valve 27, liquid outlet pneumatic on-off valve 27 is connected with liquid outlet 10, liquid turns back to production equipment from liquid outlet 10, and another road links to each other with reserve filter 2 with filtrator 1 respectively with reserve filter feed liquor pneumatic on-off valve 18 by filtrator feed liquor pneumatic on-off valve 12.
The temperature control interlayer of temperature control device 4 connects temperature control medium inlet 30 by temperature control medium flow pneumatic control valve 29, the main line other end of temperature control device 4 links to each other with snubber assembly 5, snubber assembly 5 tops are provided with exhausr port 33, and the bottom links to each other with flowmeter 6 by testing liquid flow control valve 32.
The other end of flowmeter 6 links to each other with near infrared spectra collection device 7.The other end of near infrared spectra collection device 7 is divided into three the tunnel, gather spectrum liquid afterwards, the sampling pneumatic on-off valve 28 of leading up to links to each other with automatic sampling device 8, another road links to each other with waste liquid mouth 31 by flowing to switching Pneumatic three-way valve 25, as blowoff line, the temperature control medium waste liquid is discharged from waste liquid mouth 31, and Third Road switches Pneumatic three-way valve 25 connection liquid outlet pneumatic on-off valves 27 through flowing to, and has surveyed liquid and has been back to production equipment from liquid outlet 10.The other end of near infrared spectra collection device 7 comprises fibre-optical probe and flow cell.
Inlet 9 and liquid outlet 10 butt up against respectively production equipment the corresponding interface, and cleaning fluid pneumatic on-off valve 11 connects purified water.
Purified water is divided into two-way after entering cleaning fluid pneumatic on-off valve 11, the filtrator forward of leading up to cleans feed liquor pneumatic on-off valve 13 and links to each other with filtrator 1 with filtrator reverse cleaning feed liquor pneumatic on-off valve 14, another road is cleaned fluid pneumatic on-off valve 23 by reserve filter reverse cleaning feed liquor pneumatic on-off valve 22 and reserve filter forward and is linked to each other with reserve filter 2, during the forward filter rinsed, filtrator 1 cleans fluid pneumatic on-off valve 16 by the filtrator forward respectively with sewage during reserve filter is connected and is connected waste liquid mouth 31 discharges of fluid pneumatic on-off valve 20 from connecting with the reserve filter forward; During the reverse cleaning filtering device, the sewage in filtrator 1 and the reserve filter 2 is discharged from waste liquid mouth 31 by filtrator reverse cleaning fluid pneumatic on-off valve 17 and reserve filter reverse cleaning fluid pneumatic on-off valve 19 respectively.
Automatic control system is comprised of on-the-spot PLC control station.
Embodiment 2
Referring to Fig. 1 ~ 2, radix paeoniae rubrathe leaching process: radix paeoniae rubrathe medicinal material 250 kg, after adding 10 times of amounts purified water soaking 1 h, under 100 ℃ of conditions, extracted 2 hours, at the bottom of 3 tons of extractors (production equipment) tank and between the tank deck external circulation line is installed, guarantee that extract continues circulation in the leaching process, the extractor herb liquid is evenly distributed, prevent that local concentration is too high.Inlet 9 and liquid outlet 10 are butted up against respectively interface 9 ' and the 10 ' (see figure 2) of the external circulation line of 3 tons of extractors, and cleaning fluid pneumatic on-off valve 11 connects purified water.
Start automation control system, after immersion process finishes, open frequency conversion centrifugal pump 3, inlet pneumatic on-off valve 26 and 27 pairs of liquid in-out pipelines of liquid outlet pneumatic on-off valve and carry out balance and rush in advance (0.5 minute), changing flow direction switches Pneumatic three-way valve 25 makes extract discharge from waste liquid mouth 31; Open filtrator feed liquor pneumatic on-off valve 12, filtrator fluid pneumatic on-off valve 15 and filtrator and switch Pneumatic three-way valve 24, changing flow direction switches Pneumatic three-way valve 25, close liquid outlet pneumatic on-off valve 27, the pre-service main line is carried out balance rush in advance (0.5 minute), extract is discharged from waste liquid mouth 31, after whole pipeline balances are complete, opens liquid outlet pneumatic on-off valve 27, changing flow direction switches Pneumatic three-way valve 25, makes extract return production equipment; By flowmeter 6 and testing liquid flow pneumatic control valve 32 adjust fluxes, make to reach setting value 60 L/h, regulate the extract temperature by temperature control device 4 and temperature control medium flow pneumatic control valve 29 and make it to reach 100 ℃ of design temperatures; Behind system stability, beginning online acquisition near infrared spectrum and extract sample, whole online testing process extract continues circulation and finally is back to production equipment, when arriving sampling time point, open valve sampling pneumatic on-off valve 28, automatically gather the extract sample, the radix paeoniae rubrathe extract sample that collects is respectively applied to analyze solid content, Paeoniflorin and benzoic acid value, and sets up corresponding near infrared correction.
After online testing process finishes, close inlet pneumatic on-off valve 26, liquid outlet pneumatic on-off valve 27, temperature control medium flow pneumatic control valve 29 and temperature control device 4, pretreatment system is cleaned.Close filtrator feed liquor pneumatic on-off valve 12, filtrator fluid pneumatic on-off valve 15, open cleaning fluid pneumatic on-off valve 11, opening filter reverse cleaning feed liquor pneumatic on-off valve 14, filtrator reverse cleaning fluid pneumatic on-off valve 17 and filtrator forward clean feed liquor pneumatic on-off valve 13 in turn, the filtrator forward cleans fluid pneumatic on-off valve 16, the filtrator 1 that uses is carried out forward and reverse cleaning (3 minutes), and sewage is discharged from waste liquid mouth 31.After filtrator 1 cleans and finishes, close the filtrator forward and clean fluid pneumatic on-off valve 16, filtrator reverse cleaning fluid pneumatic on-off valve 17, opening filter feed liquor pneumatic on-off valve 12, filtrator fluid pneumatic on-off valve 15, changing flow direction switches 25 pairs of residues of Pneumatic three-way valve pipeline and cleans, and sewage is discharged from waste liquid mouth 31.After all cleaning end, close cleaning fluid pneumatic on-off valve 11, open the filtrator forward and clean fluid pneumatic on-off valve 16, filtrator reverse cleaning fluid pneumatic on-off valve 17 discharge raffinates, close at last all valves and system.
Do not adopt this pretreatment system, only use conventional on-line measuring device (flow cell and fibre-optical probe) to gather the near infrared light spectrogram, collect simultaneously the extract sample, solid content, Paeoniflorin and concentration of benzoic acid in the analytic sample, set up corresponding near infrared partial least square model, and these three models are respectively applied to solid content in the radix paeoniae rubrathe leaching process, Paeoniflorin and benzoic on-line analysis.Use this pretreatment system, before extract enters the spectra collection device, carry out pre-service, remove the solid impurity particle in the extract, stablize flow velocity, keep liquid constant temperature.Adopt identical modeling parameters, set up respectively solid content, Paeoniflorin and benzoic near infrared partial least square model, be applied to equally the on-line analysis of solid content, Paeoniflorin and concentration of benzoic acid in the radix paeoniae rubrathe medicinal material leaching process.Above model is all by related coefficient (R), best number of principal components (Factor), cross validation mean square deviation (Root mean square error in cross-validation, RMSECV), calibration set mean square deviation (Root mean square error in calibration, RMSEC) and relatively analytical error (Residual predictive deviation, RPD) be the index optimization modeling parameters, investigate model performance.Adopt the evaluation index parameter of this pretreatment system front and back institute established model to see Table 1.As seen from the table, adopt that the performance of each model all is improved to some extent after this pretreatment system.
Table 1 adopts the Performance Evaluating Indexes (radix paeoniae rubrathe) of pretreatment system front and back model
| Detect index | R | Factor | RMSEC | RMSECV | RPD |
| Solid content (front) | 0.9688 | 3 | 0.098 | 0.124 | 3.67 |
| Paeoniflorin (front) | 0.9504 | 4 | 0.109 | 0.190 | 2.55 |
| Benzoic acid (front) | 0.9568 | 4 | 0.007 | 0.011 | 2.84 |
| Solid content (afterwards) | 0.9906 | 4 | 0.087 | 0.096 | 7.33 |
| Paeoniflorin (afterwards) | 0.9883 | 4 | 0.117 | 0.130 | 6.57 |
| Benzoic acid (afterwards) | 0.9861 | 3 | 0.008 | 0.009 | 6.02 |
After model is built up, be applied to on-line analysis.Referring to Fig. 3 ~ 5, do not adopt the near infrared predicted value of three models that this pretreatment system builds all to fluctuate significantly, the stage (60-100 minute) of especially seething with excitement, because bubble is more, affected the accurate collection of near infrared spectrum, cause having very big-difference between predicted value and the actual measured value, the prediction accuracy of model is greatly affected.Referring to Fig. 6 ~ 8, adopt after this pretreatment system, the Stability and veracity of solid content, Paeoniflorin and benzoic predicted value is significantly higher than the result who adopts conventional on-line measuring device to obtain, and all remains in 7% with the difference of actual measured value.Experimental result shows that the present invention has preferably pretreating effect, can improve stability and the prediction accuracy of model, makes it satisfy the accuracy requirement of Chinese Traditional Medicine real-time analysis.
Filtrator 1 and reserve filter 2 changeable uses guarantee online carrying out smoothly of detecting.Filtration unit can clean in the situation of not impact system operation, after stopping up, filtrator 1 closes filtrator feed liquor pneumatic on-off valve 12 and filtrator fluid pneumatic on-off valve 15, open reserve filter feed liquor pneumatic on-off valve 18 and reserve filter fluid pneumatic on-off valve 21, use 2 pairs of testing liquids of filtrator to filter, the opening filter forward cleans feed liquor pneumatic on-off valve 13 in turn simultaneously, the filtrator forward cleans fluid pneumatic on-off valve 16 and filtrator reverse cleaning feed liquor pneumatic on-off valve 14,17 pairs of plugged sereens of filtrator reverse cleaning fluid pneumatic on-off valve 1 carry out that forward cleans and to anti-cleaning.The filtering accuracy scope of filtrator is 10 ~ 100 microns.
Testing liquid is that relative density is lower than 1.2 liquid, especially for the complex system of the high temperature of bubbles, particle etc.
The pretreatment system pipeline is the stainless steel pipes of caliber 2 ~ 30 mm, and fluid flow is 0 ~ 1000 L/h.
Temperature control device 4 employed temperature control mediums can be tap water, industrial chilled water or high-temperature steam.When temperature does not reach setting value, by regulating temperature control medium flow pneumatic control valve 29, strengthen the flow of cooling or heating medium, make temperature reach setting value.Desired temperature is 0 ~ 200 ℃.
Flow control device comprises testing liquid flow pneumatic control valve 32 and flowmeter 6, by regulate and control the flow of liquid in pretreatment system in conjunction with frequency conversion centrifugal pump 3, makes to reach setting value.
Near infrared spectra collection device 7 comprises flow cell and fibre-optical probe, can adopt dynamical fashion when gathering spectrum, also can use static mode, when adopting dynamical fashion, liquid directly gathers spectrum under the setting flow rate regime, when adopting static mode, closed to flow to before spectra collection and switch Pneumatic three-way valve 25, open after spectra collection finishes to flow to and switch Pneumatic three-way valve 25, flow rate of liquid returns to setting value.Open sampling pneumatic on-off valve 28 during the collection liquid sample, gather simultaneously near infrared spectrum.
Embodiment 3:
Ligusticum wallichii, the red sage root and Radix Angelicae Sinensis mixing leaching process: each 60 kg of Ligusticum wallichii, the red sage root and Radix Angelicae Sinensis medicinal material, add 10 times of amount purified water and soak after 1 hour, under 95 ℃ of conditions, extracted 2 hours.
Method according to embodiment 2, do not use this pretreatment system, directly gather near infrared spectrum by conventional on-line measuring device, forulic acid concentration and solid content in the extract sample that analysis is collected, set up the partial least square model of forulic acid and solid content, and institute's established model is respectively applied to forulic acid concentration and solid content in the on-line analysis leaching process.Equally, adopt this pretreatment system, according to above modeling process, set up respectively the near infrared partial least square model of forulic acid and solid content, and be applied to forulic acid concentration and solid content in on-line analysis Ligusticum wallichii, the red sage root and the Radix Angelicae Sinensis mixing leaching process.Adopt the evaluation index parameter of pretreatment system front and back institute established model to see Table 1.As seen from the table, adopt that the performance of each model is improved to some extent equally after this pretreatment system.
Table 2 adopts the Performance Evaluating Indexes (Chuan Dan works as) of pretreatment system front and back model
| Detect index | R | Factor | RMSEC | RMSECV | RPD |
| Forulic acid (front) | 0.9516 | 7 | 2.271 | 1.632 | 2.55 |
| Solid content (front) | 0.9511 | 7 | 0.118 | 0.068 | 2.55 |
| Forulic acid (afterwards) | 0.9864 | 6 | 1.765 | 2.372 | 4.36 |
| Solid content (afterwards) | 0.9892 | 5 | 0.081 | 0.125 | 4.28 |
After model is built up, be applied to on-line analysis.Because not significantly boiling of this experiment so the impact of bubble is less, the big ups and downs of Fig. 3 ~ 5 do not occur being similar in Fig. 9 ~ 10, but other factors, such as solid particle, flow velocity stability and the precision of prediction that also directly has influence on model such as unstable.Therefore, do not adopt this pretreatment system, not only model performance is relatively poor, and the difference of near infrared predicted value and practical measurement value also surpasses 20%.Referring to Figure 11 ~ 12, adopt after this pretreatment system, the Stability and veracity of forulic acid and solid content predicted value is significantly higher than conventional online test method, all remains in 8% with the difference of actual measured value.Experimental result shows that pretreating effect of the present invention is better, can significantly improve the precision of prediction of online detection model, has good promotional value.
Claims (4)
1. near infrared online detection pretreatment system, it is characterized in that, by filtrator (1), reserve filter (2), frequency conversion centrifugal pump (3), temperature control device (4), snubber assembly (5), flowmeter (6), near infrared spectra collection device (7), automatic sampling device (8), inlet (9), liquid outlet (10) forms, filtrator (1) is by filtrator fluid pneumatic on-off valve (15), reserve filter (2) is by reserve filter fluid pneumatic on-off valve (21), the common connection links to each other with the main line of temperature control device (4) after filtrator switches Pneumatic three-way valve (24), frequency conversion centrifugal pump (3) links to each other with inlet pneumatic on-off valve (26), be divided into afterwards two-way, one the tunnel links to each other with liquid outlet pneumatic on-off valve (27), liquid outlet pneumatic on-off valve (27) is connected with liquid outlet (10), another road links to each other with reserve filter (2) with filtrator (1) respectively with reserve filter feed liquor pneumatic on-off valve (18) by filtrator feed liquor pneumatic on-off valve (12), the temperature control interlayer of temperature control device (4) connects temperature control medium inlet (30) by temperature control medium flow pneumatic control valve (29), the other end of temperature control device (4) main line links to each other with snubber assembly (5), snubber assembly (5) top is provided with exhausr port (33), the bottom links to each other with flowmeter (6) by testing liquid flow control valve (32), the other end of flowmeter (6) links to each other with near infrared spectra collection device (7), the other end of near infrared spectra collection device (7) is divided into three the tunnel, the sampling pneumatic on-off valve (28) of leading up to links to each other with automatic sampling device (8), another road links to each other with waste liquid mouth (31) by flowing to switching Pneumatic three-way valve (25), as blowoff line, Third Road switches Pneumatic three-way valve (25) connection liquid outlet pneumatic on-off valve (27) through flowing to, inlet (9) and liquid outlet (10) butt up against respectively production equipment the corresponding interface, cleaning fluid pneumatic on-off valve (11) connects purified water, cleaning fluid pneumatic on-off valve (11) is divided into two-way, the filtrator forward of leading up to cleans feed liquor pneumatic on-off valve (13) and links to each other with filtrator (1) with filtrator reverse cleaning feed liquor pneumatic on-off valve (14), another road is cleaned fluid pneumatic on-off valve (23) by reserve filter reverse cleaning feed liquor pneumatic on-off valve (22) and reserve filter forward and is linked to each other with reserve filter (2), filtrator (1) is connected 2 with reserve filter) the upper end clean fluid pneumatic on-off valve (16) by the filtrator forward respectively and be connected fluid pneumatic on-off valve (20) with the reserve filter forward and be connected with waste liquid mouth (31), filtrator (1) is connected 2 with reserve filter) the lower end pass through respectively filtrator reverse cleaning fluid pneumatic on-off valve (17) and be connected 19 with reserve filter reverse cleaning fluid pneumatic on-off valve) be connected with waste liquid mouth (31).
2. a kind of near infrared online detection pretreatment system according to claim 1 is characterized in that, all pipelines of system are the stainless steel pipes of caliber 2 ~ 30 mm.
3. the application of a kind of near infrared online detection pretreatment system according to claim 1 in the drug production process line Quality Control is characterized in that, described system is that relative density is lower than the application in 1.2 the liquid at testing liquid.
4. the application of a kind of near infrared online detection pretreatment system according to claim 1 in the drug production process line Quality Control is characterized in that, the application of described system in the complex system of the high temperature of bubbles, particle.
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| JP3229129B2 (en) * | 1994-08-03 | 2001-11-12 | 三菱重工業株式会社 | Ethylene removal equipment |
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| CN1982873A (en) * | 2005-12-16 | 2007-06-20 | 天津天士力制药股份有限公司 | Near-infrared diffuse reflection spectral method for fastly inspecting drop appearance quality |
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| CN101421613A (en) * | 2006-04-14 | 2009-04-29 | 申允好 | The ultra filteration system for on-line analyzer |
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| JPS6298255A (en) * | 1985-10-25 | 1987-05-07 | Denki Kagaku Keiki Co Ltd | Method and apparatus for pretreatment in automatic analysis of liquid mixture to be treated in biochemical treatment vessel |
| JPH03229129A (en) * | 1990-02-05 | 1991-10-11 | Sumitomo Jukikai Envirotec Kk | Sample device for measuring water quality |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| EP0288425A2 (en) * | 1987-04-22 | 1988-10-26 | Sekisui Kagaku Kogyo Kabushiki Kaisha | An apparatus for the treatment of biological samples and treatment methods using the same |
| JP3229129B2 (en) * | 1994-08-03 | 2001-11-12 | 三菱重工業株式会社 | Ethylene removal equipment |
| CN1602830A (en) * | 2004-11-09 | 2005-04-06 | 清华大学 | Real-time monitoring method for traditional Chinese medicine process |
| CN1982873A (en) * | 2005-12-16 | 2007-06-20 | 天津天士力制药股份有限公司 | Near-infrared diffuse reflection spectral method for fastly inspecting drop appearance quality |
| CN1982872A (en) * | 2005-12-16 | 2007-06-20 | 天津天士力制药股份有限公司 | Near-infrared diffuse reflection spectral method for fastly inspecting drop water content |
| CN101421613A (en) * | 2006-04-14 | 2009-04-29 | 申允好 | The ultra filteration system for on-line analyzer |
| CN101241072A (en) * | 2007-02-09 | 2008-08-13 | 北京中医药大学 | Medicament ingredient on-line detection method in pharmacy procedure and on-line detection system |
| CN101078685A (en) * | 2007-05-17 | 2007-11-28 | 常熟雷允上制药有限公司 | Method for quickly on-line detection of traditional Chinese medicine Kuhuang injection effective ingredient using near infra red spectrum |
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