CN101249042A - Chinese medicine liquid formulation automatic production line - Google Patents
Chinese medicine liquid formulation automatic production line Download PDFInfo
- Publication number
- CN101249042A CN101249042A CNA2008100906561A CN200810090656A CN101249042A CN 101249042 A CN101249042 A CN 101249042A CN A2008100906561 A CNA2008100906561 A CN A2008100906561A CN 200810090656 A CN200810090656 A CN 200810090656A CN 101249042 A CN101249042 A CN 101249042A
- Authority
- CN
- China
- Prior art keywords
- unit
- control
- chinese medicine
- production line
- automatic production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 83
- 239000003814 drug Substances 0.000 title claims description 55
- 239000012669 liquid formulation Substances 0.000 title 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 95
- 239000007788 liquid Substances 0.000 claims abstract description 82
- 238000001514 detection method Methods 0.000 claims abstract description 38
- 238000002360 preparation method Methods 0.000 claims abstract description 38
- 239000000463 material Substances 0.000 claims abstract description 30
- 238000000605 extraction Methods 0.000 claims abstract description 29
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims description 22
- 239000012141 concentrate Substances 0.000 claims description 14
- 230000007062 hydrolysis Effects 0.000 claims description 14
- 238000006460 hydrolysis reaction Methods 0.000 claims description 14
- 239000002244 precipitate Substances 0.000 claims description 14
- 238000004458 analytical method Methods 0.000 claims description 12
- 230000001105 regulatory effect Effects 0.000 claims description 12
- 238000006386 neutralization reaction Methods 0.000 claims description 11
- 229910021529 ammonia Inorganic materials 0.000 claims description 10
- 238000007599 discharging Methods 0.000 claims description 10
- 239000000126 substance Substances 0.000 claims description 9
- 229940079593 drug Drugs 0.000 claims description 8
- 238000005516 engineering process Methods 0.000 claims description 6
- 238000011084 recovery Methods 0.000 abstract description 11
- 238000002156 mixing Methods 0.000 abstract description 5
- 238000012869 ethanol precipitation Methods 0.000 abstract description 2
- 238000007670 refining Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 description 21
- 230000008569 process Effects 0.000 description 16
- 238000010438 heat treatment Methods 0.000 description 15
- 239000000243 solution Substances 0.000 description 15
- 239000000047 product Substances 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 238000005070 sampling Methods 0.000 description 8
- 239000002253 acid Substances 0.000 description 7
- 239000003513 alkali Substances 0.000 description 7
- 238000013461 design Methods 0.000 description 6
- 239000006228 supernatant Substances 0.000 description 6
- 238000012163 sequencing technique Methods 0.000 description 5
- 238000003860 storage Methods 0.000 description 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
- 239000010231 banlangen Substances 0.000 description 4
- 239000000284 extract Substances 0.000 description 4
- 239000012535 impurity Substances 0.000 description 4
- 239000012567 medical material Substances 0.000 description 4
- 238000011897 real-time detection Methods 0.000 description 4
- 230000001276 controlling effect Effects 0.000 description 3
- 230000006837 decompression Effects 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 230000003472 neutralizing effect Effects 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- 230000009183 running Effects 0.000 description 3
- 230000004308 accommodation Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 230000002596 correlated effect Effects 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 229910052757 nitrogen Inorganic materials 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 238000010992 reflux Methods 0.000 description 2
- 230000000630 rising effect Effects 0.000 description 2
- 230000008054 signal transmission Effects 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000002699 waste material Substances 0.000 description 2
- 241000404030 Anacyclus clavatus Species 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 238000005903 acid hydrolysis reaction Methods 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 238000010923 batch production Methods 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 238000000354 decomposition reaction Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000010259 detection of temperature stimulus Effects 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 238000002481 ethanol extraction Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 239000002360 explosive Substances 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 230000008676 import Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000000638 solvent extraction Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000007306 turnover Effects 0.000 description 1
- 238000010977 unit operation Methods 0.000 description 1
- 238000009834 vaporization Methods 0.000 description 1
- 230000008016 vaporization Effects 0.000 description 1
Images
Abstract
The invention relates to an automatic production line of Chinese medicinal liquid preparations, comprising an extraction unit connected with pipelines and used for extracting and refining Chinese medicinal materials, an ethanol concentration/recovery unit, an ethanol precipitation unit, a mixing unit, and an automatic detection and control system connected with the above units and used for automatic detection and regulation of the above units. The inventive automatic production line can realize automatic production of Chinese medicinal liquid preparations, ensure stable product quality, reduce production cost, and ensure the safety of the production process.
Description
Technical field
The present invention relates to the automatic production line of liquid preparation of Chinese medicine production process, more particularly, relate to and to realize the input and output material sequencing contro, the automatic production line of parameter detecting such as temperature, pressure, liquid level, pH and control and the online detection of index components.
Background technology
At present, China's Chinese medicine production process ubiquity controlling index lacks, shortcomings such as production process control dynamics deficiency.From the mode of production, Chinese medicine enterprise mostly is batch production, and extracting, concentrate etc. between the unit operations has certain time interval, and the turnover of material is by Artificial Control, complex operation, and the production cycle is long, is easy to pollute the change with pharmaceutical properties.On the other hand, the main artificial experience that relies on of the technological parameter control of production process is finished, though the unitary technological parameter control of part that develops into of drugs manufacture equipment provides method, has temperature, pressure-detecting device as concentrator, can add thermal control according to temperature, pressure.But because the checkout gear of pharmaceutical equipment is demonstration on the spot, operator's certain interval of time is just once monitored parameter, and then determines the degree of heating steam valve regulated according to operator's experience.This mode can not be monitored in real time, and the not enough science of Artificial Control is objective, can cause control not enough or excessive, causes the process conditions of different production batch to be difficult to reach stable, homogeneous, has influenced the quality of final products.What is more important, the detection of quality index is not carried out in Chinese medicine production at present to intermediate in technical process, only the intermediate after finished product or the end of a certain technical process is carried out quality index and detect.Find that index is defective if detect, can only do and scrap processing, cause raw-material waste.
Present situation in view of China's Chinese medicine production process, the present invention is an object with liquid preparation of Chinese medicine (as aqueous injection, oral liquid etc.), set up the production line that a cover can carry out material continuous-flow, the real-time Detection ﹠ Controling of technological parameter and the online detection of production process quality index, for China Chinese medicine manufacturing enterprise provides technical equipment.
Summary of the invention
The technical problem to be solved in the present invention is: at existing each unit intermittently operated of production process, technological parameter by Artificial Control and the problem that lacks the online detection of index components, the production line of liquid preparation of Chinese medicine production key link is contained in foundation, set up each unit input and output material control unit, production process technology parameter detecting and control unit, make it can realize the automatization of liquid preparation of Chinese medicine production process, guarantee the stable of product quality, reduce production costs, guarantee the safety of production process.
Therefore, the purpose of this invention is to provide a kind of liquid preparation of Chinese medicine automatic production line.
Liquid preparation of Chinese medicine automatic production line of the present invention, comprise: Chinese crude drug is extracted, the purified extraction unit that connects with pipeline, concentrates/reclaim ethanol unit, precipitate with ethanol unit, mixed cell, also comprise be connected with above-mentioned each unit above-mentioned each unit is detected automatically, thus the automatic checkout and control system that above-mentioned each unit is regulated and control.
Above-mentioned liquid preparation of Chinese medicine automatic production line can also comprise hydrolysis unit and neutralisation unit.
Above-mentioned automatic checkout and control system comprises technological parameter online detection unit, chemical analysis amount online detection unit, index components online detection unit, at least one in the alarm unit and control unit are formed automatically.
Described technological parameter online detection unit comprises one or more in temperature detecting unit, pressure sensing cell, Level Detection unit, the speed of agitator detecting unit.
Described chemical analysis amount online detection unit comprises one or more in pH value detecting unit, ethanol content detecting unit, the ammonia content detecting unit.
Described automatic alarm unit comprises one or more in technology alarm unit and the security alarm unit.
Described control unit is regulated and control by monitoring software, and this monitoring software can be gathered data and/or the signal that above-mentioned each detecting unit detects, thereby aforementioned each unit is controlled.
Further, above-mentioned automatic checkout and control system can also comprise charging and go out material unit.
Described charging with go out material unit, comprise charging and discharging timing unit, inlet amount ratio unit, regulate and control by control unit.
Above-mentioned automatic production line of the present invention can also comprise manual control and control switch unit automatically.
Certainly, in the production of reality, as required, can select in the said units two or several; The unit of selecting can be identical, also can be different.
Liquid preparation of Chinese medicine automatic production line of the present invention, Chinese medicine is extracted, in the purified process, real-time detection and control have been realized fully, can realize the automatization of liquid preparation of Chinese medicine production process, guarantee the stable of product quality, reduce production costs, guarantee the safety of production process.
Description of drawings
Fig. 1 is the process chart of production line of the present invention.
Fig. 2 is temperature control loop sketch map among the present invention.
Fig. 3 is pH value control loop sketch map among the present invention.
Fig. 4 is the automatic sample analysis sketch map of index components among the present invention.
Fig. 5 is charging and discharging sequencing contro sketch map among the present invention.
Fig. 6 is inlet amount ratio control unit sketch map among the present invention.
Fig. 7 is the sketch map of each unit Detection ﹠ Controling operation of the present invention.
The specific embodiment
Below in conjunction with specific embodiment the present invention is done with detailed description, but be not in order to restriction the present invention.
Unit such as the liquid preparation of Chinese medicine production process mostly comprises extraction, concentrates, precipitate with ethanol, receipts alcohol, mixing, the part preparation also comprises the hydrolysis and the neutralisation unit of animal drugs.In order to make production line can embody the general flow of Chinese medicine production process, and form a rounded system, the production line that the present invention set up comprises extraction, hydrolysis, neutralization, concentrates, receives unit such as alcohol, precipitate with ethanol, mixing.Because upgrading unit all carries out in the decompression heater with recovery ethanol unit, therefore a unit is merged in two unit.
Extraction unit: be to carry out the covering device that Chinese crude drug extracts, comprise the piping filter composition of the extraction pot of be with heating jacket, stram condenser (playing solvent refluxing when adopting organic solvent extraction), extraction pot bottom extracting liquid outlet.Chinese crude drug is placed in the extraction pot, adds an amount of solvent (water or ethanol) that extracts, and extracts by the uniform temperature that is steam heated to of chuck.When adopting ethanol extraction, stram condenser is opened, with evaporable alcohol reflux to jar in.After extracting end, extracting solution enters the extracting solution storage tank from the extraction pot outlet through filter.What match with extraction unit has temperature, liquid level, speed of agitator detecting unit and an index composition online detection unit.
Hydrolysis unit: comprise the acid and alkali-resistance retort of being with heating jacket, Chinese crude drug adds wherein, adds acid (or alkali), is heated to uniform temperature, makes medical material be hydrolyzed into small-molecule substance.This unit contains temperature, liquid level, speed of agitator detecting unit and index components online detection unit.
Neutralisation unit: comprise the retort of acid and alkali-resistance, the acid after the hydrolysis/alkaline medicinal liquid adds wherein, neutralizes, and pH value is measured in the neutralization back.This unit pack contains the pH value detecting unit.
Said hydrolyzed and neutralisation unit are two comparatively special unit, just use when needing the medicine of hydrolysis.
Concentrate/reclaim the ethanol unit: Chinese medicine extraction liquid need carry out the precipitate with ethanol remove impurity, for reducing the ethanol consumption, needs earlier Chinese medicine extraction liquid to be concentrated into certain volume.Upgrading unit is a cover decompression heater, is made of concentration tank, vacuum pump and collection still.Feed liquid through the decompression heating, boils off large quantity of moisture in concentration tank.Concentrated solution needs evaporation recovery ethanol wherein after precipitate with ethanol is removed impurity, method adopts reduction vaporization with concentrated identical.This unit pack contains temperature, liquid level, pressure, gaseous ethanol content detection unit.
Precipitate with ethanol unit:, add a certain amount of ethanol, to remove macromole impurity wherein through spissated Chinese medicine extraction liquid.This unit comprises a jacket reactor and storage tank.Can carry out the detection of temperature, liquid level.
Mixed cell: in liquid preparation is produced, need sometimes different extracting solution are mixed by a certain percentage, related equipment is the agitator tank of band heating jacket.
Above-mentioned automatic checkout and control system is by technological parameter online detection unit, chemical analysis amount online detection unit, index components online detection unit, at least one in the alarm unit and control unit are formed automatically.
Above-mentioned technological parameter online detection unit is meant carries out online real-time detection to the every technological parameter in the production line production process, so that it maintains the optimum process state.The technological parameter that needs to detect mainly comprises heating unit retort temperature, vacuum unit retort vacuum, each retort liquid level.Comprising following unitary one or more:
(1) temperature detecting unit is a mounting temperature sensor in extraction pot, detect the difference of actual temperature and design temperature and pass the signal to control unit, if difference surpasses certain value, the aperture size that control unit will be regulated chuck steam inlet valve is adjusted the size of heating steam amount, finally makes actual temperature near design temperature.Promptly be online real-time measuring data, adopt the steam flow of control valve control water back, temperature is controlled in the scope of requirement according to temperature.It mainly comprises temperature control loop.Temperature control loop is use in the liquid preparation of Chinese medicine production line automatic control unit maximum, also is of paramount importance control loop.Temperature control loop utilization pid control algorithm makes the retort temperature remain on the target setting temperature by the aperture of regulating the heating steam valve.
(2) pressure sensing cell is the online real-time measuring data according to pressure, adopts the control converter to regulate the rotating speed of vacuum pump, pressure is controlled in the scope of requirement.
(3) the Level Detection unit is to provide liquid level data and be sent to control unit by the liquid level sensor that is installed on the tank body, if liquid level is lower than setting value, control unit can be opened inlet pipeline.Promptly be to adopt liquid level sensor to detect the interior liquid level of each retort, provide liquid level data in real time.
(4) speed of agitator detecting unit operator import the numerical value that needs in control unit, are controlled by the frequency of control unit control stirring motor, and show the numerical value of speed of agitator.Speed of agitator relates to extraction pot in the liquid preparation of Chinese medicine production line, acid hydrolysis jar, neutralizing tank, blending tank, Alcohol-settling tank totally five retort.In fact speed of agitator control be exactly to control the stirring motor rotating speed.Frequency Converter Control is adopted in motor speed control usually, changes motor electricity consumption frequency by converter and reduces rotating speed.Compare with the method that reduces motor speed by the method that reduces current of electric, frequency control has efficient height, the little advantage of motor infringement.According to the process characteristic of liquid preparation of Chinese medicine production line, project adopts two to drag five method control motor, that is to say by the approach of switch switching and controls five motor speeds respectively with two converters.
Above-mentioned chemical analysis amount online detection unit is meant carries out online real-time detection to every chemistry amount that needs to analyze in the production line production process, maintains in the optimum set point to control it.The chemical analysis amount that needs to detect comprises neutralization, mixed cell retort pH value and concentrates and reclaim unitary ammonia content of ethanol and ethanol content etc.Comprising following unitary one or more:
(1) the pH value detecting unit is the pH value that detects neutralization and mixed cell, and decision starts the sour pump of benefit or mends alkali pump according to the pH value testing result, makes the intermediate pH value in the retort reach setting value.It mainly comprises the pH value control loop.The pH value control loop relates to two retort in the liquid preparation of Chinese medicine automatic assembly line: neutralizing tank and blending tank.The unitary loop utilization of pH value Detection ﹠ Controling nonlinear control algorithm reaches retort by adjusting neutralizer (acid or alkali) valve switch and valve opening and finally reaches the target pH value.
(2) the ethanol content detecting unit is to adopt alcohol gas sensor to detect to reclaim ethanol unit concentration of ethanol, when concentration is lower than setting value, closes vacuum pipe and water back.
(3) the ammonia content detecting unit is the concentration that adopts the ammonia gas sensor to catch up with ammonia unit ammonia, when concentration is lower than setting value, closes vacuum pipe and water back.
Ethanol and ammonia content are controlled to be non-closed loop formula control, are open loop control.Whether the control of ethanol and ammonia content decides reaction to finish by detecting ethanol or ammonia concentration, when ethanol or ammonia concentration reach the concentration value of setting, then stops Steam Heating, the retort discharging.
Above-mentioned index components online detection unit is in the liquid preparation of Chinese medicine production line, and some retort is carried out the continuous sampling analysis.The sample connection of retort is connected with the index components on-line measuring device, and institute's collected specimens enters the index components on-line measuring device after flowing out from sample connection, reads component content information.Because directly the continuous sampling meeting causes the waste of material, the present invention has designed reverse-flow type and has sampled automatically.Being connected between index components online detection unit and the retort is designed to detachable.On retort, reserve sample connection, in the production process index components online detection unit is attached thereto, the micropump continuous running is carried out sample analysis according to formulating sampling period time opening sampling electromagnetic valve again with the concordance of material in material and the retort in the assurance return duct.Index components online detection unit gained data are transferred to control unit by the RS232 interface.
Above-mentioned automatic alarm unit comprises in the following unit one or more:
(1) the technology alarm unit is at liquid preparation of Chinese medicine production process technology parameter, and control unit has been set high limit and lower bound.When technological parameter superelevation limit or ultralowly report to the police in limited time, to guarantee the safe operation of product quality and production process.
(2) the security alarm unit is big at liquid preparation of Chinese medicine production process ethanol consumption, uses the many characteristics in unit to design.Ethanol is volatile, inflammable, explosive dangerous liquid, and alcohol vapour content reaches 3.5% and just may be detonated in the air, so liquid preparation of Chinese medicine production line alcohol vapour content detection is very important, and this is the necessary means that ensure safety in production.
Above-mentioned control unit, gather technological parameter (comprising temperature, pressure, liquid level) that above-mentioned each online detection unit transmits, chemical analysis amount (pH value, ethanol content, ammonia content), the index components data signal of sampling etc. automatically, then each unit is regulated and control.It is made up of computer and monitoring software.
Above-mentioned automatic checkout and control system can also comprise: the charging that can be regulated and control by above-mentioned control unit with go out material unit.
Above-mentioned charging with go out mode that material unit adopts negative pressure and carry out material and transmit, so the switching sequence control of related valve just seems extremely important when charging and discharging.According to the technological process of liquid preparation of Chinese medicine production line, charging and discharging unit comprise:
(1) charging and discharging timing unit mainly are input and output material valve and the vacuum tube valve switch sequential about correlated response jar and storage tank.To transmit material between following typical two jars is example, and the unit need be controlled electric switching valve 1-6 according to the sequential of strictness and open or close, and could guarantee that material safety transmits.
(2) input and output material ratio unit is when the charging of retort different batches also will be controlled adding proportion, except control, also to guarantee that feeding quantity meets technological requirement according to the switch of volume metering (liquid level mode) control different feeds pipeline to the correlation unit switch valve.
Further, automatic production line of the present invention can also comprise manual control and control switch unit automatically.Manually control is a function of monitoring software with controlling switch unit automatically.Under automatic control mode, detection signal and pre-set parameter that monitoring software is sent here pick off compare, and provide control signal, and control signal sends control valve to, realize parameter control.Under manual control model, the detected value of a monitoring software display parameters does not provide control signal, and the aperture of control valve is by manual adjustment.
There are two kinds of operator schemes in the liquid preparation of Chinese medicine production line: manual operation and control automatically.Generally all can adopt automatic control, finish production process at host computer by person skilled or operator.When automatic control unit fault or emergency, available manual operation replaces automatic control unit, to guarantee unit safety.
Automatic production line of the present invention can be used for the production of liquid preparation of Chinese medicine, certainly, also can be used for the leaching process of solid preparation of Chinese medicine.
Automatic production line of the present invention is particularly useful for the middle trial production of liquid preparation of Chinese medicine.
Below in conjunction with accompanying drawing the present invention is described in detail.
Fig. 1 is the process chart of production line of the present invention.As seen from Figure 1, liquid preparation of Chinese medicine automatic production line of the present invention comprises the extraction unit that connects successively with pipeline, concentrates/reclaim ethanol unit, precipitate with ethanol unit, mixed cell, can also comprise hydrolysis unit and neutralisation unit.Certainly, in actual production, said units can increase or removes according to different needs.
Fig. 2 is temperature control loop sketch map among the present invention.1 is that retort, 2 is that temperature sensor, 3 is that control unit, 4 is the heating steam valve.Temperature sensor 2 is installed on the retort 1, and retort 1 is the extraction pot of extraction unit, the hydrolytic decomposition pot of hydrolysis unit or concentrated/unitary concentration tank of recovery ethanol etc.Temperature sensor 2 detected temperature signals are transferred to control unit 3, setting value with temperature in control unit 3 compares, calculate the flow of heat medium according to comparative result, change heating medium flow by regulating heating steam valve 4 apertures, make the retort temperature remain on design temperature.Control unit is the monitoring software in the computer.Dotted line is represented the signal transmission among the figure, and solid line is represented the material transmission.
Fig. 3 is pH value control loop sketch map among the present invention.1-retort, 2-pH pick off, 3-control centre, 4-acid-alkali accommodation valve.PH pick off 2 is installed on the retort 1, pH pick off 2 detected pH signals are transferred to control unit 3, setting value with pH in control unit 3 compares, calculate the kind and the flow of the acid-alkali medium that should add according to comparative result, make by regulating acid-alkali accommodation valve 4 (acid or alkali) valve switch and valve opening that material finally reaches the setting pH value in the retort.Dotted line is represented the signal transmission among the figure, and solid line is represented the material transmission.
Fig. 4 is the automatic sample analysis sketch map of index components among the present invention.1-retort, 2-sampling electromagnetic valve, 3-detector, 4-micropump.Retort 1 sidewall connects bypass duct, and micropump 4 is installed on the pipeline.At production period, micropump 4 continuous runnings are taken a sample according to formulating sampling period time opening sampling electromagnetic valve 2 with the concordance of material in material and the retort 1 in the assurance return duct again, and sample liquid flows into detector 3 and detects.
Fig. 5 is charging and discharging sequencing contro sketch map among the present invention.1-retort 1,2-retort 2,3-retort 1 vacuum valve, 4-retort 1 outlet valve, 5-retort 2 vacuum valves, 6-retort 2 outlet valves, 7-control unit.Charging and discharging sequencing contro are mainly paid close attention to the input and output material valve and the vacuum tube valve switch sequential of correlated response jar.Accompanying drawing 5 is sent to the signal of retort 2 by retort 1 for material.After retort 1 finishes reaction, need material is sent to retort 2, guarantee that the vacuum valve 3 of retort 1 and the outlet valve 6 of retort 2 are in closed condition this moment, successively opens the vacuum valve 5 of retort 2 and the outlet valve 4 of retort 1, and material will flow into retort 2 by retort 1.After mass transport finishes, the outlet valve 4 of off-response jar 1 and the vacuum valve 5 of retort 2, can begin the operation in retort 2 this moment.The opening and closing of all valves provide instruction by control unit 7 and finish.
Fig. 6 is inlet amount proportion control sketch map among the present invention.1-retort 1,2-retort 2,3-retort 3,4-retort 1 vacuum valve, 5-retort 1 outlet valve, 6-retort 2 vacuum valves, 7-retort 2 outlet valves, 8-retort 3 vacuum valves, 9-retort 3 outlet valves, 10-liquid level sensor, 11-control unit.
When 1 retort need be added different material with certain proportion, will use charge proportion control.Enter retort 3 in varing proportions for the feed liquid in retort 1 and the retort 2 shown in Fig. 6.Two kinds of different feed liquid from retort 1 and retort 2 successively enter retort 3 according to the mode of input and output material sequencing contro respectively, and different feed liquid inlet amount is separately set in control unit 11.Liquid level sensor 10 is installed on the retort 3, and liquid level sensor 10 detects the liquid level of feed liquid in jar, and calculates the amount of feed liquid according to the relation between liquid level and the volume.The inlet amount that detects certain feed liquid when liquid level sensor 10 reaches preset value, promptly closes related valve, stops the conveying of this feed liquid.By the way, the switch of may command different feeds pipeline guarantees that feeding quantity meets technological requirement.
Fig. 7 is the sketch map of each unit Detection ﹠ Controling operation of the present invention.With the neutralizing tank is how the example explanation utilizes monitoring software to operate in control unit.
1) numeral in the white box needs the artificial setting value of importing in the interface, as
The setting value of the artificial input of expression speed of agitator is 90rpm,
Expression target setting pH value is 7.5, after input setting value and carriage return are errorless, further presses
Button, setting value can come into force.
2) numeral metrical information and the measured value in square frame not in the interface, as
The current measured value of expression pH is 6.9.
3) switching controls of white button indication switch, for example
Know
The control that can be respectively dosing pump and switch valve be opened or closed clicks button and opens, and then clicks the pass again.Its valve state can be judged by the valve color,
The expression valve closing,
The expression valve open.
4)
The controlled state of table automatic control loop when using manual control mode, needs manually valve opening to be operated; When using automatic control mode, valve opening is set by COMPUTER CALCULATION.When using automatic control mode, need artificial input goal setting value; During manual control mode, setting value lost efficacy.Whether automated manner uses and can be judged by setting value numerical value square frame, as
In numeral " 7.5 " back show " certainly ", the expression control operation is a computer controlled automatic,
In numeral " 7.5 " back show " hands ", expression is control manually.
Embodiment
The production of Radix Isatidis liquid preparation of Chinese medicine, subtractive process.
Therefore Radix Isatidis is a conventional Chinese medicine, and use is all arranged in many liquid preparation of Chinese medicine, and its extraction, subtractive process be the typical case comparatively, is example with the Radix Isatidis, and the operating process of production line is described.
Extraction, subtractive process device therefor are listed as follows.
The tabulation of table 1 apparatus for production line
| Sequence number | Title | Model | | Performance specification | |
| 1 | Extraction pot | TQ-100 | 1 | Swept volume 100L, the equipment atmospheric operation; The flame-proof converter motor, speed of agitator 100- |
|
| 2 | |
1 | |||
| 3 | The extracting solution basin | ZG-100 | 3 | Swept volume 100L, normal pressure equipment |
|
| 4 | Vacuum | 100L | 1 | Swept volume 100L, the equipment vacuumizing | |
| 5 | Alcohol-settling tank | JC-100 | 1 | Swept volume 100L, normal pressure equipment atmospheric operation; The flame-proof converter motor, speed of agitator 100-200rpm | |
| 6 | | 100L | 1 | ||
| 7 | | 100L | 1 | Swept volume 100L, normal pressure equipment atmospheric operation; The flame-proof converter motor, speed of agitator 100-200rpm | |
| 8 | The finished | 200L | 1 | Swept volume 100L, normal pressure equipment atmospheric operation |
| 9 | | 24KW | 1 | Running voltage 380V, electric thermal power 24KW, rated current 63A, rated capacity 34Kg/h, rated operating pressure 0.7MPa, 171 ℃ of saturated-steam temperatures | |
| 10 | Vacuum pump | SK-0.8 | 1 | Material Q235A | |
| 11 | | 50L | 1 | ||
| 12 | | 85L | 1 |
Processing step is as follows:
1, medical material decocts
Get Radix Isatidis medical material 10kg, put into the extraction pot of extraction unit, monitoring software is set and is added 6 times of water gagings, and amount of water is detected by the unitary liquid level sensor of Level Detection, and when amount of water arrived setting value, monitoring software control inlet valve was closed.It is 100 ℃ that monitoring software is set heating-up temperature, and temperature is detected by the temperature sensor of temperature detecting unit.Open the steam generator switch, when treating that steam pressure rises to 0.15MP, open the extraction pot steam valve, temperature clocks when rising to 100 ℃, decocts 1 hour.In decoction process, temperature can fluctuate, descend as temperature, temperature sensor is transferred to monitoring software on the computer with detected temperature data, monitoring software calculates the amount that the heating steam valve opening should increase according to speed and the decline degree that temperature descends, and this instruction is sent to the heating steam valve, valve can be held greatly, makes temperature recovery and maintains setting value.After decocting end, open vacuum pump and extracting solution storage tank vacuum valve, open the extraction pot bleeder valve, make extracting solution be drawn into fluid reservoir through filter.Add 4 times of water gagings again in extraction pot, similarity condition decocted 1 hour, and extracting solution is squeezed into the extracting solution storage tank after filtering equally.
2, extracting solution concentrates
Open concentrated/recovery unitary concentration tank inlet valve of ethanol and vacuum valve, open the fluid reservoir bleeder valve, with filtrate suction concentration tank, design temperature is 70 ℃, opens steam valve, and being concentrated into volume is 10L, stops to concentrate.The concentrated solution volume is detected by liquid level sensor.
3, precipitate with ethanol
Open unitary Alcohol-settling tank inlet valve of precipitate with ethanol and vacuum valve, open the concentration tank bleeder valve, concentrated solution is squeezed into Alcohol-settling tank, add ethanol and make that to contain the alcohol amount be 60%, precipitate with ethanol 24 hours is opened supernatant tank inlet valve and vacuum pump, open the Alcohol-settling tank bleeder valve, the precipitate with ethanol supernatant is squeezed into supernatant tank.
4, receive alcohol
Open to concentrate/reclaim unitary concentration tank inlet valve of ethanol and vacuum pump, open the supernatant tank bleeder valve, the precipitate with ethanol supernatant is squeezed into concentration tank, design temperature is 70 ℃, opens steam valve, reclaims ethanol, is lower than 10ppm to concentration of alcohol, stops to concentrate.Concentration of alcohol is detected by ethanol sensor.
5, decolouring
Open bleacher inlet valve and vacuum valve, open the concentration tank bleeder valve, will receive pure liquid and squeeze into bleacher, add 1% medicinal carbon, setting heating-up temperature is 100 ℃, opens the bleacher steam valve, and temperature clocks when rising to 100 ℃, heats 15 minutes.Decolouring is opened vacuum pump and finished product jar vacuum valve after finishing, and opens the bleacher bleeder valve, makes destaining solution be drawn into the finished product jar through filter, and is standby.
In above-mentioned production process, when the deviation of temperature value with setting value generation 0.5%, the heating steam valve is promptly started working, and makes whole technical process maintain comparatively stable status as far as possible.Carry out 5 batches and extract experiment on this production line, the scope of total nitrogen concentration is 9.12～9.75mg/ml in the extracting solution, and fluctuation range is 6.68%.Carry out same experiment on the automatic production equipment that is unrealized, the scope that obtains total nitrogen concentration is 8.15～10.61mg/ml, and its fluctuation range is 26.23%.This result shows, the stability that automatic production line of the present invention can improve the quality of products greatly.
Claims (7)
1. liquid preparation of Chinese medicine automatic production line, it is characterized in that, it comprises Chinese crude drug is extracted, the purified extraction unit that connects with pipeline, concentrates/reclaim ethanol unit, precipitate with ethanol unit, mixed cell, thus also comprise be connected with above-mentioned each unit above-mentioned each unit is detected automatic checkout and control system that above-mentioned each unit is regulated and control automatically.
2. liquid preparation of Chinese medicine automatic production line according to claim 1 is characterized in that, can also comprise hydrolysis unit and neutralisation unit.
3. liquid preparation of Chinese medicine automatic production line according to claim 1 and 2, it is characterized in that above-mentioned automatic checkout and control system comprises technological parameter online detection unit, chemical analysis amount online detection unit, index components online detection unit, at least one in the alarm unit and control unit are formed automatically.
4. liquid preparation of Chinese medicine automatic production line according to claim 3, it is characterized in that, described technological parameter online detection unit comprises one or more in temperature detecting unit, pressure sensing cell, Level Detection unit, the speed of agitator detecting unit; Described chemical analysis amount online detection unit comprises one or more in pH value detecting unit, ethanol content detecting unit, the ammonia content detecting unit; Described automatic alarm unit comprises one or more in technology alarm unit and the security alarm unit.
5. liquid preparation of Chinese medicine automatic production line according to claim 3 is characterized in that described control unit is regulated and control by monitoring software.
6. liquid preparation of Chinese medicine automatic production line according to claim 3, it is characterized in that, above-mentioned automatic checkout and control system can also comprise charging and go out material unit, this charging and discharging unit comprise charging and discharging timing unit, inlet amount ratio unit, regulate and control by control unit.
7. liquid preparation of Chinese medicine automatic production line according to claim 1 and 2 is characterized in that, can also comprise manual control and control switch unit automatically.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810090656.1A CN101249042B (en) | 2008-04-07 | 2008-04-07 | Chinese medicine liquid formulation automatic production line |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810090656.1A CN101249042B (en) | 2008-04-07 | 2008-04-07 | Chinese medicine liquid formulation automatic production line |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101249042A true CN101249042A (en) | 2008-08-27 |
| CN101249042B CN101249042B (en) | 2015-05-20 |
Family
ID=39952760
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200810090656.1A Expired - Fee Related CN101249042B (en) | 2008-04-07 | 2008-04-07 | Chinese medicine liquid formulation automatic production line |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101249042B (en) |
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102109846A (en) * | 2011-03-01 | 2011-06-29 | 南昌弘益科技有限公司 | Intelligent automated control method for traditional Chinese medicine production |
| CN102128800A (en) * | 2010-12-16 | 2011-07-20 | 东莞广州中医药大学中医药数理工程研究院 | Method and device for online detection in traditional Chinese medicine extracting process |
| CN102566524A (en) * | 2010-12-27 | 2012-07-11 | 四川恩威制药有限公司 | Production control method for Chinese medicine extraction tank |
| CN102566620A (en) * | 2010-12-27 | 2012-07-11 | 四川恩威制药有限公司 | Double-temperature sensor control method for traditional Chinese medicine extracting tank |
| CN103628709A (en) * | 2013-12-05 | 2014-03-12 | 云南昆船设计研究院 | Pretreatment processing technology layout structure for traditional Chinese medicine |
| WO2014114108A1 (en) * | 2013-01-25 | 2014-07-31 | 四川川大华西药业股份有限公司 | Chinese herbal medicine shengmai injectant production line |
| CN104524790A (en) * | 2014-12-24 | 2015-04-22 | 安徽华润金蟾药业股份有限公司 | Device and method for maintaining stable vacuum degree in concentrating process of traditional Chinese medicinal granules |
| CN105434172A (en) * | 2016-01-08 | 2016-03-30 | 严修长 | Automatic traditional Chinese medicine decocting system |
| CN105784778A (en) * | 2016-05-25 | 2016-07-20 | 安徽华润金蟾药业股份有限公司 | System and method for judging terminal point of cinobufagin ethanol recycling section |
| CN105842195B (en) * | 2016-03-24 | 2018-12-14 | 安徽华润金蟾药业股份有限公司 | The judgment method of cream terminal is received in cinobufagin concentration |
| CN110917034A (en) * | 2019-12-05 | 2020-03-27 | 广东容大生物股份有限公司 | Animal remedy manufacturing installation of chinese medicine composition |
| CN113413417A (en) * | 2020-12-25 | 2021-09-21 | 江中药业股份有限公司 | Peony and licorice soup granule and preparation method thereof |
| CN113509386A (en) * | 2021-09-10 | 2021-10-19 | 江西中医药大学 | Decoction monitoring method and device, electronic equipment and storage medium |
| CN115999173A (en) * | 2023-01-30 | 2023-04-25 | 广东青云山药业有限公司 | Intelligent control method and system for continuous low-temperature concentration device of red sage root |
| CN117234168A (en) * | 2023-11-13 | 2023-12-15 | 山东天振药业有限公司 | Intelligent management system for liquid veterinary medicine production workshop |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2738791Y (en) * | 2004-10-18 | 2005-11-09 | 黑龙江迪尔制药机械有限责任公司 | Round-pill device for finishing pills |
| CN1846663A (en) * | 2005-04-11 | 2006-10-18 | 王成东 | Modern Chinese medicine producing line |
| CN101032447B (en) * | 2007-04-10 | 2011-02-16 | 浙江大学 | Alcohol precipitating method and device based on the principle of hydraulic cyclone |
-
2008
- 2008-04-07 CN CN200810090656.1A patent/CN101249042B/en not_active Expired - Fee Related
Cited By (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102128800A (en) * | 2010-12-16 | 2011-07-20 | 东莞广州中医药大学中医药数理工程研究院 | Method and device for online detection in traditional Chinese medicine extracting process |
| CN102128800B (en) * | 2010-12-16 | 2012-12-05 | 东莞广州中医药大学中医药数理工程研究院 | Method and device for online detection in traditional Chinese medicine extracting process |
| CN102566524A (en) * | 2010-12-27 | 2012-07-11 | 四川恩威制药有限公司 | Production control method for Chinese medicine extraction tank |
| CN102566620A (en) * | 2010-12-27 | 2012-07-11 | 四川恩威制药有限公司 | Double-temperature sensor control method for traditional Chinese medicine extracting tank |
| CN102109846A (en) * | 2011-03-01 | 2011-06-29 | 南昌弘益科技有限公司 | Intelligent automated control method for traditional Chinese medicine production |
| WO2014114108A1 (en) * | 2013-01-25 | 2014-07-31 | 四川川大华西药业股份有限公司 | Chinese herbal medicine shengmai injectant production line |
| CN103628709A (en) * | 2013-12-05 | 2014-03-12 | 云南昆船设计研究院 | Pretreatment processing technology layout structure for traditional Chinese medicine |
| CN103628709B (en) * | 2013-12-05 | 2016-01-13 | 云南昆船设计研究院 | A kind of Chinese crude drug pre-treatment processing technique layout structure |
| CN104524790A (en) * | 2014-12-24 | 2015-04-22 | 安徽华润金蟾药业股份有限公司 | Device and method for maintaining stable vacuum degree in concentrating process of traditional Chinese medicinal granules |
| CN104524790B (en) * | 2014-12-24 | 2015-12-09 | 安徽华润金蟾药业股份有限公司 | A kind of Chinese medicinal granule concentration process maintains the device and method of vacustat |
| CN105434172A (en) * | 2016-01-08 | 2016-03-30 | 严修长 | Automatic traditional Chinese medicine decocting system |
| CN105842195B (en) * | 2016-03-24 | 2018-12-14 | 安徽华润金蟾药业股份有限公司 | The judgment method of cream terminal is received in cinobufagin concentration |
| CN105784778A (en) * | 2016-05-25 | 2016-07-20 | 安徽华润金蟾药业股份有限公司 | System and method for judging terminal point of cinobufagin ethanol recycling section |
| CN105784778B (en) * | 2016-05-25 | 2018-08-10 | 安徽华润金蟾药业股份有限公司 | A kind of cinobufagin ethyl alcohol recycle section endpoint system and method |
| CN110917034A (en) * | 2019-12-05 | 2020-03-27 | 广东容大生物股份有限公司 | Animal remedy manufacturing installation of chinese medicine composition |
| CN113413417A (en) * | 2020-12-25 | 2021-09-21 | 江中药业股份有限公司 | Peony and licorice soup granule and preparation method thereof |
| CN113509386A (en) * | 2021-09-10 | 2021-10-19 | 江西中医药大学 | Decoction monitoring method and device, electronic equipment and storage medium |
| CN115999173A (en) * | 2023-01-30 | 2023-04-25 | 广东青云山药业有限公司 | Intelligent control method and system for continuous low-temperature concentration device of red sage root |
| CN115999173B (en) * | 2023-01-30 | 2024-01-26 | 广东青云山药业有限公司 | Intelligent control method and system for continuous low-temperature concentration device of red sage root |
| CN117234168A (en) * | 2023-11-13 | 2023-12-15 | 山东天振药业有限公司 | Intelligent management system for liquid veterinary medicine production workshop |
| CN117234168B (en) * | 2023-11-13 | 2024-01-26 | 山东天振药业有限公司 | Intelligent management system for liquid veterinary medicine production workshop |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101249042B (en) | 2015-05-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101249042A (en) | Chinese medicine liquid formulation automatic production line | |
| CN101477843B (en) | High temperature high pressure water circulation system | |
| CN104474988B (en) | A kind of automatic control method neutralizing reaction unit | |
| CN105435716A (en) | SCWO (supercritical water oxidation) reaction control system | |
| CN203493930U (en) | Traditional Chinese medicine extraction process production device | |
| CN102603144B (en) | Subcritical hydrothermal equipment for sludge treatment | |
| CN103173593A (en) | Molten steel vacuum refining system based on mechanical pump group | |
| CN201386100Y (en) | Biogas experiment device with function of pressure automatic control | |
| CN104787877B (en) | One way of life sewage recycling treatment method and device | |
| CN202315405U (en) | Automatic liquid medicine extracting control system based on proportion integration differentiation (PID) control | |
| CN201359593Y (en) | High-temperature and high-pressure water circulating system | |
| CN2909009Y (en) | On-line monitoring device for boiler explosion-proof | |
| CN101352618B (en) | Extraction system for continuously extracting effective ingredients in plant | |
| CN201042717Y (en) | Castoff processing equipment | |
| CN207276584U (en) | A kind of fragrant plant hydrosol extraction of essential oil system | |
| CN203525348U (en) | Self-control production system of traditional Chinese medicines | |
| CN100589862C (en) | System for continuously extracting effective ingredients in plant | |
| CN102419548B (en) | The medicinal liquid that waste water residual heat recycles extracts concentration automatic control system and method | |
| CN205127912U (en) | Supercritical water oxidization reaction control system | |
| CN205420242U (en) | Furfural cleaner production assembly line | |
| CN2760537Y (en) | Differential pressure type extractor | |
| CN104876408B (en) | Method for sludge treatment, system | |
| CN209383432U (en) | A kind of energy-saving distilling water process units | |
| CN111056542A (en) | Method and device for preparing trichloro-sulfur phosphorus | |
| CN203825499U (en) | Electrical temperature linkage control system for using heat transfer oil to heat chemical reactor |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20180802 Address after: 071200 No. 12, South Ring Road, modern Chinese medicine industrial park, Anguo City, Hebei Patentee after: HEBEI XINMINHE MEDICINE TECHNOLOGY DEVELOPMENT Co.,Ltd. Address before: 100029, No. 11 East Third Ring Road, Chaoyang District, Beijing Patentee before: Beijing University of Chinese Medicine |
|
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20150520 |