WO2014114108A1

WO2014114108A1 - Chinese herbal medicine shengmai injectant production line

Info

Publication number: WO2014114108A1
Application number: PCT/CN2013/084551
Authority: WO
Inventors: 刘娅; 姚喆; 刘兴萍; 郜宁
Original assignee: 四川川大华西药业股份有限公司
Priority date: 2013-01-25
Filing date: 2013-09-28
Publication date: 2014-07-31

Abstract

A Chinese herbal medicine Shengmai injectant production line, comprising: a Chinese herbal medicine extraction device, a sterile medicinal liquid transfer device, and a refined Chinese herbal medicine Shengmai injectant formulation device. The production line can complete the production of the Chinese herbal medicine injectant, including medicinal liquid extraction, transportation and formulation.

Description

Traditional Chinese medicine Shengmai injection production line

The invention relates to a traditional Chinese medicine production device, in particular to a traditional Chinese medicine Shengmai injection liquid production line.

Background technique

The production of traditional Chinese medicine injection includes the process of extracting, transporting and preparing the liquid; the extraction method is a common method for separating the active ingredients of Chinese herbal medicines. The existing Chinese herbal medicine extraction device generally adopts Chinese herbal medicine extraction tank, and the production cycle is long. The production efficiency is low and the production cost is high. Continuous extraction, as a means of energy saving, environmental protection and high efficiency saving in Chinese herbal medicine extraction, has received more and more attention and adoption.

After the liquid medicine is extracted, the semi-finished Chinese medicine solution needs to be stored or transferred to the next station. Generally, the liquid medicine is first transferred to the storage tank, then the storage tank is moved to the desired position, and then the liquid medicine is removed. In this process, the pipes and storage tanks in contact with the liquid have some bacteria. If they are not sterilized, the liquid will be contaminated.

The preparation of traditional Chinese medicine injection is based on a variety of traditional Chinese medicine extracts and traditional Chinese medicine slips. After dilution, the traditional Chinese medicine injections are formed by mixing together in a certain ratio. The existing method is to weigh according to each type of extract raw materials. The steps of dilution and impurity removal are carried out separately, and all the ingredients of the formula are mixed together. The transfer process is complicated, the process is complicated, the production efficiency is low, and the product quality is difficult to control.

Summary of the invention

The invention aims to provide a production line of traditional Chinese medicine Shengmai injection, which is used for completing the production of traditional Chinese medicine injection, including the extraction, transportation and preparation of the liquid medicine, and the devices are arranged reasonably, the production efficiency is high, and the product quality is improved. In order to achieve the above object, the present invention is achieved by the following technical solutions:

The traditional Chinese medicine Shengmai injection production line disclosed by the invention comprises a Chinese herbal medicine material extraction device, a chemical liquid aseptic transfer device, and a traditional Chinese medicine Shengmai injection liquid refining liquid distribution device.

Further, the Chinese medicinal material extraction device includes a heating container, a storage container, an extraction container, and a condensing device; the heating container is provided with an interlayer that is not in communication with the inner cavity thereof, and the interlayer is provided with a steam inlet; a liquid pipe and a first gas pipe are connected to the heating container, the top of the storage container is provided with a solvent inlet, and the bottom is provided with a liquid medicine outlet; the top of the extraction container is provided with a second gas pipe connected to the top of the storage container, and the bottom of the container is extracted a second liquid conduit is disposed in communication with a lower portion of the storage container, the inside of the extraction container is provided with a sieve plate to divide the inner cavity into upper and lower portions, and the extraction container is provided with a closable feed door above the sieve plate; the condensation device A position on the second gas pipe that is close to the extraction container.

Preferably, the horizontal position of the first gas pipe is higher than the sieve plate, the first liquid pipe, and the second liquid pipe, and the horizontal position of the extract liquid outlet is lower than the first liquid pipe, the second liquid pipe, and the first liquid The pipeline is disposed at a bottom position of the heating vessel; the solvent inlet, the extract liquid outlet, and the second liquid pipeline are all provided with a shut-off valve; and the condensing device is connected in series by two circulating water condensers.

Further, the medical liquid aseptic transfer device comprises a steam tube, a moving tank, a liquid medicine extraction tank, a storage tank, a top of the moving tank is provided with a feeding port a, a feeding port a is connected with the tee pipe A, and the moving tank is a bottom of the shutoff valve a is connected to the three-way pipe B, and the liquid chemical extraction tank is provided with a discharge port b with a shut-off valve b, The other end of the shutoff valve b is connected to the tee pipe C, and the top of the tank has a pipe a with a shutoff valve c, the tank is provided with a pipe b with a vacuum pump, and the other end of the pipe b is connected with a cutoff Valve d, the other end of the shut-off valve d is connected with a three-way pipe D, all of which have a shut-off valve; the sterilization treatment before the liquid medicine is moved into the moving tank and before the liquid medicine is removed from the moving tank are respectively the following two One of the connection methods: The first type of connection, the connection of the liquid medicine into the sterilization process before moving the can, the tee

The two nozzles of A are respectively connected to the steam pipe and the chemical liquid extraction tank;

The second connection mode is that the liquid medicine is removed from the connection during the sterilization process before moving the tank, and the two nozzles of the three-way pipe B are respectively connected to the steam pipe and the three-way pipe D, and the other end of the shut-off valve c is connected to the steam pipe. .

Preferably, the moving can has three supporting legs with rollers; the first connection manner further includes: a B-end of the three-way pipe at the discharge port a and another port of the three-way pipe C The water outlet pipe is connected to a water temperature meter a; the second connection mode further includes: the other port of the three-way pipe D is connected to the water outlet pipe b, and the water outlet pipe b is connected to a temperature. Table b; all pipes are metal hoses.

Further, the traditional Chinese medicine Shengmai injection refining and dispensing device comprises at least one set of weighing, diluting and removing devices for the extract, at least one set of weighing device for the slipping liquid, and a mixing weighing and diluting device. The weighing, diluting and removing device for the single product of the extract comprises a storage tank, a dilution tank, a refrigerating tank and a decontamination tank which are sequentially connected by a pipe and a pump, and the diluting tank is provided with a first water inlet and a first agitator And a weighing device comprising: a liquid storage tank connected by a pipe and a pump, a slip weighing tank; the mixing weighing and dilution device comprising a mixing tank connected in series through a pipe and a pump, a batch tank and a finished tank, wherein the mixing tank is further connected with a de-mixing tank and a liquid-sweet weighing tank through a pipe and a pump, and the mixing tank is provided with a second agitator and a weighing device, wherein the finished tank is provided with a second water inlet, The third agitator, the discharge port and the weighing device.

Preferably, the pump between the storage tank and the dilution tank is a peristaltic pump; the refrigerating tank is connected to the pipeline at the top of the pipeline.

The traditional Chinese medicine Shengmai injection production line disclosed by the invention has the following beneficial effects:

1. The solvent extraction is used to realize the continuous extraction of Chinese herbal medicines. The solvent circulation mode adopts the gaseous circulation, which makes the solvent purity of Chinese herbal medicines higher, which is beneficial to the diffusion of Chinese herbal medicines. Thereby shortening the production cycle, improving production efficiency, energy saving and environmental protection.

2. Effectively avoid bacterial contamination of the drug during transport.

3. Complete multiple processes of liquid medicine injection in one time to improve production efficiency and improve product quality.

DRAWINGS

Figure 1 is a schematic view showing the structure of a Chinese herbal medicine extracting device of the present invention;

2 is a schematic structural view of a first connection mode of the medical liquid aseptic transfer device of the present invention; FIG. 3 is a schematic structural view of a second connection mode of the medical liquid aseptic transfer device of the present invention; Schematic diagram of the structure of the refined liquid dispensing device;

In the figure: 1-heating vessel, 2-interlayer, 3-steam inlet, 4-storage vessel, 5-drug outlet, 6-stop valve, 7-solvent inlet, 8-stop valve, 9-extraction vessel, 10- Sieve plate, 11-feed gate, 12-condenser, 13-first liquid pipe, 14-first gas pipe, 15-second liquid pipe, 16-stop valve, 17-second gas pipe, 18-steam Tube, 19-moving tank, 20-feed port a, 21-discharge port a, 22-stop valve a, 23-way tube A, 24-way tube B, 25-chemical extraction tank, 26- Storage tank, 27-temperature gauge a, 28-discharge port b, 29-stop valve b, 30-way tube C, 31-stop valve c, 32-pipe a, 33-vacuum pump, 34-pipe b, 35 - Globe valve d, 36-way pipe D, 37-outlet pipe a, 38-outlet pipe b, 39-temperature gauge b, 40-storage tank, 41-pump, 42-dilution tank, 43-first agitator , 44-refrigerator, 45-depletion tank, 46-slip storage tank, 47-slip weighing tank, 48-first water inlet, 49-mixing tank, 50-second mixer, 51-batch Can, 52-finished can, 53-third agitator, 54-outlet, 55-second inlet.

detailed description

In order to make the objects, technical solutions, and advantages of the present invention more comprehensible, the present invention will be further described in detail with reference to the accompanying drawings. An embodiment of the traditional Chinese medicine Shengmai injection production line disclosed by the invention comprises a Chinese medicinal material extraction device, a chemical liquid aseptic transfer device, and a traditional Chinese medicine Shengmai injection refined liquid distribution device.

As shown in Figure 1, the Chinese medicinal material extraction device comprises a heating container 1, a storage container 4, an extraction container 9, and a condensing device 12; the heating container 1 is provided with a sandwich 2 that is not in communication with its inner cavity, and the interlayer 2 is provided with a steam inlet 3; The container 4 is connected to the heating container 1 through the first liquid pipe 13 and the first gas pipe 14, the top of the storage container 4 is provided with a solvent inlet 7, and the bottom is provided with a liquid medicine outlet 5; the top of the extraction container 9 is provided with a second gas pipe 17 and The top of the storage container 4 is in communication, and the second liquid pipe 15 is disposed at the bottom of the extraction container 9 to communicate with the lower portion of the storage container 4. The inside of the extraction container 9 is provided with a sieve plate 10 to divide the inner cavity into upper and lower portions, and the extraction container 9 is Located above the sieve plate 10 is provided a closable feed door 11; the condensing device 12 is disposed on the second gas pipe 17 near the extraction vessel 9; the horizontal position of the first gas conduit 14 is higher than the sieve plate 10, the first liquid The pipe 13, the second liquid pipe 15, the horizontal position of the extract liquid outlet 5 is lower than the first liquid pipe 13, the second liquid pipe 15, the first liquid pipe 13 is disposed at a bottom position of the heating vessel 1; the solvent inlet 7, the extracting liquid outlet 5, and the second liquid conduit 15 are each provided with a shut-off valve; and the condensing device 12 is connected in series by two circulating water condensers.

The working process of the Chinese herbal medicine extracting device is: closing the liquid medicine outlet 5, the shut-off valve 6 on the second liquid pipe 15, and 16, after adding the Chinese herbal medicine raw material to the sieve plate 10 from the feeding door 11, closing the feeding door 11, opening the solvent The shut-off valve 8 on the inlet 7 is filled with a suitable amount of solvent, and the shut-off valve 8 is closed. The steam is introduced into the interlayer 2 through the steam inlet 3, and the solvent in the heating vessel 1 is heated to become a gas after passing through the first gas conduit 14 and the second gas conduit 17. After being condensed into a liquid state by the condensing device 12, it enters the extraction container 9, and when the solvent in the extraction container 9 reaches a set amount, the shut-off valve 16 on the second liquid pipe 15 is opened, thereby forming a working mode of solvent circulation; when the liquid is completed, the liquid medicine is opened. The shut-off valve 6 on the outlet 5 takes out the liquid medicine. As shown in FIG. 2, the sterilizing treatment of the chemical liquid aseptic transfer device before the chemical liquid is moved into the moving tank 19 includes a steam tube 18, a moving tank 19, a liquid medicine extracting tank 25, a storage tank 26, and the top of the moving tank 19 A feed port a20 is provided, and a feed port a20 is connected to the tee pipe A23. The bottom of the moving tank 19 is provided with a discharge port a21 with a shut-off valve a22, and the other end of the shut-off valve a22 is connected with a tee pipe B24. The chemical liquid extraction tank 25 is provided with a discharge port b28 with a shut-off valve b29, the other end of which is connected to a three-way pipe C30, and a pipe a32 having a shut-off valve c31 is arranged at the top of the storage tank 26, The tank 26 is provided with a pipe b34 with a vacuum pump 33, the other end of the pipe b34 is connected with a shut-off valve d35, and the other end of the shut-off valve d35 is connected with a three-way pipe D36, all of which have a shut-off valve; The two nozzles of the three-way pipe A23 are respectively connected to the steam pipe 18 and the chemical liquid extraction tank 25; the other end of the three-way pipe B24-end and the three-way pipe C30 at the discharge port a21 are connected On the water pipe a37, the water outlet pipe a37 is connected to a temperature gauge a27. Sterilization can be achieved by switching the valve to high temperature steam.

As shown in FIG. 3, the sterilization operation of the chemical liquid aseptic transfer device before the chemical liquid is transferred from the moving can 19 to the storage tank 26 includes a steam pipe 18, a moving tank 19, a chemical liquid extraction tank 25, and a storage tank 26, The top of the moving tank 19 is provided with a feeding port a20, the feeding port a20 is connected to the tee pipe A23, the bottom of the moving tank 19 is provided with a discharge port a21 with a shut-off valve a22, and the other end of the shut-off valve a22 is connected with a tee a tube B24, the liquid medicine extraction tank 25 is provided with a discharge port b28 with a shut-off valve b29, the other end of the shut-off valve b29 is connected with a three-way pipe C30, and the top of the storage tank 26 has a shut-off valve c31 a pipe a32, the storage tank 26 is provided with a pipe b34 with a vacuum pump 33, the other end of the pipe b34 is connected with a shut-off valve d35, and the other end of the shut-off valve d35 is connected with a three-way pipe D36, all of which are provided There is a shut-off valve; the two nozzles of the three-way pipe B24 are respectively connected to the steam pipe 18 and the three-way pipe D36, and the other end of the shut-off valve c31 is connected to the steam pipe 18, and the other pipe of the three-way pipe D36 is connected The water pipe b38 is connected to a temperature meter b39. Through the opening and closing of the valve, high temperature steam can be passed to achieve sterilization effect. fruit.

As shown in Fig. 4, the Chinese medicine Shengmai injection refining and dispensing device comprises: at least one set of single weighing, diluting and removing devices for the extract, at least one set of measuring device for the slipping liquid and the mixing weighing and diluting device The weighing, diluting and removing device for the extracting product includes a storage tank 40, a dilution tank 42, a refrigerating tank 44, and a decontamination tank 45 which are sequentially connected by a pipe and a pump, and the dilution tank 42 is provided with a first water inlet. 48. The first agitator 43 and the weighing device; the weighing device for the slipping liquid comprises a liquid storage tank 46 connected by a pipe and a pump, and a slip weighing tank 47; the mixing weighing and diluting device comprises sequentially passing the pipeline and the pump The mixing tank 49, the batch tank 51, the finished tank 52, the mixing tank 49 are also connected to the de-mixing tank 45 and the slip weighing tank 47 through a pipe and a pump, and the mixing tank 49 is provided with a second agitator 50 and a weighing device. The finished product tank 52 is provided with a second water inlet 55, a third agitator 53, a discharge port 54 and a weighing device; the pump 41 between the storage tank 40 and the dilution tank 42 is a peristaltic pump; the position of the refrigerating tank 44 connected to the pipeline Both are at the top.

The specific use method of the traditional Chinese medicine Shengmai injection refining and dispensing device is as follows: The storage tank 40 is used for storing the traditional Chinese medicine extract, and the traditional Chinese medicine extract is transported to the dilution tank 42 by the peristaltic pump 41, and the dilution tank 42 weighs the weight of the traditional Chinese medicine extract. Distilled water is added from the first water inlet 48 according to a certain ratio, and is uniformly stirred into a refrigerating tank 44 by the first agitator 43 and then sent to the refrigerating tank 44 for refrigerating. The refrigerated Chinese medicine liquid is then sent to the decontamination tank 45 for decontamination. After obtaining the refined liquid; three kinds of refined liquids (such as red ginseng, Ophiopogon japonicus and Schisandra) and the slick (such as Schisandra slick) weighed through the slick weighing tank 47 are passed through the pipeline. And pumping to the mixing tank 49 for mixing and mixing uniformly, and then passing part of the traditional Chinese medicine liquid (usually half) through the batch tank 51 to the finished product tank 52, weighing, adding distilled water (adding through the second water inlet 55), After stirring, the required traditional Chinese medicine injection is formed, and finally the Chinese medicine injection is obtained through the discharge port 54.

The invention completes the liquid medicine extraction of the traditional Chinese medicine Shengmai injection, the aseptic transfer of the medical liquid, the refining and preparation of the chemical liquid through the use of the above three devices, and has high production efficiency, safety and hygiene, and good quality. Good social and economic benefits.

Of course, the present invention may be embodied in various other various modifications and changes without departing from the spirit and scope of the invention. Modifications are intended to fall within the scope of the appended claims. Industrial applicability

The invention adopts the solvent circulation method to realize the continuous extraction of the Chinese medicinal materials, and the solvent circulation mode adopts the monthly gaseous state circulation, so that the solvent purity of the Chinese medicinal materials is high, which is beneficial to the dispersion of the medicinal materials of the Chinese medicinal materials, thereby shortening the production cycle and improving the production efficiency. , Energy saving and environmental protection. At the same time, it effectively prevents bacterial contamination during drug transfer. And it can complete multiple processes of Chinese medicine injection liquid dispensing in one time, improve production efficiency and improve product quality. It can be seen that the invention has a good application prospect and is suitable for wide application in engineering.

Claims

1. Traditional Chinese medicine Shengmai injection production line, which is characterized by: including Chinese herbal medicine extraction device, chemical liquid non-bacterial transfer device, and Chinese medicine Shengmai injection refined liquid distribution device.

The Chinese medicine Shengmai injection production line according to claim 1, wherein the Chinese herbal medicine extraction device comprises a heating container (1), a storage container (4), an extraction container (9), and a condensing device.

(12); the heating vessel (1) is provided with an interlayer (2) that is not in communication with its inner cavity, the interlayer (2) is provided with a steam inlet (3); the storage container (4) passes through the first liquid conduit (13) and the first gas pipe (14) is connected to the heating container (1), the top of the storage container (4) is provided with a solvent inlet (7), and the bottom is provided with a liquid medicine outlet (5); the extraction container (9) The top is provided with a second gas pipe (17) communicating with the top of the storage container (4), and the bottom of the extraction container (9) is provided with a second liquid pipe (15) communicating with the lower portion of the storage container (4), the extraction container (9) The inside is provided with a sieve plate (10) separating the inner cavity into upper and lower portions, and the extraction container (9) is provided with a closable feeding door (11) above the sieve plate (10); the condensing device (12) ) Positioned on the second gas pipe (17) close to the extraction vessel (9).

The traditional Chinese medicine Shengmai injection production line according to claim 2, wherein: the horizontal position of the first gas pipe (14) is higher than the sieve plate (10), the first liquid pipe (13), and the second a liquid pipe (15), the horizontal position of the extract liquid outlet (5) is lower than the first liquid pipe (13), the second liquid pipe (15), and the first liquid pipe (13) is disposed in the heating container (1) The bottom position; the solvent inlet (7), the extract outlet (5), and the second liquid conduit (15) are each provided with a shut-off valve; and the condensing device (12) is connected in series by two circulating water condensers.

The traditional Chinese medicine Shengmai injection production line according to claim 1, wherein: the medical liquid aseptic transfer device comprises a steam tube (18), a moving tank (19), a liquid medicine extraction tank (25), Storage tank

(26), the top of the moving tank (19) is provided with a feed port a (20), and the feed port a (20) is connected to three Through the pipe A (23), the bottom of the moving tank (19) is provided with a discharge port a (21) with a shut-off valve a (22), and the other end of the shut-off valve a (22) is connected to the tee pipe B ( 24), the liquid extraction tank (25) is provided with a discharge port b (28) with a shut-off valve b (29), and the other end of the shut-off valve b (29) is connected to the tee C (30) The top of the storage tank (26) has a pipe a (32) with a shut-off valve c (31), and the storage tank (26) is provided with a pipe b (34) with a vacuum pump (33), the pipe The other end of b (34) is connected with a shut-off valve d (35), and the other end of the shut-off valve d (35) is connected with a three-way pipe D (36), all of which have a shut-off valve; The sterilization process before the tank (19) and before the liquid medicine moves out of the moving tank (19) is one of the following two connection methods:

The first connection method is to connect the liquid medicine into the sterilization process before the moving tank (19), and the two nozzles of the three-way tube A (23) are respectively connected to the steam tube (18) and the liquid medicine extraction tank ( 25);

In the second connection mode, the connection of the liquid medicine before the sterilization process is removed from the moving tank (19), and the two nozzles of the three-way pipe B (24) are respectively connected to the steam pipe (18) and the three-way pipe D ( 36), the other end of the shutoff valve c (31) is connected to the steam pipe (18).

The traditional Chinese medicine Shengmai injection production line according to claim 4, wherein: the moving can (19) has three support legs with rollers; the first connection manner further includes: The end of the tee B (24) at the port a (21) and the other port of the tee C (30) are connected to the outlet pipe (37), and the outlet pipe (37) is connected to a temperature gauge a (27); the second connection manner further includes: the other port of the three-way pipe D (36) is connected to the water outlet pipe b (38), and the water outlet pipe b (38) is connected to a temperature meter b (39) ); All pipes are metal hoses.

The traditional Chinese medicine Shengmai injection production line according to claim 1, wherein: the traditional Chinese medicine Shengmai injection refining and dispensing device comprises at least one set of weighing, diluting and decontaminating devices for the extract, at least A weighing device for separating liquid and a weighing and diluting device, wherein the weighing, diluting and removing device for the single product includes a storage tank (40) and a dilution tank (42) which are sequentially connected by a pipe and a pump. , cold a storage tank (44), a decontamination tank (45), the dilution tank (42) is provided with a first water inlet (48), a first agitator (43) and a weighing device; The utility model comprises a liquid storage tank (46) connected by a pipeline and a pump, and a liquid weighing tank (47); the mixing weighing and dilution device comprises a mixing tank (49) and a batch tank which are sequentially connected by a pipeline and a pump ( 51) a finished product tank (52), wherein the mixing tank (49) is further connected to the de-mixing tank (45) and the liquid-sweating weighing tank (47) through a pipe and a pump, and the mixing tank (49) is provided with a second agitator (50) And a weighing device, the finished tank (52) is provided with a second water inlet (55), a third agitator (53), a discharge port (54) and a weighing device.

The Chinese medicine Shengmai injection production line according to claim 6, wherein: the pump (41) between the storage tank (40) and the dilution tank (42) is a peristaltic pump; ) The location where the pipe is connected is at the top.