CN105842195B - The judgment method of cream terminal is received in cinobufagin concentration - Google Patents
The judgment method of cream terminal is received in cinobufagin concentration Download PDFInfo
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- CN105842195B CN105842195B CN201610187683.5A CN201610187683A CN105842195B CN 105842195 B CN105842195 B CN 105842195B CN 201610187683 A CN201610187683 A CN 201610187683A CN 105842195 B CN105842195 B CN 105842195B
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
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Abstract
The judgment method for receiving cream terminal is concentrated the invention discloses a kind of cinobufagin, includes the following steps: index of refraction-concentration of alcohol curve when step 1) draws 20 DEG C；Step 2) establishes cinobufagin concentration and receives cream process quality control device；Step 3) detects cinobufagin concentration and receives cream process condensate liquid concentration of alcohol；Step 4) quickly judges that cream course end is received in cinobufagin concentration.The judgment method for receiving cream terminal is concentrated the present invention provides a kind of cinobufagin, this method can be realized the accurate detection that condensate liquid concentration during cream is received in cinobufagin concentration, and then make the quick judgement that cream terminal is received in cinobufagin concentration, stability between the batch of raising cinobufagin medicinal extract quality, improves product quality.
Description
Technical field
The invention belongs to field of traditional Chinese medicine pharmacy, it is more particularly related to which cream terminal is received in a kind of concentration of cinobufagin
Judgment method.
Background technique
Cinobufagin derives from bufo gargarizans Cantor Bufo bufo gargarizans Cantor or Bufo melanostictus Bufo
The skin of melanostictus Schneider is isolated by extracting, and is in two kind new medicines and country that China voluntarily develops
Medicine protects kind, has and adjusts pharmacological action that is immune, inhibiting tumor cell proliferation, anti-hepatitis virus, antitumor, treatment is slow
It has been widely used on the clinical treatment of property hepatitis B and other diseases.
The production technology of cinobufagin is toad skin extracting in water, concentration, alcohol precipitation, secondary concentration, secondary alcohol precipitation, concentration receipts at present
Cream etc., wherein secondary concentration and concentration receive cream process and are required to recycling ethyl alcohol to no alcohol taste.Main cause is in order to avoid ethyl alcohol
Residual in cinobufagin medicinal extract.Ethyl alcohol is not thorough as anaphylactogen and liver microsomalinducer, such as removal, it is possible to be influenced a variety of
Drug metabolism even results in allergic reaction etc..
Traditional Chinese drug inspissation receives cream process at present, and recycling ethyl alcohol to the judgment criteria without alcohol taste is all made of artificial judgment, by rule of thumb
Judgement, but since the otherness of artificial judgment is larger, stability between the batch of cinobufagin medicinal extract quality is easily influenced, or even influence most
Finished product quality.
Summary of the invention
The judgment method for receiving cream terminal is concentrated the object of the present invention is to provide a kind of cinobufagin, this method can be realized magnificent toad
The accurate detection of condensate liquid concentration during cream is received in element concentration, and then makes the quick judgement that cream terminal is received in cinobufagin concentration, is mentioned
Stability between the batch of high cinobufagin medicinal extract quality improves product quality.
In order to realize object of the present invention and further advantage, a kind of judgement side of cinobufagin concentration receipts cream terminal is provided
Method includes the following steps:
Step 1) prepares the ethanol water of various concentration, measures its index of refraction at 20 DEG C using abbe's refractometer,
And index of refraction-concentration of alcohol curve at 20 DEG C of drafting；
Step 2) on the pipeline that condenser is connected to drop pan by installing condensate temperature transmitter and online refractive power
Instrument measures condensate temperature T1And the index of refraction n (T of condensate liquid at such a temperature1)；By installing vaporization chamber on vaporization chamber
Temperature transmitter, measurement evaporation room temperature T2；The online refractometer, vaporization chamber temperature transmitter and condensate temperature pick-up
Device is respectively connected with a controller；
Step 3) is n (20) by the index of refraction that controller calculates 20 DEG C of condensate liquid, and according to 20 drawn in step 1)
DEG C when index of refraction-concentration of alcohol curve calculate condensate liquid concentration of alcohol be c；
The quick judgement of cream course end is received in the concentration of step 4) cinobufagin, if meeting the following conditions simultaneously: the second of condensate liquid
Determining alcohol c < 1%, time continue 5 minutes, evaporation room temperature T280 DEG C of >；Then cinobufagin concentration is received cream and is terminated.
Preferably, in the step 3), the calculation method of n (20) is n (20)=n (T1)-α (T1- 20), wherein α
=2.2 × 10-4。
Preferably, in the step 1), in the step 1), draw two 20 DEG C when index of refraction-ethyl alcohol it is dense
It writes music line, respectively the first curve and the second curve, wherein the value range of concentration of alcohol is 0~10% in the first curve, the
The value range of concentration of alcohol is 0~100% in two curves.
Preferably, it in the step 3), when n (20)≤1.3395, then calculates and condenses according to first curve
The concentration of alcohol c of liquid；As n (20) > 1.3395, then the concentration of alcohol c of condensate liquid is calculated according to second curve.
Preferably, in the step 2), the index of refraction of the online refractometer real-time measurement condensate liquid is simultaneously transmitted to
Controller, the condensate temperature transmitter real-time measurement condensate temperature are simultaneously transmitted to controller, and the evaporation room temperature becomes
It send device real-time measurement evaporation room temperature and is transmitted to controller.
Preferably, the structure of the vaporization chamber described in the step 2) is spherical shape.
The present invention is include at least the following beneficial effects:
(1) judgment method for receiving cream terminal is concentrated the invention discloses a kind of cinobufagin, this method uses automation control
System is avoided by manual operation bring randomness and blindness, is realized cinobufagin concentration and is received cream process condensate liquid concentration
Accurate detection；
(2) judgment method of cream terminal is received in cinobufagin concentration disclosed by the invention, realizes that cream terminal is received in cinobufagin concentration
Quickly judgement improves stability and the efficiency of production between the batch of cinobufagin medicinal extract quality, reduces production cost, to improve China
Toad element quality stability provides new technology.
Further advantage, target and feature of the invention will be partially reflected by the following instructions, and part will also be by this
The research and practice of invention and be understood by the person skilled in the art.
Detailed description of the invention
Fig. 1 is the judgment method control flow chart that cream terminal is received in cinobufagin of the present invention concentration；
Fig. 2 is the structural schematic diagram that cream process quality control device is received in cinobufagin of the present invention concentration；
Fig. 3 is the first curve of the present invention；
Fig. 4 is the second curve of the present invention；
In figure: 1- spherical shape vaporization chamber, 2- steam-water separator, 3- condenser, 4- pipeline, 5- condensate liquid liquid feed valve, 6- is by water
Device, 7- vaporization chamber temperature transmitter, the online refractometer of 8-, 9- condensate temperature transmitter, 10- blow valve.
Specific embodiment
To describe the technical solutions in the embodiments of the present invention more clearly, make required in being described below to embodiment
Attached drawing is briefly described, it should be apparent that, drawings in the following description are only some embodiments of the invention, for
For those of ordinary skill in the art, without creative efforts, it can also be obtained according to these attached drawings other
Attached drawing.
As shown in Figure 1, the judgment method for receiving cream terminal is concentrated the present invention provides a kind of cinobufagin, include the following steps:
Step 1) prepares the ethanol water of various concentration, measures its index of refraction at 20 DEG C using abbe's refractometer,
And index of refraction-concentration of alcohol curve at 20 DEG C of drafting；
Step 2) on the pipeline that condenser is connected to drop pan by installing condensate temperature transmitter and online refractive power
Instrument measures condensate temperature T1And the index of refraction n (T of condensate liquid at such a temperature1)；By installing vaporization chamber on vaporization chamber
Temperature transmitter, measurement evaporation room temperature T2；The online refractometer, vaporization chamber temperature transmitter and condensate temperature pick-up
Device is respectively connected with a controller；
Step 3) is n (20) by the index of refraction that controller calculates 20 DEG C of condensate liquid, and according to 20 drawn in step 1)
DEG C when index of refraction-concentration of alcohol curve calculate condensate liquid concentration of alcohol be c；
The quick judgement of cream course end is received in the concentration of step 4) cinobufagin, if meeting the following conditions simultaneously: the second of condensate liquid
Determining alcohol c < 1%, time continue 5 minutes, evaporation room temperature T280 DEG C of >；Then cinobufagin concentration is received cream and is terminated.
In the above-mentioned technical solutions, in the step 3), the calculation method of n (20) is n (20)=n (T1)-α (T1?
20), wherein α=2.2 × 10-4。
In the above-mentioned technical solutions, in the step 1), in the step 1), draw two 20 DEG C when refractive power
Rate-concentration of alcohol curve, respectively the first curve and the second curve, wherein the value range of concentration of alcohol is 0 in the first curve
~10%, the value range of concentration of alcohol is 0~100% in the second curve.
In the above-mentioned technical solutions, it in the step 3), when n (20)≤1.3395, is then calculated according to the first curve
The concentration of alcohol c of condensate liquid；As n (20) > 1.3395, then the concentration of alcohol c of condensate liquid is calculated by the second curve.
In the above-mentioned technical solutions, in the step 2), the index of refraction of the online refractometer real-time measurement condensate liquid
And it is transmitted to controller, the condensate temperature transmitter real-time measurement condensate temperature is simultaneously transmitted to controller, the evaporation
Room temperature transmitter real-time measurement evaporation room temperature is simultaneously transmitted to controller.
In the above-mentioned technical solutions, in the step 2), the structure of the vaporization chamber is spherical shape, and the structure of vaporization chamber is in
Spherical shape accelerates heat transfer evaporation rate, heating efficiency is improved, so as to reduce production cost so that heating surface increases.
It should be noted that the device that the judgment method that cream terminal is received in above-mentioned cinobufagin concentration uses is as shown in Fig. 2, include
By the sequentially connected spherical shape vaporization chamber 1 of pipeline, steam-water separator 2, condenser 3 and drop pan 6, on the spherical shape vaporization chamber 1
Vaporization chamber temperature transmitter 7 is installed, on the pipeline 4 that condenser 3 is directly connected to drop pan install condensate liquid liquid feed valve 5,
Online refractometer 8 and condensate temperature transmitter 9, the tail end of pipeline 4 are connected with blow valve 10, and cinobufagin receives cream process in concentration
In, alcohol vapour is evaporated by spherical vaporization chamber 1, and by steam-water separator 2, into condensate liquid is formed in condenser 3, condensate liquid is passed through
Pipeline 4, condensate liquid liquid feed valve 5 enter in drop pan 6, and the index of refraction of online 8 real-time measurement condensate liquid of refractometer is simultaneously transmitted to control
Device processed, the 9 real-time measurement condensate temperature of condensate temperature transmitter are simultaneously transmitted to controller, the evaporation room temperature pick-up
7 real-time measurement of device evaporation room temperature is simultaneously transmitted to controller.
Embodiment 1
Step 1) draws index of refraction-concentration of alcohol curve at 20 DEG C:
Compound concentration is respectively 0%, 1.0%, 2.0%, 3.0%, 4.0%, 5.0%, 6.0%, 7.0%, 8.0%,
9.0%, 10.0% ethanol water measures its index of refraction at 20 DEG C using abbe's refractometer and draws curve, obtains
First curve, as shown in Figure 3；
Compound concentration is respectively 0%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 100%
Ethanol water, its index of refraction at 20 DEG C is measured using abbe's refractometer and draws curve, the second curve is obtained, such as schemes
Shown in 4；
Step 2): it is T that condensate temperature transmitter, which measures condensate temperature,1=22 DEG C, online refractometer is surveyed cold in real time
Lime set is T in temperature1When index of refraction be n (T1)=1.3638；The index of refraction that controller calculates 20 DEG C of condensate liquid is n (20)=n
(T1)-α (T1- 20)=1.3638-2.2 × 10-4* (22-20)=1.3634,
Because of n (20)=1.3634 > 1.3395, then the concentration of alcohol c=of condensate liquid is calculated according to Article 2 curve
57.74%；
Step 3): because concentration of alcohol c=57.74% does not meet the condition of concentration of alcohol c < 1%, then cinobufagin is concentrated
The step of cream process continues, repeats step 2) is received, until there is concentration of alcohol c < 1%, and the time continues 5 minutes, evaporates simultaneously
Room temperature T280 DEG C of >, then cinobufagin concentration is received cream and is terminated, into next process.
Although the embodiments of the present invention have been disclosed as above, but its is not only in the description and the implementation listed
With it can be fully applied to various fields suitable for the present invention, for those skilled in the art, can be easily
Realize other modification, therefore without departing from the general concept defined in the claims and the equivalent scope, the present invention is simultaneously unlimited
In specific details and legend shown and described herein.
Claims (3)
1. the judgment method that cream terminal is received in a kind of cinobufagin concentration, which comprises the steps of:
Step 1) prepares the ethanol water of various concentration, measures its index of refraction at 20 DEG C using abbe's refractometer, and draw
Index of refraction-concentration of alcohol curve when making 20 DEG C；
Step 2) is surveyed by installing condensate temperature transmitter and online refractometer on the pipeline that condenser is connected to drop pan
Measure condensate temperature T1And the index of refraction n (T of condensate liquid at such a temperature1)；Become by installing evaporation room temperature on vaporization chamber
Send device, measurement evaporation room temperature T2；The online refractometer, vaporization chamber temperature transmitter and condensate temperature transmitter connect
It is connected to a controller；
Step 3) is n (20) by the index of refraction that controller calculates 20 DEG C of condensate liquid, and when 20 DEG C drawn middle according to step 1)
Index of refraction-concentration of alcohol curve calculate condensate liquid concentration of alcohol be c；
The quick judgement of cream course end is received in the concentration of step 4) cinobufagin, if meeting the following conditions simultaneously: the ethyl alcohol of condensate liquid is dense
Degree c < 1%, time continue 5 minutes, evaporation room temperature T280 DEG C of >；Then cinobufagin concentration is received cream and is terminated；
In the step 1), index of refraction-concentration of alcohol curve when drawing two 20 DEG C, respectively the first curve and second bent
Line, wherein the value range of concentration of alcohol is 0~10% in the first curve, the value range of concentration of alcohol is 0 in the second curve
~100%；
In the step 3), the calculation method of n (20) is n (20)=n (T1)-α (T1- 20), wherein α=2.2 × 10-4；
In the step 3), when n (20)≤1.3395, then the concentration of alcohol c of condensate liquid is calculated according to first curve；
As n (20) > 1.3395, then the concentration of alcohol c of condensate liquid is calculated according to second curve.
2. the judgment method that cream terminal is received in cinobufagin concentration as described in claim 1, which is characterized in that in the step 2)
In, the index of refraction of the online refractometer real-time measurement condensate liquid is simultaneously transmitted to controller, and the condensate temperature transmitter is real
When measurement condensate temperature and be transmitted to controller, the vaporization chamber temperature transmitter real-time measurement evaporation room temperature is simultaneously transmitted to
Controller.
3. the judgment method that cream terminal is received in cinobufagin concentration as described in claim 1, which is characterized in that in the step 2)
The structure of the vaporization chamber is spherical shape.
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| CN110567915A (en) * | 2019-09-06 | 2019-12-13 | 云南大唐汉方制药股份有限公司 | online detection method for ethanol concentration in dragon blood residue steaming process |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01232239A (en) * | 1988-03-11 | 1989-09-18 | Stanley Electric Co Ltd | Alcohol concentration meter |
| CN1831518A (en) * | 2005-12-19 | 2006-09-13 | 江西本草天工科技有限责任公司 | Quick monitoring method for elution start or end of column separation eluent of Chinese medicine |
| CN101249042A (en) * | 2008-04-07 | 2008-08-27 | 北京中医药大学 | Chinese medicine liquid formulation automatic production line |
| CN102109846A (en) * | 2011-03-01 | 2011-06-29 | 南昌弘益科技有限公司 | Intelligent automated control method for traditional Chinese medicine production |
-
2016
- 2016-03-24 CN CN201610187683.5A patent/CN105842195B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01232239A (en) * | 1988-03-11 | 1989-09-18 | Stanley Electric Co Ltd | Alcohol concentration meter |
| CN1831518A (en) * | 2005-12-19 | 2006-09-13 | 江西本草天工科技有限责任公司 | Quick monitoring method for elution start or end of column separation eluent of Chinese medicine |
| CN101249042A (en) * | 2008-04-07 | 2008-08-27 | 北京中医药大学 | Chinese medicine liquid formulation automatic production line |
| CN102109846A (en) * | 2011-03-01 | 2011-06-29 | 南昌弘益科技有限公司 | Intelligent automated control method for traditional Chinese medicine production |
Non-Patent Citations (2)
| Title |
|---|
| 多指标综合评分法优选华蟾素提取液醇沉工艺的研究;胡晓雁 等;《时珍国医国药》;20121231;第23卷(第4期);第1016-1019页 * |
| 折光率控制中草药汤剂质量的方法;夏定兵 等;《湖北中医杂志》;20110531;第33卷(第5期);第69-70页 * |
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