CN102125625A - Traditional Chinese medicine for treating ankylosing spondylitis - Google Patents

Abstract

The invention discloses a traditional Chinese medicine for treating ankylosing spondylitis, which is a Chinese medicinal mixture prepared from the following raw materials: heracleum, Chinese taxillus twig, root of largeleaf gentian, achyranthes root, rhizoma drynariae, Chinese angelica, east Asian tree fern rhizome, eucommia bark, cowherb seed, prepared rehmannia root, south dodder seed and fried pangolin scales. The traditional Chinese medicine is applied to selective cases of clinical observation since 2002, one month is a course of treatment, the interval between two courses of treatment is five days, the next courses of treatment are continued with halfyear observation, and the traditional Chinese medicine is taken twice every day and 100 ml each time. In 1,200 treated patients with completed data, the traditional Chinese medicine has the total effective rate of 90 percent if related inspection indexes are improved and the pain of the patients is relieved.

Description

A kind of Chinese medicine medicine for the treatment of ankylosing spondylitis

Technical field the invention belongs to the Chinese medicine technical field of pharmaceuticals, is specifically related to a kind of Chinese medicine medicine for the treatment of ankylosing spondylitis.

Background technology ankylosing spondylitis (AS) is that a kind of cause of disease is not bright, based on the systemic disease of axis joint chronic inflammatory disease.Mainly involve sacroiliac joint, hip joint, articuli intervertebrales, costovertebral joints, see have 1/3 patient inflammation to occur in the joint on every side approximately, and can involve eye, heart, lungs, nervous system and urinary system more so that the sacroiliac joint pathological changes is the most.Its main pathology is the calcification that changes joint and joint surrounding tissue, ligament, intervertebral disc, and rigid spine finally takes place.Ankylosing spondylitis is the disability rate height, has a strong impact on the disease of health of people thus.

Ankylosing spondylitis (AS) should belong to the category of the traditional Chinese medical science " arthromyodynia " or " waist disease ", in " internal diameter " description of " BI-syndrome involved the kidney " and " rheumatism involving the bone " and (AS) clinical symptoms is rather similar.The site of pathological change of primary disease mainly is lumbosacral region and ridge, and is the closest with kidney and governor vessel relation.The kidney being the origin of congenital constitution, and main bone is given birth to marrow, and ridge is full of in kidney system, and the narrow ridge of governor vessel is full of in the waist, and the sun of governor's the whole body is particularly close with the kidney relation, so relevant with deficiency of kidney-QI governor vessel inanition more than the generation of primary disease.Lose under the empty situation in healthy energy, take advantage of a weak point at the beginning of the puckery heat of wind and cold, numbness resistance arteries and veins is superintended and directed, and QI-blood circulation is not smooth, and general rule is sick and cause low-back pain.The primary disease pilosity is born in adolescents in male, and the trouble patient was rare later in 40 years old.Because the mechanism of the cause of disease of primary disease, morbidity is still indeterminate, so lack specificity therapeutic method, the medicine of studying a kind of safe and effective reliable treatment AS is imperative.At present, mainly contain physical exercise therapy, physical therapy, medicine and surgical intervention etc.

1. physical exercise therapy: physical exercise therapy is all beneficial to various chronic diseases, and is even more important to AS.Can keep the physiological bending of spinal column, prevent deformity; Keep normal respiratory function, keep bone density and intensity, prevent osteoporosis and limbs disuse muscle atrophy etc., specifically can do following motion.

(1) deeply breathe: every morning, work time of having a rest and sleep before the motion that all should routine breathes deeply, deep breathing can be kept the mobility of thorax maximum, keeps good respiratory function;

(2) cervical vertebra motion: incidence can do forward, backward, left, turn right, and head rotatablely moves, to keep the normal activity degree of cervical vertebra;

(3) lumbar vertebra motion: make waist movement, anteflexion, layback, lateral bending and left rotation and right rotation body every day, make lumbar spinal column keep normal mobility;

(4) limb motion: can make push-up, diagonal brace, lower limb anterior flexion and rear stretching, chest expanding exercise and swimming etc., swimming had both helped quadruped locomotion, and help to increase pulmonary function again and make spinal column keep the physiology curvature, be the optimal all-around exercises of AS.

2. naturopathy: the general available thermotherapy of physical therapy, to bathe or shower as hot bath, basin, mineral spring spas etc. to increase local blood circulation, make loosening all muscles, ease the pain, and help joint motion, keep normal function, prevent deformity.

3. Drug therapy: the medicine of treatment AS can be divided three classes: 1. disease controlling activity, influence the medicine of course of disease progress, as sulfasalazine, methotrexate, now up-to-date " biological preparation " benefit evident in efficacy that also has is matched spectrum-tnf antibody fusion rotein, be applicable to the active AS of the state of an illness, companion arthritic AS of periphery and the AS that finds recently; 2. NSAID (non-steroidal anti-inflammatory drug) is applicable to serious pain and stiff patient at night, can take before sleeping; 3. analgesic and muscle relaxant such as pentazocine, strong pain pyridine Nefopam are usually used in prolonged application nonsteroidal antiinflammatory drug nonresponder.

4. operative treatment: the bow-backed deformity of serious spinal column is treated can make corrective procedure after the stable disease; The feasible vertebra osteotomy of lumbar vertebra deformity person is corrected bow-backed; The rectifiable cervical vertebra severe deformities of neck 7 breasts 1 osteotomy; The serious flexion deformity of hip joint, feasible full hip-joint conversion art or arthroplasty of hip, but effect is not ideal enough, and postoperative is easily tetanic again.

There are the problem of long, the weak effect course of treatment in the physical exercise therapy of prior art, physical therapy method; And pharmacotherapy mostly is oral western medicine greatly, has treatment cost height and the problem that side effect is arranged; And there is the big problem of patient suffering in operative treatment.

Summary of the invention the objective of the invention is to solve prior art and has long, the treatment cost height course of treatment, side effect and the big technical problem of patient suffering are arranged, and a kind for the treatment of both the principal and secondary aspects of a disease is provided, has no side effect, the Chinese medicine medicine of cheap treatment ankylosing spondylitis.

Solution of the present invention is based on understanding and the Therapeutic Principle of motherland's medical science to the pathogeny and the human body immunity improving power of ankylosing spondylitis, with reference to ancient, modern pharmacological research achievement, from motherland's medical treasure-house, filter out the kidney invigorating and superintend and direct the natural Chinese medicine of a surname's numbness, strengthening vital QI to eliminate pathogenic factors by force,, skim the cream off milk by the theory of Chinese medical science prescription, make its performance promote that yang blood and qi is regulated in the human body, vital organs of the human body twelve channels and collaterals balance, human body immunity improving power, the effect that ankylosing spondylitis is had treatment and suppresses.

Medicine of the present invention is made (consumption is a weight portion) by following component:

Radix Angelicae Pubescentis 9 Herba Taxillis 9 Radix Gentianae Macrophyllae 15 Radix Achyranthis Bidentataes 15 Rhizoma Drynariae 12 Radix Angelicae Sinensis 15 Rhizoma Cibotii 15 Cortexs Eucommiae 12 Semen Vaccariae 9 Radix Rehmanniae Preparata 15 Semen Cuscutae 15 stir-baked SQUAMA MANITISs 6

Above-mentioned each component is made the Chinese medicine drug mixture according to a conventional method, finishes by following step successively:

1) decoct: above-mentioned all medicines are put into pot, add water by 1: 2 of medicine total amount, slow fire boiling was boiled back 20 minutes, and medicinal liquid is leached, and 1: 1 by the medicine total amount adds the fiery decoction of the hydrology again, boils back 20 minutes, and medicinal liquid is leached;

2) bottling: seal in the disinfectant bottle in advance with packing into behind twice filtrate mixing;

3) sterilization: the medicinal liquid bottle is put into pressure cooker sterilization 20 minutes, promptly get Chinese medicine medicine decoction of the present invention.

Chinese medicine medicine decoction of the present invention is named and is " superintend and direct by force the kidney invigorating a surname numbness mixture ".

Radix Angelicae Pubescentis nature and flavor in the medicine of the present invention are arduous, warm, return kidney, urinary bladder channel, have dispeling the wind, win wet, cold expelling, the function of pain relieving, cure mainly anemofrigid-damp arthralgia, soreness of waist and knee joint, trick spasm and pain, chronic tracheitis, headache, all diseases of toothache; Herba Taxilli nature and flavor hardship, sweet, flat is returned liver, kidney channel, has wind-damp dispelling, invigorating the liver and kidney, bone and muscle strengthening, antiabortive function, cures mainly rheumatic Bi syndrome; Radix Gentianae Macrophyllae nature and flavor toil, flat is returned liver, stomach, gallbladder meridian, has the function of expelling wind and removing dampness and blood Shujin, clearing away heat and promoting diuresis, cures mainly rheumatic arthralgia, muscles and bones contracture, jaundice, has blood in stool, osteopyrexia and fever, children's's infantile malnutrition with fever, all diseases of dysuria; Rhizoma Drynariae nature and flavor hardship, temperature are returned liver, kidney channel, and the function of have the kidney invigorating, invigorate blood circulation, stopping blooding cures mainly suffer from a deficiency of the kidney chronic diarrhea and lumbago, rheumatic arthralgia, toothache, tinnitus, traumatic injury sprain and contusion, bone injury, appendicitis, alopecia areata, all diseases of clavus; The Radix Angelicae Sinensis nature and flavor are sweet, hot, warm in nature, return liver, the heart, spleen channel, have sweet Wen Zhirun, enrich blood invigorate blood circulation, the function of dispersing cold for relieving pain, reducing swelling and alleviating pain, tonic blood and growing muscle, cure mainly heart-liver blood deficiency, shallow complexion, dizzy cardiopalmus, blood deficiency, stasis and have the diseases such as pain of cold coagulation, traumatic injury, wind-damp numbness concurrently; The effect that Radix Clematidis has wind-damp dispelling, the meridian dredging, the bone that disappears is choked; Radix Achyranthis Bidentatae flavor is flat, bitter, sweet, sour, has the effect of invigorating the liver and kidney, bone and muscle strengthening, eliminating blood stasis and inducing menstruation, conducting blood to flow downwards, is used to control that soreness of waist and knee joint, muscles and bones are unable, the disease such as dizzy of amenorrhea lump in the abdomen, excessive rising of liver-YANG; Rhizoma Cibotii bitter but sweet flavor, temperature are returned liver, kidney channel, have invigorating the liver and kidney, remove rheumatism, the effect in strong waist foot, sharp joint, be used to control back ache, gonalgia flaccidity of the lower limbs, cold-damp general arthralgia, lose drown, diseases such as frequent micturition, seminal emission, leucorrhea; The sweet little suffering of Cortex Eucommiae nature and flavor, temperature are returned liver, kidney channel, have invigorating the liver and kidney, bone and muscle strengthening, antiabortive effect, are used to control that spinal column ache, foot and knee flaccidity, dribbling urination, uncontrolled urination are itched, diseases such as vaginal bleeding during pregnancy is desired to fall, frequent fetal movement, hypertension; Semen Vaccariae mildly bitter flavor, property are flat, have the effect of promoting blood circulation to restore menstrual flow, stimulating milk secretion eliminating carbuncle, cure mainly diseases such as women's pain fibre, amenorrhea, mastitis, simultaneously the good medicine of sufficient lactogenic also; Radix Rehmanniae Preparata also claims Radix Rehmanniae Preparata, and sweet, the tepor of nature and flavor is gone into liver, kidney channel, has the effect of nourishing the blood and yin, vital essence replenishing and marrow benifiting, cures mainly blood deficiency and yellow complexion, dizzy, cardiopalmus, insomnia, menoxenia, diseases such as metrorrhagia; Semen Cuscutae acrid-sweet flavor, flat is returned liver, kidney channel, the effect that have invigorating the liver and kidney, beneficial marrow, makes eye bright, diseases such as curing mainly soreness of waist and knee joint, pass out semen, quench one's thirst, dripping urination, order are dark; Stir-baked SQUAMA MANITIS is exactly to be the scale of Squama Manis(parched), the scute of Squama Manis is the important component of Chinese medicine for a long time always, its property of medicine: Squama Manis salty in the mouth, cold nature is gone into liver, stomach two warps, effect: detumescence suppurate, loose the silt collateral dredging, stimulate the menstrual flow, stimulating milk secretion, invigorating blood circulation analgesia, cure mainly: diseases such as the carbuncle skin ulcer is swollen, anemofrigid-damp arthralgia, amenorrhea, galactostasis, hemostasis, disease crust gather.Above-mentioned all medicines are through rationally compatibility is obvious to the ankylosing spondylitis therapeutic effect.

Medicine of the present invention " is superintended and directed the kidney invigorating a surname numbness mixture by force ", and clinical use result shows that following advantage is arranged:

1, the present invention selects the natural Chinese medicines raw material for use, and each component meets the pharmaceutical control law regulation, utilizes the comprehensive function of the Chinese medicine of respectively distinguishing the flavor of, and ankylosing spondylitis is had specially good effect, does not have chemical sweeting agent, and is nontoxic to human body.

2, the present invention distinguish the flavor of little sweet, no bitterness sense, taking convenience.

Be the curative effect that shows that the present invention " superintends and directs the kidney invigorating a surname numbness mixture by force ", case is selected in the present invention's clinical observation since two thousand two, and one month is a course of treatment, the intermittently 5 days course of treatment, continue next course of treatment, observe half a year, day clothes 2 times, each 100ml, 1200 complete examples of treatment patient data, relevant inspection index is improved, and pain disappearance person is that effectively total effective rate is 90%.

Model case is as follows:

1, old XX, man, 21 years old, university students.The readme back pain moon is surplus, and the sacroiliac joint gap is fuzzy, and be diagnosed as: the ASI level is suspicious sacroiliitis.Take " superintending and directing the kidney invigorating a surname numbness mixture by force ", every day twice, pain alleviates gradually, and pain disappears after 3 months.

2, appoint XX, man, 30 years old, the armyman transferred to civilian work, readme lumbosacral region and back pain 2 years are surplus, once are diagnosed as ankylosing spondylitis by county hospital, be in by medicines such as the oral indomethacin of doctor's advice, ibuprofen and piroxicams, symptom does not only alleviate, and feels gastrointestinal upset on the contrary.The X ray examination: sacroiliac joint sawtooth sample changes, and is diagnosed as: ASII level, erythrocyte sedimentation rate 58mm/h.Take " superintending and directing the kidney invigorating a surname numbness mixture by force ", every day twice, pain alleviates gradually, and pain disappears after 5 months, and erythrocyte sedimentation rate is normal.

3, Lee XX, the man, 25 years old, readme lumbosacral region and back pain have half a year surplus, and pain constantly increases the weight of, and is diagnosed as ankylosing spondylitis by county hospital, by medicines such as the oral indomethacin of doctor's advice, ibuprofen, piroxicam, methotrexate and sulfasalazines, symptom alleviates to some extent, but occurs feeling sick, and day by day becomes thin.The X ray examination: the ASIII level, the sclerosis of sacroiliac joint both sides, the joint edge blurry is unclear, has worm-eaten to change erythrocyte sedimentation rate 58mm/h.Take " superintend and direct by force the kidney invigorating a surname numbness mixture ", every day twice, symptom alleviates gradually, and pain disappears after 6 months, and erythrocyte sedimentation rate is normal.

The specific embodiment

Take by weighing raw material (gram) by following proportioning

Radix Angelicae Pubescentis 9 Herba Taxillis 9 Radix Gentianae Macrophyllae 15 Radix Achyranthis Bidentataes 15 Rhizoma Drynariae 12 Radix Angelicae Sinensis 15 Rhizoma Cibotii 15 Cortexs Eucommiae 12 Semen Vaccariae 9 Radix Rehmanniae Preparata 15 Semen Cuscutae 15 stir-baked SQUAMA MANITISs 6

Above-mentioned each component is made the Chinese medicine drug mixture according to a conventional method, finishes by following step successively:

1) decoct: above-mentioned all medicines are put into pot, add water by 1: 2 of medicine total amount, slow fire boiling was boiled back 20 minutes, and medicinal liquid is leached, and 1: 1 by the medicine total amount adds the fiery decoction of the hydrology again, boils back 20 minutes, and medicinal liquid is leached;

2) bottling: seal in the disinfectant bottle in advance with packing into behind twice filtrate mixing;

3) sterilization: the medicinal liquid bottle is put into pressure cooker sterilization 20 minutes, promptly get Chinese medicine drug mixture of the present invention.

Claims (1)

1. Chinese medicine medicine for the treatment of ankylosing spondylitis, it is the Chinese medicine drug mixture of making according to a conventional method, it is characterized in that making by weight ratio: Radix Angelicae Pubescentis 9, Herba Taxilli 9, Radix Gentianae Macrophyllae 15, Radix Achyranthis Bidentatae 15, Rhizoma Drynariae 12, Radix Angelicae Sinensis 15, Rhizoma Cibotii 15, the Cortex Eucommiae 12, Semen Vaccariae 9, Radix Rehmanniae Preparata 15, Semen Cuscutae 15, stir-baked SQUAMA MANITIS 6 by following raw material medicaments, above-mentioned each crude drug is made the Chinese medicine drug mixture, finishes by following step successively:

1) decoct: above-mentioned all medicines are put into pot, add water by 1: 2 of medicine total amount, slow fire boiling was boiled back 20 minutes, and medicinal liquid is leached, and 1: 1 by the medicine total amount adds the fiery decoction of the hydrology again, boils back 20 minutes, and medicinal liquid is leached;

2) bottling: seal in the disinfectant bottle in advance with packing into behind twice filtrate mixing;

3) sterilization: the medicinal liquid bottle is put into pressure cooker sterilization 20 minutes, get final product.