CN102125617A - Medicine for treating acnevulgaris - Google Patents
Medicine for treating acnevulgaris Download PDFInfo
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- CN102125617A CN102125617A CN 201110045587 CN201110045587A CN102125617A CN 102125617 A CN102125617 A CN 102125617A CN 201110045587 CN201110045587 CN 201110045587 CN 201110045587 A CN201110045587 A CN 201110045587A CN 102125617 A CN102125617 A CN 102125617A
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Abstract
The invention relates to a medicine prepared by using plants as raw materials, in particular to a medicine for treating acnevulgaris, which consists of active ingredients and medically acceptable excipient, and is characterized in that the active ingredients are prepared from the following raw material medicines in percentage by weight: 9 to 15 percent of baical skullcap root, 9 to 15 percent of loguat leaves, 13 to 19 percent of salvia miltiorrhiza bunge, 13 to 19 percent of oldenlandia diffusa, 10 to 15 percent of red paeony root, 7 to 12 percent of Chinese angelica and 7 to 12 percent of liquoric root. The active ingredients used in the invention can be prepared into granules or capsules and have the effect of dispelling lung wind and dispelling dampness and heat.
Description
Invention field
The present invention relates to the field of Chinese medicines, be specifically related to the Chinese medicine composition that a kind of Chinese crude drug crude drug is made.
Background technology
Acne is commonly called as " comedo ", " acne ", is a kind of pilosebaceous chronic inflammation disease, is its feature with acne, pimple, pustule, tuberosity etc., often accompanies seborrhea, and pilosity is born in the adolescence men and women.The traditional Chinese medical science thinks that the cause of disease that acne takes place is many because of the long-pending heat of lung stomach, the damp and hot skin that accumulates, and QI and blood is stopped up and is hindered in last and cause.Western medicine thinks and removes the endocrine disturbance, androgen secretion is vigorous cause outer also relevant with some pathogenic bacterial infections, such as pityrosporum furfur, propionibacterium acnes, staphylococcus aureus and acarid etc.Southern area is located in damp and hot ground, and rain is wet contains and the weather sweltering heat wind and heat in the lung meridian acne pilosity, common.The medicine of treatment acne is in the majority with medicine for external use at present, as Da Fuwen, acne ointment, beauty mask etc., its effect is to eliminate the hair follicle inflammation, dredging pore, reduce fat secretion, overweight Zhi Biao and be negligent of effecting a permanent cure, outbreak repeatedly easily, and also external used medicine causes discomforts such as pruritus, desquamation, drying, erythema even anaphylaxis easily mostly.Take Western medicine such as suppressing sebaceous gland function medicament, gonadal hormone and antibiotic for a long time and then cause gastrointestinal reaction, drying, teratogenesis, drug resistance, endocrine disturbance easily, even to untoward reaction such as hepatic and renal function exert an influence, it is slow to take effect, and this makes people more be ready to select Chinese medicine.Chinese medicine has globality, multi-level, multipath advantage aspect the treatment acne.Therefore, seeking a kind of method of preventing and treating that can bring into play the popular again homeliness type acne of tcm characteristic is desirability.
Summary of the invention
The object of the present invention is to provide a kind of medicine for the treatment of homeliness type acne, this medicine has advantages such as good effect, untoward reaction be little.
The inventor investigates by massive epidemiology, find that wet Sheng of heat in blood is the main etiology and pathogenesis of southern area acne vulgaris morbidity, wind and heat in the lung meridian, damp-heat accumulation are its main differentiation of symptoms and signs for classification of syndrome, be more common in the adolescence of oily skin, erythra is based on blackhead, inflammatory pimple, pustule or tuberosity (being equivalent to pimple, acne pustulosa), and often fester with thirsty, halitosis, laryngopharynx swelling and pain or gingival swelling and pain or hemorrhage, yellow urine and be short of, constipation with dry stool, red tongue with yellowish and greasy fur, rolling pulse, number or equality hygropyrexia symptom.At above-mentioned main diseases because of and pathogenesis, be principle with the clearing away heat and cooling blood eliminating dampness method, be widely used in clinical 10 surplus year, and obtain good curative effect.Concrete technical solution is as described below:
A kind of medicine for the treatment of acne, this medicine is made up of active ingredient and medically acceptable excipient, it is characterized in that described active ingredient made by following raw materials by weight percent medicine:
Radix Scutellariae 9～15%, Folium Eriobotryae 9～15%, Radix Salviae Miltiorrhizae 13～19%, Herba Hedyotidis Diffusae 13～19%, Spica Prunellae 10～15%, Radix Paeoniae Rubra 10～15%, Radix Angelicae Sinensis 7～12%, Radix Glycyrrhizae 7～12%.
Medicine of the present invention, the preferred weight percent of wherein said active ingredient is:
Radix Scutellariae 11～13%, Folium Eriobotryae 11～13%, Radix Salviae Miltiorrhizae 16～18%, Herba Hedyotidis Diffusae 16～18%, Spica Prunellae 10～15%, Radix Paeoniae Rubra 10～15%, Radix Angelicae Sinensis 8～10%, Radix Glycyrrhizae 8～10%.
Medicine of the present invention, the optimum weight percentage ratio of wherein said active ingredient is:
Radix Scutellariae 12.5%, Folium Eriobotryae 12.5%, Radix Salviae Miltiorrhizae 16.7%, Herba Hedyotidis Diffusae 16.7%, Spica Prunellae 12.5%, Radix Paeoniae Rubra 12.5%, Radix Angelicae Sinensis 8.3%, Radix Glycyrrhizae 8.3%.
Medicine of the present invention is an oral agents, as granule or capsule.
Active ingredient of the present invention is common water extract, and this water extract can adopt various common preparation methoies to obtain, and wherein a kind of simple and easy to do method is made up of following steps:
(1) by the proportioning weighting raw materials, add 8 times of water gagings at every turn and decoct 3 times, boil the back intense fire for the first time and fry in shallow oil 30min, boil the back intense fire for the second time and fry in shallow oil 1h, boil the back intense fire for the third time and fry in shallow oil 1.5h;
(2) collecting decoction filters the back and under 80 ℃ filtrate is concentrated into clear paste, puts in the baking oven in 75 ℃ and bakes dried cream, is ground into fine powder;
Active ingredient of the present invention adds an amount of medically acceptable excipient, can be made into conventional oral agents according to a conventional method, as granule or capsule.
Medicine of the present invention is a principal agent with Radix Scutellariae and Folium Eriobotryae, is equipped with Herba Hedyotidis Diffusae, Spica Prunellae, Radix Paeoniae Rubra, Radix Angelicae Sinensis, Radix Glycyrrhizae and makes.In the described medicine, Radix Scutellariae heat clearing and damp drying, eliminating fire and detoxication, the Folium Eriobotryae making lung-QI pure and descending closes and the removing summer-heat wind and heat in the lung meridian, is monarch drug altogether; Herba Hedyotidis Diffusae is a minister, strengthens the effect of clearing heat and expelling damp toxin expelling; Assistant with, Spica Prunellae, Radix Paeoniae Rubra heat clearing away eliminating stagnation, the Radix Salviae Miltiorrhizae cooling blood and removing stasis, Radix Angelicae Sinensis replenishing vital QI with drugs of warm nature blood vessels, it is cold and cool to supervise its medicine; Make with Radix Glycyrrhizae heat-clearing and toxic substances removing, coordinating the actions of various ingredients in a prescription.All medicines are played the effect of lung heat clearing wind, damp eliminating heat altogether.
Medicine of the present invention can observe further being confirmed by following clinical case to the therapeutic effect of homeliness type acne.
1. patient profile: we adopt this Drug therapy from year June in June, 2002 to 2004 to 96 routine wind and heat in the lung meridian, damp-heat accumulation type patients with acne (being the surgery of Chinese medicine outpatient of Nanfang Hospital), and contrast treatment at random with tetracycline, spironolactone, vitamin B6 treatment group.Adopt the random table method to be divided into 4 groups (treatment is organized 3 groups, 1 group of matched group), every group 24 example at random.Wherein male 33 examples, women 57 examples; Minimum 16 years old of age, maximum 40 years old, average 23.4 years old; The course of disease is the shortest 1 month, and is the longest 10 years.Divide fraction by the state of an illness: slight 1 grade of 16 example, 2 grade of 21 example, 3 grade of 20 example; 4 grade of 23 example of moderate, 5 grade of 9 example, 6 grade of 7 example.Each organizes the age, and through a plurality of independent sample non parametric testss, difference that there are no significant has comparability through x 2 checks, state of an illness classification through t check, sex.
2. case choice criteria: (1) belongs to wind and heat in the lung meridian type person according to " Surgery of Chinese Medicine " typing standard, and disease is seen: the pimple color is red, or the pain of itching is arranged, or pustule is arranged, companion's thirst and liking drink, constipation, oliguria with reddish urine, red tongue, yellow and thin fur, stringy and rolling pulse; Belong to the damp-heat accumulation type person, disease is seen: facial skin is greasy, and erythra is seen inflammatory pimple, pus pimple, pustule, tuberosity etc., with halitosis, constipation, yellowish urine etc., and red tongue, yellow and greasy fur, slippery and rapid pulse; (2) man, women volunteer; (3) enter not oral or other Retinoids, Retin-A, Renova, Accutane of external person in 2 weeks of test; (4) rejecting standard: while other Retinoids, Retin-A, Renova, Accutane of oral administration and externally person during the treatment, fail to finish person's course of treatment.
3. Therapeutic Method: 1. treatment group 1,2, the 3 granule administration of the method preparation of embodiment 1,2,3 in the corresponding specific embodiment respectively, each 1 bag, every day 2 times; 2. matched group oral tetracycline 250mg, every day 4 times; Spironolactone 20mg, vitamin B6 10mg, every day 3 times.Each group is 1 course of treatment with 4 weeks all, observes the statistics curative effect after 3 courses of treatment.
4. state of an illness classification and curative effect determinate standard: with reference to Chinese medical aesthstic with cosmetology branch beautifying skin group. acne vulgaris classification and criterion of therapeutical effect are tentatively formulated (Chinese medical beauty treatment magazine, 1998,4 (1): 41).
(1) grade scale (9 grades of classification method of 3 degree): calculate with a side surface part (a right or left side) acne, pimple, pustule number.Slightly: 1 grade is less than 25, and 2 grades 26～50,3 grades 51～75; Moderate: 4 grades 76～100,5 grades more than 100, and 6 grades with 1～2 tuberosity or cyst; Severe: 7 grades with 3～5 tuberositys or cyst, 8 grades with 6 with superior thyroid tubercle or cyst, 9 grades of tuberositys, cysts companion's hypertrophic cicatrix or sinus tracts.
(2) standards of grading: treat 9 grades of preceding 3 degree, per 1 grade is chosen as 1 fen; After the treatment, every reduction deducts 1 fen for 1 grade, if all disappearance then is 0 minute; Therapeutic index=(mark before treating-treatment back mark)/index * 100% before treating.If after the treatment still is simple, but alleviates to some extent, then can calculate little branch, every improvement 10% can deduct 0.1 fen.Skin lesion counting position selects the right side or left side facial, demarcates with centrage, comprises that half side forehead, cheekbone portion, buccal, chin portion and jaw portion summation calculate.The inactivity pathological changes comprises pigmentation, hole point-like cicatrix, ice pick sample cicatrix, the index of not marking.
(3) criterion of therapeutical effect: be divided into 4 grades.Therapeutic index reaches and is clinical cure more than 95%; Therapeutic index 60%～95% is a produce effects; Therapeutic index 20%～59% is effective; Therapeutic index＜20% is invalid.
5. statistical procedures: adopt the SPSS10.0 statistical software, measurement data relatively adopts one way analysis of variance, and enumeration data relatively adopts a plurality of independent sample non parametric testss.
6. result:
Table 1 respectively organize onset time relatively (
Unit: day)
* P＜0.05 of comparing with matched group, * * P＜0.01.
Table 2 is respectively organized clinical efficacy relatively
Compare * P＜0.05 with matched group.
With clinical cure, produce effects and effectively and the data basis of calculating as total effective rate, treatment group 1, treatment are organized 2 total effective rates and are 87.5%, it is 79.1% that 3 total effective rates are organized in treatment, matched group is 75.0%, compare with matched group, through the Friedman check, treatment group 1, treatment group 2 have significance with matched group difference, and treatment group 3 does not have significance with matched group difference.
7. untoward reaction: in taking the medicine process, the patient is if occur to feel sick, gastrointestinal reactions such as vomiting, stomachache, diarrhoea, perhaps anaphylaxis such as erythema and pimple companion pruritus, and xerostomia, pharyngitis, angular cheilitis, glossitis etc. are the untoward reaction of drug-induced.During treating, treatment group 1 appearance that has no adverse reaction; It is slight nauseating that treatment group 2 all has 2 routine patients to occur; Treatment group 3 has 1 routine patient the patient to occur to occur slight feeling sick; Matched group has 4 routine patients xerostomia symptom (seeing Table 3) to occur.
Table 3 is respectively organized the untoward reaction rate relatively
* * P＜0.01 of comparing with matched group.
8. recurrence situation: drug withdrawal was followed up a case by regular visits to after 2 months, treatment group 1 recurrence 3 examples, relapse rate 12.5%; Treatment group 2 recurrences 5 examples, relapse rate 20.8%; Treatment is organized 3 matched groups and is recurred 5 examples, relapse rate 20.8%, and matched group recurs 7 examples, relapse rate 29.1%.
Table 4 is respectively organized relapse rate relatively
* * P＜0.01 of comparing with matched group, * P＜0.05.
9. efficacy analysis: The above results shows that medicine of the present invention has good and clinical curative effect to wind and heat in the lung meridian type, damp-heat accumulation type acne, and have untoward reaction little, be difficult for characteristics such as recurrence, can be used as the active drug for the treatment of homeliness type acne.
The specific embodiment
Embodiment 1 (granule)
Take by weighing Radix Scutellariae 750g, Folium Eriobotryae 750g, Radix Salviae Miltiorrhizae 1000g, Herba Hedyotidis Diffusae 1000g, Radix Paeoniae Rubra 750g, Spica Prunellae 750g, Radix Angelicae Sinensis 500g, Radix Glycyrrhizae 500g, adding 8 times of water gagings decocts 3 times, boil for the first time the back intense fire and fry in shallow oil 30min, boil for the second time the back intense fire and fry in shallow oil 1h, boil the back intense fire for the third time and fry in shallow oil 1.5h.Collecting decoction then, filtering under back 80 ℃ and filtrate being concentrated into relative density is 1.25 clear paste, puts in the baking oven in 75 ℃ and bakes dried cream, is ground into fine powder.Add an amount of dextrin and starch to 1000g in the dried cream fine powder that obtains, add water again and make granule, dry then, granulate are distributed into 10g/ bag (whenever comprising the about 3.5g of medicine dry powder).
Embodiment 2 (granule)
Take by weighing Radix Scutellariae 500g, Folium Eriobotryae 500g, Radix Salviae Miltiorrhizae 650g, Herba Hedyotidis Diffusae 650g, Radix Paeoniae Rubra 350g, Spica Prunellae 350g, Radix Angelicae Sinensis 250g, Radix Glycyrrhizae 250g, adding 8 times of water gagings decocts 3 times, boil for the first time the back intense fire and fry in shallow oil 30min, boil the back intense fire for the second time and fry in shallow oil 1h, boil the back intense fire for the third time and fry in shallow oil 1.5h.Collecting decoction then, filtering under back 80 ℃ and filtrate being concentrated into relative density is 1.25 clear paste, puts in the baking oven in 75 ℃ and bakes dried cream, is ground into fine powder.Add an amount of dextrin and starch to 1000g in the dried cream fine powder that obtains, add water again and make granule, dry then, granulate are distributed into 10g/ bag (whenever comprising the about 3.5g of medicine dry powder).
Embodiment 3 (granule)
Take by weighing Radix Scutellariae 500g, Folium Eriobotryae 500g, Radix Salviae Miltiorrhizae 700g, Herba Hedyotidis Diffusae 700g, Radix Paeoniae Rubra 750g, Spica Prunellae 750g, Radix Angelicae Sinensis 600g, Radix Glycyrrhizae 600g, adding 8 times of water gagings decocts 3 times, boil for the first time the back intense fire and fry in shallow oil 30min, boil the back intense fire for the second time and fry in shallow oil 1h, boil the back intense fire for the third time and fry in shallow oil 1.5h.Collecting decoction then, filtering under back 80 ℃ and filtrate being concentrated into relative density is 1.25 clear paste, puts in the baking oven in 75 ℃ and bakes dried cream, is ground into fine powder.Add an amount of dextrin and starch to 1000g in the dried cream fine powder that obtains, add water again and make granule, dry then, granulate are distributed into 10g/ bag (whenever comprising the about 3.5g of medicine dry powder).
Embodiment 4 (capsule)
The drug particles that will be prepared into according to the method for embodiment 1, the gelatine capsule of packing into is made capsule.
Claims (5)
1. medicine for the treatment of homeliness type acne, this medicine is made up of active ingredient and medically acceptable excipient, wherein said active ingredient is made by following raw materials by weight percent medicine: Radix Scutellariae 9～15%, Folium Eriobotryae 9～15%, Radix Salviae Miltiorrhizae 13～19%, Herba Hedyotidis Diffusae 13～19%, Spica Prunellae 10～15%, Radix Paeoniae Rubra 10～15%, Radix Angelicae Sinensis 7～12%, Radix Glycyrrhizae 7～12%.
2. a kind of medicine for the treatment of homeliness type acne according to claim 1, it is characterized in that described active ingredient made by following raw materials by weight percent medicine: Radix Scutellariae 11～13%, Folium Eriobotryae 11～13%, Radix Salviae Miltiorrhizae 16～18%, Herba Hedyotidis Diffusae 16～18%, Spica Prunellae 10～15%, Radix Paeoniae Rubra 10～15%, Radix Angelicae Sinensis 8～10%, Radix Glycyrrhizae 8～10%.
3. a kind of medicine for the treatment of homeliness type acne according to claim 1, active ingredient make by following raw materials by weight percent medicine: Radix Scutellariae 12.5%, Folium Eriobotryae 12.5%, Radix Salviae Miltiorrhizae 16.7%, Herba Hedyotidis Diffusae 16.7%, Spica Prunellae 12.5%, Radix Paeoniae Rubra 12.5%, Radix Angelicae Sinensis 8.3%, Radix Glycyrrhizae 8.3%.
4. according to claim 1,2 or 3 described a kind of medicines for the treatment of homeliness type acne, its feature is being that described active ingredient is prepared by following method:
(1) by the proportioning weighting raw materials, add 8 times of water gagings at every turn and decoct 3 times, boil the back intense fire for the first time and fry in shallow oil 30min, boil the back intense fire for the second time and fry in shallow oil 1h, boil the back intense fire for the third time and fry in shallow oil 1.5h;
(2) collecting decoction filters the back and under 80 ℃ filtrate is concentrated into clear paste, puts in the baking oven in 75 ℃ and bakes dried cream, is ground into fine powder.
5. according to claim 1,2 or 3 described a kind of medicines for the treatment of homeliness type acne, it is characterized in that described medicine is granule or capsule.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104958633A (en) * | 2015-07-20 | 2015-10-07 | 吴强 | Medicine for treating acne vulgaris and preparation method thereof |
| CN107375737A (en) * | 2017-07-11 | 2017-11-24 | 张挺 | A kind of Chinese medicine of the treatment acne containing oldenlandia diffusa |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1443545A (en) * | 2002-03-07 | 2003-09-24 | 陈惠� | Medicine for curing acne and its preparation method |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1443545A (en) * | 2002-03-07 | 2003-09-24 | 陈惠� | Medicine for curing acne and its preparation method |
Non-Patent Citations (1)
| Title |
|---|
| 《吉林中医药》 20080420 周佳等 中医药辨证治疗痤疮经验 261-262 1-5 第28卷, 第04期 2 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104958633A (en) * | 2015-07-20 | 2015-10-07 | 吴强 | Medicine for treating acne vulgaris and preparation method thereof |
| CN107375737A (en) * | 2017-07-11 | 2017-11-24 | 张挺 | A kind of Chinese medicine of the treatment acne containing oldenlandia diffusa |
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| CN102125617B (en) | 2012-05-30 |
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Effective date of registration: 20220803 Address after: Room 201, Building 63, Universiade Software Town, No. 8288 Longgang Avenue, Heao Community, Yuanshan Street, Longgang District, Shenzhen, Guangdong 518000 Patentee after: Shenzhen hepulan Cosmetics Co.,Ltd. Address before: 510515, No. 1023 Sha Sha Road, Baiyun District, Guangdong, Guangzhou Patentee before: SOUTHERN MEDICAL University |