CN102120009B - Prunella vulgaris capsule capable of stabilizing blood pressure - Google Patents
Prunella vulgaris capsule capable of stabilizing blood pressure Download PDFInfo
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Abstract
The invention discloses a prunella vulgaris capsule capable of stabilizing blood pressure, which comprises the following components in parts by weight: 8-15 parts of stephania tetrandra, 20-40 parts of corn silk, 10-20 parts of uncaria, 8-15 parts of cassia seed, 8-15 parts of prunella vulgaris and 10-30 parts of radish seed. Compared with the prior art, the capsule disclosed by the invention is safe and effective, has small side effects, has a better treatment effect on patients with phlegm-dampness accumulation type hypertension, and also has a good treatment effect on patients with liver-yang hyperactivity type hypertension.
Description
Technical field
The invention belongs to and be used for the treatment of hypertensive compositions, belong to especially beautiful summer voltage stabilizing capsule.
Background technology
Hypertension is one of principal disease that threatens now China's people ' s health, and causes thus the target organ damages such as the heart, brain, kidney, blood vessel, need to take medicine all the life to keep the normal of blood pressure.The basic pattern of syndrome regularity of distribution of the hypertension traditional Chinese medical science is at present: phlegm-damp is stopped up Sheng card＞syndrome of upper hyperactivity of liver yang＞syndrome of hyperactivity of yang due to yin deficiency＞deficiency syndrome of both YIN and YANG; The document type regularity of distribution is: syndrome of upper hyperactivity of liver yang＞phlegm-damp is stopped up Sheng card＞syndrome of hyperactivity of yang due to yin deficiency＞deficiency syndrome of both YIN and YANG, and maximum with syndrome of blood stasis in the accompanied symptoms, secondly is the liver-fire card, and the QI and blood deficiency syndrome are few, illustrate that phlegm-damp and blood stasis are the common pathological factor of primary disease.Beautiful summer voltage stabilizing capsule be derive from national distinguished veteran doctors of TCM director Zheng Meisheng through proved recipe, " combination of Chinese and Western medicine cardiovascular and cerebrovascular disease magazine " in JIUYUE, 2009 discloses " observation of curative effect of beautiful summer voltage stabilizing capsule for treating phlegm-damp card senile hypertension ", the Main Ingredients and Appearance of beautiful summer voltage stabilizing capsule wherein is Spica Prunellae, Radix Stephaniae Tetrandrae, Stigma Maydis, Semen Raphani composition, cube foundation of above-mentioned capsule is for controlling from the expectorant opinion, focus on liver heat removing and reduce phlegm, the treating the liver sun rising disease of can not holding concurrently.
Summary of the invention
Technical problem to be solved by this invention provides a kind of phlegm-damp of not only can treating and stops up the beautiful summer voltage stabilizing capsule of containing card, can also treating excessive rising of liver-YANG disease.
The technical scheme of technical solution problem of the present invention is: a kind of beautiful summer voltage stabilizing capsule comprises following material and weight portion:
Radix Stephaniae Tetrandrae 8-15
Stigma Maydis 20-40
Ramulus Uncariae Cum Uncis 10-20
Semen Cassiae 8-15
Spica Prunellae 8-15
Semen Raphani 10-30.
Preferred beautiful summer voltage stabilizing capsule contains following material and weight portion:
Radix Stephaniae Tetrandrae 10
Stigma Maydis 30
Ramulus Uncariae Cum Uncis 15
Semen Cassiae 10
Spica Prunellae 10
Semen Raphani 20.
Stigma Maydis contains a large amount of potassium nitrate, vitamin K, α tocopheryl quinone and Semen Maydis acid and a kind of volatile alkaloid among the present invention; Its pharmacological action proves, obviously and lasting, hypotensive effect appears to hypotensive effect in repeat administration, illustrate without tachylaxis, and its hypotensive effect is relevant with vagus nerve, the Stigma Maydis a small amount of on heart without impact, the relatively large bradycardia that makes.
Spica Prunellae contains triterpenoid saponin, its glycoside unit oleanolic acid; Pharmacological research thinks, the alcohol-water of this product and 30% alcohol leaching liquid have hypotensive effect to postanesthetic animal.Dog intravenous injection Spica Prunellae is fried in shallow oil 100umol/kg, and obvious hypotensive effect is arranged.
Semen Raphani property suffering is sweet, and merit is arrogated to oneself the de-swelling that helps digestion, lowering the adverse-rising QI to resolve phlegm, is applicable to stagnation of QI due to dyspepsia, expectorant and stops up the excess syndrome of breathing with cough.Semen Raphani contains a small amount of volatile oil, contain the water extract such as methanthiol α and β hexanal in the volatile oil obvious hypotensive effect is arranged, for postanesthetic rabbit, cat and dog, intravenous injection can cause that all animal blood pressure descends, its effect is slowly and lasting, and being both has obvious reducing effect to the Rabbits with Acute hypoxic pulmonary hypertension.Its decompression principle can be by blood vessel dilating, reduces vascular resistance and onset.
Its main antihypertensive compositions of Radix Stephaniae Tetrandrae is tetrandrine, and result of study in recent years proves, tetrandrine has the anti-effect of calcium Fructus Citri tangerinae, is that a kind of calcium is believed anti-dose all.Patient's effect to hypertensive crisis or part acute left heart failure, acute cerebrovascular disease is good equally, and produces without the situation that causes the internal organs blood supply insufficiencies such as the heart, brain, kidney because blood pressure drops is too fast, and the blood pressure lowering total effective rate can reach about 84%.
The infusion of Semen Cassiae, pure infusion and alcohol leaching liquid reduce blood pressure and diuresis to Canis familiaris L., cat, the rabbit of anesthesia, SHH rat systolic pressure and diastolic pressure are obviously reduced, and its hypotensive effect intensity and persistent period significantly are better than reserpine.
Ramulus Uncariae Cum Uncis has the effects such as heat clearing away, suppressing the hyperactive liver are flame-out, spasmolytic, the diseases such as dizzy, the infantile convulsion tic of being used for having a headache, pre-eclampsia, hypertension.Not only have antihypertensive function, and have antiplatelet aggregation and suppress the formation of thrombosis, lax vascular smooth muscle effect.
The present invention compares with original beautiful summer capsule, two newly-increased flavor Chinese medicines, and one is Ramulus Uncariae Cum Uncis, two is Semen Cassiae.We are comprised of the Chinese medicine of purging liver-fire, the dampness removing effect of reducing phlegm, and Radix Stephaniae Tetrandrae is monarch drug, and dampness removing reduces phlegm; Semen Cassiae, suppressing the hyperactive liver and subsiding YANG, heat extraction make eye bright and share with Stigma Maydis, are ministerial drug altogether, strengthen the merit of suppressing the hyperactive liver to relieve the wind syndrome; Stigma Maydis liver heat removing dampness removing is ministerial drug, and assisting a ruler in governing a country monarch drug increases its liver heat removing dampness removing effect; The heat clearing away suppressing the hyperactive liver, the arresting convulsion that relieves dizziness, high fever, infantile convulsions, epilepsy, etc. is used in conjunction with Semen Cassiae, increases the effect of suppressing the hyperactive liver to relieve the wind syndrome; The Spica Prunellae purging liver-fire is played the reduce phlegm effect of eliminating dampness by diuresis of monarch-minister drug; The Semen Raphani spleen invigorating is regulated the flow of vital energy, clearing away liver-fire, draws that behavior makes medicine under the phlegm-damp.
The present invention compared with prior art, have safe and effective, side effect is little, not only phlegm-damp is stopped up the patients with hypertension curative effect of Sheng type better, also liver-Yang sthenia type hypertension is had good efficacy.
The specific embodiment
The present invention is described in detail below in conjunction with embodiment.
Embodiment 1:
A kind of beautiful summer voltage stabilizing capsule contains following material and weight portion: 8 parts of Radix Stephaniae Tetrandrae, 20 parts of Stigma Maydis, 10 parts of Ramulus Uncariae Cum Uncis, 8 parts of Semen Cassiaes, 8 parts of Spica Prunellaes, 10 parts of Semen Raphanis.
Embodiment 2:
A kind of beautiful summer voltage stabilizing capsule contains following material and weight portion: 10 parts of Radix Stephaniae Tetrandrae, 30 parts of Stigma Maydis, 15 parts of Ramulus Uncariae Cum Uncis, 10 parts of Semen Cassiaes, 10 parts of Spica Prunellaes, 20 parts of Semen Raphanis.
Embodiment 3:
A kind of beautiful summer voltage stabilizing capsule contains following material and weight portion: 15 parts of Radix Stephaniae Tetrandrae, 40 parts of Stigma Maydis, 20 parts of Ramulus Uncariae Cum Uncis, 15 parts of Semen Cassiaes, 15 parts of Spica Prunellaes, 30 parts of Semen Raphanis.
The dosage form of clinical usefulness is that every of capsule contains former medicine 0.33g, and former medicine is equivalent to the 20g crude drug.
Embodiment 4:
Impact on the renal hypertensive rat blood pressure
2-KIC (copying two kidneys, one folder) method hypertensive rat model is set up, and makes SD rat postoperative the 5th all rat systolic pressures reach the above person of 160mmHg and is considered as Hypertensive Rats.
The beautiful summer capsule of dosage setting and experiment grouping every consumption per day of being grown up is 1.32～1.98g (4-6 grain), pressing 60kg calculates, being converted to rat equivalent (pressing body-mass index) is 0.154g～0.231g/kg, take 0.2g/kg as low dosage, increases progressively by 3 times and to be high dose group 0.6g/kg.With above-mentioned 32 of the successful Hypertensive Rats that copy, be divided at random 4 groups, be model control group (distilled water 5ml/kg), the high low dose group of beautiful summer capsule (0.6g/kg, 0.2g/kg), nitrendipine (0.001g/kg) positive controls, 8 every group.Other establishes 8 of normal group (distilled water 5ml/kg).In the 6th week of postoperative (36 days), give rats gavaged by the dosage of above-mentioned setting respectively at 9 of every mornings, normal group and model group all gavage isometric distilled water.
Medication is by above-mentioned setting dosage, in every morning 9 gastric infusions (the molten long-pending 5ml/kg that is), every day 1 time, continuous 4 weeks.
Observation index: rat blood pressure weekly before the administration and after the administration; Blood fat (serum total cholesterol, triglyceride, low density lipoprotein, LDL, high density lipoprotein); Renal function (carbamide, creatinine) and uric acid.
Before the administration, compare with normal group, each organize rat blood pressure obviously raise (160～230mmHg), have remarkable statistical significance (P＜0.01), modeling success is described.After the administration, compare with model group, positive group 1～4 week of administration of high dose group of the present invention and nitrendipine, blood pressure obviously reduces, has remarkable statistical significance (P＜0.01), 1 week of low dose group administration, blood pressure descend to some extent (P＜0.05), administration 2～4 all blood pressures obviously descend, and have remarkable statistical significance (P＜0.01); Compare with the positive group of nitrendipine, in 3～4 weeks of high dose group administration of the present invention, its hypotensive effect is stronger, has statistical significance (P＜0.05).Prompting the present invention has obvious hypotensive effect, and onset is very fast, effect is stronger, and especially in administration during 3～4 week, 0.6g/kg dosage group hypotensive effect is strong than nitrendipine.The results are shown in Table 1.
Table 1 on the impact of renal hypertensive rat blood pressure (
N=8)
Annotate: be blood pressure value (mmHg) before and after the administration in the bracket.Compare with normal group
aP＜0.05,
AaP＜0.01; Compare with model group
bP＜0.05,
BbP＜0.01; Compare with the positive group of nitrendipine
cP＜0.05.
Embodiment 5:
Impact on the renal hypertensive rat blood fat
Compare with model group with normal group, though embodiment 1 made capsule HDL has remarkable statistical significance (P＜0.01), belong in the range of normal value all other indexs CHOL, the equal not statistically significant of TG, LDL (P＞0.05).Prompting the present invention and nitrendipine to renal hypertensive rat without obvious effect for reducing blood fat.The results are shown in Table 2.
Table 2 on the impact of renal hypertensive rat blood fat (
N=8)
Annotate: compare with model group
AaP＜0.01.
Embodiment 6:
Impact on renal hypertensive rat renal function and uric acid
Compare with model group with normal group, the renal function of embodiment 3 and nitrendipine group and uric acid not statistically significant (P＞0.05), prompting the present invention have no significant effect renal hypertensive rat renal function and uric acid.The results are shown in Table 3.
Table 3 on the impact of renal hypertensive rat renal function (
N=8)
Embodiment 7:
The treatment example:
1 hypertensive diagnostic criteria
Dizzy (essential hypertension) disease is dirty at Liver and kidney two, and pathogenesis is excess in the upper and deficiency in the lower, and take excess syndrome or deficiency in origin and excess in superficiality as main, late period is then take deficient syndrome as main in early days.Clinical main syndromes take headache feeling of fullness in the head, palpitation and insomnia, feeling of oppression and pain in the chest, have a dizzy spell, flushing conjunctival congestion, xerostomia dysphoria with smothery sensation, rigidity of the neck, numb limbs and tense tendons or the diseases such as swelling, soreness of the waist and knees are as main.Primary disease is equivalent to the essential hypertension in the modern Western medicine diagnose, is a kind of modal cardiovascular disease.
Chinese and western medicine diagnostic criteria and typing
2005 " the Chinese hypertension prevention and control guides " that dizzy (essential hypertension) diagnostic criteria adopts Chinese hypertension alliance to formulate.
The definition of blood pressure level and classification
Traditional Chinese medical science Disease Diagnosis Standard adopts National Drug Administration's " new Chinese medicine guideline of clinical investigations ", in August, 2008 in 2002 " tcm internal medicine commonly encountered diseases practice guidelines "
TCM syndrome diagnostic criteria
1) overabundant liver-fire syndrome
Primary symptom: dizzy, headache, being irritable and getting angry easily.
Inferior disease: flushing, conjunctival congestion, xerostomia, bitter taste, constipation, red, the red tongue with yellow fur of urinating, wiry and frequent pulse.
2) syndrome of hyperactivity of yang due to yin deficiency
Primary symptom: dizzy, headache, the soreness of waist, knee joint are soft, dysphoria with feverish sensation in the chest palms and soles.
Inferior disease: cardiopalmus, insomnia, tinnitus, forgetful, the few Feng of red tongue, thin fur are few, stringy and thready pulse and counting.
3) phlegm-damp is stopped up the Sheng card
Primary symptom: dizzy, the headache, the head as wrap up in, uncomfortable in chest, the vomiting sputum.
Inferior disease: cardiopalmus, insomnia, tastelessness, lack of appetite, enlarged tongue greasy fur, rolling pulse.
4) deficiency syndrome of both YIN and YANG
Primary symptom: dizzy, have a headache tinnitus, soreness of waist and knee, aversion to cold and cold limbs.
Inferior disease: cardiopalmus is weak, breathe hard, a little less than the nocturia frequency, pale tongue with white fur, deep-thready pulse.
2 curative effect evaluations
The standard of curative effect evaluation is with reference to " traditional Chinese medical science cardiopathia Standardization of diagnosis and curative effect and medication standard " book, by Shen Shaogong, Wang Chengde, Yan Xijun chief editor " hypertension " piece, calendar year 2001 JIUYUE published by Beijing Publishing House
The efficacy of antihypertensive treatment evaluation criteria
Produce effects: more than the diastolic pressure decline 10mmHg, and reach normal range; Though diastolic pressure is not down to normally, descended 20mmHg or more than.Must possess wherein one;
Effectively: diastolic pressure descends not as good as 10mmHg, but has reached normal range; Diastolic pressure is treated front decline 10～19mmHg, but does not reach normal range; Systolic pressure is treated more than the front decline 30mmHg.Must possess wherein one;
Invalid: Blood pressure drop, but do not reach above standard person;
Increase the weight of: the organ injury performance appears in hypertension.In the damage of target organ, mainly pay close attention to the heart brain, kidney, blood vessel, the impact on optical fundus, mainly comprise: left chamber wall thickness, diastolic function, blood inosine, blood urea nitrogen, twenty-four-hour urine protein quantification, the blood vessel doppler ultrasound: speckle, vessel wall thickening, the arteria retina blood vessel is depending on the variation of the indexs such as nipple.
Tcm syndrome score quantitative criterion
0 minute: disappear without syndrome or syndrome;
1 minute: upper card was lighter, occurs once in a while, does not affect work and life;
2 minutes: on heavy when light when demonstrate,proving, be interrupted and occur, do not affect work and life;
3 minutes: upper proof was aobvious, often occurs, and does not affect work and life;
4 minutes: upper card continued to occur, and affects work and life.
The tcm syndrome curative effect determinate standard
Produce effects: syndrome all disappears after the treatment, and integration is 0, or the syndrome integration is treated front minimizing 70% above person after the treatment.
Effectively: the syndrome integration is treated front minimizing 50%～70% after the treatment.
Invalid: the syndrome integration is treated front minimizing deficiency after the treatment.
Increase the weight of: the syndrome integration is above treating the former after the treatment.
4. safety indexes
Observing medicine has no adverse effects to the biochemical indicator such as hepatic and renal function, blood glucose, blood fat, uric acid, routine urinalysis, routine blood test and heart.
5. method of administration
Treatment group: embodiment 2, at 6 o'clock in the morning and afternoon 5 o'clock took, one time two, one day secondary.
In the research process, pass judgment in strict accordance with above-mentioned standard, thus scientific and precise as a result, its treatment group 5 examples that come off, contrast 3 examples that come off are finished 1054 examples, report the test following (table 1, table 2, table 3, table 4) altogether
Contrast before and after blood pressure and the biochemical analysis before and after the table 1. treatment group treatment of control group
* contrast before and after the treatment, there is statistical significance P＜0.05
ΔContrast between two groups, there is statistical significance P＜0.05
Contrast before and after blood pressure and the biochemical analysis before and after the treatment by Chinese herbs, systolic pressure, diastolic pressure, blood glucose, urine trace albumin, use paired t-test, P＜0.05, refusal H0, statistical significance is arranged, can find out the treatment by Chinese herbs front and back by above data, systolic pressure and diastolic pressure obviously reduce, simultaneously can be to blood sugar level and urine trace albumin, before and after being arranged, certain improvement effect western medicine front and back blood pressure and biochemical analysis contrast, systolic pressure, diastolic pressure, blood glucose, urine trace albumin and creatinine level are used paired t-test, P＜0.05, refusal H0 has statistical significance.The contrast of Chinese and western drugs group, the present invention is to systolic pressure and diastolic pressure control, and antihypertensive effect is better than the Western medicine group, and contrast is checked with independent sample t between group, P＜0.05, refusal H0 has statistical significance.
Symptom score contrast before and after the table 2. treatment group treatment of control group
* contrast before and after the treatment, there is statistical significance P＜0.05
ΔContrast between two groups, there is statistical significance P＜0.05
Before and after the western medicines in treatment, by symptom score (standards of grading: according to traditional Chinese medical science diagnosis of coronary heart disease criterion of therapeutical effect and medication standard), headache, cardiopalmus, uncomfortable in chest, the soreness of waist, fat weakly all be improved, paired t-test is used in contrast before and after the treatment, and H is refused in P＜0.05
0, statistical significance is arranged; Contrast between western medicines in treatment group group, with the independent sample t check, except uncomfortable in chest, remaining doing well,improving is analyzed through scoring, P＜0.05, refusal H
0, statistical significance is arranged;
Table 3 therapeutic evaluation
As can be seen from the above data, liver-kidney yin deficiency, obvious effective rate are 31.25%; Phlegm-damp is stopped up Sheng type type, and obvious effective rate is 37.5%, and the qi stagnation and blood stasis type obvious effective rate is 27.27%; The liver-Yang sthenia type obvious effective rate is 65.62%; New beautiful summer capsule is more obvious to hypertension phlegm-damp heap soil or fertilizer over and around the roots Sheng type hypertension curative effect.
Claims (2)
1. beautiful summer voltage stabilizing capsule, it is characterized in that: crude drug is comprised of the material of following weight portion:
2. described a kind of beautiful summer voltage stabilizing capsule according to claim 1, it is characterized in that: crude drug is comprised of the material of following weight portion:
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| CN107410577A (en) * | 2017-09-20 | 2017-12-01 | 贵州健瑞安药业有限公司 | A kind of health protection tea of the stable hypotensive of energy and preparation method thereof |
| CN116098957A (en) * | 2023-01-06 | 2023-05-12 | 中国中医科学院广安门医院 | Acupoint application formula for reducing blood pressure |
Citations (1)
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| CN1824174A (en) * | 2005-12-30 | 2006-08-30 | 吕宝俊 | Medicinal preparation made of gastrodia and uncaria |
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| CN1824174A (en) * | 2005-12-30 | 2006-08-30 | 吕宝俊 | Medicinal preparation made of gastrodia and uncaria |
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| 周鲁等.治疗高血压常用中药复方用药规律分析.《中医杂志》.2005,第16卷(第5期), * |
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| 王小顺.中药降压药物的多效性临床研究思考.《中华中医药杂志》.2010,第25卷(第4期), * |
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