CN102106874A - New method for correcting flavor of traditional Chinese medicine granule - Google Patents
New method for correcting flavor of traditional Chinese medicine granule Download PDFInfo
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- CN102106874A CN102106874A CN2009102006961A CN200910200696A CN102106874A CN 102106874 A CN102106874 A CN 102106874A CN 2009102006961 A CN2009102006961 A CN 2009102006961A CN 200910200696 A CN200910200696 A CN 200910200696A CN 102106874 A CN102106874 A CN 102106874A
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Abstract
The invention discloses a new method for correcting flavor of a traditional Chinese medicine granule, comprising the following steps: independently processing auxiliary materials for correcting the flavor; independently internally packaging to form an independently packaged flavoring agent; packaging together with the traditional Chinese medicine granule so that patients can select whether to use the flavoring agent or not. According the invention, the purposes of satisfying the requirements of different people can be finally met, and a greater right is given to patients for selection. The method is suitable for industrial production; and by utilizing the method, the different requirements of different people on the mouth feel of the medicament can be ensured, and the requirements of special people on the flavoring agent can be satisfied; and the traditional Chinese medicine granule subjected to flavor correction by the method provided by the invention has the advantages of good mouth feel and wide application range, and is especially beneficial for the old, the children, and the patients with diabetes to take.
Description
Technical field
The present invention relates to the method to modify taste in a kind of Chinese medicine preparation, particularly relate to a kind of new-type traditional Chinese granule method to modify taste.
Background technology
The taste of medicine can influence patient's compliance of taking medicine.For the medicine of mouthfeel difference, the preparation R﹠D process is usually covered bad mouthfeel by adding correctives.And these correctivess are readily good treatment effects for the patient, for especial patient, may also have some side effect.Find that in clinical some people is stronger to the disagreeable taste endurance, they think does not need the help of correctives, takes the burden that too much correctives can increase the weight of health yet.Some crowd is unique to the perception of taste, and these people often can not accept certain specific taste, even causes vomiting, and this specific taste may be from correctives.Therefore, in medicine, add correctives, cause unnecessary trouble may for some patients.
For Chinese medicine, the composition of Chinese medicine compound mostly is natural product, and effect is gentle, little, the treating both the principal and secondary aspects of a disease of side effect, is suitable for children, the medication of old conditioning property, and the medication of chronic disease long-term control.Child's digestive system is zoon not as yet, and the correctives of safety also should be taken in concerning the child less; The old man takes medicine for a long time, and the metabolic system aging may cause the body accumulation to certain composition.Therefore, the interpolation of the correctives of Chinese medicine more should be prudent.
In order to satisfy the needs of different crowd, give the patient with bigger right to choose, the present invention intends setting forth a kind of new-type traditional Chinese granule method to modify taste.Literature search shows, present domestic still do not have pertinent literature or patent report the method.
Summary of the invention
The technical problem to be solved in the present invention provides a kind of new-type traditional Chinese granule method to modify taste, and this method can provide bigger right to choose for the patient, satisfies the needs of different crowd.
For solving the problems of the technologies described above, a kind of new-type traditional Chinese granule method to modify taste of the present invention comprises step:
After the adjuvant individual processing and independent inner packing that are used for flavoring, form the correctives of independent packaging, pack with Chinese medicine granules again, so that the patient can select whether to use this correctives.
The described adjuvant that is used for flavoring is to be added on Chinese medicine granules, upsets the correctives of people to the perception of taste of medicine own or abnormal smells from the patient by self mouthfeel and abnormal smells from the patient, comprises sweeting agent, bitter tasting retarding agent, aromatic three major types.Wherein sweeting agent comprises sucrose, glucose, saccharin sodium, cyclamate, stevioside, aspartame, sucralose etc.; Bitter tasting retarding agent comprises monosodium glutamate, adenylic acid etc.; Aromatic comprises the natural volatile oil spice that menthol, apple essence, Cortex cinnamomi japonici (Ramulus Cinnamomi) essence, flavoring banana essence, cinnamic aldehyde, ethyl acetate etc. are edible and the essence and flavoring agent of synthetic.Three class flavoring adjuvants can mix use.
The described proportioning that is used for the adjuvant of flavoring is to study by experiment taste of medicine is had the improvement effect, and does not influence curative effect of medication, the consumption when not influencing drug safety.
The described adjuvant individual processing that is used for flavoring is meant that the preparation process of adjuvant and medicine separate.This processing method comprises wherein aromatic cyclodextrin inclusion compound; mix with other flavoring adjuvant again; selectivity adds the adjuvant that helps molding and disintegrate and mixes back granulation or pill, and the granule of gained or the melting of pill are close with corresponding drug particles dissolution time.Method of granulating comprises dry granulation, centrifugal granulating, one-step palletizing (fluidized bed granulation).The pill method comprises extrudes round as a ball pill, centrifugal pill, fluid bed side spray ball.Can select wherein a kind of granulation or pill method to handle adjuvant, help the adjuvant of molding to comprise dextrin, starch, cellulose family composition, help the adjuvant of disintegrate to comprise disintegrating agent commonly used in the preparations such as polyvinylpolypyrrolidone, carboxymethyl starch sodium.
Described independent inner packing is to adopt filtration cotton paper or non-woven fabrics to pack, and this packing does not react with medicine.
The correctives bag number of described independent packaging is identical with Chinese medicine granules bag number, and wherein, comparatively preferably, the gross weight of every bag of correctives accounts for the 0.1%-15% of every bag of Chinese medicine granules gross weight.Whether the patient can select correctives with independent packaging to dissolve with medicine and take when using granule.
Described Chinese medicine granules comprises the granule of Chinese medicine extract preparation, particularly includes the granule of following one or more Chinese medicine extract preparations: Rhizoma Coptidis; Fructus Forsythiae; Radix Et Rhizoma Rhei; Radix Gentianae Macrophyllae; Radix Gentianae; Radix Isatidis; the Rhizoma Anemarrhenae; Plumula Nelumbinis; Fel Ursi; Herba Commelinae; Fructus Gardeniae; Spica Prunellae; Radix Scutellariae; Cortex Phellodendri; Radix Sophorae Flavescentis; Cortex Dictamni; Cortex Ailanthi; Folium Isatidis; Rhizoma Osmundae; Herba Taraxaci; Herba Violae; Flos Chrysanthemi Indici; Herba Senecionis Scandentis; Ilex purpurea Hassk.[I.chinensis Sims; Herba Andrographis; Herba Scutellariae Barbatae; Radix Rhapontici; Caulis Sargentodoxae; Herba Patriniae; the Radix Pulsatillae; Cortex Fraxini; Herba Schizonepetae; Rhizoma Belamcandae; Radix Sophorae Tonkinensis; Cortex Moutan; Radix Paeoniae Rubra; Herba Artemisiae Annuae; Rhizoma Picrorhizae; Semen Pharbitidis; Radix Stephaniae Tetrandrae; Radix Tripterygii Wilfordii; Cortex Acanthopancis; Caulis Akebiae; Herba Agrimoniae; the Pseudobulbus Bletillae (Rhizoma Bletillae); Rhizoma Corydalis; Radix Curcumae; Radix Salviae Miltiorrhizae; Herba Leonuri; Semen Vaccariae; catechu; Rhizoma Arisaematis; Radix Peucedani; Bulbus Fritillariae Cirrhosae; Calculus Bovis and Fructus Cnidii.
The present invention is by to packing with granule after the correctives individual processing of adding in the Chinese medicine granules and the independent packaging again, finally reach the needs that satisfy different crowd, give the patient purpose, improve compliance, the safety of the medication of specific crowd with bigger right to choose.This method is fit to suitability for industrialized production.
The present invention guarantees the different needs of different crowd to the medicine mouthfeel, satisfies special population to the correctives requirement, and mouthfeel is good, is widely used, and product is easy to old man, child especially, has the patient of diabetes to take.
The specific embodiment
The invention will be further described below in conjunction with embodiment.
Embodiment 1 SHUANGHUANLIAN flavoring granule
Prescription is formed: Fructus Forsythiae Radix Scutellariae Flos Lonicerae
Each medical material prepares the 9kg drug particles according to 2005 editions officinal processes, does not add any correctives.Be distributed into 3000 bags.
Other gets menthol 200g, and cyclodextrin 1kg carries out enclose, gets sweeting agent aspartame 150g, and evenly mixed with the menthol clathrate, dry granulation obtains the correctives granule.Packing is in filter cotton paper bag (this packing does not react with medicine), and every bag of 0.45g granule seals.Prepare 3000 bags altogether.
This filter cotton paper bag independent packaging is adorned box with medicinal granule, guarantee that the correctives granule bag number in the box is identical with medicinal granule bag number.
The composition granule of can directly getting it filled when the patient uses, hot water dissolves, and takes; Also drug particles can be poured in the cup, be got one bag of correctives again, add the 200ml hot water dissolving, sweet, the little hardship of mouthfeel, refrigerant.
The adjuvant that is used for flavoring in the present embodiment meets 2005 editions pharmacopeia requirements, and the proportioning between this adjuvant is that institute gets by experiment.This correctives granule can improve the medicine mouthfeel.The particulate melting of correctives in the present embodiment is close with corresponding drug particles dissolution time, specifically can see Table 1.
Table 1
Embodiment 2 xiao'er ganmao granules
Prescription is formed: Herba Pogostemonis Fructus Forsythiae Flos Chrysanthemi Folium Isatidis Radix Isatidis Radix Rehmanniae Cortex Lycii Radix Cynanchi Atrati Herba Menthae Gypsum Fibrosum
Each medical material prepares drug particles 30kg according to 2005 editions officinal processes, does not add any correctives.Be distributed into 2500 bags.
Other gets sweeting agent stevioside 150g, microcrystalline Cellulose 200g, and mixing, centrifugal pill obtains the correctives micropill.Divide to install in the non-woven cloth bag (this packing does not react with medicine), every bag of 0.14g granule seals.Prepare 2500 bags altogether.
This non-woven fabrics paper bag independent packaging with the medicinal granule packing, is all comprised one bag of correctives in every bag of granule.
Can directly tear the granule packing when patient uses, pour out granule and correctives bag, add the 200ml hot water dissolving, take; Also can before adding hot water the correctives bag be taken out, directly brew drug particles, mouthfeel how.
The adjuvant that is used for flavoring in the present embodiment meets 2005 editions pharmacopeia requirements, and the proportioning between this adjuvant is that institute gets by experiment.This correctives granule can improve the medicine mouthfeel.The particulate melting of correctives in the present embodiment is close with corresponding drug particles dissolution time, specifically can see Table 2.
Table 2
The embodiment 3 clear granules that drench
Prescription is formed: Qu Mai Herba Polygoni Avicularis Caulis Akebiae Semen Plantaginis (salt stir-fry) Talcum gardenia-rhubarb Radix Glycyrrhizae Preparata
Each medical material prepares drug particles 10kg according to 2005 editions officinal processes, does not add any correctives.Be distributed into 1000 bags.
Other gets sweeting agent saccharin sodium 50g, monosodium glutamate 20g, and carboxymethyl starch sodium 50g, evenly mixed, the GLATTmini fluidized bed granulation obtains the correctives granule.Packing is in filter cotton paper bag (this packing does not react with medicine), and every bag of 0.12g granule seals.Prepare 1000 bags altogether.
This non-woven fabrics paper bag independent packaging is adorned box with granule, guarantee that the correctives granule bag number in the box is identical with drug particles bag number.
The composition granule of can directly getting it filled when the patient uses, hot water dissolves, and takes; Also drug particles can be poured in the cup, be got one bag of correctives again, add the 200ml hot water dissolving, take, mouthfeel is sweet, little hardship.
The adjuvant that is used for flavoring in the present embodiment meets 2005 editions pharmacopeia requirements, and the proportioning between this adjuvant is that institute gets by experiment.This correctives granule can improve the medicine mouthfeel.The particulate melting of correctives in the present embodiment is close with corresponding drug particles dissolution time, specifically can see Table 3.
Table 3
Claims (10)
1. new-type traditional Chinese granule method to modify taste is characterized in that: comprise step:
After the adjuvant individual processing and independent inner packing that are used for flavoring, form the correctives of independent packaging, pack with Chinese medicine granules again, make the patient can select whether to use this correctives.
2. new-type traditional Chinese granule method to modify taste as claimed in claim 1, it is characterized in that: the described adjuvant that is used for flavoring is to be added on Chinese medicine granules, mouthfeel and abnormal smells from the patient by self are upset the correctives of people to the perception of taste of medicine own or abnormal smells from the patient, comprise sweeting agent, bitter tasting retarding agent, aromatic three major types, this three classes flavoring adjuvant can mix use.
3. new-type traditional Chinese granule method to modify taste as claimed in claim 2, it is characterized in that: described sweeting agent comprises sucrose, glucose, saccharin sodium, cyclamate, stevioside, aspartame, sucralose;
Bitter tasting retarding agent comprises monosodium glutamate, adenylic acid;
Aromatic comprises menthol, apple essence, Cortex cinnamomi japonici (Ramulus Cinnamomi) essence, flavoring banana essence, cinnamic aldehyde, ethyl acetate.
4. new-type traditional Chinese granule method to modify taste as claimed in claim 1 is characterized in that: the described proportioning that is used for the adjuvant of flavoring is to study by experiment taste of medicine is had the improvement effect and do not influence curative effect of medication, consumption when not influencing drug safety.
5. new-type traditional Chinese granule method to modify taste as claimed in claim 1 is characterized in that: the described adjuvant individual processing that is used for flavoring is meant that the adjuvant preparation process that is used for flavoring separates with medicine; This processing method comprises wherein aromatic cyclodextrin inclusion compound, mix with other flavoring adjuvant again, selectivity adds the adjuvant that helps molding and disintegrate and mixes back granulation or pill, and the granule of gained or the melting of pill are close with corresponding drug particles dissolution time;
Wherein, method of granulating comprises dry granulation, centrifugal granulating, one-step palletizing; The pill method comprises extrudes round as a ball pill, centrifugal pill, fluid bed side spray ball; Can select wherein a kind of granulation or pill method to handle adjuvant.
6. new-type traditional Chinese granule method to modify taste as claimed in claim 5 is characterized in that: the described adjuvant of molding that helps comprises dextrin, starch, cellulose family composition;
Help the adjuvant of disintegrate to comprise polyvinylpolypyrrolidone, carboxymethyl starch sodium.
7. new-type traditional Chinese granule method to modify taste as claimed in claim 1 is characterized in that: described independent inner packing is to adopt filtration cotton paper or non-woven fabrics to pack, and this packing does not react with medicine.
8. new-type traditional Chinese granule method to modify taste as claimed in claim 1 is characterized in that: the correctives bag number of described independent packaging is identical with Chinese medicine granules bag number.
9. new-type traditional Chinese granule method to modify taste as claimed in claim 8, it is characterized in that: the gross weight of described every bag of correctives accounts for the 0.1%-15% of every bag of Chinese medicine granules gross weight.
10. new-type traditional Chinese granule method to modify taste as claimed in claim 1 is characterized in that: described Chinese medicine granules is the granule that includes following one or more Chinese medicine extract preparations: Rhizoma Coptidis; Fructus Forsythiae; Radix Et Rhizoma Rhei; Radix Gentianae Macrophyllae; Radix Gentianae; Radix Isatidis; the Rhizoma Anemarrhenae; Plumula Nelumbinis; Fel Ursi; Herba Commelinae; Fructus Gardeniae; Spica Prunellae; Radix Scutellariae; Cortex Phellodendri; Radix Sophorae Flavescentis; Cortex Dictamni; Cortex Ailanthi; Folium Isatidis; Rhizoma Osmundae; Herba Taraxaci; Herba Violae; Flos Chrysanthemi Indici; Herba Senecionis Scandentis; Ilex purpurea Hassk.[I.chinensis Sims; Herba Andrographis; Herba Scutellariae Barbatae; Radix Rhapontici; Caulis Sargentodoxae; Herba Patriniae; the Radix Pulsatillae; Cortex Fraxini; Herba Schizonepetae; Rhizoma Belamcandae; Radix Sophorae Tonkinensis; Cortex Moutan; Radix Paeoniae Rubra; Herba Artemisiae Annuae; Rhizoma Picrorhizae; Semen Pharbitidis; Radix Stephaniae Tetrandrae; Radix Tripterygii Wilfordii; Cortex Acanthopancis; Caulis Akebiae; Herba Agrimoniae; the Pseudobulbus Bletillae (Rhizoma Bletillae); Rhizoma Corydalis; Radix Curcumae; Radix Salviae Miltiorrhizae; Herba Leonuri; Semen Vaccariae; catechu; Rhizoma Arisaematis; Radix Peucedani; Bulbus Fritillariae Cirrhosae; Calculus Bovis and Fructus Cnidii.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112972398A (en) * | 2021-02-25 | 2021-06-18 | 江苏睿实生物科技有限公司 | Berberine hydrochloride granules and preparation method thereof |
| CN113081979A (en) * | 2021-03-30 | 2021-07-09 | 天圣制药集团股份有限公司 | Instant tea for treating common cold in children and production process thereof |
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- 2009-12-24 CN CN200910200696.1A patent/CN102106874B/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112972398A (en) * | 2021-02-25 | 2021-06-18 | 江苏睿实生物科技有限公司 | Berberine hydrochloride granules and preparation method thereof |
| CN113081979A (en) * | 2021-03-30 | 2021-07-09 | 天圣制药集团股份有限公司 | Instant tea for treating common cold in children and production process thereof |
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| CN102106874B (en) | 2014-01-22 |
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Effective date of registration: 20200109 Address after: 201203 Shanghai city Pudong New Area Cailun Road No. 1200 Patentee after: Shanghai University of Traditional Chinese Medicine Address before: 201203 Shanghai city Pudong New Area Cailun Road No. 781 room 423 Patentee before: Shanghai Zhangjiang Traditional Chinese Medicine Modern Pharmaceutical Preparation Technology Engineering Research Center |