CN102103114A - Biosensor capable of automatically sensing sense code and sensing method thereof - Google Patents
Biosensor capable of automatically sensing sense code and sensing method thereof Download PDFInfo
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- CN102103114A CN102103114A CN2009102613358A CN200910261335A CN102103114A CN 102103114 A CN102103114 A CN 102103114A CN 2009102613358 A CN2009102613358 A CN 2009102613358A CN 200910261335 A CN200910261335 A CN 200910261335A CN 102103114 A CN102103114 A CN 102103114A
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Abstract
The invention relates to a biosensor capable of automatically sensing a sense code and a sensing method thereof. The biosensor capable of automatically sensing the sense code comprises: a biological sensing test piece and a processing display unit, wherein the biological sensing test piece is provided with a passive element a physical numerical value of which can represent a sense code; and when the biological sensing test piece is inserted into the processing display unit, the processing display unit can read the sense code automatically to calculate a proper compensation value of a tested object. In addition, through the sensing method of the biosensor, the processing display unit can be enabled to sense the sense code of the biological sensing test piece automatically, and read, calculate, compensate and display a tested object quantity value of the tested object.
Description
Technical field
The present invention relates to a kind of biosensing apparatus, particularly relate to and a kind ofly on a biological sensing test piece, a passive device is set, but but make a kind of biosensing apparatus of Auto-Sensing sensing sign indicating number of a sensing sign indicating number of processes and displays unit this biological sensing test sheet of Auto-Sensing and the method for sensing thereof.
Background technology
Because sensor technology rapid development in recent years, the various biological sensors of ferment redox reaction that utilize constantly are suggested, and one after the other weed out the old and bring forth the new, wherein, again with the most species of the biological sensor of giving birth to the doctor field, for example: the blood sugar sensor, it can be in order to the blood-sugar content in the check blood, therefore, the blood sugar sensor becomes the important device of diabetic's self-checking, it can help the diabetic oneself to detect the concentration of blood-sugar content in the health, make the diabetic can momentarily note and control the blood sugar concentration in the health, blood sugar concentration is maintained within the normal scope, in case the patient finds that the blood sugar concentration of health is too high, just can be by diet, modes such as motion and insulin injection are come control of blood sugar content, yet these control modes must be just fair with employing under doctor's supervision and suggestion.
See also Fig. 1 and shown in Figure 2, be a kind of stereographic map of the existing blood sugar sensing apparatus of commonly using and a kind of exploded view of the existing blood sugar sensing test piece of commonly using, a kind of existing blood sugar sensing apparatus of commonly using 1 ', comprise: a blood sugar sensing test piece 12 ' and a processes and displays unit 10 ', wherein, this blood sugar sensing test piece 12 ' comprising: a strip substrate 122 ', a responding layer 124 ', a spacing body 126 ', an and cover plate 128 '.The front end of this strip substrate 122 ' is provided with an electrode part 1221 ', the top of this electrode part 1221 ' then is coated with this responding layer 124 ', this spacing body 126 ' and this cover plate 128 ' in regular turn, and, electrode part 1221 ' is provided with the corresponding electrode 1224 ' with of an operation electrode 1222 ', and this operation electrode 1222 ' and this counter electrode 1224 ' are connected to one first lead 1226 ' and one second lead 1228 ' of strip substrate 122 ' tail end respectively.In addition, be covered in the responding layer 124 ' of electrode part 1221 ' top, it has the ferment enzyme can carry out the ferment redox reaction.
When the diabetic states this existing blood sugar sensing apparatus of commonly using 1 ' in the use, earlier this blood sugar sensing test piece 12 ' is inserted in this processes and displays unit 10 ', then, the patient must handle display unit 10 ' with a sensing sign indicating number (strip code) input of blood sugar sensing test piece 12 ' earlier, then just can take the blood of own body, and blood directly dripped on this responding layer 124 ' of blood sugar sensing test piece 12 ', after electrochemical reaction after a while, processes and displays unit 10 ' just can change by reading the electric current that electrochemical reaction produces, and calculates the blood sugar concentration in the blood.
The above-mentioned blood sugar sensing apparatus 1 ' that should existing commonly use is a quite practical and blood sugar sensing apparatus accurately, yet its maximum shortcoming is: this sensing sign indicating number that can't this blood sugar sensing test piece 12 ' of Auto-Sensing.When the diabetic uses the existing blood sugar sensing apparatus of commonly using 1 ', must splash into this responding layer 124 ' before at blood, import this sensing sign indicating number of blood sugar sensing test piece 12 ' in advance, with usefulness as the blood sugar concentration correction, yet, in case patient's input sensing sign indicating number mistake, certainly will have influence on the degree of accuracy that processes and displays unit 10 ' calculates the blood sugar concentration in the blood, severe patient will make the patient judge the state of an illness of own body diabetes by accident, and unluckily thing takes place.
This shows that above-mentioned existing blood sugar sensing apparatus obviously still has inconvenience and defective, and demands urgently further being improved in product structure and use.In order to solve the problem of above-mentioned existence, relevant manufacturer there's no one who doesn't or isn't seeks solution painstakingly, but do not see always that for a long time suitable design finished by development, and common product and method do not have appropriate structure and method to address the above problem, and this obviously is the problem that the anxious desire of relevant dealer solves.But therefore how to found a kind of biosensing apparatus of Auto-Sensing sensing sign indicating number newly and the method for sensing thereof, real one of the current important research and development problem that belongs to, also becoming the current industry utmost point needs improved target.
Summary of the invention
Fundamental purpose of the present invention is, overcome the defective that existing blood sugar sensing apparatus exists, and but a kind of biosensing apparatus of new Auto-Sensing sensing sign indicating number is provided, technical matters to be solved is to make it passive device is set to represent a sensing sign indicating number on a biological sensing test piece, make that a processes and displays unit can be by the physical values of this passive device of detecting, and obtain this sensing sign indicating number automatically, can avoid because the sensing sign indicating number of user's input error, and cause this processes and displays unit to calculate wrong corpse or other object for laboratory examination and chemical testing value, be very suitable for practicality.
Another object of the present invention is to, overcome the defective that existing blood sugar sensing apparatus exists, and provide a kind of method for sensing of biosensing apparatus, technical matters to be solved be make it so that this processes and displays unit except can this sensing sign indicating number of this biological sensing test sheet of Auto-Sensing, and can read, calculate, compensate, reach the accurate corpse or other object for laboratory examination and chemical testing value of demonstration, thereby be suitable for practicality more.
The object of the invention to solve the technical problems realizes by the following technical solutions.But the biosensing apparatus of a kind of Auto-Sensing sensing sign indicating number that proposes according to the present invention, it comprises: a biological sensing test piece, this biological sensing test sheet comprises: one first electrode, electrically connect an electronic circuit, and this first electrode has a ferment enzyme and a corpse or other object for laboratory examination and chemical testing reacts; One second electrode electrically connects this electronic circuit, and this second electrode has this ferment enzyme and this corpse or other object for laboratory examination and chemical testing reacts; One passive device is to be connected in first electrode with the one end, and this passive device has the sensing sign indicating number that a physical quantity is represented this biological sensing test sheet; Reach a third electrode, be connected in the other end of passive device, so that passive device electrically connects electronic circuit; An and processes and displays unit, in order to an electrochemical reaction number of signals value with a corpse or other object for laboratory examination and chemical testing and ferment enzyme, this processes and displays unit comprises: a circuit for detecting is electrically connected at biological sensing test sheet this physical quantity with the detecting passive device, and is converted into one first digital signal; One reads circuit, is electrically connected at biological sensing test sheet so that this electrochemical reaction signal of a corpse or other object for laboratory examination and chemical testing and ferment enzyme is read, and is converted into one second digital signal; One microprocessor, be electrically connected at this circuit for detecting and this reads circuit, this microprocessor is confirmed the sensing sign indicating number of biological sensing test sheet by handling this first digital signal, and further set an adequate compensation value, and microprocessor receives this second digital signal and it is treated to a corpse or other object for laboratory examination and chemical testing measuring value, in addition, microprocessor is carried out numerical compensation based on this adequate compensation value to this corpse or other object for laboratory examination and chemical testing measuring value, to export an accurate corpse or other object for laboratory examination and chemical testing value; And a display, be electrically connected at microprocessor to show accurate this corpse or other object for laboratory examination and chemical testing value.
The object of the invention to solve the technical problems also can be applied to the following technical measures to achieve further.
But the biosensing apparatus of aforesaid Auto-Sensing sensing sign indicating number, wherein said first electrode is a working electrode, and this second electrode is the counter electrode corresponding to this working electrode, and this third electrode is then as a sensing sign indicating number electrode that links this passive device.
But the biosensing apparatus of aforesaid Auto-Sensing sensing sign indicating number, a wherein said corpse or other object for laboratory examination and chemical testing are blood.
But the biosensing apparatus of aforesaid Auto-Sensing sensing sign indicating number, wherein said passive device be following any: resistance, electric capacity and inductance.
But the biosensing apparatus of aforesaid Auto-Sensing sensing sign indicating number, wherein said display be following any: LCD display and light-emitting diode display.
But the biosensing apparatus of aforesaid Auto-Sensing sensing sign indicating number, the wherein said circuit that reads more comprises: one first operational amplifier, it has one first amplifier positive input terminal, one first amplifier negative input end, reaches one first amplifier out, wherein, this first amplifier positive input terminal couples one first reference voltage, and one second voltage signal is read and be converted into to this first operational amplifier with this electrochemical reaction signal; One input resistance is coupled to this first amplifier negative input end with the input buffering resistance as first operational amplifier; One amplifies resistance, is coupled between the first amplifier negative input end and this first amplifier out, and this amplifies the output gain that resistance assists to amplify first operational amplifier; And one first analog-digital converter, being coupled to first operational amplifier output terminal to receive this second voltage signal, this first analog-digital converter is converted to this second digital signal with second voltage signal.
But the biosensing apparatus of aforesaid Auto-Sensing sensing sign indicating number, wherein said circuit for detecting is more drawn together: one second operational amplifier, have one second amplifier negative input end, one second amplifier positive input terminal, reach one second amplifier out, this second operational amplifier converts this physical quantity of this passive device to one first voltage signal; One transfer resistance is coupled between this second amplifier negative input end and this second amplifier out, and this transfer resistance assists to convert the physical quantity of passive device to this first voltage signal; And one second analog-digital converter, be coupled to second amplifier out receiving first voltage signal, and be converted into this first digital signal.
But the biosensing apparatus of aforesaid Auto-Sensing sensing sign indicating number, wherein said circuit for detecting more comprises: a current source, this current source makes it produce a charging voltage to this passive device charging; One comparer, it comprises a comparer positive input terminal, a comparer negative input end, reaches a comparator output terminal, wherein, this comparer negative input end couples one second reference voltage, and this comparer positive input terminal is coupled to passive device, and this comparer compares this charging voltage and this second reference voltage, when the value of charging voltage was higher than second reference voltage, comparer was promptly exported a high levle signal; An and counter, couple this microprocessor, comparer, reach an enabling signal, when this enabling signal is set as high levle, current source promptly charges to passive device, simultaneously, counter begins counting, promptly exports after this high levle signal gives counter up to comparer, and counter promptly stops counting and writes down a count value.
The object of the invention to solve the technical problems also realizes by the following technical solutions.The method for sensing of a kind of biosensing apparatus that proposes according to the present invention, it may further comprise the steps: the biological sensing test piece that (1) will have a passive device inserts a processes and displays unit; One circuit for detecting of (2) one its inside of processes and displays unit starting; (3) this circuit for detecting is detected a physical quantity of this passive device, and is converted into one first digital signal; (4) one microprocessors receive this first digital signal, to confirm a sensing sign indicating number of this biological sensing test sheet; (5) microprocessor is set an adequate compensation value further by this sensing sign indicating number; (6) one corpse or other object for laboratory examination and chemical testing splash on a ferment enzyme of biological sensing test sheet; (7) one of this its inside of processes and displays unit starting read circuit; (8) this reads circuit one electrochemical reaction signal of this corpse or other object for laboratory examination and chemical testing and this ferment enzyme is read, and is converted into one second digital signal; (9) microprocessor receives this second digital signal, and it is treated to a corpse or other object for laboratory examination and chemical testing measuring value; And (10) microprocessor is based on this adequate compensation value and to corpse or other object for laboratory examination and chemical testing measuring value execution numerical compensation, to obtain and to export an accurate corpse or other object for laboratory examination and chemical testing value.
The object of the invention to solve the technical problems also can be applied to the following technical measures to achieve further.
The method for sensing of aforesaid biosensing apparatus, wherein said step (8) more comprises: (81) one first operational amplifiers receive this electrochemical reaction signal, and are converted into one second voltage signal; Reach (82) one first analog-digital converters and receive this second voltage signal, and be converted into this second digital signal.
The method for sensing of aforesaid biosensing apparatus, wherein said step (3) more comprises: (31) are set as high levle with an enabling signal, to start a current source and a counter; (32) this current source makes it produce a charging voltage to this passive device charging; (33) one comparers receive this charging voltage and one second reference voltage simultaneously; (34) this comparer judges whether that charging voltage is higher than second reference voltage, if, execution in step (35) then, if not, execution in step (33) then; (35) comparer is exported a high levle signal and is given this counter; (36) counter stops counting and writes down a count value; And (37) counter is exported this first digital signal.
The present invention compared with prior art has tangible advantage and beneficial effect.By technique scheme, but the biosensing apparatus of the present invention's Auto-Sensing sensing sign indicating number and the method for sensing thereof have following advantage and beneficial effect at least: the present invention is provided with this passive device on this biological sensing test sheet, and set up this circuit for detecting this physical quantity in this processes and displays unit with the detecting passive device, to obtain this sensing sign indicating number automatically and to calculate this adequate compensation value, to carry out numerical compensation for this corpse or other object for laboratory examination and chemical testing measuring value, so can avoid sensing sign indicating number, and cause the processes and displays unit to calculate wrong corpse or other object for laboratory examination and chemical testing value because of user (diabetic) input error.
In sum, but the biosensing apparatus of a kind of Auto-Sensing sensing of the present invention sign indicating number and the method for sensing thereof, but the biosensing apparatus that is somebody's turn to do Auto-Sensing sensing sign indicating number comprises: a biological sensing test piece and a processes and displays unit, this biological sensing test sheet has a passive device, and a physical quantity of this passive device can be represented a sensing sign indicating number; When biological sensing test sheet inserted this processes and displays unit, the processes and displays unit can read this sensing sign indicating number automatically to calculate an adequate compensation value of a corpse or other object for laboratory examination and chemical testing.In addition,, but can make the sensing sign indicating number of processes and displays unit Auto-Sensing biological sensing test sheet, and read, calculate, compensate, and show a corpse or other object for laboratory examination and chemical testing value of this corpse or other object for laboratory examination and chemical testing by the method for sensing of this biosensing apparatus.The present invention has obvious improvement technically, and has tangible good effect, really is a new and innovative, progressive, practical new design.
Above-mentioned explanation only is the general introduction of technical solution of the present invention, for can clearer understanding technological means of the present invention, and can be implemented according to the content of instructions, and state with other purposes, feature and advantage and can become apparent on the present invention in order to allow, below especially exemplified by preferred embodiment, and conjunction with figs., be described in detail as follows.
Description of drawings
Fig. 1 is a kind of stereographic map of the existing blood sugar sensing apparatus of commonly using.
Fig. 2 is a kind of exploded view of the existing blood sugar sensing test piece of commonly using.
But Fig. 3 is the Organization Chart of the biosensing apparatus of a kind of Auto-Sensing sensing sign indicating number of the present invention.
But Fig. 4 is a biological sensing test piece vertical view of the biosensing apparatus of Auto-Sensing sensing sign indicating number.
But 5 figure are first circuit framework figure of a circuit for detecting of the biosensing apparatus of Auto-Sensing sensing sign indicating number.
Fig. 6 is the second circuit Organization Chart of circuit for detecting.
But Fig. 7 is the charging sequential chart of a sensing sign indicating number electric capacity of the biosensing apparatus of Auto-Sensing sensing sign indicating number.
But Fig. 8 is an Organization Chart that reads circuit of the biosensing apparatus of Auto-Sensing sensing sign indicating number.
Fig. 9 is a kind of method for sensing process flow diagram of biosensing apparatus.
Figure 10 is the first detailed step process flow diagram of step (203).
Figure 11 is the second detailed step process flow diagram of step (203).
Figure 12 is the detailed step process flow diagram of step (208).
1: but the biosensing apparatus of Auto-Sensing sensing sign indicating number
1 ': the existing blood sugar sensing apparatus of commonly using 10 ': processes and displays unit
11: 111: the first electrodes of biological sensing test sheet
1111: 112: the second electrodes of ferment enzyme
114: third electrode 12: the processes and displays unit
12 ': blood sugar sensing test piece 121: circuit for detecting
1210: current source 1211: comparer
1212: comparer positive input terminal 1213: the comparer negative input end
1214: comparator output terminal 1215: counter
1217: the second amplifier negative input ends of 1216: the second operational amplifiers
1219: the second amplifier outs of 1218: the second amplifier positive input terminals
121A: first analog-digital converter 122: read circuit
122 ': 1220: the first operational amplifiers of strip substrate
1221: the first amplifier positive input terminals 1221 ': electrode part
1222: the first amplifier negative input ends 1222 ': operation electrode
1223: the first amplifier outs 1224 ': counter electrode
1226: the first analog-digital converter 1226 ': the first leads
1228 ': the second lead 123: microprocessor
124: display 124 ': responding layer
126 ': spacing body 128 ': cover plate
2: a corpse or other object for laboratory examination and chemical testing 201～210: method step
2031～2032: method step 2031 '～2037 ': method step
2081～2082: method step 3: enabling signal
Cc: sensing sign indicating number capacitor C p: capacitance
Ic: current value N: count value
Ra: amplify resistance R c: sensing sign indicating number resistance
Rf: transfer resistance Ri: input resistance
Vc: charging voltage Vout: first magnitude of voltage
Vref1: 2: the second reference voltages of first reference voltage Vref
Vref3: the 3rd reference voltage
Embodiment
Reach technological means and the effect that predetermined goal of the invention is taked for further setting forth the present invention, below in conjunction with accompanying drawing and preferred embodiment, but the biosensing apparatus of the Auto-Sensing sensing sign indicating number that foundation the present invention is proposed and its embodiment of method, structure, method, step, feature and the effect thereof of sensing thereof, describe in detail as after.
See also shown in Figure 3, but be the Organization Chart of the biosensing apparatus of a kind of Auto-Sensing sensing sign indicating number of the present invention, but biosensing apparatus 1 that should Auto-Sensing sensing sign indicating number comprises: a biological sensing test piece 11 and a processes and displays unit 12.
Please consult Fig. 3 and shown in Figure 4 simultaneously, wherein, the 4th figure is the vertical view of biological sensing test sheet, above-mentioned this biological sensing test sheet 11 comprises: one first electrode 111, can electrically connect an electronic circuit of these 12 inside, processes and displays unit, this first electrode 111 has a ferment enzyme 1111 and can react with a corpse or other object for laboratory examination and chemical testing 2; One second electrode 112 can electrically connect this electronic circuits of 12 inside, processes and displays unit, and this second electrode 112 has this ferment enzyme 1111 to react with this corpse or other object for laboratory examination and chemical testing 2; One passive device 113 is to be connected in first electrode 111 with the one end, and this passive device 113 has the sensing sign indicating number that a physical quantity can be represented biological sensing test sheet 11, and wherein, passive device 113 can be a resistance, an electric capacity or an inductance; Reach a third electrode 114, be connected in the other end of passive device 113, so that passive device 113 can electrically connect electronic circuit, in the present embodiment, first electrode 111 is as a working electrode (working electrode); Second electrode 112 is the counter electrode (counter electrode) corresponding to this working electrode; 114 sensing sign indicating number electrodes (sensing code electrode) of third electrode as binding passive device 113.
Please continue to consult shown in Figure 3, above-mentioned this processes and displays unit 12 comprises: a circuit for detecting 121 can be electrically connected at this biological sensing test sheet 11 detecting this physical quantity of this passive device 113, and be converted into one first digital signal; One reads circuit 122, can be electrically connected at biological sensing test sheet 11 so that this corpse or other object for laboratory examination and chemical testing 2 and this electrochemical reaction signal of this ferment enzyme 1111 are read, and be converted into one second digital signal; One microprocessor 123, be to be electrically connected at this circuit for detecting 121 to read circuit 122 with this, this microprocessor 123 can be confirmed the sensing sign indicating number of biological sensing test sheet 11 by handling this first digital signal, and further set an adequate compensation value, and microprocessor 123 can receive this second digital signal and it is treated to a corpse or other object for laboratory examination and chemical testing measuring value, in addition, microprocessor 123 also can be carried out numerical compensation to this corpse or other object for laboratory examination and chemical testing measuring value based on this adequate compensation value, to export an accurate corpse or other object for laboratory examination and chemical testing value; And a display 124, be to be electrically connected at microprocessor 123 to show this corpse or other object for laboratory examination and chemical testing value, this display 124 can be a LCD display or a light-emitting diode display, and preferably, present embodiment adopts the display 124 of this LCD display as processes and displays unit 12.
Please continue to consult simultaneously shown in Figure 5, be the first circuit framework figure of circuit for detecting, and this circuit for detecting 121 of above-mentioned this processes and displays unit 12 has two kinds of circuit frameworks, with this physical quantity of different these passive devices 113 of detecting respectively.As shown in Figure 5, when passive device 113 is a sensing sign indicating number resistance R c, the physical quantity of circuit for detecting 121 this sensing sign indicating number resistance R of detecting c, promptly, one resistance value Rp (Rp is that formula uses symbol but not component symbol), wherein, circuit for detecting 121 comprises: one second operational amplifier 1216, a transfer resistance Rf and one second analog-digital converter 121A.This second operational amplifier 1216 is to have one second amplifier negative input end 1217, one second amplifier positive input terminal 1218, and one second amplifier out 1219, second operational amplifier 1216 can convert the physical quantity of passive device 113 to one first voltage signal, and this first voltage signal is to have one first magnitude of voltage Vout (Vout is that formula uses symbol but not component symbol); This transfer resistance Rf is coupled between this second amplifier negative input end 1217 and this second amplifier out 1219, and transfer resistance Rf can assist to convert the physical quantity of passive device 113 to first voltage signal; And this second analog-digital converter 121A is coupled to second amplifier out 1219 receiving first voltage signal, and be converted into this first digital signal.Because the second amplifier positive input terminal 1218 is to be coupled to one the 3rd reference voltage Vref 3, therefore, pass through computing formula: (Vref3 * Rf)/(Vout-Vref3), can calculate this resistance value Rp, resistance value Rp promptly can be used to represent this sensing sign indicating number to Rp=.
Please consult shown in Figure 6 simultaneously, it is the second circuit Organization Chart of circuit for detecting, if above-mentioned this passive device 113 is not to be this sensing sign indicating number resistance R c, and be a sensing sign indicating number capacitor C c, 121 these physical quantities that must detect this sensing sign indicating number capacitor C c of this circuit for detecting, promptly, one capacitance Cp (Cp is that formula uses symbol), wherein, in order to detect the circuit for detecting 121 of this capacitance Cp, comprising: a current source 1210, a comparer 1211 and a counter 1215.This current source 1210 can make it produce a charging voltage Vc (Vc is that formula uses symbol but not component symbol) to sensing sign indicating number capacitor C c charging; This comparer 1211 comprises a comparer positive input terminal 1212, a comparer negative input end 1213, reaches a comparator output terminal 1214, wherein, this comparer negative input end 1213 is to couple one second reference voltage Vref 2, and this comparer positive input terminal 1212 is coupled to sensing sign indicating number capacitor C c, comparer 1211 can be carried out this charging voltage Vc and this second reference voltage Vref 2 relatively, when the value of charging voltage Vc was higher than second reference voltage Vref 2, comparer 1211 was promptly exported a high levle signal; This counter 1215 couples this microprocessor 123, comparer 1211, reaches an enabling signal (sensing code) 3, please consult shown in Figure 7 simultaneously, it is the charging sequential chart of sensing sign indicating number electric capacity, when this enabling signal (sensingcode) 3 is set as high levle, current source 1210 promptly charges to sensing sign indicating number capacitor C c, simultaneously, counter 1215 begins counting, after comparer 1211 these high levle signals of output gave counter 1215, counter 1215 promptly stopped counting and writes down a count value N (N is that formula uses symbol).As shown in Figure 7, a curve A and a curve B are represented the charging voltage Vc of the sensing sign indicating number capacitor C c with different capacitance Cp respectively; One Ts is the zero-time that expression counter 1215 begins to carry out counting; One TenA and a TenB then represent the time that counter 1215 stops to count respectively; One clock_in represents an input clock signal; One Tclk then imports time one-period of clock signal for this; And, one codeA and a codeB are that comparer 1211 is behind the charging voltage Vc that receives this curve A and this curve B, after comparing with second reference voltage Vref 2 again, the signal of being exported, wherein, this codeA changes the high levle signal at this TenA place, and this codeB changes the high levle signal at this TenB place; In addition, a clock_outA and a clock_outB represent that then counter 1215 exports the signal of microprocessor 123 to, and microprocessor can be by this clock_outA and this clock_outB and calculated this count value N in the duration of charging of curve A and curve B.Because the value of charging voltage Vc is that the product in a current value I c (Ic is that formula uses symbol but not component symbol) and the duration of charging of sensing sign indicating number capacitor C c of current source 1210 is again divided by capacitance Cp, therefore, pass through computing formula: Cp=(N * Tclk * Ic)/Vc, can calculate capacitance Cp, capacitance Cp promptly is used for representing this sensing sign indicating number.
Please continue to consult simultaneously shown in Figure 8 again, it is the Organization Chart that reads circuit, included this of above-mentioned this microprocessor 123 reads circuit 122, comprising: one first operational amplifier 1220, an input resistance Ri, amplify resistance R a, and one first analog-digital converter 1226.This first operational amplifier 1220 has one first amplifier positive input terminal 1221, one first amplifier negative input end 1222, reaches one first amplifier out 1223, wherein, this first amplifier positive input terminal 1221 couples one first reference voltage Vref, 1, the first operational amplifier 1220 can read this electrochemical reaction signal and be converted into one second voltage signal; This input resistance Ri is coupled to this first amplifier negative input end 1222 with the input buffering resistance as first operational amplifier 1220; This amplification resistance R a is coupled between the first amplifier negative input end 1222 and this first amplifier out 1223, amplifies the output gain that resistance R a can assist to amplify first operational amplifier 1220; This first analog-digital converter 1226 is coupled to first operational amplifier output terminal 1223 to receive this second voltage signal, and first analog-digital converter 1226 can be converted to second voltage signal this second digital signal.Afterwards, this microprocessor 123 can receive second digital signal, it is treated as this corpse or other object for laboratory examination and chemical testing measuring value, then, make suitable compensation for corpse or other object for laboratory examination and chemical testing measuring value after, demonstrate accurate this corpse or other object for laboratory examination and chemical testing value by this display 124 again.
But above-mentionedly done quite complete exposure for the preferred embodiment of the biosensing apparatus 1 of this Auto-Sensing sensing sign indicating number, in addition, but in order to control the biosensing apparatus 1 of above-mentioned Auto-Sensing sensing sign indicating number, make the method for sensing of a kind of biosensing apparatus of its sensing that can finish this corpse or other object for laboratory examination and chemical testing 2 and magnitude calculation will be by complete exposure in following narration, please consult shown in Figure 9 simultaneously, it is a kind of method for sensing process flow diagram of biosensing apparatus, the method for sensing of this biosensing apparatus may further comprise the steps:
At first, execution in step (201), this biological sensing test sheet 11 that will have this passive device 113 inserts this processes and displays unit 12; Then, execution in step (202), processes and displays unit 12 starts this circuit for detecting 121 of its inside; Then, execution in step (203), this physical quantity of circuit for detecting 121 detecting passive devices 113, and be converted into this first digital signal; Then execution in step (204) and step (205), this microprocessor 123 receives first digital signal, and confirming this sensing sign indicating number of biological sensing test sheet 11, microprocessor 123 is also set this adequate compensation value further by the sensing sign indicating number; Learn after the sensing sign indicating number, can begin this corpse or other object for laboratory examination and chemical testing 2 is carried out sensing and check, that is, execution in step (206), a corpse or other object for laboratory examination and chemical testing 2 splashes on this ferment enzyme 1111 of biological sensing test sheet 11; Then, execution in step (207), this of 12 its inside of startup, processes and displays unit reads circuit 122; Execution in step (208) reads circuit 122 corpse or other object for laboratory examination and chemical testing 2 and this electrochemical reaction signal of ferment enzyme 1111 is read, and is converted into this second digital signal then; Then, execution in step (209), microprocessor 123 receives second digital signal, and it is treated to this corpse or other object for laboratory examination and chemical testing measuring value; And, execution in step (210), microprocessor 123 is carried out numerical compensation based on the adequate compensation value to corpse or other object for laboratory examination and chemical testing measuring value, to obtain and to export accurate this corpse or other object for laboratory examination and chemical testing value.
Above-mentioned steps (203) is the step of this physical quantity of these circuit for detecting 121 these passive devices 113 of detecting, yet, if passive device 113 is this sensing sign indicating number resistance R c, first circuit framework that then must use circuit for detecting 121 is to read this resistance value Rp of sensing sign indicating number resistance R c, see also shown in Figure 10, the first detailed step process flow diagram of step (203), step (203) comprises following detailed step:
At first, execution in step (2031), this second operational amplifier 1213 receives this physical quantity of this passive device 113, and converts thereof into this first voltage signal; And, execution in step (2032), this second analog-digital converter 1217 receives first voltage signal, and is converted into this first digital signal.
And, if this passive device 113 is this sensing sign indicating number capacitor C c, the second circuit framework that then must use this circuit for detecting 121 is to read this charging voltage Vc of sensing sign indicating number capacitor C c, so that can continuing, this microprocessor 123 calculates this capacitance Cp, see also shown in Figure 11, the second detailed step process flow diagram of step (203), above-mentioned steps (203) then comprises following second detailed step:
At first, execution in step (2031 ') is set as high levle with this enabling signal, to start this current source 1210 and this counter 1215; Then, execution in step (2032 '), 113 chargings of 1210 pairs of these passive devices of current source promptly, to this sensing sign indicating number capacitor C c, make it produce this charging voltage Vc; Then, execution in step (2033 '), this comparer 1211 receives charging voltage Vc and this second reference voltage Vef2 simultaneously; Follow execution in step (2034 '), comparer 1211 judges whether that charging voltage Vc is higher than the second reference voltage Vef2, if, then continue execution in step (2035 ') and step (2036 '), comparer 1211 outputs one high levle signal gives this counter 1215, then, counter 1215 promptly stops counting and writes down a count value N; And, execution in step (2037 '), counter 1215 these first digital signals of output; In addition, in step (2034 '), if not, then continue execution in step (2033 '), promptly comparer 1211 receives the charging voltage Vc and the second reference voltage Vef2 unceasingly.
At last, see also shown in Figure 12, the detailed step process flow diagram of step (208), step (208) reads the step that circuit 122 reads this electrochemical reaction for this, step (208) comprises following detailed step:
At first, execution in step (2081), this first operational amplifier 1220 receives this electrochemical reaction signal, and is converted into this second voltage signal; And, execution in step (2082), this first analog-digital converter 1226 receives second voltage signal, and is converted into this second digital signal.
But above-mentioned complete and clearly disclose the biosensing apparatus of a kind of Auto-Sensing sensing sign indicating number of the present invention and the method for sensing thereof, therefore comprehensively above-mentioned, can learn that the present invention has following advantage:
The present invention is provided with this passive device on this biological sensing test sheet, and set up this circuit for detecting this physical quantity in this processes and displays unit with the detecting passive device, to obtain this sensing sign indicating number automatically and to calculate this adequate compensation value, to carry out numerical compensation for this corpse or other object for laboratory examination and chemical testing measuring value, so can avoid sensing sign indicating number, and cause the processes and displays unit to calculate wrong corpse or other object for laboratory examination and chemical testing value because of user (diabetic) input error.
Method for sensing by this biosensing apparatus can make this processes and displays unit automatically detect this sensing sign indicating number of this biological sensing test sheet, and reads, calculates, compensates, reaches the accurate corpse or other object for laboratory examination and chemical testing value of demonstration.
The above, it only is preferred embodiment of the present invention, be not that the present invention is done any pro forma restriction, though the present invention discloses as above with preferred embodiment, yet be not in order to limit the present invention, any those skilled in the art, in not breaking away from the technical solution of the present invention scope, when the method that can utilize above-mentioned announcement and technology contents are made a little change or be modified to the equivalent embodiment of equivalent variations, in every case be the content that does not break away from technical solution of the present invention, according to technical spirit of the present invention to any simple modification that above embodiment did, equivalent variations and modification all still belong in the scope of technical solution of the present invention.
Claims (12)
1. but the biosensing apparatus of an Auto-Sensing sensing sign indicating number is characterized in that it comprises:
One biological sensing test piece, this biological sensing test sheet comprises:
One first electrode electrically connects an electronic circuit, and this first electrode has a ferment enzyme and a corpse or other object for laboratory examination and chemical testing reacts;
One second electrode electrically connects this electronic circuit, and this second electrode has this ferment enzyme and this corpse or other object for laboratory examination and chemical testing reacts;
One passive device is to be connected in first electrode with the one end, and this passive device has the sensing sign indicating number that a physical quantity is represented this biological sensing test sheet; And
One third electrode is connected in the other end of passive device, so that passive device electrically connects electronic circuit; And
One processes and displays unit, in order to the electrochemical reaction number of signals value with a corpse or other object for laboratory examination and chemical testing and ferment enzyme, this processes and displays unit comprises:
One circuit for detecting is electrically connected at biological sensing test sheet this physical quantity with the detecting passive device, and is converted into one first digital signal;
One reads circuit, is electrically connected at biological sensing test sheet so that this electrochemical reaction signal of a corpse or other object for laboratory examination and chemical testing and ferment enzyme is read, and is converted into one second digital signal;
One microprocessor, be electrically connected at this circuit for detecting and this reads circuit, this microprocessor is confirmed the sensing sign indicating number of biological sensing test sheet by handling this first digital signal, and further set an adequate compensation value, and microprocessor receives this second digital signal and it is treated to a corpse or other object for laboratory examination and chemical testing measuring value, in addition, microprocessor is carried out numerical compensation based on this adequate compensation value to this corpse or other object for laboratory examination and chemical testing measuring value, to export an accurate corpse or other object for laboratory examination and chemical testing value; And
One display is electrically connected at microprocessor to show accurate this corpse or other object for laboratory examination and chemical testing value.
2. but the biosensing apparatus of Auto-Sensing sensing sign indicating number according to claim 1, it is characterized in that wherein said first electrode is a working electrode, this second electrode is the counter electrode corresponding to this working electrode, and this third electrode is then as a sensing sign indicating number electrode that links this passive device.
3. but the biosensing apparatus of Auto-Sensing sensing sign indicating number according to claim 1 is characterized in that a wherein said corpse or other object for laboratory examination and chemical testing is a blood.
But 4. the biosensing apparatus of Auto-Sensing sensing sign indicating number according to claim 1, it is characterized in that wherein said passive device be following any: resistance, electric capacity and inductance.
But 5. the biosensing apparatus of Auto-Sensing sensing sign indicating number according to claim 1, it is characterized in that wherein said display be following any: LCD display and light-emitting diode display.
6. but the biosensing apparatus of Auto-Sensing sensing sign indicating number according to claim 1 is characterized in that the wherein said circuit that reads more comprises:
One first operational amplifier, it has one first amplifier positive input terminal, one first amplifier negative input end, reaches one first amplifier out, wherein, this first amplifier positive input terminal couples one first reference voltage, and one second voltage signal is read and be converted into to this first operational amplifier with this electrochemical reaction signal;
One input resistance is coupled to this first amplifier negative input end with the input buffering resistance as first operational amplifier;
One amplifies resistance, is coupled between the first amplifier negative input end and this first amplifier out, and this amplifies the output gain that resistance assists to amplify first operational amplifier; And
One first analog-digital converter is coupled to first operational amplifier output terminal to receive this second voltage signal, and this first analog-digital converter is converted to this second digital signal with second voltage signal.
7. but the biosensing apparatus of Auto-Sensing sensing sign indicating number according to claim 6 is characterized in that wherein said circuit for detecting more draws together:
One second operational amplifier has one second amplifier negative input end, one second amplifier positive input terminal, reaches one second amplifier out, and this second operational amplifier converts this physical quantity of this passive device to one first voltage signal;
One transfer resistance is coupled between this second amplifier negative input end and this second amplifier out, and this transfer resistance assists to convert the physical quantity of passive device to this first voltage signal; And
One second analog-digital converter is coupled to second amplifier out receiving first voltage signal, and is converted into this first digital signal.
8. but the biosensing apparatus of Auto-Sensing sensing sign indicating number according to claim 6 is characterized in that wherein said circuit for detecting more comprises:
One current source, this current source makes it produce a charging voltage to this passive device charging;
One comparer, it comprises a comparer positive input terminal, a comparer negative input end, reaches a comparator output terminal, wherein, this comparer negative input end couples one second reference voltage, and this comparer positive input terminal is coupled to passive device, and this comparer compares this charging voltage and this second reference voltage, when the value of charging voltage was higher than second reference voltage, comparer was promptly exported a high levle signal; And
One counter, couple this microprocessor, comparer, reach an enabling signal, when this enabling signal is set as high levle, current source promptly charges to passive device, simultaneously, counter begins counting, promptly exports after this high levle signal gives counter up to comparer, and counter promptly stops counting and writes down a count value.
9. the method for sensing of a biosensing apparatus is characterized in that it may further comprise the steps:
(1) a biological sensing test piece that will have a passive device inserts a processes and displays unit;
One circuit for detecting of (2) one its inside of processes and displays unit starting;
(3) this circuit for detecting is detected a physical quantity of this passive device, and is converted into one first digital signal;
(4) one microprocessors receive this first digital signal, to confirm a sensing sign indicating number of this biological sensing test sheet;
(5) microprocessor is set an adequate compensation value further by this sensing sign indicating number;
(6) one corpse or other object for laboratory examination and chemical testing splash on a ferment enzyme of biological sensing test sheet;
(7) one of this its inside of processes and displays unit starting read circuit;
(8) this reads circuit one electrochemical reaction signal of this corpse or other object for laboratory examination and chemical testing and this ferment enzyme is read, and is converted into one second digital signal;
(9) microprocessor receives this second digital signal, and it is treated to a corpse or other object for laboratory examination and chemical testing measuring value; And
(10) microprocessor is carried out numerical compensation based on this adequate compensation value to corpse or other object for laboratory examination and chemical testing measuring value, to obtain and to export an accurate corpse or other object for laboratory examination and chemical testing value.
10. the method for sensing of biosensing apparatus according to claim 9 is characterized in that wherein said step (3) more comprises:
(31) one second operational amplifiers receive this physical quantity of this passive device, and convert thereof into one first voltage signal; And
(32) one second analog-digital converters receive this first voltage signal, and are converted into this first digital signal.
11. the method for sensing of biosensing apparatus according to claim 9 is characterized in that wherein said step (8) more comprises:
(81) one first operational amplifiers receive this electrochemical reaction signal, and are converted into one second voltage signal; And
(82) one first analog-digital converters receive this second voltage signal, and are converted into this second digital signal.
12. the method for sensing of biosensing apparatus according to claim 9 is characterized in that wherein said step (3) more comprises:
(31) enabling signal is set as high levle, to start a current source and a counter;
(32) this current source makes it produce a charging voltage to this passive device charging;
(33) one comparers receive this charging voltage and one second reference voltage simultaneously;
(34) this comparer judges whether that charging voltage is higher than second reference voltage, if, execution in step (35) then, if not, execution in step (33) then;
(35) comparer is exported this counter of high levle signal subspace;
(36) counter stops counting and writes down a count value; And
(37) counter is exported this first digital signal.
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| CN2009102613358A CN102103114A (en) | 2009-12-18 | 2009-12-18 | Biosensor capable of automatically sensing sense code and sensing method thereof |
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| CN2009102613358A CN102103114A (en) | 2009-12-18 | 2009-12-18 | Biosensor capable of automatically sensing sense code and sensing method thereof |
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Application publication date: 20110622 |