CN102091271A - Medicine for treating hyperplasia of mammary glands and preparation method thereof - Google Patents

Abstract

The invention relates to a medicine for treating hyperplasia of mammary glands, which is prepared by: soaking snakegourd fruit, bupleurum, cochinchina momordica seed, scrophularia, fritillary, oyster, cowherb seed, lychee seed, tangerine seed, spina gleditsiae, common burreed rhizome, pangolin scales and loofah sponge in a container, decocting, filtering and extracting filtrate to obtain decoction. The medicine gives full play to the mixed use of medicines in traditional Chinese medicine, is capable of soothing liver-qi stagnation, reducing phlegm, resolving masses, promoting qi flow, relieving chest stuffiness, promoting qi circulation, relieving pain, resolving hard lump, promoting blood circulation and removing blood stasis, and has good effect for preventing mastocarcinoma. Meanwhile, the medicine has the advantages of quickly improving emotion damage, reducing use and toxic and side effects of western medicines, and the like.

Description

A kind of medicine for the treatment of cyclomastopathy and preparation method thereof

Technical field

The present invention relates to a kind of medicine, particularly relating to a kind of is the medicine and preparation method thereof of the treatment cyclomastopathy of feedstock production with the Chinese herbal medicine.

Background technology

Hyperplasia of mammary glands is the benign proliferative diseases of mammary gland tissue, be breast duct and lobule degeneration structurally and the variation of carrying out property, this disease is sent out the year young women in 30-55 well, especially with married do not educate or puerperal not lactication person for seeing more, it also is disease than refractory, and have the minority disease that the possibility that cancerates is arranged, so should draw attention.Along with the quickening of human lives's rhythm and the change of social environment and daily life, the disease of hyperplasia of mammary glands is more and more.Many because feelings will is not smooth, due to stress must not be alleviated for a long time, there is 70%～80% women that in various degree cyclomastopathy is all arranged according to investigations approximately.Mainly be operative treatment and Drug therapy at present, operative treatment exists promptly inconvenient, and the expense of bearing is also higher, and effect neither be too desirable, and Drug therapy does not equally reach ideal therapeutic purposes yet.

Summary of the invention

The objective of the invention is to bring into play the Chinese medical discrimination medication, provide a kind of effective, the medicine of the treatment cyclomastopathy that expense is low according to the dialectical principle of reason, method, side, medicine of the traditional Chinese medical science.

Another goal of the invention of the present invention provides the preparation method of this medicine.

Doctor trained in Western medicine thinks that the morbidity of cyclomastopathy is relevant with the female incretion imbalance.Primary disease belongs to Chinese medicine " nodules of the breast " category, and the traditional Chinese medical science has more rich experience and argumentation to the understanding and the treatment of primary disease." Waike Zhengzong, Orthodox Manual of External Diseases " said: " nodules of the breast is a nodule in the breast, shape such as ball ovum, or hang down to weigh down and ache, or painful, color of the leather is constant, and it is examined with the susceptible to anger disappearance, how by worry impairing spleen, depressed rage impairing the liver, pent-up forms "." Elementary Medicine " said: " lid is desired excessively by anger or room, so that the deficiency of the liver essence but must not be not all right, and phlegm retention stagnates, also can tuberculosis." illustrate that thus the etiology and pathogenesis of cyclomastopathy is a worry impairing spleen, depressed rage impairing the liver, so that stagnation of QI expectorant is with fixed attention, stagnation of Qi and phelgm, and the stasis in bulk blocks newborn network, and the disease that forms nodules of the breast or mammary gland is far to be gathered.This project is by the four diagnostic methods: hear, ask, hope, cut; The utilization eight guiding principles for diagnosis, negative and positive, table reason, cold and heat and asthenia and sthenia are made a clear distinction the etiology and pathogenesis syndrome and are determined principle-method-recipe-medicines.Its emphasis is differentiation of eight pricipales, etiological analysis and differentiation, QI and blood is dialectical, the expectorant silt is dialectical, meridians are dialectical.Human body is an organic whole, puts forth effort on " eliminating pathogenic factor for supporting vital QI ", is able to normalization so that the far ascending or descending movement of vital Qi that gathers the position of disease is come in and gone out.

Based on above-mentioned Therapeutic Principle, medicine of the present invention is to make with following parts of medicines by weight:

Fructus Trichosanthis 14～16, Radix Bupleuri 9～11, Semen Momordicae 9～11, Radix Scrophulariae 14～16, Bulbus Fritillariae Uninbracteatae 9～11, Concha Ostreae 28～32, king do not stay 14～16, LIZIHE 22～28, Semen Citri Reticulatae 22～28, Spina Gleditsiae 14～16, rhizoma sparganic 14～16, big gun Squama Manis 1～3, Retinervus Luffae Fructus 4～6.

The present invention is preferably, and wherein the weight proportion of each raw material is:

Fructus Trichosanthis 15, Radix Bupleuri 10, Semen Momordicae 10, Radix Scrophulariae 15, Bulbus Fritillariae Uninbracteatae 10, Concha Ostreae 30, king do not stay 15, LIZIHE 25, Semen Citri Reticulatae 25, Spina Gleditsiae 15, rhizoma sparganic 15, big gun Squama Manis 3, Retinervus Luffae Fructus 5.

Above medicine can be made into any dosage form on the pharmaceutics, as decoction, tablet, pill, powder, capsule.

The preferred dosage form of the present invention is a decoction.

The preparation method of medicine of the present invention comprises that the following step poly-:

1) Semen Momordicae is gone the point peeling standby;

2) Concha Ostreae is placed in the container, the clear water immersion that adds 8 times decocted 30 minutes after 4 hours again;

3) and then with Semen Momordicae, Fructus Trichosanthis, Radix Bupleuri, Semen Momordicae, Radix Scrophulariae, Bulbus Fritillariae Uninbracteatae, Wang Buliu, LIZIHE, Semen Citri Reticulatae, Spina Gleditsiae, rhizoma sparganic, big gun Squama Manis put into container, the clear water immersion that adds 8 times again decocted 15 minutes in 4 hours again, extracted filtrate;

4) filtering residue is added 5 times clear water again and decocted 15 minutes, extract filtrate and make decoction with the filtrate mix homogeneously that extracts first.

Using method:

Every dose of every day sooner or later respectively once, and is oral on an empty stomach.Ten doses is a course of treatment.

Avoid pungent, the product of tobacco and wine stimulation.

In the prescription of the present invention, be dispersing the stagnated live-QI to relieve the stagnation of QI, promoting the circulation of QI to relieve pain, be used for feelings will and do not relax, breast side of body distending pain of the breast with Radix Bupleuri; Big gun Squama Manis promoting blood circulation to restore menstrual flow, stimulating milk secretion, detumescence and apocenosis, the treatment carbuncle from the beginning of or difficulty in discharging of pus; The Semen Momordicae reducing swelling and alleviating pain, hard masses softening and resolving is specially controlled carbuncle, scrofula; Retinervus Luffae Fructus clearing away liver-fire Disperse hepatic depression, specially control that acute mastitis swells and ache, breast carcinoma, scrofula; Spina Gleditsiae moistening dryness for relaxing bowels, mass dissipating and swelling eliminating, the treatment swollen ulcer drug, acute acute mastitis or enclosed mass, the king does not stay and is good at walking to scurry, but the meridian dredging and reach disease institute; Semen Citri Reticulatae promoting of the circulation of QI and removing the obstruction in the collaterals, removing obstruction for relieving pain, the treatment carbuncle is from the beginning of the hard swollen pain of, scrofula; Fructus Trichosanthis dissipating phlegm and resolving masses, promoting the circulation of QI the chest stuffiness relieving; Radix Scrophulariae heat clearing away YIN nourishing, eliminating fire and detoxication, Bulbus Fritillariae Uninbracteatae, removing heat-phlegm, hard masses softening and resolving, treatment swollen ulcer drug, acute mastitis, swelling and sore throat; Concha Ostreae hard masses softening and resolving, the scrofula that disappears eliminating carbuncle; Rhizoma sparganic activating blood circulation to dissipate blood stasis and pain relieving.All medicine compatibilities can make irritability dredge, and the expectorant stasis of blood is loose, and pain is ended, swollen painful disappearance of mammary gland.

The present invention is a purpose with the effect of dispersing the stagnated live-QI to relieve the stagnation of QI, promoting the circulation of QI to relieve pain dissipating phlegm and resolving masses, promoting the circulation of QI the chest stuffiness relieving, a large amount of Fructus Trichosanthis promoting the circulation of QI that reduce phlegm that use, join Radix Scrophulariae, Bulbus Fritillariae Uninbracteatae, Concha Ostreae, outstanding promoting the circulation of QI, hard masses softening and resolving, reduce phlegm, effect, and with the Radix Bupleuri dispersing the stagnated live-QI to relieve the stagnation of QI of capacity to treat smouldering of Liver Channel; Be aided with Rhizoma Corydalis, rhizoma sparganic and strengthen activating blood circulation to dissipate blood stasis promoting the circulation of QI to relieve pain function, make unobstructed fast the reaching of QI-blood circulation, be equipped with big gun Squama Manis, Semen Momordicae, Spina Gleditsiae and reach the effect of antiinflammatory, detumescence, detoxifcation, reach the effect of treatment hyperplasia of mammary glands, anti-cancer with Radix Bupleuri.

For showing that the present invention treats the curing mammary gland hyperplasia effect, the present invention is according to clinical use final report such as following table finding:

Table 1 liang group basic condition relatively

Two groups relatively: p＞0.05 table 2 liang group therapeutic outcome relatively

Compare with the treatment group: p＜0.05, p＜0.01

The present invention effectively brings into play traditional Chinese medical science combination drug, and hyperplasia of mammary glands is had dispersing the stagnated live-QI to relieve the stagnation of QI, dissipating phlegm and resolving masses, promoting the circulation of QI the chest stuffiness relieving, promoting the circulation of QI to relieve pain, hard masses softening and resolving activating blood circulation to dissipate blood stasis ability, prevents that breast carcinoma from having good effect.Can improve simultaneously the damage of feelings will rapidly, reduce advantages such as Western medicine medication and toxic and side effects thereof.

The specific embodiment

Embodiment 1:

Take by weighing raw material by following proportioning:

Fructus Trichosanthis 15g, Radix Bupleuri 10g, Semen Momordicae 10g, Radix Scrophulariae 15g, Bulbus Fritillariae Uninbracteatae 10g, Concha Ostreae 30g, king do not stay 15g, LIZIHE 25g, Semen Citri Reticulatae 25g, Spina Gleditsiae 15g, rhizoma sparganic 15g, big gun Squama Manis 3g, Retinervus Luffae Fructus 5g.

Concrete preparation method is:

1) Semen Momordicae is gone the point peeling standby;

2) Concha Ostreae is placed in the container, the clear water immersion that adds 8 times decocted 30 minutes after 4 hours again;

3) and then with Semen Momordicae, Fructus Trichosanthis, Radix Bupleuri, Semen Momordicae, Radix Scrophulariae, Bulbus Fritillariae Uninbracteatae, Wang Buliu, LIZIHE, Semen Citri Reticulatae, Spina Gleditsiae, rhizoma sparganic, big gun Squama Manis put into container, the clear water immersion that adds 8 times again decocted 15 minutes in 4 hours again, extracted filtrate;

4) filtering residue is added 5 times clear water again and decocted 15 minutes, extract filtrate and make decoction with the filtrate mix homogeneously that extracts first.

Using method:

Every dose of every day sooner or later respectively once, and is oral on an empty stomach.Ten doses is a course of treatment.

Avoid pungent, the product of tobacco and wine stimulation.

Embodiment 2:

Take by weighing raw material by following proportioning:

Fructus Trichosanthis 14g, Radix Bupleuri 9g, Semen Momordicae 9g, Radix Scrophulariae 14g, Bulbus Fritillariae Uninbracteatae 9g, Concha Ostreae 28g, king do not stay 14g, LIZIHE 22g, Semen Citri Reticulatae 22g, Spina Gleditsiae 14g, rhizoma sparganic 14g, big gun Squama Manis 1g, Retinervus Luffae Fructus 4g.

Concrete preparation method is:

1) Semen Momordicae is gone the point peeling standby;

2) Concha Ostreae is placed in the container, the clear water immersion that adds 8 times decocted 30 minutes after 4 hours again;

3) and then with Semen Momordicae, Fructus Trichosanthis, Radix Bupleuri, Semen Momordicae, Radix Scrophulariae, Bulbus Fritillariae Uninbracteatae, Wang Buliu, LIZIHE, Semen Citri Reticulatae, Spina Gleditsiae, rhizoma sparganic, big gun Squama Manis put into container, the clear water immersion that adds 8 times again decocted 15 minutes in 4 hours again, extracted filtrate;

4) filtering residue is added 5 times clear water again and decocted 15 minutes, extract filtrate and make decoction with the filtrate mix homogeneously that extracts first.

Using method:

Every dose of every day is respectively once oral sooner or later, send down on an empty stomach.Ten doses is a course of treatment.

Avoid pungent, the product of tobacco and wine stimulation.

Embodiment 3:

Take by weighing raw material by following proportioning:

Fructus Trichosanthis 16g, Radix Bupleuri 11g, Semen Momordicae 11g, Radix Scrophulariae 16g, Bulbus Fritillariae Uninbracteatae 11g, Concha Ostreae 32g, king do not stay 16g, LIZIHE 28g, Semen Citri Reticulatae 28g, Spina Gleditsiae 16g, rhizoma sparganic 16g, big gun Squama Manis 2g, Retinervus Luffae Fructus 6g.

Concrete preparation method is:

1) Semen Momordicae is gone the point peeling standby;

2) Concha Ostreae is placed in the container, the clear water immersion that adds 8 times decocted 30 minutes after 4 hours again;

3) and then with Semen Momordicae, Fructus Trichosanthis, Radix Bupleuri, Semen Momordicae, Radix Scrophulariae, Bulbus Fritillariae Uninbracteatae, Wang Buliu, LIZIHE, Semen Citri Reticulatae, Spina Gleditsiae, rhizoma sparganic, big gun Squama Manis put into container, the clear water immersion that adds 8 times again decocted 15 minutes in 4 hours again, extracted filtrate;

4) filtering residue is added 5 times clear water again and decocted 15 minutes, extract filtrate and make decoction with the filtrate mix homogeneously that extracts first.

Using method:

Every dose of every day is respectively once oral sooner or later, send down on an empty stomach.Ten doses is a course of treatment.

Avoid pungent, the product of tobacco and wine stimulation.

Claims (3)

1. medicine for the treatment of cyclomastopathy is characterized in that being made by following parts of medicines by weight:

Fructus Trichosanthis 14～16, Radix Bupleuri 9～11, Semen Momordicae 9～11, Radix Scrophulariae 14～16, Bulbus Fritillariae Uninbracteatae 9～11, Concha Ostreae 28～32, king do not stay 14～16, LIZIHE 22～28, Semen Citri Reticulatae 22～28, Spina Gleditsiae 14～16, rhizoma sparganic 14～16, big gun Squama Manis 1～3, Retinervus Luffae Fructus 4～6.

2. according to the described a kind of medicine for the treatment of cyclomastopathy of claim 1, it is characterized in that making by following parts of medicines by weight:

Fructus Trichosanthis 15, Radix Bupleuri 10, Semen Momordicae 10, Radix Scrophulariae 15, Bulbus Fritillariae Uninbracteatae 10, Concha Ostreae 30, king do not stay 15, LIZIHE 25, Semen Citri Reticulatae 25, Spina Gleditsiae 15, rhizoma sparganic 15, big gun Squama Manis 3, Retinervus Luffae Fructus 5.

3. according to claim 1 or 2 described a kind of preparation methoies for the treatment of the medicine of cyclomastopathy, it is characterized in that: comprise that the following step poly-: according to parts by weight

1) Semen Momordicae is gone the point peeling standby;

2) Concha Ostreae is placed in the container, the clear water immersion that adds 8 times decocted 30 minutes after 4 hours again;

3) and then with Semen Momordicae, Fructus Trichosanthis, Radix Bupleuri, Semen Momordicae, Radix Scrophulariae, Bulbus Fritillariae Uninbracteatae, Wang Buliu, LIZIHE, Semen Citri Reticulatae, Spina Gleditsiae, rhizoma sparganic, big gun Squama Manis put into container, the clear water immersion that adds 8 times again decocted 15 minutes in 4 hours again, extracted filtrate;

4) filtering residue is added 5 times clear water again and decocted 15 minutes, extract filtrate and make decoction with the filtrate mix homogeneously that extracts first.