CN102091029B - Sulfadimidine solution and preparation method thereof - Google Patents
Sulfadimidine solution and preparation method thereof Download PDFInfo
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- CN102091029B CN102091029B CN201010582404A CN201010582404A CN102091029B CN 102091029 B CN102091029 B CN 102091029B CN 201010582404 A CN201010582404 A CN 201010582404A CN 201010582404 A CN201010582404 A CN 201010582404A CN 102091029 B CN102091029 B CN 102091029B
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Abstract
The invention relates to a sulfadimidine solution and a preparation method thereof. The solution comprises the following components in parts by weight: 5-10 parts of sulfadimidine, 20-40 parts of N,N-dimethylformamide, 15-25 parts of polyoxyethylene ether castor oil, and 100 parts of water. The preparation method of the solution comprises the following steps: preparing 30 ml of the N,N-dimethylformamide, adding the sulfadimidine, and stirring until the sulfadimidine is dissolved; and then adding the polyoxyethylene ether castor oil, and stirring until the polyoxyethylene ether castor oil is dissolved; adding the water till the total volume is 100 ml, and stirring to obtain the clean solution. In the invention, the sulfadimidine solution is prepared by using an advanced nanometer technology; in the solution, a cosolvent is utilized to ensure that the sulfadimidine slightly dissolved in water to be dissolved the oil phase, and a proper amount of emulsifier is added to form a uniform system; and the sulfadimidine solution prepared by using the method provided by the invention can be dissolved in water in any proportion.
Description
Technical field
The present invention relates to a kind of sulfadimidine solution and preparation method thereof.
Technical background
Sulfa drugs is a broad-spectrum antibacterial agent, structurally similar para-amino benzoic acid (PABA), can act on the intravital dihydrofolate synthetase of antibacterial with PABA competitiveness, thereby stop the process of PABA as the synthetic required folic acid of antibacterial of raw material, reduced the amount of tetrahydrofolic acid with metabolic activity, the latter then is the essential material of synthetic fast cry of certain animals, thymidine and DNA (deoxyribonucleic acid) (DNA) of antibacterial, has therefore suppressed the growth and breeding of antibacterial.The effect of sulphonamides can be by PABA and derivant (procaine, tetracaine) institute antagonism thereof, and the existence of the catabolite of pus and tissue also plays antagonism in addition, because of it can provide the essential material of bacterial growth.
Along with the expansion of intensive culture scale, the disease of poultry each side is more and more serious.Simultaneously because the abuse of antibiotics aspect livestock and poultry cultivation makes the problem of Resistant strain also serious day by day.Because the outburst of the collective of fowl bacterial disease and parasitic disease usually has a strong impact on poultry increment and efficiency of feed utilization, and the poultry laying rate is reduced, the carcass quality degradation, even cause a considerable amount of death, influenced raiser's economic benefit.Fowl bacterial disease also more complicated in the production of poultry, the kind of disease is a lot, by single bacterial, also has antibacterial and mycoplasma mixed infection to cause that M ﹠ M does not wait.Coccidiosis has also become a big problem of puzzlement poultry producer, usually because of preventing and malpractice causes secondary infection.
Sulfadimidine is insoluble in water, and therefore, in the diseases prevention and treatment of animal, mostly sulfadimidine is to use with the form of powder spice, for the poultry farming of scale, uses inconvenience very.Be subjected to very big restriction in the clinical use.
Summary of the invention:
In order to overcome the problems referred to above, the objective of the invention is to, a kind of sulfadimidine solution and preparation method thereof is provided.
This technical scheme thes contents are as follows:
A kind of sulfadimidine solution, the component of this solution comprises sulfadimidine, N, N dimethyl formamide (DMF), polyoxyethylene ether Oleum Ricini and water, and each constituent mass is such as following: sulfadimidine: N, N dimethyl formamide (DMF): polyoxyethylene ether Oleum Ricini: water=(5-10): (20-40): (15-25): 100.
Further, described each constituent mass ratio is: sulfadimidine: N, N dimethyl formamide (DMF): polyoxyethylene ether Oleum Ricini: water=10:30:20:100.
The preparation method of described sulfadimidine solution is characterized in that may further comprise the steps:
Step (1): get 30 milliliters of DMF, add sulfadimidine, stirring and dissolving;
Step (2): add the polyoxyethylene ether Oleum Ricini then, stir and made its dissolving in 2 minutes,
Step (3): add entry to 100 milliliter, be stirred to molten clear.
Further, sulfadimidine: N, N dimethyl formamide (DMF): polyoxyethylene ether Oleum Ricini: water=(5-10): (20-40): (15-25): 100.
Each constituent mass ratio is in the preparation method of described sulfadimidine solution: sulfadimidine: N, N dimethyl formamide (DMF): polyoxyethylene ether Oleum Ricini: water=10:30:20:100.
Above-mentioned preparation process is carried out at normal temperatures.
The present invention has adopted advanced nanotechnology to prepare sulfadimidine solution, this solution is to utilize cosolvent to make to be slightly soluble in the sulfadimidine of water to be dissolved in the oil phase, add an amount of emulsifying agent then, make it form the system of homogeneous, the sulfadimidine solution that uses this method to prepare can be soluble in water with any ratio, improve the bioavailability of product widely, had quick-acting, long-acting, characteristics of high efficiency.In the fowl carcass, can keep very long effective blood drug concentration.
The present invention prepares easy, and is with low cost, and low toxicity is efficient, and preferable therapeutic effect is arranged, and is of value to the healthy growth of fowl poultry, brings good income to the raiser.
The specific embodiment:
[embodiment 1]
A kind of sulfadimidine solution is made with following method
Step (1): get 30 milliliters of DMF, add sulfadimidine 10 grams, stirring and dissolving;
Step (2): add 20 milliliters of polyoxyethylene ether Oleum Ricini then, stir and made its dissolving in 2 minutes,
Step (3): add entry to 100 milliliter, be stirred to molten clear.
[embodiment 2]
A kind of sulfadimidine solution is made with following method
Step (1): get 30 milliliters of DMF, add sulfadimidine 5 grams, stirring and dissolving;
Step (2): add 25 milliliters of polyoxyethylene ether Oleum Ricini then, stir and made its dissolving in 2 minutes,
Step (3): add entry to 100 milliliter, be stirred to molten clear.
[embodiment 3]
A kind of sulfadimidine solution is made with following method
Step (1): get 40 milliliters of DMF, add sulfadimidine 5 grams, stirring and dissolving;
Step (2): add 15 milliliters of polyoxyethylene ether Oleum Ricini then, stir and made its dissolving in 2 minutes,
Step (3): add entry to 100 milliliter, be stirred to molten clear.
[embodiment 4]
A kind of sulfadimidine solution is made with following method
Step (1): get 35 milliliters of DMF, add sulfadimidine 10 grams, stirring and dissolving;
Step (2): add 25 milliliters of polyoxyethylene ether Oleum Ricini then, stir and made its dissolving in 2 minutes,
Step (3): add entry to 100 milliliter, be stirred to molten clear.
[embodiment 5]
A kind of sulfadimidine solution is made with following method
Step (1): get 20 milliliters of DMF, add sulfadimidine 5 grams, stirring and dissolving;
Step (2): add 25 milliliters of polyoxyethylene ether Oleum Ricini then, stir and made its dissolving in 2 minutes,
Step (3): add entry to 100 milliliter, be stirred to molten clear
Above embodiment is all stable in laboratory is done lab scale and produced, and does actual test, has good stable.
Only for the preferred embodiment of invention, be not to be used for limiting practical range of the present invention in sum.Be that all equivalences of doing according to the content of the present patent application claim change and modification, all should be technology category of the present invention.
Claims (4)
1. sulfadimidine solution, it is characterized in that, the component of this solution comprises sulfadimidine, N, N dimethyl formamide, polyoxyethylene ether Oleum Ricini and water, each constituent mass is such as following: sulfadimidine: N, N dimethyl formamide: polyoxyethylene ether Oleum Ricini: water=5～10:20～40:15～25:100.
2. solution as claimed in claim 1 is characterized in that, described each constituent mass ratio is: sulfadimidine: N, N dimethyl formamide: polyoxyethylene ether Oleum Ricini: water=10:30:20:100.
3. one kind prepares the method for solution according to claim 1, it is characterized in that, may further comprise the steps:
Step 1: get N, the N dimethyl formamide adds sulfadimidine, is stirred to dissolving;
Step 2: add the polyoxyethylene ether Oleum Ricini then, be stirred to dissolving;
Step 3: add entry, be stirred to molten clear;
Described constituent mass ratio is: sulfadimidine: N, and N dimethyl formamide: polyoxyethylene ether Oleum Ricini: water=(5-10): (20-40): (15-25): 100.
4. method as claimed in claim 3 is characterized in that, each constituent mass ratio is: sulfadimidine: N, N dimethyl formamide: polyoxyethylene ether Oleum Ricini: water=10:30:20:100.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201010582404A CN102091029B (en) | 2010-12-10 | 2010-12-10 | Sulfadimidine solution and preparation method thereof |
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| CN201010582404A CN102091029B (en) | 2010-12-10 | 2010-12-10 | Sulfadimidine solution and preparation method thereof |
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| CN102091029A CN102091029A (en) | 2011-06-15 |
| CN102091029B true CN102091029B (en) | 2011-12-14 |
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| CN102406601A (en) * | 2011-09-30 | 2012-04-11 | 上海恒丰强动物药业有限公司 | Enramycin solution and preparation method thereof |
| CN102406600A (en) * | 2011-09-30 | 2012-04-11 | 上海恒丰强动物药业有限公司 | Decoquinate solution and preparation method thereof |
| CN105878181A (en) * | 2014-11-28 | 2016-08-24 | 北京海吉星医疗科技有限公司 | Preparation method of sulfadimidine solution |
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| CN101606945A (en) * | 2009-07-23 | 2009-12-23 | 天津生机集团股份有限公司 | Compound sodium sulfadimidine injection liquid for pig and preparation method thereof |
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Owner name: JIANGSU HENGFENGQIANG BIO-TECHNOLOGY CO., LTD. Free format text: FORMER OWNER: SHANGHAI HENGFENGQIANG ANIMAL PHARMACEUTICAL CO., LTD. Effective date: 20140328 |
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Effective date of registration: 20140328 Address after: 226100 East Road of Qinglong Road, Qinglong Industrial Zone, Linjiang New District, Haimen, Jiangsu Patentee after: Jiangsu Hengfengqiang Biotechnology Co., Ltd. Address before: 201620, room 1060, 508 Songjiang Road, Shanghai, Songjiang District Patentee before: Shanghai Heng Feng Qiang Animal Pharmaceutical Co., Ltd. |
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Denomination of invention: Sulfadimidine solution and its preparation method Effective date of registration: 20210705 Granted publication date: 20111214 Pledgee: Bank of China Limited Nantong Haimen sub branch Pledgor: JIANGSU HFQ BIO-TECHNOLOGY Co.,Ltd. Registration number: Y2021980005744 |
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