CN102090536A - Agent for repairing barrier function of rumen - Google Patents
Agent for repairing barrier function of rumen Download PDFInfo
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- CN102090536A CN102090536A CN201010604994XA CN201010604994A CN102090536A CN 102090536 A CN102090536 A CN 102090536A CN 201010604994X A CN201010604994X A CN 201010604994XA CN 201010604994 A CN201010604994 A CN 201010604994A CN 102090536 A CN102090536 A CN 102090536A
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- vitamin
- cud
- glutamine
- barrier function
- renovation agent
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Abstract
The invention relates to an agent for repairing a barrier function of rumen and a preparation method thereof, and the agent is prepared manly from trace elements, vitamins, glutamine (Gln) and corn gluten meal through the steps of crushing, filtering, mixing and packaging. Zinc sulfate, copper sulfate, and vitamins A and B1 are added according to the proportion, thereby not only supplementing the trace elements and the vitamins, but also enhancing the barrier function of the rumen and improving the daily milk yield of dairy cows by 0.3-0.8kg; and simultaneously, the nutritional and metabolic diseases of the dairy cows can be reduced by 2-10%, and the feed intake of the dairy cows can be increased by 0.2-1%.
Description
Technical field
The present invention relates to a kind of renovation agent, a kind of specifically cud barrier function renovation agent.
Background technology
Cud be not only ruminant main digest and assimilate organ, also be a huge armour simultaneously, the cud epithelium can prevent passing through of harmful substance and microorganism, body health watches for animals.The cud epithelium is impaired, ubiquity under the modern raising pattern of the high fine fodder of current milk cow.States such as North America improve year by year owing to the milk cow per unit area yield, a large amount of fine fodders that use in diet, thus diet nutrient concentration improved, produce needs to satisfy milk cow, cause metabolism problems such as subclinical acid poisoning, the direct economic loss that annual only subclinical acid poisoning causes just reaches 5-10 hundred million dollars.Though do not see the statistics report of direct economic loss in China, though the milk cow per unit area yield is lower than the North America, but because the milk cow individuality is generally less, dry matter intake is on the low side, and China generally lacks high-quality roughage, cause the main dependence high fine fodder of feeding to keep the high output of milk, roughage is based on ensiling simultaneously.So in China, to cross the low a series of problems that cause equally very serious owing to rumen ph, the loss that causes is inestimable.The cud epithelial damage is lower for a long time and cause by pH environment in the cud.The high fine fodder daily ration of feeding, owing to contain a large amount of easily carbohydrate feeds of fermentation in the fine fodder, cud general volatile aliphatic acid (Total Volatile Fatty Acid, TVFA) generation improves, as general volatile aliphatic acid (Total Volatile Fatty Acid, TVFA) growing amount has surpassed the absorbability of cud mucous membrane, ruminant tumor gastric general volatile aliphatic acid (Total Volatile Fatty Acid, TVFA) concentrations build-up, prolonged the duration of rumen ph value, reduced the height of cud epithelium nipple at reduced levels; Long-term low pH state of value reduces the expression of pyruvic dehydrogenase mRNA, reduces the absorbability to volatile fatty acid, causes acid poisoning, makes the necrosis of cud wall mucomembranous epithelial cell, and cud epithelium keratinization is incomplete; Simultaneously, osmotic pressure raises and rumen peristalsis slows down, and this further influences the timely eliminating of TVFA in the cud, and the accumulation of aggravation cud organic acid causes the further reduction of pH.When the cud epithelial damage, the metalloproteinases that epithelium discharges will cause that tissue decomposes, change its permeability, destroyed the physiologic barrier between rumen content and the blood circulation system, made invasive organisms such as downright bad bacillus fusiformis and the concealed bacillus of suppuration enter blood by the cud mucous membrane of breakage.These invasive organisms are bred in a large number, not only cause thrombus and infraction, and may arrive histoorgan such as liver along with blood, cause pathology, and wherein hepatapostema is the most common.The damage of cud epithelial tissue causes histamine and endotoxin absorption to enter blood.These endotoxins can influence blood circulation, stimulate vessel retraction, cause oxygen content of blood to descend, and cause hoof leaf ischaemic, bring out milk cow founder and sudden death disease.
The problem of cud epithelial damage causes many scholars' concern both at home and abroad, and the research in past mainly is by proofreading and correct low excessively this problem that solves of rumen ph.Topmost method is the method for emphasizing with the regulation and control of feed nutrition and raising, this be directly connected to the cud organic acid produce speed and growing amount, in and salivary secretion amount, body fluid ionic equilibrium and the animal energy intake of acidic materials, this is to solve the basis of cud epithelial damage and crucial.But in actual production, owing to pursue the restriction of the high output of milk and roughage source and quality, most culturists are difficult to strictness and follow this principle.The another one method is to add buffer such as sodium acid carbonate or make and lick brick in daily ration, but long-term a large amount of use not only can increase milk cow metabolism burden, also may cause kidney stone; Also have by adding ionophore or antibiotic, control rumen ph and reduce, but because a lot of countries of antibiotic quilt forbidding.Once had by adding microorganism or organic acid method, it is low excessively that adding multiple-effect valency polyclonal antibody changes rumen ph.But these methods because the low excessively cud epithelial damage that causes of rumen ph is very effective, have been done very significant exploration to slowing down milk cow, have obtained certain success.But along with the milk individual milk yield continues to increase and China's high-quality roughage can not effectively solve, above-mentioned technological means has only effective under certain condition, can not solve the difficult problem that this puzzlement milk cow produces completely.
Summary of the invention
The present invention is directed to the problems referred to above, to provide a kind of be the cud barrier function renovation agent of effective ingredient with glutamine, rhubarb polyoses, vitamin A, vitamin B1 and trace element zinc and copper, can prevent effectively that rumen ph from reducing the milk metabolic disorder that causes, improve the output of milk, prolong high yield milk service life.
The present invention addresses the above problem the technical scheme that is adopted to be: a kind of cud barrier function renovation agent and preparation method:
A kind of cud barrier function renovation agent, adopt trace element, vitamin, glutamine and corn protein powder, after pulverizing, filter, mixing, make product, the cud barrier function renovation agent that makes is grouped into by following one-tenth: the vitamin B1 of white vitriol 10-20mg, anhydrous cupric sulfate 3-5mg, 4-10g, glutamine (Glutamine, Gln) 10-20g, corn protein powder 100-180g and retinol1 0000-20000IU.
The copper sulphate main application fields has inorganic industry, is used to make other and raises salt such as stannous chloride, copper chloride, cupric pyrophosphate, cuprous oxide, Schweinfurt green, copper carbonate etc.Dyestuff and pigment industry are used to make cupric monoazo dyes such as reactive brilliant bule, reactive violet etc.Organic industry is as the catalyst of synthetic perfume and dyestuff intermediate, the polymerization inhibitor of methyl methacrylate.Coatings industry is as the bactericide of producing ship bottom anti-fouling paint.Electroplating industry is as full acidic copper-plating of bright master salt and copper ion additive.Printing and dyeing industry is as mordant and smart pro-oxygenic agent of dying cloth.On the agricultural as bactericide.Copper sulphate is a kind of inorganic compound, and inorganic industry is used to make other mantoquitas such as stannous chloride, copper chloride, cupric pyrophosphate, cuprous oxide, Schweinfurt green, copper carbonate etc.
(Glutamine Gln) is nonessential amino acid to glutamine, because of it has unique and complex physiological function, has become the primary study object of ambits such as nutrition, physiology, nutrition immune; Keeping the body acid-base balance, regulating human body immune function and, in the activity of the integrality of keeping health status or reparation pathological state lower body enteron aisle 26S Proteasome Structure and Function, having irreplaceable effect especially for the matter and energy metabolism of certain organs, tissue even cell aspect such as supply raw materials has important function.Find in the research, inject the external source glutaminase, induce the blood plasma glutamine to exhaust, will cause oedema, ulcer and the partial necrosis of mucous membrane of small intestine; But can alleviate the intestinal mucosa atrophy after providing glutamine by parenteral nutrition, improve the eucaryotic cell structure of small intestine and jejunal mucous membrane simultaneously; Glutamine lacks the expression that can reduce active tight junction protein, increases enteric epithelium barrier permeability, and glutamine has irreplaceable effect in the integrality of keeping health status or reparation pathological state lower body enteron aisle 26S Proteasome Structure and Function.Simultaneously, glutamine reduces enteric bacteria and endotoxic displacement; Add synthetic glutamine to the early-weaned piglets daily ration and help safeguarding weanling pig enteron aisle normal configuration and function.
The preparation method of a kind of cud barrier function renovation agent of the present invention:
Step 1: get white vitriol 10-20mg and anhydrous cupric sulfate 3-5mg and put into baking oven and carry out drying and handle, be to dry under 105-300 ℃ the condition to make white vitriol and cupric sulfate pentahydrate lose the crystallization water fully to end in temperature, zinc sulfate and copper sulphate after the oven dry are put into ball mill, pulverize, filter with 200 mesh filter screens, standby;
Step 2: get the 100-180g corn protein powder earlier and put into miniature mixer, the back adds the glutamine of 10-20g, the rhubarb polyoses of 5-10g more successively in miniature mixer, the vitamin A of 10000-20000IU, zinc sulfate and copper sulphate that the vitamin B1 of 4-10g and step 1 crush mix, incorporation time is 3-10 minute, form mixture, the coefficient of variation of its mixture homogeneity is less than 2%;
Step 3:, make product with mixture compacting, packing.
Described mixture homogeneity is the important indicator of compound feed products quality.
The coefficient of variation is the indicator of variation of one group of data and the ratio of its average index, and it is a relative variability index; The application conditions of the coefficient of variation is: when the level of two ordered series of numbers that contrasted height not simultaneously, just can not adopt range, mean difference or standard deviation to be analyzed, because they all are absolute indexs, the size of its numerical value not only is subjected to the influence of constituent parts value of statistical indicant difference degree, and is subjected to the influence of the level height of population unit's value of statistical indicant own; For the degree of variation of value of statistical indicant between the variable series of comparative analysis varying level, just must eliminate the influence of ordered series of numbers level height, at this moment will calculate the coefficient of variation.What the coefficient of variation reflected is the dispersion degree of value of statistical indicant under the unit average level, thereby provides the basis of contrast for two different ordered series of numbers of level height by calculating the coefficient of variation.
Beneficial effect of the present invention
Use glutamine (Glutamine in the present invention, Gln) can keep the body acid-base balance, regulate human body immune function and, in the activity of the integrality of keeping health status or reparation pathological state lower body enteron aisle 26S Proteasome Structure and Function, have irreplaceable effect especially for the matter and energy metabolism of certain organs, tissue even cell aspect such as supply raw materials has important function.Glutamine has irreplaceable effect in the activity of the integrality of keeping health status or reparation pathological state lower body enteron aisle 26S Proteasome Structure and Function.
Adopt corn protein powder as diluent among the present invention, can make vitamin and mineral matter in the renovation agent more stable, help the vitamin reparation impaired to the cud epithelium, add zinc sulfate, copper sulphate and vitamin A, B1 in the ratio among the present invention, not only microelement-supplementing and vitamin, can also strengthen the barrier function of cud, output of milk every day that improves milk cow improves the 0.3-0.8 kilogram; Can make simultaneously the sick 2-10% of reduction of Nutrition and Metabolism of milk cow, make the feed intake of milk cow improve 0.2-1%.
The specific embodiment
Embodiment one:
A kind of cud barrier function renovation agent and preparation method:
Step 1: get white vitriol 10mg and anhydrous cupric sulfate 3mg and put into baking oven and carry out drying and handle, be to dry under 105 ℃ the condition to make white vitriol and cupric sulfate pentahydrate lose the crystallization water fully to end in temperature, zinc sulfate and copper sulphate after the oven dry are put into ball mill, pulverize, filter with 200 mesh filter screens, standby;
Step 2: get the 100g corn protein powder earlier and put into miniature mixer, the back adds the glutamine of 10g, the rhubarb polyoses of 5g more successively in miniature mixer, the vitamin A of 10000IU, zinc sulfate and copper sulphate that the vitamin B1 of 4g and step 1 crush mix, incorporation time is 3 minutes, form mixture, the coefficient of variation of its mixture homogeneity is 2%;
Step 3:, make product with mixture compacting, packing.
Embodiment two:
A kind of cud barrier function renovation agent and preparation method:
Step 1: get white vitriol 12mg and anhydrous cupric sulfate 3mg and put into baking oven and carry out drying and handle, be to dry under 150 ℃ the condition to make white vitriol and cupric sulfate pentahydrate lose the crystallization water fully to end in temperature, zinc sulfate and copper sulphate after the oven dry are put into ball mill, pulverize, filter with 200 mesh filter screens, standby;
Step 2: get the 115g corn protein powder earlier and put into miniature mixer, the back adds the glutamine of 12g, the rhubarb polyoses of 6g more successively in miniature mixer, the vitamin A of 12000IU, zinc sulfate and copper sulphate that the vitamin B1 of 5g and step 1 crush mix, incorporation time is 5 minutes, form mixture, the coefficient of variation of its mixture homogeneity is 1.8%;
Step 3:, make product with mixture compacting, packing.
Embodiment three:
A kind of cud barrier function renovation agent and preparation method:
Step 1: get white vitriol 14mg and anhydrous cupric sulfate 4mg and put into baking oven and carry out drying and handle, be to dry under 200 ℃ the condition to make white vitriol and cupric sulfate pentahydrate lose the crystallization water fully to end in temperature, zinc sulfate and copper sulphate after the oven dry are put into ball mill, pulverize, filter with 200 mesh filter screens, standby;
Step 2: get the 130g corn protein powder earlier and put into miniature mixer, the back adds the glutamine of 14g, the rhubarb polyoses of 7g more successively in miniature mixer, the vitamin A of 14000IU, zinc sulfate and copper sulphate that the vitamin B1 of 6g and step 1 crush mix, incorporation time is 7 minutes, form mixture, the coefficient of variation of its mixture homogeneity is 1.6%;
Step 3:, make product with mixture compacting, packing.
Embodiment four:
A kind of cud barrier function renovation agent and preparation method:
Step 1: get white vitriol 16mg and anhydrous cupric sulfate 4mg and put into baking oven and carry out drying and handle, be to dry under 240 ℃ the condition to make white vitriol and cupric sulfate pentahydrate lose the crystallization water fully to end in temperature, zinc sulfate and copper sulphate after the oven dry are put into ball mill, pulverize, filter with 200 mesh filter screens, standby;
Step 2: get the 160g corn protein powder earlier and put into miniature mixer, the back adds the glutamine of 16g, the rhubarb polyoses of 8g more successively in miniature mixer, the vitamin A of 16000IU, zinc sulfate and copper sulphate that the vitamin B1 of 8g and step 1 crush mix, incorporation time is 8 minutes, form mixture, the coefficient of variation of its mixture homogeneity is 1.4%;
Step 3:, make product with mixture compacting, packing.
Embodiment five:
Step 1: get white vitriol 18mg and anhydrous cupric sulfate 5mg and put into baking oven and carry out drying and handle, be to dry under 280 ℃ the condition to make white vitriol and cupric sulfate pentahydrate lose the crystallization water fully to end in temperature, zinc sulfate and copper sulphate after the oven dry are put into ball mill, pulverize, filter with 200 mesh filter screens, standby;
Step 2: get the 170g corn protein powder earlier and put into miniature mixer, the back adds the glutamine of 18g, the rhubarb polyoses of 9g more successively in miniature mixer, the vitamin A of 18000IU, zinc sulfate and copper sulphate that the vitamin B1 of 9g and step 1 crush mix, incorporation time is 9 minutes, form mixture, the coefficient of variation of its mixture homogeneity is 1.2%;
Step 3:, make product with mixture compacting, packing.
Embodiment six:
Step 1: get white vitriol 20mg and anhydrous cupric sulfate 5mg and put into baking oven and carry out drying and handle, be to dry under 300 ℃ the condition to make white vitriol and cupric sulfate pentahydrate lose the crystallization water fully to end in temperature, zinc sulfate and copper sulphate after the oven dry are put into ball mill, pulverize, filter with 200 mesh filter screens, standby;
Step 2: get the 180g corn protein powder earlier and put into miniature mixer, the back adds the glutamine of 20g, the rhubarb polyoses of 10g more successively in miniature mixer, the vitamin A of 20000IU, zinc sulfate and copper sulphate that the vitamin B1 of 10g and step 1 crush mix, incorporation time is 10 minutes, form mixture, the coefficient of variation of its mixture homogeneity is 0.8%;
Step 3:, make product with mixture compacting, packing.
Claims (2)
1. cud barrier function renovation agent, adopt trace element, vitamin, glutamine and corn protein powder, make product after pulverizing, filter, mixing, it is characterized in that: the cud barrier function renovation agent that makes is grouped into by following one-tenth: the vitamin B1 of white vitriol 10-20mg, anhydrous cupric sulfate 3-5mg, 4-10g, glutamine 10-20g, corn protein powder 100-180g and vitamin A 10000-20000IU.
2. the preparation method of a kind of cud barrier function renovation agent according to claim 1 is characterized in that:
Step 1: get white vitriol 10-20mg and anhydrous cupric sulfate 3-5mg and put into baking oven and carry out drying and handle, be to dry under 105-300 ℃ the condition to make white vitriol and cupric sulfate pentahydrate lose the crystallization water fully to end in temperature, zinc sulfate and copper sulphate after the oven dry are put into ball mill, pulverize, filter with 200 mesh filter screens, standby;
Step 2: get the 100-180g corn protein powder earlier and put into miniature mixer, the back adds the glutamine of 10-20g, the rhubarb polyoses of 5-10g more successively in miniature mixer, the vitamin A of 10000-20000IU, zinc sulfate and copper sulphate that the vitamin B1 of 4-10g and step 1 crush mix, incorporation time is 3-10 minute, form mixture, the coefficient of variation of its mixture homogeneity is less than 2%;
Step 3:, make product with mixture compacting, packing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010604994XA CN102090536B (en) | 2010-12-25 | 2010-12-25 | Agent for repairing barrier function of rumen |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201010604994XA CN102090536B (en) | 2010-12-25 | 2010-12-25 | Agent for repairing barrier function of rumen |
Publications (2)
| Publication Number | Publication Date |
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| CN102090536A true CN102090536A (en) | 2011-06-15 |
| CN102090536B CN102090536B (en) | 2012-11-28 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201010604994XA Expired - Fee Related CN102090536B (en) | 2010-12-25 | 2010-12-25 | Agent for repairing barrier function of rumen |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103300227A (en) * | 2013-07-04 | 2013-09-18 | 扬州大学 | Thiamine preparation for preventing and treating rumen acid chronic acidosis |
| CN103829094A (en) * | 2014-03-11 | 2014-06-04 | 山东省农业科学院畜牧兽医研究所 | Feed additive for improving intestinal development of piglets and using method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL9300356A (en) * | 1993-02-25 | 1994-09-16 | Stichting Instituut Veevoeding | Method of increasing the production of economically useful animals, method for preparing a dry composition to be fed to economically useful animals, and the use of glutamine or an analogue thereof |
| CN1226140A (en) * | 1996-07-26 | 1999-08-18 | 味之素株式会社 | Method for breeding highly lactiferous cows by using lumen-protective amino acids |
| US20090252837A1 (en) * | 2006-06-23 | 2009-10-08 | Hendel Robert A | Ruminant feedstock dietary supplement |
-
2010
- 2010-12-25 CN CN201010604994XA patent/CN102090536B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL9300356A (en) * | 1993-02-25 | 1994-09-16 | Stichting Instituut Veevoeding | Method of increasing the production of economically useful animals, method for preparing a dry composition to be fed to economically useful animals, and the use of glutamine or an analogue thereof |
| CN1226140A (en) * | 1996-07-26 | 1999-08-18 | 味之素株式会社 | Method for breeding highly lactiferous cows by using lumen-protective amino acids |
| US20090252837A1 (en) * | 2006-06-23 | 2009-10-08 | Hendel Robert A | Ruminant feedstock dietary supplement |
Non-Patent Citations (3)
| Title |
|---|
| 《内蒙古医学杂志》 20071231 胡志伟等 谷氨酰胺对肠黏膜屏障的免疫调节 第39卷, 第10期 * |
| 《广东畜牧兽医科技》 20031231 黄彦云等 谷氨酰胺作为饲料添加剂的应用研究进展 第28卷, 第03期 * |
| 《畜牧与兽医》 20081231 周玉香等 不同水平谷氨酰胺对早期断奶犊牛生产性能的影响 第40卷, 第08期 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103300227A (en) * | 2013-07-04 | 2013-09-18 | 扬州大学 | Thiamine preparation for preventing and treating rumen acid chronic acidosis |
| CN103829094A (en) * | 2014-03-11 | 2014-06-04 | 山东省农业科学院畜牧兽医研究所 | Feed additive for improving intestinal development of piglets and using method thereof |
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| Publication number | Publication date |
|---|---|
| CN102090536B (en) | 2012-11-28 |
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