CN102088965B - 水杨酸盐(酯)缀合物在制备用于治疗代谢性病症的药物中的应用 - Google Patents

水杨酸盐(酯)缀合物在制备用于治疗代谢性病症的药物中的应用 Download PDF

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CN102088965B
CN102088965B CN2009801273287A CN200980127328A CN102088965B CN 102088965 B CN102088965 B CN 102088965B CN 2009801273287 A CN2009801273287 A CN 2009801273287A CN 200980127328 A CN200980127328 A CN 200980127328A CN 102088965 B CN102088965 B CN 102088965B
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compound
patient
hydrogen
alkyl
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CN102088965A (zh
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亚历克.梅因
卢克.马蒂克劳泽尔
埃里克.马约克斯
西尔维亚.加西亚维森特
马塔.塞拉诺穆诺兹
安东尼奥.佐尔扎诺奥拉特
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Genmedica Therapeutics SL
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
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    • A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
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  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
CN2009801273287A 2008-05-13 2009-05-13 水杨酸盐(酯)缀合物在制备用于治疗代谢性病症的药物中的应用 Expired - Fee Related CN102088965B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5283908P 2008-05-13 2008-05-13
US61/052,839 2008-05-13
PCT/EP2009/055788 WO2009138437A1 (en) 2008-05-13 2009-05-13 Salicylate conjugates useful for treating metabolic disorders

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CN102088965A CN102088965A (zh) 2011-06-08
CN102088965B true CN102088965B (zh) 2013-05-08

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CN2009801273287A Expired - Fee Related CN102088965B (zh) 2008-05-13 2009-05-13 水杨酸盐(酯)缀合物在制备用于治疗代谢性病症的药物中的应用
CN2013101223642A Pending CN103251631A (zh) 2008-05-13 2009-05-13 用于治疗代谢性病症的水杨酸盐(酯)缀合物

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US (2) US20090298923A1 (https=)
EP (1) EP2291182A1 (https=)
JP (1) JP5669729B2 (https=)
CN (2) CN102088965B (https=)
AU (1) AU2009248057B2 (https=)
BR (1) BRPI0912716A2 (https=)
CA (1) CA2724023C (https=)
WO (1) WO2009138437A1 (https=)

Families Citing this family (10)

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US9085527B2 (en) 2008-07-08 2015-07-21 Catabasis Pharmaceuticals, Inc. Fatty acid acylated salicylates and their uses
EP2315740B1 (en) 2008-07-08 2017-10-25 Catabasis Pharmaceuticals, Inc. Fatty acid acetylated salicylates and their uses
CA2755069A1 (en) * 2009-03-16 2010-09-23 Genmedica Therapeutics Sl Anti-inflammatory and antioxidant conjugates useful for treating metabolic disorders
US8946451B2 (en) 2009-10-05 2015-02-03 Catabasis Pharmaceuticals, Inc. Lipoic acid acylated salicylate derivatives and their uses
US8466197B2 (en) 2010-12-14 2013-06-18 Genmedica Therapeutics Sl Thiocarbonates as anti-inflammatory and antioxidant compounds useful for treating metabolic disorders
US8440723B2 (en) * 2011-05-11 2013-05-14 Banavara L. Mylari Metformin salts of salicylic acid and its congeners
WO2013037984A1 (en) * 2011-09-16 2013-03-21 Genmedica Therapeutics Sl Anti-inflammatory and antioxidant conjugates useful for treating metabolic disorders
BR112014006150A2 (pt) * 2011-09-16 2017-04-04 Genmedica Therapeutics Sl combinação farmacêutica, e, métodos para tratar doença, síndrome ou condição, e para proteger beta-células pancreáticas
MA53188A1 (fr) 2018-10-11 2021-12-31 Basf As Composés aromatiques et leurs utilisations pharmaceutiques
CN109761815A (zh) * 2019-02-26 2019-05-17 首都医科大学附属北京天坛医院 一种基于白藜芦醇治疗神经系统疾病的化合物及制备方法

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