CN102085341B - Degreasing and hair-growing preparation for preventing and treating seborrheic alopecia and preparation method thereof - Google Patents
Degreasing and hair-growing preparation for preventing and treating seborrheic alopecia and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a degreasing and hair-growing preparation for preventing and treating seborrheic alopecia, which is prepared from the following active pharmaceutical ingredients in parts by weight: 1-50 parts of dried ginger, 1-50 parts of pericarpium zanthoxyli, 1-50 parts of hemlock parsley, 1-50 parts of safflower, 1-50 parts of chastetree fruit, 1-50 parts of radix sileris, 1-50 parts of Baikal skullcap root and 1-50 parts of angelica. The preparation method comprises the following steps: soaking the active pharmaceutical ingredients in 70% ethanol for 20-40 minutes, and extracting by heating under reflux for 2.5-3.5 hours while controlling the temperature at 75-85 DEG C; keeping the extracting solution in a slight boiling state, filtering at normal temperature, standing for 10-12 hours, and centrifugalizing the supernatant for 15-25 minutes; and adding auxiliary materials or excipient to prepare into various preparation formulations for external use. The traditional Chinese medicine degreasing and hair-growing preparation can promote hair to grow and prevent and treat seborrheic alopecia, and has the advantages of clear curative effect and high safety.
Description
Technical field
The present invention relates to Chinese prescription, particularly a kind of removing fat and generating hair side that is used to prevent and treat seborrheic alopecia and preparation method thereof.
Background technology
According to authoritative institution statistics, the ratio that 25 years old～35 years old man of China suffers from male pattern alopecia is up to 40%, and total number of persons surpasses 1.5 hundred million; Alopecia is just demonstrating the trend of rejuvenation, and 84.8% is diagnosed as seborrheic alopecia.
The unique 5a-reductase inhibitor-Bao Fa that is used for the clinical treatment primary disease of U.S. FDA (Food and Drug Administration, Food and Drug Administration) approval ends (finasteride), can reduce serum and hair follicle dihydrotestosterone level.
In realizing process of the present invention; The inventor finds that there is following problem at least in prior art: use existing method untoward reaction to have slight abnormal liver function, sexual dysfunction, middle severe depression, emotionally disturbed, sleep and dietary habit unusual etc.; Be prone to recurrence after the drug withdrawal, be difficult to keep curative effect.
Summary of the invention
The purpose of the embodiment of the invention is the defective to above-mentioned prior art, and a kind of determined curative effect, the removing fat and generating hair side that is used to prevent and treat seborrheic alopecia that toxic and side effects is little are provided.
Another purpose of the purpose of the embodiment of the invention is to provide the method for preparing of Chinese prescription.
The technical scheme taked of the present invention is to achieve these goals:
A kind of removing fat and generating hair side that is used to prevent and treat seborrheic alopecia comprises following medicaments in part by weight:
Rhizoma Zingiberis 1～50 weight portion, Fructus Zanthoxyli 1～50 weight portion, Rhizoma Chuanxiong 1～50 weight portion, Flos Carthami 1～50 weight portion, Fructus Viticis 1～50 weight portion, windproof 1～50 weight portion, Radix Scutellariae 1～50 weight portion, Radix Angelicae Sinensis 1～50 weight portion.
The present invention provides optimized technical scheme to be: a kind of removing fat and generating hair side that is used to prevent and treat seborrheic alopecia comprises following medicaments in part by weight:
Rhizoma Zingiberis 10～40 weight portions, Fructus Zanthoxyli 10～40 weight portions, Rhizoma Chuanxiong 10～40 weight portions, Flos Carthami 10～40 weight portions, Fructus Viticis 5～30 weight portions, windproof 5～30 weight portions, Radix Scutellariae 5～30 weight portions, Radix Angelicae Sinensis 10～40 weight portions.
The present invention provides preferred technical scheme to be: a kind of removing fat and generating hair side that is used to prevent and treat seborrheic alopecia comprises following medicaments in part by weight:
Rhizoma Zingiberis 30 weight portions, Fructus Zanthoxyli 30 weight portions, Rhizoma Chuanxiong 20 weight portions, Flos Carthami 20 weight portions, Fructus Viticis 10 weight portions, windproof 10 weight portions, Radix Scutellariae 10 weight portions, Radix Angelicae Sinensis 10 weight portions.
The present invention also provides a kind of Chinese prescription, contains the above-mentioned removing fat and generating hair side and the pharmaceutical carrier of effective dose.
The method for preparing of Chinese prescription of the present invention may further comprise the steps:
Take by weighing Rhizoma Zingiberis, Fructus Zanthoxyli, Rhizoma Chuanxiong, Flos Carthami by weight, Fructus Viticis, windproof, Radix Scutellariae and Radix Angelicae Sinensis add 70% soak with ethanol 20-40min; Reheat reflux, extract, 2.5-3.5 hour, temperature are controlled at 75-85 ℃, keep that extracting solution is little to boil; Room temperature filters, and leaves standstill 10-12 hour, gets the centrifugal 15-25min of supernatant; Add adjuvant or excipient, process various exterior-applied formulations.
Said various exterior-applied formulation is selected from lotion, ointment, oil preparation, cream, paste, liniment or liniment.
The method for preparing of lotion of the present invention is: get above eight flavor Chinese medicines, add 70% soak with ethanol 30min, reheat reflux, extract, 3 hours, temperature are controlled at 80-85 ℃, keep that extracting solution is little to boil.Room temperature filters, and leaves standstill 12h, gets the centrifugal 20min of supernatant, adds water to 1400ml, with citric acid adjustment pH to 6.5-7.0, filters, and adding preservative agent promptly gets lotion.
The method for preparing of ointment of the present invention is: get above eight flavor Chinese medicines, add 70% soak with ethanol 30min, reheat reflux, extract, 3 hours, temperature are controlled at 80-85 ℃, keep that extracting solution is little to boil.Room temperature filters, and leaves standstill 12h, get the centrifugal 20min of supernatant after, being concentrated into relative density is 1.20, adds lanoline, vaseline, hydroxy benzoic acid second fat, mixing promptly gets ointment.
The method for preparing of oil preparation of the present invention is: get above eight flavor Chinese medicines, add 70% soak with ethanol 30min, reheat reflux, extract, 3 hours, temperature are controlled at 80-85 ℃, keep that extracting solution is little to boil.Room temperature filters, and leaves standstill 12h, gets the centrifugal 20min of supernatant, is dissolved in an amount of hot glycerine, constantly stirs, and glycerol adding is to 1400ml, and fully mixing promptly gets oil preparation.
The method for preparing of cream of the present invention is:
The preparation Chinese medicine extract: take by weighing Rhizoma Zingiberis, Fructus Zanthoxyli, Rhizoma Chuanxiong, Flos Carthami by weight, Fructus Viticis, windproof, Radix Scutellariae and Radix Angelicae Sinensis add 70% soak with ethanol 30min; Reheat reflux, extract, 3 hours, temperature are controlled at 75-85 ℃, keep that extracting solution is little to boil; Room temperature filters; Leave standstill 12h, get the centrifugal 20min of supernatant after, water-bath is steamed into thick paste for 100 ℃;
Water constituent and oil phase constituent are placed container respectively, and the water constituent is heated to 85-95 ℃, and the oil phase constituent is heated to fusing; Under constant temperature; The oil phase constituent is slowly added in the water constituent, do not stop to mix, treat that temperature reduces to 45 ℃ by same direction; Stir to condensation, promptly get cream;
Said water constituent is: Chinese medicine extract 10.0 weight portions, and azone 6.0 weight portions, glycerol 21 weight portions, propylene glycol 6.0 weight portions, 1.5 milliliters of parts of Tween-60,0.5 milliliter of part of sodium laurylsulfate, distilled water adds to 100 milliliters of parts;
Said oil phase constituent is: octadecanol 6.5 weight portions, white oil 6.0 weight portions, glyceryl monostearate 4.0 weight portions; Isopropyl palmitate 3.0 weight portions, vaseline 7.0 weight portions, 0.15 milliliter of part of methyl hydroxybenzoate; 0.05 milliliter of part of propylparaben, 0.05 milliliter of part of Kazon.
The method for preparing of paste of the present invention is: get above eight flavor Chinese medicines, add 70% soak with ethanol 30min, reheat reflux, extract, 3 hours, temperature are controlled at 75-85 ℃, keep that extracting solution is little to boil.Room temperature filters, and leaves standstill 12h, get the centrifugal 20min of supernatant after, 60 ℃ are concentrated into thick paste, with ethanol dilution to 140ml.Add starch, heated and stirred becomes pasty state, promptly gets paste.
The method for preparing of liniment/tincture of the present invention is: get above eight flavors, add 70% soak with ethanol 30min, heating and refluxing extraction 3 hours, keeps that extracting solution is little to boil by temperature 75-85 ℃.Room temperature filters, and leaves standstill 12h, get the centrifugal 20min of supernatant after, add an amount of antiseptic, add 70% alcoholic solution to 1400ml, promptly get liniment/tincture.
The method for preparing of plaster of the present invention is: get above eight flavor Chinese medicines, every flavor Chinese medicine is given as one thinks fit cataclasm, after every flavor Chinese medicine and siritch 500-600 weight portion are put and be heated to 50-80 ℃ in the iron pan; Decoct, decoct the time: 3-8 hour, when treating that all medicine appearances are dark brown inside coke yellow; Cross and filter filtrating, add red lead powder 1400-1500 weight portion in the filtrating again, stir the back and receive cream; Ointment was soaked in cold water 3-7 days, and change water 3-5 every day, ointment is spread out in mounts on the backing material at last; Be stained with cream face covering, process plaster.
The method for preparing of liniment of the present invention is: get above eight flavors, add 70% soak with ethanol 30min, heating and refluxing extraction 3 hours, keeps that extracting solution is little to boil by temperature 75-85 ℃.Room temperature filters, and leaves standstill 12h, gets the centrifugal 20min of supernatant, gets supernatant, and 60 ℃ are condensed into the about 140ml of thick paste.The substrate preparation: get polyvinyl alcohol 17-88 50g and spend the night with an amount of purification watery distension is molten, it is fully expanded, put the heating in water bath dissolving, it is subsequent use to make substrate.Adding Chinese medicine extract and glycerol are an amount of in substrate, stir, and add distilled water to 1400ml.Filtered while hot was sterilized 30 minutes, and was promptly got liniment for 100 ℃.
The method for preparing of external pulvis of the present invention is: gets above eight flavor Chinese medicine powders and is broken into fine powder, sieve, add starch to 1400g, and mixing, packing is subsequent use, promptly gets external pulvis.
The beneficial effect that the technical scheme that the embodiment of the invention provides is brought is: prescription meets Chinese medical theory, and determined curative effect is safe.
Removing fat and generating hair Chinese prescription of the present invention is by Rhizoma Zingiberis, Fructus Zanthoxyli, Rhizoma Chuanxiong, Flos Carthami, and Fructus Viticis, windproof, Radix Scutellariae, when being grouped into are all inequality with the prescription of existing market product sold.Chinese prescription of the present invention is in line with nourishing the liver and kidney, the method for treatment rule of treatment of vital energy regualting and blood circulation-promoting.In the Chinese prescription, Rhizoma Zingiberis and Fructus Zanthoxyli anti-bacterial, anti-itching Flos Carthami are hot and sweet temperature hardship has promoting blood circulation to remove obstruction in the collateral, blood stasis removing pain relieving effect, the removing heat from blood hair growth promoting; The Fructus Viticis QI invigorating makes us gloss fat and causes, and can send out by long moustache; It is active that windproof, Radix Scutellariae rushes down relieving heat and toxins circulation of qi promoting dispelling wind clearly; Radix Angelicae Sinensis, Rhizoma Chuanxiong nourshing blood and promoting blood circulation, blood stasis dispelling, all expansible blood capillary quickens microcirculation, improves the nutriture of hair; Chinese drug-treated group of the present invention can play jointly and promote skin QI-blood circulation, dredging the meridian, trichogenous effect.
Chinese prescription of the present invention has tangible growth promoting function to hair growth; And it is next with the side's of tearing open prescription to be superior to each single medicinal material; Chinese prescription of the present invention meets Chinese medical theory; Eight medicine mutual-assistance compatibilities have synergistic function preferably to the control seborrheic alopecia, have the advantage of comprehensive, too many levels and many target spots.
Description of drawings
Fig. 1 is the influence figure of Chinese medicine hair growth liquor to mice hair growth process;
Fig. 2 is the influence figure of Chinese medicine hair growth liquor to mice depilation district chaeta growth weight;
Fig. 3 is the influence figure of Chinese medicine hair growth liquor to mice depilation district chaeta growth length;
Fig. 4 is that the full side in removing fat and generating hair side and the side of tearing open thereof respectively organize the figure that influences to mice hair growth process;
Fig. 5 distinguishes the figure that influences of chaeta growth weight to the mice depilation for the full side in removing fat and generating hair side and each group of the side of tearing open thereof;
Fig. 6 distinguishes the figure that influences of chaeta growth length to the mice depilation for the full side in removing fat and generating hair side and each group of the side of tearing open thereof.
The specific embodiment
For making the object of the invention, technical scheme and advantage clearer, will combine accompanying drawing that embodiment of the present invention is done to describe in detail further below.
Take by weighing raw material (g) according to following weight:
Rhizoma Zingiberis 30g, Fructus Zanthoxyli 30g, Rhizoma Chuanxiong 20g, Flos Carthami 20g, Fructus Viticis 10g, windproof 10g, Radix Scutellariae 10g, Radix Angelicae Sinensis 10g.
The method for preparing of lotion of the present invention:
Get Rhizoma Zingiberis 30g, Fructus Zanthoxyli 30g, Rhizoma Chuanxiong 20g, Flos Carthami 20g, Fructus Viticis 10g, windproof 10g, Radix Scutellariae 10g, Radix Angelicae Sinensis 10g, add 70% soak with ethanol 30min, reheat reflux, extract, 3 hours, temperature are controlled at 80 ℃, keep that extracting solution is little to boil.Room temperature filters, and leaves standstill 12h, gets the centrifugal 20min of supernatant, adds water to 1400ml, with citric acid adjustment pH to 6.5-7.5, filters, and adds methyl hydroxybenzoate 0.15g, and propylparaben 0.15g promptly gets lotion.
Take by weighing raw material (g) according to following weight:
Rhizoma Zingiberis 10g, Fructus Zanthoxyli 40g, Rhizoma Chuanxiong 10g, Flos Carthami 40g, Fructus Viticis 5g, windproof 30g, Radix Scutellariae 5g, Radix Angelicae Sinensis 40g.
The preparation of ointment of the present invention:
Get Rhizoma Zingiberis 10g, Fructus Zanthoxyli 40g, Rhizoma Chuanxiong 10g, Flos Carthami 40g, Fructus Viticis 5g, windproof 30g, Radix Scutellariae 5g, Radix Angelicae Sinensis 40g, add 70% soak with ethanol 40min, reheat reflux, extract, 2.5 hours, temperature are controlled at 85 ℃, keep that extracting solution is little to boil.Room temperature filters, and leaves standstill 12h, get the centrifugal 15min of supernatant after, being concentrated into relative density is 1.20, adds lanoline 200g, vaseline 100g, hydroxy benzoic acid second fat 1g, mixing promptly gets ointment.
Take by weighing raw material (g) according to following weight:
Rhizoma Zingiberis 40g, Fructus Zanthoxyli 10g, Rhizoma Chuanxiong 40g, Flos Carthami 10g, Fructus Viticis 30g, windproof 5g, Radix Scutellariae 30g, Radix Angelicae Sinensis 10g.
The preparation of oil preparation of the present invention:
Get Rhizoma Zingiberis 40g, Fructus Zanthoxyli 10g, Rhizoma Chuanxiong 40g, Flos Carthami 10g, Fructus Viticis 30g, windproof 5g, Radix Scutellariae 30g, Radix Angelicae Sinensis 10g, add 70% soak with ethanol 20min, reheat reflux, extract, 3.5 hours, temperature are controlled at 75 ℃, keep that extracting solution is little to boil.Room temperature filters, and leaves standstill 10h, gets the centrifugal 25min of supernatant, is dissolved in an amount of hot glycerine, constantly stirs, and glycerol adding is to 1400ml, and fully mixing promptly gets oil preparation.
Take by weighing raw material (g) according to following weight:
Rhizoma Zingiberis 20g, Fructus Zanthoxyli 20g, Rhizoma Chuanxiong 15g, Flos Carthami 35g, Fructus Viticis 10g, windproof 15g, Radix Scutellariae 10g, Radix Angelicae Sinensis 20g.
The preparation of cream of the present invention:
Chinese medicine extract preparation: get Rhizoma Zingiberis 20g, Fructus Zanthoxyli 20g, Rhizoma Chuanxiong 15g, Flos Carthami 35g, Fructus Viticis 10g, windproof 15g, Radix Scutellariae 10g, Radix Angelicae Sinensis 20g; Add 70% soak with ethanol 30min; Reheat reflux, extract, 3 hours, temperature are controlled at 75-85 ℃, keep that extracting solution is little to boil.Room temperature filters, and leaves standstill 12h, get the centrifugal 20min of supernatant after, water-bath is steamed into thick paste for 100 ℃.
The water component: Chinese medicine extract 10.0g, azone 6.0g, glycerol 21.0g, propylene glycol 6.0g, Tween-60 1.5ml, sodium laurylsulfate 0.5ml, distilled water adds to 100ml.
Oil phase component: octadecanol 6.5g, white oil 6.0g, glyceryl monostearate 4.0g, isopropyl palmitate 3.0g, vaseline 7.0g, methyl hydroxybenzoate 0.15ml, propylparaben 0.05ml, Kazon 0.05ml.
Water component and oil phase component are placed container respectively, and the water component is heated to 90 ℃, and the oil phase component is heated to fusing; Under constant temperature; The oil phase component is slowly added in the water component, do not stop to mix, treat that temperature reduces to 45 ℃ by same direction; Stir to condensation, promptly get cream.
Embodiment 5
Take by weighing raw material (g) according to following weight:
Rhizoma Zingiberis 30g, Fructus Zanthoxyli 35g, Rhizoma Chuanxiong 30g, Flos Carthami 20g, Fructus Viticis 15g, windproof 20g, Radix Scutellariae 20g, Radix Angelicae Sinensis 30g.
The preparation of paste of the present invention:
Get Rhizoma Zingiberis 30g, Fructus Zanthoxyli 35g, Rhizoma Chuanxiong 30g, Flos Carthami 20g, Fructus Viticis 15g, windproof 20g, Radix Scutellariae 20g, Radix Angelicae Sinensis 30g add 70% soak with ethanol 30min, and reheat reflux, extract, 3 hours, temperature are controlled at 80 ℃, keep that extracting solution is little to boil.Room temperature filters, and leaves standstill 12h, get the centrifugal 20min of supernatant after, 60 ℃ are concentrated into thick paste, with ethanol dilution to 140ml.Add starch 350g, heated and stirred becomes pasty state, promptly gets paste.
Take by weighing raw material (g) according to following weight:
Rhizoma Zingiberis 25g, Fructus Zanthoxyli 15g, Rhizoma Chuanxiong 20g, Flos Carthami 15g, Fructus Viticis 20g, windproof 10g, Radix Scutellariae 15g, Radix Angelicae Sinensis 25g.
The preparation of liniment of the present invention:
Get Rhizoma Zingiberis 25g, Fructus Zanthoxyli 15g, Rhizoma Chuanxiong 20g, Flos Carthami 15g, Fructus Viticis 20g, windproof 10g, Radix Scutellariae 15g, Radix Angelicae Sinensis 25g add 70% soak with ethanol 30min, and heating and refluxing extraction 3 hours, keeps that extracting solution is little to boil by temperature 80-85 ℃.Room temperature filters, and leaves standstill 12h, get the centrifugal 20min of supernatant after, add antiseptic hydroxy benzoic acid second fat 1g, add 70% alcoholic solution to 1400ml, promptly get liniment.
Take by weighing raw material (g) according to following weight:
Rhizoma Zingiberis 50g, Fructus Zanthoxyli 45g, Rhizoma Chuanxiong 20g, Flos Carthami 50g, Fructus Viticis 45g, windproof 5g, Radix Scutellariae 45g, Radix Angelicae Sinensis 50g.
The preparation of plaster of the present invention:
Get Rhizoma Zingiberis 50g, Fructus Zanthoxyli 45g, Rhizoma Chuanxiong 20g, Flos Carthami 50g, Fructus Viticis 45g, windproof 5g, Radix Scutellariae 45g, Radix Angelicae Sinensis 50g, every flavor Chinese medicine is given as one thinks fit cataclasm, with siritch 560g put be heated to 50-80 ℃ in the iron pan after; Decoct, decoct 5 hours, when treating that all medicine appearances are dark brown inside coke yellow, remove slag; Cross and filter filtrating, refining adds red lead powder 1450g when dripping into pearl again, stirs the back and receives cream; Ointment was soaked in cold water 3-7 days, and change water 3-5 every day, removes releasing fire-toxin; At last ointment is spread out in and mounts on the backing material, be stained with cream face covering, process plaster.
Take by weighing raw material (g) according to following weight:
Rhizoma Zingiberis 50g, Fructus Zanthoxyli 35g, Rhizoma Chuanxiong 50g, Flos Carthami 50g, Fructus Viticis 15g, windproof 20g, Radix Scutellariae 20g, Radix Angelicae Sinensis 1g.
The preparation of liniment of the present invention:
Chinese medicine extract: Rhizoma Zingiberis 50g, Fructus Zanthoxyli 35g, Rhizoma Chuanxiong 50g, Flos Carthami 50g, Fructus Viticis 15g, windproof 20g, Radix Scutellariae 20g, Radix Angelicae Sinensis 1g, add 70% soak with ethanol 30min, heating and refluxing extraction 3 hours, keeps that extracting solution is little to boil by temperature 80-85 ℃.Room temperature filters, and leaves standstill 12h, gets the centrifugal 20min of supernatant, gets supernatant, and 60 ℃ are condensed into the about 140ml of thick paste.
The substrate preparation: get polyvinyl alcohol 17-88 50g and spend the night with an amount of purification watery distension is molten, it is fully expanded, put the heating in water bath dissolving, it is subsequent use to make substrate.
Preparation technology: in substrate, add Chinese medicine extract and glycerol 50g, stir, add distilled water to 1400ml.Filtered while hot was sterilized 30 minutes, and was promptly got liniment for 100 ℃.
Take by weighing raw material (g) according to following weight:
Rhizoma Zingiberis 25g, Fructus Zanthoxyli 50g, Rhizoma Chuanxiong 1g, Flos Carthami 1g, Fructus Viticis 20g, windproof 50g, Radix Scutellariae 15g, Radix Angelicae Sinensis 25g.
The preparation of external pulvis of the present invention:
With Rhizoma Zingiberis 25g, Fructus Zanthoxyli 50g, Rhizoma Chuanxiong 1g, Flos Carthami 1g, Fructus Viticis 20g, windproof 50g, Radix Scutellariae 15g, Radix Angelicae Sinensis 25g eight flavor Chinese medicine powders are broken into fine powder, sieve, and add starch to 1400g, mixing, and packing is subsequent use, promptly gets external pulvis.
The present invention has following pharmacological action: can significantly promote the newborn hair growth in mice depilation district; Improve mice depilation district hair growth density, increase hair weight; Significantly increase mice depilation district hair growth length.Above pharmacological action is used to prevent and treat seborrheic alopecia for it is clinical provides experimental basis.
Below in conjunction with some tests effect of the present invention is described further:
The screening experiment of experiment one, removing fat and generating hair Chinese prescription
1.1 experiment purpose
Through removing fat and generating hair side prescription I, II, III, IV experimentation, filter out the most effectively removing fat and generating hair side of control seborrheic alopecia to depilation mice hair growth situation.
1.2 experiment material
1.2.1 receive the reagent thing
Removing fat and generating hair side prescription I, II, III, IV contain crude drug 0.1g/ml, 1. removing fat and generating hair side's prescription I: Rhizoma Zingiberis, each 30g of Fructus Zanthoxyli, Rhizoma Chuanxiong, each 20g of Flos Carthami, Fructus Viticis, windproof, Radix Scutellariae, each 10g of Radix Angelicae Sinensis; 2. removing fat and generating hair side prescription II: Cortex Dictamni, Radix Sophorae Flavescentis, each 30g of Fructus Viticis, Fructus Zanthoxyli 15g, windproof, Rhizoma Chuanxiong, Radix Scutellariae, each 10g of Radix Angelicae Sinensis; 3. Chinese medicine hair growth liquor prescription III: Cacumen Platycladi, Radix Angelicae Sinensis, Rhizoma Zingiberis 30g, Fructus Zanthoxyli 15g, Radix Salviae Miltiorrhizae, Fructus Viticis, windproof, each 10g of Rhizoma Chuanxiong, Radix Scutellariae 5g; 4. removing fat and generating hair side prescription IV: Radix Ginseng, Radix Polygoni Multiflori, each 30g of the Radix Astragali, Fructus Viticis, each 20g of Fructus Zanthoxyli, Radix Angelicae Sinensis 15g, windproof, Rhizoma Chuanxiong, each 10g of Radix Scutellariae.
1.2.2 positive control drug
ZHANGGUANG101 YUFAJI, Zhejiang ZHANGGUANG 101 group, lot number: 20091101.
1.2.3 experiment material and reagent
090707), picric acid (Guangzhou Chemical Reagent Factory, lot number: 20080401-1), (Fanyu, Guangzhou power is strengthened factory, lot number: 20090512) to 6% sodium sulfide depilatory 75% ethanol (Tianjin Fu Xue Fine Chemical Co., Ltd, lot number:; Liquid-transfering gun (Dragon-med), 100,000/analytical balance (DENVER TB-215D), 14mm card punch, slide gauge (Tricle Brand).
1.2.4 laboratory animal
Kunming mouse, body weight 18-22g, (the SPF level is provided by Traditional Chinese Medicine University Of Guangzhou's Experimental Animal Center male and female half and half, the quality certification number: SCXK (Guangdong) 2008-0020).
1.3 experimental technique
1.3.1 modeling method
Get 30 of Kunming mouses, back wool is cut short, depilatory (6%Na2S) is applied to the about 2-3 of mouse back minute after, use warm water cleaning, smooth with mouse back, do not have hindering no residual hair be only, the about 3 * 4cm of area loses hair or feathers
2
1.3.2 experiment is divided into groups
Depilation next day, divide 6 groups at random with mice, 10 every group, be respectively: 1. blank control group: smear 75% ethanol; 2. positive controls: smear 101 HAIR BREEDING AGENT; 3. experimental group (prescription I): the Chinese medicine extraction liquid of smearing prescription I; 4. experimental group (prescription II): the Chinese medicine extraction liquid of smearing prescription II; 5. experimental group (prescription III): the Chinese medicine extraction liquid of smearing prescription III; 6. experimental group (prescription IV): the Chinese medicine extraction liquid of smearing prescription IV.
1.3.3 medication
Local skin uses liquid-transfering gun quantitatively to smear administration, and every day 2 times, each dosage is 0.1ml/12cm
2Give feeding animal preceding administration in the morning, afternoon, successive administration 10 days.
1.3.4 observation index
New setation upgrowth situation: per 2 days to every Mus depilation district's virgin wool upgrowth situation scoring; Standards of grading are seen table 1:
Newborn gross weight: test and took off neck execution mice on the 11st, back depilation district fur is cut, distinguish same position with the 14mm card punch in every Mus depilation and get a circular skin graft, scrape all chaetas on the skin graft with scalpel, 100,000/analytical balance is weighed;
Newborn staple length: every Mus depilation is distinguished on the residue skin after the punching, gets with magnifier and tweezers in same position and becomes mildewed 10 most, and magnifier is down with the newborn staple length of vernier caliper measurement.
The new setation upgrowth situation of mice appraisal result, newborn gross weight, newborn staple length measured value respectively organized in record.
The new setation upgrowth situation of table 1 mice standards of grading
| Score value | The new setation upgrowth situation of |
| 0 minute | There is not the |
| 1 minute | The shallow staple length district of completely losing hair or |
| 2 minutes | Newborn staple length and density are about the half the of not depilation |
| 3 minutes | The newborn staple length and the district's indifference 20 of not losing hair or feathers |
| Remarks | The mice that irregular hair growth occurs is pressed area ratio calculating |
1.4 experimental result
Table 2 Chinese medicine hair growth liquor is to mice depilation district chaeta growth " scoring " result
Annotate:
*P＜0.05 is compared with the ethanol group
Table 2 and Fig. 1 result show: compare with blank control group, 101 HAIR BREEDING AGENT to 10d, maintains the effect (P＜0.05) of significantly short mice hair growth from 2d behind the coating always, prompting modeling success; Compare with blank control group, prescription I group begins that at 2d the effect (P＜0.05) of significantly urging the mice hair growth is arranged, and the III group of writing out a prescription begins to have obviously short hair growth effect (P＜0.05) at 4d, and produce effects is later; Compare with blank control group, the II group of writing out a prescription, prescription IV group have the effect of short mice hair growth, but urge hair growth effect remarkable and unstable (P＞0.05).
Table 3 removing fat and generating hair side is to the influence
of mice depilation district chaeta growth weight
Annotate:
*P＜0.05,
*P＜0.01 is compared with the ethanol group
Table 3, Fig. 2 result show: compare with blank control group, 101 hair nourishing liquids can significantly increase depilation district chaeta weight (P＜0.05), prompting modeling success; Compare with blank control group, prescription I group, prescription III group can significantly increase mice gross weight (P＜0.05), point out prescription I, prescription III that hair growth is had significant facilitation effect; Do not have significant difference (P＞0.05) with the comparison of 101 HAIR BREEDING AGENT group, prescription I group, prescription III group, the prompting 101 HAIR BREEDING AGENT is educated with prescription I, prescription III and is sent out the effect basically identical; Prescription II group, prescription IV group and blank control group relatively do not have significant difference (P＞0.05), and prompting prescription II group, the IV group of writing out a prescription are educated and sent out DeGrain.
Table 4 removing fat and generating hair side is to the influence
of mice depilation district chaeta growth length
Annotate:
*P＜0.05 is compared with the ethanol group
Table 4, Fig. 3 result show: compare with blank control group, 101 hair nourishing liquids can the depilation of phenomenal growth mice be distinguished chaeta length (P＜0.05), and the prompting modeling is successful; With blank control group relatively, prescription I can phenomenal growth mice depilation district chaeta length (P＜0.05), prescription II group, prescription III group, prescription IV group do not have significant difference (P＞0.05); The prescription I group then there was no significant difference (P＞0.05) of comparing with the 101 HAIR BREEDING AGENT group; Prompting prescription I group can significantly increase the newborn staple length in mice depilation district, with 101 HAIR BREEDING AGENT effect basically identical.
1.5 discuss
This experiment is 6%Na2S mice depilation, and with the positive contrast of 101 hair nourishing liquids, comprehensive new setation upgrowth situation, newborn gross weight, three measurement index results of newborn staple length screen the prescription of Chinese medicine hair growth liquor.Experimental result shows: Chinese medicine hair growth liquor prescription I, prescription II, prescription III, prescription IV group all have facilitation to hair growth; Prescription I, prescription III can significantly increase hair growth weight; Prescription I can significantly increase the length of hair growth; Totally think the short hair growth effect of prescription I be superior to writing out a prescription II, prescription III, prescription IV.
The short mice hair growth test in experiment two, the full side in removing fat and generating hair side and the side of tearing open thereof
Summary: cause mice depilation model through setting up 6%Na2S, the measurement index result of comprehensive newborn gross weight, newborn staple length is to the full side and the side of tearing open thereof of removing fat and generating hair side carrying out effect assessment.
1. experiment material
1.1 laboratory animal
Kunming mouse, body weight 18-22g, (the SPF level is provided by Traditional Chinese Medicine University Of Guangzhou's Experimental Animal Center male and female half and half, the quality certification number: SCXK (Guangdong) 2008-0020)
1.2 receive the reagent thing
(1) perfect square Chinese medicine extraction liquid: contain crude drug 1g/ml.
Method for preparing: get Rhizoma Zingiberis 30g, Fructus Zanthoxyli 30g, Rhizoma Chuanxiong 20g, Flos Carthami 20g, Fructus Viticis 10g, windproof 10g, Radix Scutellariae 10g, Radix Angelicae Sinensis 10g eight flavor Chinese medicines; Clean, add 75% soak with ethanol 30 minutes, heating and refluxing extraction 2 times; 75% ethanol that adds for the first time 8 times of amounts of medical material total amount is 75% ethanol of 6 times of amounts for the second time, 1.5h/ time; 85 ℃ of temperature, it is subsequent use that filtrating is concentrated into 140ml.
(2) mix Chinese medicine extraction liquid:
(1) Fructus Viticis, windproof, Radix Scutellariae, Radix Angelicae Sinensis mixed extract: contain Fructus Viticis, windproof, Radix Scutellariae, each 0.07g/ml of Radix Angelicae Sinensis.
Method for preparing: get Fructus Viticis 10g, windproof 10g, Radix Scutellariae 10g, Radix Angelicae Sinensis 10g and clean; Add 75% soak with ethanol 30 minutes; Heating and refluxing extraction 2 times adds for the first time 75% ethanol of 8 times of amounts of medical material total amount, is for the second time 75% ethanol 1.5h/ time of 6 times of amounts; 85 ℃ of temperature, it is subsequent use that filtrating is concentrated into 140ml.
(2) Rhizoma Zingiberis, Fructus Zanthoxyli mixed extract: contain Rhizoma Zingiberis, each 0.21g/ml of Fructus Zanthoxyli.
Method for preparing: get Rhizoma Zingiberis 30g, Fructus Zanthoxyli 30g and clean, add 75% soak with ethanol 30 minutes, heating and refluxing extraction 2 times; 75% ethanol that adds for the first time 8 times of amounts of medical material total amount; For the second time be 75% ethanol 1.5h/ time of 6 times of amounts, 85 ℃ of temperature, filtrating, it is subsequent use to be concentrated into 140ml.
(3) Rhizoma Chuanxiong, Flos Carthami mixed extract: contain Rhizoma Chuanxiong, each 0.14g/ml of Flos Carthami.
Method for preparing: get Rhizoma Chuanxiong 20g, Flos Carthami 20g and clean, add 75% soak with ethanol 30 minutes, heating and refluxing extraction 2 times; 75% ethanol that adds for the first time 8 times of amounts of medical material total amount is 75% ethanol of 6 times of amounts for the second time, 1.5h/ time; 85 ℃ of temperature, it is subsequent use that filtrating is concentrated into 140ml.
(3) single medicinal material extracting solution:
(1) Flos Carthami extract: contain Flos Carthami 0.14g/ml.
Method for preparing: get Flos Carthami 20g and clean, add 75% soak with ethanol 30 minutes, heating and refluxing extraction 2 times adds 75% ethanol of 8 times of amounts of medical material total amount the first time, is 75% ethanol of 6 times of amounts for the second time, and 1.5h/ time, 85 ℃ of temperature, it is subsequent use that filtrating is concentrated into 140ml.
(2) Rhizoma Chuanxiong extracting solution: contain Rhizoma Chuanxiong 0.14g/ml.
Method for preparing: get Rhizoma Chuanxiong 20g and clean, add 75% soak with ethanol 30 minutes, heating and refluxing extraction 2 times adds 75% ethanol of 8 times of amounts of medical material total amount the first time, is 75% ethanol of 6 times of amounts for the second time, and 1.5h/ time, 85 ℃ of temperature, it is subsequent use that filtrating is concentrated into 140ml.
(3) Rhizoma Zingiberis extracting solution: contain Rhizoma Zingiberis 0.21g/ml
Method for preparing: get Rhizoma Zingiberis 30g and clean, add 75% soak with ethanol 30 minutes, heating and refluxing extraction 2 times adds 75% ethanol of 8 times of amounts of medical material total amount the first time, is 75% ethanol of 6 times of amounts for the second time, and 1.5h/ time, 85 ℃ of temperature, it is subsequent use that filtrating is concentrated into 140ml.
(4) Fructus Zanthoxyli extracting solution: contain Fructus Zanthoxyli 0.21g/ml
Method for preparing: get Fructus Zanthoxyli 30g and clean, add 75% soak with ethanol 30 minutes, heating and refluxing extraction 2 times adds 75% ethanol of 8 times of amounts of medical material total amount the first time, is 75% ethanol of 6 times of amounts for the second time, and 1.5h/ time, 85 ℃ of temperature, it is subsequent use that filtrating is concentrated into 140ml.
(5) Fructus Viticis extracting solution: contain Fructus Viticis 0.07g/ml
Method for preparing: get Fructus Viticis 10g and clean, add 75% soak with ethanol 30 minutes, heating and refluxing extraction 2 times; 75% ethanol that adds for the first time 8 times of amounts of medical material total amount is 75% ethanol of 6 times of amounts for the second time, 1.5h/ time; 85 degrees centigrade of temperature, it is subsequent use that filtrating is concentrated into 140ml.
(6) windproof extracting solution: contain windproof 0.07g/ml.
Method for preparing: get windproof 10g and clean, add 75% soak with ethanol 30 minutes, heating and refluxing extraction 2 times adds 75% ethanol of 8 times of amounts of medical material total amount the first time, is 75% ethanol of 6 times of amounts for the second time, and 1.5h/ time, 85 ℃ of temperature, it is subsequent use that filtrating is concentrated into 140ml.
(7) Radix Scutellariae extracting solution: contain Radix Scutellariae 0.07g/ml.
Method for preparing: get Radix Scutellariae 10g and clean, add 75% soak with ethanol 30 minutes, heating and refluxing extraction 2 times adds 75% ethanol of 8 times of amounts of medical material total amount the first time, is 75% ethanol of 6 times of amounts for the second time, and 1.5h/ time, 85 ℃ of temperature, it is subsequent use that filtrating is concentrated into 140ml.
(8) Radix Angelicae Sinensis extracting solution: contain Radix Angelicae Sinensis 0.07g/ml.
Method for preparing: get Radix Angelicae Sinensis 10g and clean, add 75% soak with ethanol 30 minutes, heating and refluxing extraction 2 times adds 75% ethanol of 8 times of amounts of medical material total amount the first time, is 75% ethanol of 6 times of amounts for the second time, and 1.5h/ time, 85 ℃ of temperature, it is subsequent use that filtrating is concentrated into 140ml.
1.3 reagent
090707), picric acid (Guangzhou Chemical Reagent Factory, lot number: 20080401-1), (Fanyu, Guangzhou power is strengthened factory, lot number: 20090512) to 6% sodium sulfide depilatory 75% ethanol (Tianjin Fu Xue Fine Chemical Co., Ltd, lot number:.
1.4 instrument
(Sai Mo flies generation that (Shanghai) Instr Ltd., model: FP Freshman 20-200 μ L Serial No.ZY24816) to liquid-transfering gun; (Sai Mo flies generation that (Shanghai) Instr Ltd., model: FP Freshman 100-1000 μ L Serial No.ZY10462) to liquid-transfering gun; (Sai Mo flies generation that (Shanghai) Instr Ltd., model: FP Freshman 100-1000 μ L Serial No.ZY10460) to liquid-transfering gun; 100,000/analytical balance (the positive Science and Technology Ltd. in Guangzhou, model: CP225DMax220g d=0.01mg (220g)); The 14mm card punch; Slide gauge (Guangzhou tools factory, model: Tricle Brand).
2. experimental technique
2.1 modeling method
Get 130 of Kunming mouses, back wool is cut short, depilatory (6%Na2S) is applied to the about 2-3 of mouse back minute after, use warm water cleaning, smooth with mouse back, do not have hindering no residual hair be only, the about 3 * 4cm of area loses hair or feathers
2
2.2 experiment is divided into groups
Lose hair or feathers next day, divide 13 groups at random, 10 every group, be respectively: (1) blank control group: smear 75% ethanol mice; (2) experimental group (full side group): the Chinese medicine extraction liquid of smearing full side; (3) experimental group (Fructus Viticis, Radix Angelicae Sinensis, windproof, Radix Scutellariae group): the herbal mixture extracting solution of smearing Fructus Viticis, Radix Angelicae Sinensis, windproof, Radix Scutellariae; (4) experimental group (Rhizoma Zingiberis, Fructus Zanthoxyli group): the herbal mixture extracting solution of smearing Rhizoma Zingiberis, Fructus Zanthoxyli; (5) experimental group (Flos Carthami, Rhizoma Chuanxiong group): the herbal mixture extracting solution of smearing Flos Carthami, Rhizoma Chuanxiong; (6) experimental group (Flos Carthami group): the Chinese medicine extraction liquid of smearing Flos Carthami; (7) experimental group (Rhizoma Chuanxiong group): the Chinese medicine extraction liquid of smearing Rhizoma Chuanxiong; (8) experimental group (Rhizoma Zingiberis group): the Chinese medicine extraction liquid of smearing Rhizoma Zingiberis; (9) experimental group (Fructus Zanthoxyli group): the Chinese medicine extraction liquid of smearing Fructus Zanthoxyli; (10) experimental group (Fructus Viticis group): the Chinese medicine extraction liquid of smearing Fructus Viticis; (11) experimental group (working as grouping): the Chinese medicine extraction liquid of smearing Radix Angelicae Sinensis; (12) experimental group (windproof group): smear windproof Chinese medicine extraction liquid; (13) experimental group (Radix Scutellariae group): the Chinese medicine extraction liquid of smearing Radix Scutellariae.
2.3 medication
Local skin uses liquid-transfering gun quantitatively to smear administration, and every day 2 times, each dosage is 0.1ml/12cm
2Give feeding animal preceding administration in the morning, afternoon, successive administration 10 days.
2.4 observation index
New setation upgrowth situation: 2 experimenters marked simultaneously, averaged to every Mus depilation district's virgin wool upgrowth situation scoring in per 2 days; Standards of grading are seen table 1:
Newborn gross weight: test and took off neck execution mice on the 11st day; Back depilation district fur is cut, distinguished same position with the 14mm card punch in every Mus depilation and get a circular skin graft, scrape all chaetas on the skin graft with scalpel; 100,000/analytical balance is weighed, and calculates and respectively organizes mice gross weight average;
Newborn staple length: on the residue skin after every Mus depilation district's punching, get with magnifier and tweezers in same position and to become mildewed 10 most, with vernier caliper measurement new life staple length, and calculate every group of mice staple length average under the magnifier.
2.5 statistical analysis
Each is organized The data SPSS 18.0 statistical softwares and carries out one factor analysis of variance (ANOVA) and add up, and experimental result is represented with
.
3 experimental results
3.1 table 5, Fig. 4 see to mice depilation district chaeta growth scoring experimental result in the full side in removing fat and generating hair side and the side of tearing open thereof:
Each group of the full side in table 5 removing fat and generating hair side and the side of tearing open thereof is to mice depilation district chaeta growth " scoring " result
Annotate:
*P＜0.05 is compared with blank control group, and #P＜0.05 is compared with full side's group
Table 5, Fig. 4 result shows: with blank control group relatively, full side in removing fat and generating hair side and the major part side of tearing open thereof (remove single medicinal material extracting solution: Radix Scutellariae, Fructus Zanthoxyli) all has the effect (P＜0.05) of the newborn hair growth in short mice depilation district, points out modeling successful; Since 2d, full side's group and blank control group, windproof group, Radix Scutellariae group, when grouping, Rhizoma Zingiberis group and Fructus Zanthoxyli group relatively, all there were significant differences (P＜0.05) for mice depilation district hair growth situation; Since 4d, full side group compares with Fructus Viticis group, compound recipe Rhizoma Zingiberis, Fructus Zanthoxyli group, Rhizoma Chuanxiong group, Flos Carthami group and compound rhizome of Sichuan lovage, Flos Carthami group, and all there were significant differences (P＜0.05) for mice depilation district hair growth situation; Since 6d, full side group and compound recipe Fructus Viticis, windproof, Radix Scutellariae, when grouping relatively, significantly promote mice depilation district hair growth situation (P＜0.05).Prompting, Chinese medicine extraction liquid have the effect that promotes the mice hair growth, and the short mice hair growth effect of removing fat and generating hair Fang Quanfang is the most remarkable.
3.2 each group of the full side in removing fat and generating hair side and the side of tearing open thereof influences the result to the new piliation weight of mice and sees table 6, Fig. 5:
Each group of the full side in table 6 removing fat and generating hair side and the side of tearing open thereof is to the influence
of mice depilation district chaeta growth weight
Annotate:
*P＜0.05 is compared with blank control group, and #P＜0.05 is compared with full side's group
Table 6, Fig. 5 result show: compare removing fat and generating hair Fang Quanfang and the part side of tearing open (single medicinal material extracting solution: Fructus Viticis, Radix Angelicae Sinensis, Rhizoma Zingiberis, Rhizoma Chuanxiong, Flos Carthami with blank control group; The mixing Chinese medicine extraction liquid of Fructus Viticis, windproof, Radix Scutellariae, Radix Angelicae Sinensis, the mixing Chinese medicine extraction liquid of Rhizoma Zingiberis, Fructus Zanthoxyli, the mixing Chinese medicine extraction liquid of Flos Carthami, Rhizoma Chuanxiong) can significantly increase mice depilation district hair weight (P＜0.05); Full side group relatively can significantly promote mice depilation district hair growth situation with the side of tearing open group respectively, increases depilation and distinguishes hair weight (P＜0.05).Prompting, removing fat and generating hair Fang Quanfang is superior to the respectively side of tearing open to increasing mice depilation district hair weight.
3.3 each group of the full side in removing fat and generating hair side and the side of tearing open thereof is to the influence of mice depilation district chaeta length
Each group of the full side in table 7 removing fat and generating hair side and the side of tearing open thereof is to the influence
of mice depilation district chaeta growth length
Annotate:
*P＜0.05 is compared with blank control group, and #P＜0.05 is compared with full side's group
Table 7, Fig. 6 result show: compare with blank control group, full side in removing fat and generating hair side and the effect of tearing the newborn hair growth in Fang Junyou short mice depilation district open thereof significantly increase its new formation staple length (P＜0.05); Full side group and Radix Scutellariae group, windproof group relatively, can significantly promote mice depilation district hair growth situation, increase depilation district new formation staple length (P＜0.05).
4, brief summary:
This experiment causes mice depilation model through setting up 6%Na2S; Removing fat and generating hair side's prescription is split into some folk prescriptions and compound recipe; The full side of comprehensive new setation upgrowth situation, newborn gross weight, three measurement index comparisons as a result of newborn staple length removing fat and generating hair side is side's of tearing open drug effect with it, to the full side and the side of tearing open thereof of removing fat and generating hair side carrying out effect assessment.
Experimental result shows: compare full side in removing fat and generating hair side and the effect of tearing the newborn hair growth in Fang Douyou short mice depilation district open thereof with blank control group; Full side and its respectively side's of tearing open comparison can significantly promote mice depilation district hair growth situation, increase depilation district's hair weight and new formation staple length (P＜0.05).Think that totally removing fat and generating hair Fang Quanfang is superior to the respectively side of tearing open to the effect of mice hair growth.
Experiment is discussed
Chinese medicine compound has advantages such as determined curative effect, toxic and side effects be little.Under instruction of Chinese Medicine theory, from integral body, regulate the equilibrium between yin and yang of body, treating both the principal and secondary aspects of a disease has been obtained clinical efficacy preferably.The present invention has tangible growth promoting function to hair growth; And being superior to each single medicinal material and the side's of tearing open group, prescription of the present invention meets Chinese medical theory, eight medicine mutual-assistance compatibilities; The control seborrheic alopecia is had synergistic function preferably, have the advantage of comprehensive, too many levels and many target spots.
The above is merely preferred embodiment of the present invention, and is in order to restriction the present invention, not all within spirit of the present invention and principle, any modification of being done, is equal to replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (9)
1. a removing fat and generating hair compositions that is used to prevent and treat seborrheic alopecia is characterized in that, comprises following medicaments in part by weight:
Rhizoma Zingiberis 1～50 weight portion, Fructus Zanthoxyli 1～50 weight portion, Rhizoma Chuanxiong 1～50 weight portion, Flos Carthami 1～50 weight portion, Fructus Viticis 1～50 weight portion, windproof 1～50 weight portion, Radix Scutellariae 1～50 weight portion, Radix Angelicae Sinensis 1～50 weight portion.
2. removing fat and generating hair compositions according to claim 1 is characterized in that, comprises following medicaments in part by weight:
Rhizoma Zingiberis 10～40 weight portions, Fructus Zanthoxyli 10～40 weight portions, Rhizoma Chuanxiong 10～40 weight portions, Flos Carthami 10～40 weight portions, Fructus Viticis 5～30 weight portions, windproof 5～30 weight portions, Radix Scutellariae 5～30 weight portions, Radix Angelicae Sinensis 10～40 weight portions.
3. removing fat and generating hair compositions according to claim 1 is characterized in that, comprises following medicaments in part by weight:
Rhizoma Zingiberis 30 weight portions, Fructus Zanthoxyli 30 weight portions, Rhizoma Chuanxiong 20 weight portions, Flos Carthami 20 weight portions, Fructus Viticis 10 weight portions, windproof 10 weight portions, Radix Scutellariae 10 weight portions, Radix Angelicae Sinensis 10 weight portions.
4. a Chinese medicine composition is characterized in that, contains removing fat and generating hair compositions and the pharmaceutical carrier described in each in the claim 1～3 of effective dose.
5. the method for preparing of the described Chinese medicine composition of claim 4 may further comprise the steps:
Take by weighing Rhizoma Zingiberis, Fructus Zanthoxyli, Rhizoma Chuanxiong, Flos Carthami by weight, Fructus Viticis, windproof, Radix Scutellariae and Radix Angelicae Sinensis add 70% soak with ethanol 20-40min; Reheat reflux, extract, 2.5-3.5 hour, temperature are controlled at 75-85 ℃, keep that extracting solution is little to boil; Room temperature filters, and leaves standstill 10-12 hour, gets the centrifugal 15-25min of supernatant; Add adjuvant or excipient, process various exterior-applied formulations.
6. method for preparing according to claim 5 is characterized in that, said various exterior-applied formulations are selected from lotion, ointment, oil preparation, cream, paste, liniment or liniment.
7. the method for preparing of the described Chinese medicine composition of claim 4 may further comprise the steps:
Take by weighing Rhizoma Zingiberis, Fructus Zanthoxyli, Rhizoma Chuanxiong, Flos Carthami, Fructus Viticis, windproof, Radix Scutellariae and Radix Angelicae Sinensis powder by weight and be broken into fine powder, sieve, add starch to 1400 weight portion, mix homogeneously, packing is subsequent use, promptly gets external pulvis.
8. the method for preparing of the described Chinese medicine composition of claim 4 may further comprise the steps:
Take by weighing Rhizoma Zingiberis, Fructus Zanthoxyli, Rhizoma Chuanxiong, Flos Carthami by weight, Fructus Viticis, windproof, Radix Scutellariae and Radix Angelicae Sinensis, every flavor Chinese medicine and siritch 500-600 weight portion decoct after putting and being heated to 50-80 ℃ in the iron pan; Decoct the time: 3-8 hour, cross and filter filtrating, add red lead powder 1400-1500 weight portion in the filtrating again; Stir the back and receive cream, ointment was soaked in cold water 3-7 days, change water 3-5 every day; At last ointment is spread out in and mounts on the backing material, be stained with cream face covering, process plaster.
9. the method for preparing of the described Chinese medicine composition of claim 4 may further comprise the steps:
The preparation Chinese medicine extract: take by weighing Rhizoma Zingiberis, Fructus Zanthoxyli, Rhizoma Chuanxiong, Flos Carthami by weight, Fructus Viticis, windproof, Radix Scutellariae and Radix Angelicae Sinensis add 70% soak with ethanol 30min; Reheat reflux, extract, 3 hours, temperature are controlled at 75-85 ℃, keep that extracting solution is little to boil; Room temperature filters; Leave standstill 12h, get the centrifugal 20min of supernatant after, water-bath is steamed into thick paste for 100 ℃;
Water constituent and oil phase constituent are placed container respectively, and the water constituent is heated to 85-95 ℃, and the oil phase constituent is heated to fusing; Under constant temperature; The oil phase constituent is slowly added in the water constituent, do not stop to mix, treat that temperature reduces to 45 ℃ by same direction; Stir to condensation, promptly get cream;
Said water constituent is: Chinese medicine extract 10.0 weight portions, and azone 6.0 weight portions, glycerol 21 weight portions, propylene glycol 6.0 weight portions, 1.5 milliliters of parts of Tween-60,0.5 milliliter of part of sodium laurylsulfate, distilled water adds to 100 milliliters of parts;
Said oil phase constituent is: octadecanol 6.5 weight portions, white oil 6.0 weight portions, glyceryl monostearate 4.0 weight portions; Isopropyl palmitate 3.0 weight portions, vaseline 7.0 weight portions, 0.15 milliliter of part of methyl hydroxybenzoate; 0.05 milliliter of part of propylparaben, 0.05 milliliter of part of Kazon.
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