CN102078381B - Medicament to prevent and treat neurasthenia and preparation method thereof - Google Patents
Medicament to prevent and treat neurasthenia and preparation method thereof Download PDFInfo
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- CN102078381B CN102078381B CN2009102164185A CN200910216418A CN102078381B CN 102078381 B CN102078381 B CN 102078381B CN 2009102164185 A CN2009102164185 A CN 2009102164185A CN 200910216418 A CN200910216418 A CN 200910216418A CN 102078381 B CN102078381 B CN 102078381B
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- extract
- betel leaf
- medicament
- semen arecae
- extractum
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Abstract
The invention belongs to the technical field of medicament and particularly relates to a medicament to prevent and treat neurasthenia and a preparation method thereof. The medicament for the prevention and treatment of neurasthenia is extracted from betel leaves or areca added with betel leaves. The medicament can refresh people's mind and eliminate people's fatigue and can be widely used to cure fatigue, dizziness, and lethargy caused by neurasthenia, so that people can put more energy into work and learning to improve work efficiency. The medicament has good efficacy and simple preparation process and is easy to realize industrial production, and people can not be addicted to the medicament.
Description
Technical field
The invention belongs to medical technical field, be specifically related to neurasthenic medicine of a kind of control and preparation method thereof.
Background technology
The neurasthenia is a kind of common nervous disorders; Because process of intercentral inhibition weakens, during external stimulus, patient's neurasthenia neurocyte is prone to excitement when receiving in; Energy expenditure is too much; Long-term so, patient just shows as a series of weak symptoms: the patient often feel deficient in energy, beach wormwood waste depressed, can not require mental skill, or mental retardation, can not focus one's attention on, hypomnesis, work efficiency go down.Energy is bad, and doze off daytime often, interferes with one's studies and works, and especially driver's doze on the enforcement road is breakneck.
The present invention relates to the medicine of the tired asthenia due to a kind of neurasthenia of control.When the economic fast development of China market, people's work and rhythm of life are accelerated, and make increasing people nervous and tired, cause working and learning efficient to reduce, even contingency occurs.People are tired unable, and this is chronic, and multiple disease causes domestic and international expert's extensive concern.Therefore, develop no addiction property, carry taking convenience, outstanding effect mental hygiene food is particularly important.The invention provides prescription of a kind of refreshment medicine and preparation method thereof,, satisfy needs of people to solve fatigue and the sleepy sense that people occur when the working and learning.
Betel leaf is Piperaceae Piper plant betel leaf Piper betle L., is used as medicine with Herb or stem, leaf.Hot, little sweet, temperature; Expelling wind and cold, promoting the circulation of QI and reducing phlegm, repellent antipruritic.Be used for the cough due to wind and cold, bronchial asthma, rheumatic ostalgia, cold syndrome of the stomach pain, edema during pregnancy; Skin eczema is controlled in external, tinea pedis.Semen Arecae is the dry mature seed of Palmae (Palmae) plant Semen Arecae (Areca Catechu Linn.), mainly is distributed in Hainan, Taiwan, and also there is a small amount of plantation in Guangdong, Guangxi, Yunnan, Fujian.Semen Arecae contains the nutrient and the active component of multiple needed by human body, like arecoline, aldehydes matter, several mineral materials, aminoacid, gallic acid, volatile oil, lignin, mannose, galactose and choline.Research shows, Semen Arecae not only has the effect of antioxidation, aid digestion, blood fat reducing, helps to alleviate and eliminate the exercise fatigue of body.
Betel leaf and Semen Arecae share and be recorded in Western Jin Dynasty Qi the earliest and contain " southern vegetation shape " volume down: " betelnut tree, in fact also, bitter and puckery flavor stays rattan, ancient beautifully adorned ash and food to hold up, the then sliding U.S. therapeutic method to keep the adverse QI flowing downwards, rapid digestion of food." the two share and is mainly used in facilitating digestion, control parasite.Do not see and be useful on the neurasthenic report of control.
Summary of the invention
The present invention adopts chemical method to make Semen Arecae extract extractum or Semen Arecae/betel leaf extract extractum (mixed by 1 gram Semen Arecae+2 gram betel leafs is extracted); Find through the animal experimental model screening; The animal that the animal of per kilogram of body weight is taken 100 gram betel leaf extractum and pers kilogram of body weight is taken the animal of 50 gram betel leaf extractum and per kilogram of body weight and takes the obviously irritability of raising mice of 14 gram Semen Arecaes/betel leaf extractum 14 grams, and the tired asthenia due to the neurasthenia is had good preventive and therapeutic effect.
Medicine of the present invention has good effect, takes no addiction property, and its preparation technology is simple, is easy to advantages such as industrialization.
The specific embodiment
Following zoopery is to further explain of the present invention, but and does not mean that any restriction of the present invention.
The method for preparing of medicine:
The present invention adopts betel leaf extract and Semen Arecae/betel leaf extract, and its preparation process is following:
The preparation of Semen Arecae/betel leaf water extract: Semen Arecae/betel leaf takes by weighing the fresh Semen Arecae/betel leaf of 1000g by 1: 2 proportion requirement of mass ratio, and chopping is ground; Add 300 ml distilled waters; Through reflux, extract,, filter, repeat to extract secondary; Merge extractive liquid, uses Rotary Evaporators to reclaim solvent to the dried extractum that obtains and is Semen Arecae/betel leaf water extract extractum;
The preparation of betel leaf water extract: take by weighing the fresh betel leaf of 1000g, chopping is ground, and adds 300 ml distilled waters, through reflux, extract,, filters, and repeats to extract secondary, and merge extractive liquid, uses Rotary Evaporators to reclaim solvent to the dried extractum that obtains and is betel leaf water extract extractum.
Zoopery:
1, material
(1) laboratory animal SPF level KM mice is 90, all select for use male, 4 the week ages, body weight 18-22g, available from Sichuan Province's experimental medicine animal center, the animal credit number, SCXK [river] 2008-14, mice is raised institute of Chinese materia medica's Animal House in Southwest Jiaotong University.It is dark to accept 12h illumination/12h every day, and periodicity of illumination is 8:00-20:00,20 ± 2 ℃ of laboratory temperatures, and humidity 60%, animal can absorb standard feed and cleaning water voluntarily, and International Laboratory Animal ethics requirement is observed in zoopery.
(2) 1. A (betel leaf extractum), B (Semen Arecae/betel leaf extractum) of medicine; 2. caffeine is made positive medicine by oneself; 3. diazepam, Tianjin Pharmaceutical Jiaozuo Co., Ltd., the accurate word H41020638 of traditional Chinese medicines, lot number.Above medicine all is stored in 4 ℃ of refrigerators.A, B face with preceding distilled water preparation, and caffeine is prepared with 0.9% normal saline.
(3) the multi-functional mice autonomic activities of instrument appearance YSL-1A
2, method
90 mices are divided into nine groups at random by 10 every group, be respectively that contrast, A are high, among the A, A is low, B is high, among the B, low, the caffeine group of B, diazepam group-model group.Matched group, caffeine group, diazepam group give 0.2mL distilled water/10g the weight of animals and irritate stomach; The high group of A gives that group gives A50g/kg among A100g/kg (mice that is per kilogram of body weight feeds 100 gram betel leaf extractum), the A, the low group of A gives A25g/kg and irritates stomach; The high group of B gives that group gives B14g/kg among B28g/kg, the B, the low group of B gives B7g/kg and irritates stomach; Every day 1 time, continuous irrigation stomach 7 days.After last was irritated stomach 45min, except that matched group, it gave diazepam 2mg/kg in each group and irritates stomach, except that the caffeine group, tested behind the filling stomach 30min; The caffeine group gives 30mg caffeine/kg the weight of animals lumbar injection again, tests behind the 15min.
3, result
Annotate: compare Δ p＜0.05 with matched group, compare with the diazepam group
*P＜0.05
This experiment shows; Group is that to organize among betel leaf 100g/kg and 50g/kg, the B be that Semen Arecae/betel leaf 14g/kg and model group comparison can obviously improve the irritability of mice among the high group of A and the A; Tired asthenia to due to the neurasthenia has good preventive and therapeutic effect; Simultaneously, because betel leaf and Semen Arecae/betel leaf extract are water extract and caffeine-free addiction property, therefore has the excellent drug application prospect.
Claims (2)
1. the purposes of the extract of betel leaf in the medicine of control neurasthenia or resisting fatigue asthenia or refreshment is made is characterized in that:
The preparation method of extract of said betel leaf is: take by weighing the fresh betel leaf of 1000g, chopping is ground; Add 300 ml distilled waters,, filter through reflux, extract; Repeat to extract secondary, merge extractive liquid, uses Rotary Evaporators to reclaim solvent to the dried extractum that obtains and is betel leaf water extract extractum.
2. the purposes of the extract of Semen Arecae/betel leaf in the medicine of control neurasthenia or resisting fatigue asthenia or refreshment is made is characterized in that:
The preparation method of extract of said Semen Arecae/betel leaf is: Semen Arecae/betel leaf is pressed 1: 2 mixed of mass ratio, takes by weighing 1000g Semen Arecae/betel leaf mixture, chopping; Grind, add 300 ml distilled waters, through reflux, extract; Filter; Repeat to extract secondary, merge extractive liquid, uses Rotary Evaporators to reclaim solvent to the dried extractum that obtains and is Semen Arecae/betel leaf water extract extractum.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009102164185A CN102078381B (en) | 2009-11-30 | 2009-11-30 | Medicament to prevent and treat neurasthenia and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009102164185A CN102078381B (en) | 2009-11-30 | 2009-11-30 | Medicament to prevent and treat neurasthenia and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102078381A CN102078381A (en) | 2011-06-01 |
| CN102078381B true CN102078381B (en) | 2012-02-22 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009102164185A Expired - Fee Related CN102078381B (en) | 2009-11-30 | 2009-11-30 | Medicament to prevent and treat neurasthenia and preparation method thereof |
Country Status (1)
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| CN (1) | CN102078381B (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1054351A (en) * | 1990-12-28 | 1991-09-11 | 郭泰山 | Make the method for candy, fruit jelly of betel nut |
| CN1454096A (en) * | 2000-12-04 | 2003-11-05 | 科学与工业研究会 | Activity of extract of piper betle leaves against leishmania |
-
2009
- 2009-11-30 CN CN2009102164185A patent/CN102078381B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1054351A (en) * | 1990-12-28 | 1991-09-11 | 郭泰山 | Make the method for candy, fruit jelly of betel nut |
| CN1454096A (en) * | 2000-12-04 | 2003-11-05 | 科学与工业研究会 | Activity of extract of piper betle leaves against leishmania |
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| Publication number | Publication date |
|---|---|
| CN102078381A (en) | 2011-06-01 |
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