CN102068588B - Chinese medicinal preparation for treating hepatopathy and preparation method thereof - Google Patents
Chinese medicinal preparation for treating hepatopathy and preparation method thereof Download PDFInfo
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- CN102068588B CN102068588B CN200910154258A CN200910154258A CN102068588B CN 102068588 B CN102068588 B CN 102068588B CN 200910154258 A CN200910154258 A CN 200910154258A CN 200910154258 A CN200910154258 A CN 200910154258A CN 102068588 B CN102068588 B CN 102068588B
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Abstract
The invention discloses a Chinese medicinal preparation for treating hepatopathy and a preparation method thereof. The Chinese medicinal preparation is characterized in that according to a formula, the Chinese medicinal preparation mainly comprises the following components: 180 to 250g of fresh rhizoma smilacis glabrae, 100 to 150g of fresh root of Kakuda Figwort, and 1,400 to 1,600g of water. Compared with the prior art, the Chinese medicinal preparation has the advantages that: medicinal raw materials are low in cost and broad in sources, and the Chinese medicinal preparation can quickly alleviate illness condition of severe hepatitis patients and is remarkable in response, quick in therapeutic effect and high in recovery rate. At the same time, the invention provides the method for preparing the Chinese medicinal preparation. The method is simple in process and convenient in operation, and brings convenience to the production of batch medicaments.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation of treating hepatopathy and preparation method thereof.
Background technology
At present China's hepatitis B virus carriers has people more than 100,000,000, and Severe Viral Hepatitis (liver failure) sickness rate in hepatitis B colony is about 1%, and China and south east asia are died from the between twenty and fifty ten hundreds of of this major disease every year.Our province is the hepatitis B severely afflicated area especially, and social negative effect is bigger.Country's 11th Five-Year target is to be reduced to 55% to the mortality rate of liver failure more than 70% from present, and national traditional Chinese medical science office also focuses the consruction on the training project to the Chinese medicine liver failure as 11th Five-Year.
Viral hepatitis gravis (liver failure) is the serious disease that threatens human health, and its state of an illness is dangerous and complicated, and hepatocyte is a large amount of in a short time downright bad; Cause liver failure rapidly; And complication is many, treatment difficulty, current no specific medicine; According to " the digestive disease diagnosis and treatment " of publishing Shanghai Communications University in August, 2007, chronic severe hepatitis (acute slowly, the slow subacute liver failure) mortality rate that is caused by chronic active hepatitis and liver cirrhosis is up to more than 90%.Though Chinese scholars is carried out big quantity research to its treatment, achieve notable results at aspects such as pathogeny clinical diagnosises, in treatment, important breakthrough is not arranged yet, and in the numerous medicines in order to the treatment liver failure a kind of determined curative effect is not arranged at present.The heavy liver report of domestic employing therapy of combining Chinese and Western medicine is more, also obtains some curative effects clinically, but still not ideal enough, and case fatality rate is high always.Use Chinese medicine only not see at home that as the viral hepatitis gravis of auxiliary treatment (liver failure) the research report is arranged as master, doctor trained in Western medicine; Chinese medicine that we adopt is the main treatment severe hepatopath, and it is dirty to use eliminating evil, dampness removing, removing pathogenic heat from blood and toxic substance from the body, purging FU-organs to protect, disease controlling development rapidly; Block the Therapeutic Method of patient's condition; The pathogeny that had both met primary disease meets the clinical rule of traditional Chinese medical science treatment must aim at the pathogenesis of disease again, has important use and is worth.To walk out convenient, effective, an economic new approach for giving treatment to a large amount of livers patient that declines.
Viral hepatitis gravis (liver failure) is dangerous with the oncoming force, development is rapid, case fatality rate is high is celebrated, and at present, Therapeutic Method is not preferably arranged also both at home and abroad.Seminar changes the inspiration of the innovation theory of the important function in the incidence and development of heavy liver according to traditional experience among the people and the intestinal microecology that obtained the beautiful academician of Li Lan, and fresh Chinese prescription-liver heat removing toxin expelling of having formulated the viral hepatitis gravis of treatment (liver failure) returns contrary soup.The common problem project verification-Chinese medicine Rhizoma Smilacis Glabrae prescription that passed through Zhejiang Department of Public Health in 2007 is the viral hepatitis gravis clinical observation of main treatment.It is main that seminar adopts " the liver heat removing toxin expelling returns contrary soup " (bright Rhizoma Smilacis Glabrae is native Radix Scrophulariae prescription) to viral hepatitis gravis (liver failure) the early metaphase patient who makes a definite diagnosis through hospital above county level; Western medicine only carries out clinical treatment research as auxiliary treatment; Symptom changes rapidly the patient in back 24 hours receiving treatment; Comprise that signs such as abdominal distention, ascites, symptom of digestive tract, hepatic encephalopathy symptom, liver are smelly, the cancer of the esophagus alleviate disappearance thereupon, thereby patient's state of an illness in 3-5 days is significantly taken a turn for the better and rehabilitation rapidly.Result of study: the severe hepatopath more than 70% reaches clinical rehabilitation.On August 28,2009 18 days to 2009 May in; We have entrusted Zhejiang Province medical courses in general institute safety evaluatio research center, national Zhejiang new drug Research on Safety Assessment key lab; " the liver heat removing toxin expelling returns contrary soup " animal acute and chronic toxicological test, experimental result safety, no obvious toxic-side effects have been carried out.Certificate number: 09016JD1-B, 09016CD1-B, 09016JD2-B.On JIUYUE 14th, 2009, the Zhejiang Province State Administration of Traditional Chinese Medicines organizes our province Chinese medicine and pharmacy expert that problem is carried out an acceptance inspection, and it is qualified to evaluate, determined curative effect, and suggestion further enlarges the research of clinical practice and drug action mechanism, and certificate number: Zhe Zhongke tests word (2009) No. 19.
Chinese medicine is that the successful implementation of the viral hepatitis gravis of main treatment (liver failure) possibly have epoch-making important meaning; Can develop traditional medicine is that country wins honour for; Can make the vast liver patient that declines obtain to live again again, the research of this project is carried forward motherland's medicine to revitalizing motherland's traditional culture; Strengthen Chinese medicine popularity at home and abroad and have important function with the internationalization new drug development, its economic and social benefit will be very significantly.
China has the Chinese medical culture in 5,000 years, and its historic feats is indelible, has been listed in world's non-material cultural heritage by the United Nations, but undeniable, and motherland's traditional medicine has its certain limitation, and main theory is difficult to obtain the confirmation of modern scientific method.The task of top priority is to let our Chinese medical culture of international community's common recognition; Need be under the situation that does not have the ripe way of a cover in the control of western modern medicine to some major diseases at present; Give chance of putting skill to good use of the traditional Chinese medical science; Developing the traditional medicine culture and win honour for for country, is under the hepatitis virus undesirable element stimulation in vivo and in vitro like viral hepatitis gravis, causes the reaction of body generation abnormal immune; The large tracts of land that hepatocyte is taken place in various degree in short-term is downright bad, causes the serious depleted clinical pathology process of liver function.The viral hepatitis gravis state of an illness is heavy, poor prognosis, and case fatality rate is high.Hepatitis is to cause one of dead several big diseases of people, and the Chinese medicine preparation of treating viral hepatitis gravis now is a lot, but effect is all not ideal, is difficult to reach the purpose of radical cure.
Summary of the invention
First technical problem to be solved by this invention is the present situation to prior art, provides a kind of and can block patient's condition rapidly, takes effect significantly, curative effect is fast and the Chinese medicine preparation of the treatment hepatopathy that the rehabilitation rate is high.
Second technical problem to be solved by this invention is the present situation to prior art, and the method for preparing of the Chinese medicine preparation of a kind of technology treatment hepatopathy simple, easy to make is provided.
The present invention solves above-mentioned first technical problem and the technical scheme that adopts is: the Chinese medicine preparation of this treatment hepatopathy, and prescription is main to be formed as follows:
Rhizoma Smilacis Glabrae 180～250g, native Radix Scrophulariae 100～150g, water 1400～1600g, and through mixing the Chinese medicine preparation that decocting forms, it is characterized in that: described Rhizoma Smilacis Glabrae is fresh Rhizoma Smilacis Glabrae, and described native Radix Scrophulariae is fresh native Radix Scrophulariae.、
As improvement, said prescription also can include Rhizoma Imperatae 20～40g.
Improve, said prescription also can include Herba Lysimachiae 20～40g again.
As further improvement, said fresh Rhizoma Smilacis Glabrae 200g, fresh native Radix Scrophulariae 120g, water 1500g, Rhizoma Imperatae 30g, Herba Lysimachiae 30g.
The present invention solves above-mentioned second technical problem and the technical scheme that adopts is: the method for preparing of this treatment hepatopathy Chinese medicine preparation is characterized in that: this method for preparing may further comprise the steps as follows:
Fresh Rhizoma Smilacis Glabrae 180～250g and fresh native Radix Scrophulariae 100～150g are cleaned up with clear water respectively; The fresh Rhizoma Smilacis Glabrae that to clean then and fresh native Radix Scrophulariae are cut into slices respectively; It is that 100 ℃ capacity is that the water of 1400～1600g carried out decocting 50～70 minutes that above-mentioned fresh Rhizoma Smilacis Glabrae and bright native Radix Scrophulariae after the section are put into temperature; Gross weight to fresh Rhizoma Smilacis Glabrae, fresh native Radix Scrophulariae and water is 250g, then Chinese medicine preparation is isolated, and this isolated Chinese medicine preparation is finished product; Or/and during Herba Lysimachiae, to carry out the decocting ad pond om be 250g or/and Herba Lysimachiae 20～40g mixes with above-mentioned prescription with Rhizoma Imperatae 20～40g, then Chinese medicine preparation isolated when being added with Rhizoma Imperatae in the above-mentioned prescription, and this isolated Chinese medicine preparation is finished product.
As improvement, with Chinese medicine preparation be packaged into the bag or be packaged in the bottle, enter the storehouse then.
Compared with prior art, the present invention fills a prescription main the composition as follows: fresh Rhizoma Smilacis Glabrae 180～250g, fresh native Radix Scrophulariae 100～150g, water 1400～1600g.Its advantage is that the medicinal raw material cost is low, wide material sources, and can block patient's condition rapidly to severe hepatopath, take effect significantly, curative effect is fast and the rehabilitation rate is high.The invention provides a kind of method for preparing this Chinese medicine preparation simultaneously, it is simple that this method has technology, easy to operate, provides convenience for producing medicament in enormous quantities.
The specific embodiment
Below in conjunction with specific embodiment the present invention is done further explain:
Embodiment one, the Chinese medicine preparation of the treatment hepatopathy of present embodiment, and its prescription is formed as follows: fresh Rhizoma Smilacis Glabrae 180g, fresh native Radix Scrophulariae 100g, water 1400g.Method for preparing according to above-mentioned formula for treating hepatopathy Chinese medicine preparation; This method for preparing may further comprise the steps as follows: fresh Rhizoma Smilacis Glabrae 180g and fresh native Radix Scrophulariae 100g are cleaned up with clear water respectively; The fresh Rhizoma Smilacis Glabrae that to clean then and bright native Radix Scrophulariae are cut into slices respectively; It is that 100 ℃ capacity is that the water of 1400g carried out decocting 60 minutes that above-mentioned fresh Rhizoma Smilacis Glabrae and fresh native Radix Scrophulariae after the section are put into temperature, to the gross weight of fresh Rhizoma Smilacis Glabrae, fresh native Radix Scrophulariae and water be 250g, then Chinese medicine preparation is isolated; This isolated Chinese medicine preparation is packaged into bag or is packaged in the bottle, is finished product.
Embodiment two, the Chinese medicine preparation of the treatment hepatopathy of present embodiment, and its prescription is formed as follows: fresh Rhizoma Smilacis Glabrae 200g, fresh native Radix Scrophulariae 120g, water 1500g.Method for preparing according to above-mentioned formula for treating hepatopathy Chinese medicine preparation; This method for preparing may further comprise the steps as follows: fresh Rhizoma Smilacis Glabrae 200g and fresh native Radix Scrophulariae 120g are cleaned up with clear water respectively; The fresh Rhizoma Smilacis Glabrae that to clean then and bright native Radix Scrophulariae are cut into slices respectively; It is that 100 ℃ capacity is that the water of 1500g carried out decocting 60 minutes that above-mentioned fresh Rhizoma Smilacis Glabrae and fresh native Radix Scrophulariae after the section are put into temperature, to the gross weight of fresh Rhizoma Smilacis Glabrae, fresh native Radix Scrophulariae and water be 250g, then Chinese medicine preparation is isolated; This isolated Chinese medicine preparation is packaged into bag or is packaged in the bottle, is finished product.
Embodiment three, the Chinese medicine preparation of the treatment hepatopathy of present embodiment, and its prescription is formed as follows: fresh Rhizoma Smilacis Glabrae 250g, fresh native Radix Scrophulariae 150g, water 150g.Method for preparing according to above-mentioned formula for treating hepatopathy Chinese medicine preparation; This method for preparing may further comprise the steps as follows: fresh Rhizoma Smilacis Glabrae 250g and fresh native Radix Scrophulariae 150g are cleaned up with clear water respectively; The fresh Rhizoma Smilacis Glabrae that to clean then and bright native Radix Scrophulariae are cut into slices respectively; It is that 100 ℃ capacity is that the water of 1600g carried out decocting 70 minutes that above-mentioned fresh Rhizoma Smilacis Glabrae and fresh native Radix Scrophulariae after the section are put into temperature, to the gross weight of fresh Rhizoma Smilacis Glabrae, fresh native Radix Scrophulariae and water be 250g, then Chinese medicine preparation is isolated; This isolated Chinese medicine preparation is packaged into bag or is packaged in the bottle, is finished product.
Embodiment four, the Chinese medicine preparation of the treatment hepatopathy of present embodiment, and prescription is main to be formed as follows:
Fresh Rhizoma Smilacis Glabrae 200g, fresh native Radix Scrophulariae 1120g, water 1500g, Rhizoma Imperatae 30g.And through mixing the Chinese medicine preparation that decocting forms; Method for preparing according to above-mentioned formula for treating hepatopathy Chinese medicine preparation; This method for preparing may further comprise the steps as follows: fresh Rhizoma Smilacis Glabrae 200g and fresh native Radix Scrophulariae 120g are cleaned up with clear water respectively, and the fresh Rhizoma Smilacis Glabrae that will clean then and fresh native Radix Scrophulariae are cut into slices respectively, and Rhizoma Imperatae 30g is shredded; It is that 100 ℃ capacity is that the water of 1500g carried out decocting 60 minutes that goldenseal after fresh Rhizoma Smilacis Glabrae and bright native Radix Scrophulariae and the chopping after the section is put into temperature; Gross weight to fresh Rhizoma Smilacis Glabrae, fresh native Radix Scrophulariae, Rhizoma Imperatae and water is 250g, then Chinese medicine preparation is isolated, and this isolated Chinese medicine preparation is finished product; Again with Chinese medicine preparation be packaged into the bag or be packaged in the bottle.
Embodiment five, the Chinese medicine preparation of the treatment hepatopathy of present embodiment, and prescription is main to be formed as follows:
Fresh Rhizoma Smilacis Glabrae 200g, fresh native Radix Scrophulariae 1120g, water 1500g, money grass roots 30g.And through mixing the Chinese medicine preparation that decocting forms; Method for preparing according to above-mentioned formula for treating hepatopathy Chinese medicine preparation; This method for preparing may further comprise the steps as follows: fresh Rhizoma Smilacis Glabrae 200g and fresh native Radix Scrophulariae 120g are cleaned up with clear water respectively, and the fresh Rhizoma Smilacis Glabrae that will clean then and fresh native Radix Scrophulariae are cut into slices respectively, and Herba Lysimachiae 30g is shredded; It is that 100 ℃ capacity is that the water of 1500g carried out decocting 60 minutes that fresh Rhizoma Smilacis Glabrae and bright native Radix Scrophulariae after the section and chopping back Herba Lysimachiae are put into temperature; Gross weight to fresh Rhizoma Smilacis Glabrae, fresh native Radix Scrophulariae, Herba Lysimachiae and water is 250g, then Chinese medicine preparation is isolated, and this isolated Chinese medicine preparation is finished product; Again with Chinese medicine preparation be packaged into the bag or be packaged in the bottle.
Embodiment six, the Chinese medicine preparation of the treatment hepatopathy of present embodiment, and prescription is main to be formed as follows:
Fresh Rhizoma Smilacis Glabrae 200g, fresh native Radix Scrophulariae 1120g, water 1500g, money grass roots 30g, Rhizoma Imperatae 30g.And through mixing the Chinese medicine preparation that decocting forms; Method for preparing according to above-mentioned formula for treating hepatopathy Chinese medicine preparation; This method for preparing may further comprise the steps as follows: fresh Rhizoma Smilacis Glabrae 200g and fresh native Radix Scrophulariae 120g are cleaned up with clear water respectively; The fresh Rhizoma Smilacis Glabrae that to clean then and fresh native Radix Scrophulariae are cut into slices respectively; Herba Lysimachiae 30g and Rhizoma Imperatae 30g are shredded respectively, and it is that 100 ℃ capacity is that the water of 1500g carried out decocting 60 minutes that fresh Rhizoma Smilacis Glabrae and bright native Radix Scrophulariae after the section and chopping back Herba Lysimachiae are put into temperature, to the gross weight of fresh Rhizoma Smilacis Glabrae, fresh native Radix Scrophulariae, Herba Lysimachiae, Rhizoma Imperatae 3 and water be 250g; Then Chinese medicine preparation is isolated, this isolated Chinese medicine preparation is finished product; Again with Chinese medicine preparation be packaged into the bag or be packaged in the bottle.
Below in conjunction with example foregoing invention is described further:
Chinese medicine preparation of the present invention; It is main treatment that the typical all kinds of viral hepatitis gravis patients of 22 examples are adopted oral above-mentioned Chinese medicine preparation, and 16 routine patients just obviously take effect in 24 hours in treatment as a result, block patient's condition rapidly; After the treatment through 1～2 course of treatment, reach clinical rehabilitation; Effectively the survival back is dead for 2 examples; 4 routine invalid death.
Inspection item as the key technical indexes; Comprise prothrombin time, STB, albumin, glutamate pyruvate transaminase; TOTAL BILE ACID TBA, electrolyte, acetylcholine esterase, blood urea nitrogen etc.; Was that the patient chemically examines blanking time in the treatment phase with 3～5 days, took Chinese medicine preparation after three days, and main test index and sign transfer to well effectively; Treat after 1～2 month sign and each item test index and stabilize to survival; Test index and sign are normal basically or normal to be rehabilitation more than 12 months.Through above-mentioned check, the rehabilitation efficient of severe hepatopath is 72.73%, is significantly improved than in the past.
Below to the invention further describe:
Severe Viral Hepatitis (liver failure) case fatality rate is high; Therapeutic Method is roughly the Western medicine colligation therapy both at home and abroad at present; The artificial liver auxiliary treatment, liver transplantation, hepatocyte implantation etc.; Though patient's survival rate increases, technical factor is difficult to popularize basic unit and expensive medical expense makes most of general patients be difficult to bear.
This project is is mainly researched and developed content, key problem in technology and main innovate point
Heavy virus type hepatitis (liver failure) traditional Chinese medical science " acute jaundice " that belong to more, its pathogenesis is damp and hot Yong Sheng, the epidemic disease poison is flourishing, immediately gos deep into nutrient blood; The conscience of caving in is full of three warmers, and how dirty getting involved becomes disease and grow thickly; And because of noxious dampness caves in, cloudy QI consumed exhausts, and causes refined just closing to be taken off, and is principle with traditional Chinese medical science damp eliminating detoxifcation; Adopt heavy dose of fresh Rhizoma Smilacis Glabrae eliminating dampness and expelling toxin, native Radix Scrophulariae removing pathogenic heat from blood and toxic substance from the body suppresses fierce human immunity responsing reaction, the development of control and reverse disease.
The severe hepatopath that the present invention makes a definite diagnosis hospital above county level carries out clinical research; Make the most significantly symptom of digestive tract improvement rapidly in 24 hours of severe hepatopath; The times of defecation showed increased (5-7 time) that in therapeutic process, occurs; This phenomenon shows, the new theory of " intestinal microecology changes the important function in heavy liver incidence and development " of the beautiful academician's announcement of Li Lan that coincide.Wild fresh native Radix Scrophulariae distributes rare, but on the high mountain of ecosystem, cultivate in recent years, provenance, can satisfy the expanding application in the treatment basically.
Main research contents:
Further " the liver heat removing toxin expelling returns contrary soup " treated the clinical practice of viral hepatitis gravis (liver failure) and the effectively research of mechanism.
One, prescription: (the liver heat removing toxin expelling return contrary soup) such as fresh Rhizoma Smilacis Glabrae 180～250 or 180～300 grams, fresh native Radix Scrophulariae 100～150 grams.
Two, fresh Rhizoma Smilacis Glabrae extensively distributes at our province, and the medicine source is no problem.The Zhejiang Radix Scrophulariae can be on the basis in original cultivation base; Enlarging cultivated area with 2 years reaches more than 10 mu; And the preservation and the fresh-keeping problem of the fresh native Radix Scrophulariae of effort solution, with satisfied basically viral liver failure patient's the treatment needs inside and outside the province and the essential condition of new drug development.
Three, entrust province medical courses in general institute on the basis of testing through animal safety, carry out zoosis toxicity liver failure efficiency test; Entrust the province institute of Chinese materia medica to carry out drug identification, component analysis and the analysis of medicine Related Mechanism, carry out the fresh-keeping research of medicine.
Four, treatment diagnostic criteria: infect and the hepatology branch liver diagnosis guide that declines according to Chinese Medical Association in 2006; Viral hepatitis gravis comprises acute hepatic failure; Subacute liver failure, urgent (inferior anxious) property liver failure, chronic liver failure slowly, and with reference to the decline standard of phase morning, noon and afternoon of liver.
Five, the tcm diagnosis acute jaundice is (because of damp and hot malicious evil very grave; Burn due to the nutrient blood of burning; Make the hurried dangerous person of jaundice; " all source of disease marquis opinions. jaundice nobility "), and meet viral hepatitis occur 4 above persons of index of hepatitis gravis diagnosis comprise 4 (separation of gallbladder enzyme, severe abdominal distention, prothrombin time obviously are extended for more than 17 seconds, ascites (edema), STB greater than 171umol/L or more than the 24 hourly average rising 17.1umol/L, albumen inversion, hepatic encephalopathy etc.) can adopt the method to treat
Six, adopt the traditional decoction method of Chinese medicine, water decoction, using 1500 milliliters, once dense to fry in shallow oil into 200 milliliters be 1 dose, 1 to 2 dose of every day, 5～7 days is a course of treatment, general 1 to 2 course of treatment, indivedual state of an illness complicacy persons is extended the period of treatment.On the basis of traditional Chinese medical science eliminating dampness and expelling toxin, to being unable to leave the bed, inappetence the person infuse in right amount, corrects water-electrolyte balance, observes the absolute value and the prothrombin time of serum albumin, prevents secondary infection, and amount of infusion is controlled in 500 milliliters in principle.Should advance light an amount of liquid, to keep normal vital signs.
Seven, during treating, be that the patient chemically examines blanking time with 3～5 days, take medicine after 3 to 5 days, main experimental index and sign transfer to well effectively; Treat after 1～2 month, sign and experiments index stabilize to survival; Experimental index and sign are normal basically or normal to be rehabilitation more than 6 months.Every day, the symptom and sign of observed and recorded patient treatment process changed, and comprised that whole process such as body temperature, blood pressure, pulse condition, defecation, xanthochromia, ascites, abdominal distention degree, singultus etc. and hepatic encephalopathy, hemorrhage, hepatorenal syndrome, concurrent infection record a video and follow up a case by regular visits to more than 1 year.
Key problem in technology of this project and main innovate point
The project key problem in technology:
1, under the prerequisite that does not affect the treatment, make great efforts to solve the preservation and the fresh-keeping problem of fresh native Radix Scrophulariae,
2, holding diagnosis closes: must be according to Chinese Medical Association's infection in 2006 and hepatology branch liver the decline standard of phase morning, noon and afternoon of its liver of diagnosis guide that declines; Be diagnosed as the liver early metaphase patient that declines, or viral hepatitis 4 above persons of index of hepatitis gravis diagnosis appears comprises that 4 are treated.
3, observed in detail record state of an illness incidence and development situation, careful anti-complication occurs, and takes corresponding measure.
The project innovative point:
1, uses fresh medicine, guarantee that its curative effect is rapid.2, adopting Chinese medicine is main doctor trained in Western medicine auxiliary treatment.3, differential diagnosis of diseases is executed and is controlled.
The key technical indexes
1, planting soil Radix Scrophulariae area reaches more than 10 mu in 2 years, under the prerequisite that does not affect the treatment, solves the preservation and the fresh-keeping problem of medicine.2, through clinical treatment, the viral liver 70% or more early metaphase conditions of patients that declines is controlled rapidly, and clinical rehabilitation, reach in 2 years more than clinical case 60 examples, be examination summary index.3, the inspection item of the key technical indexes comprise prothrombin time, STB, white (ball) albumen, paddy third (grass) transaminase, TOTAL BILE ACID TBA, electrolyte, acetylcholine esterase, blood urea nitrogen, blood ammonia etc.4, be that the patient chemically examines blanking time in the treatment phase with 3～5 days; Take medicine after 3 to 5 days; Main experimental index and sign transfer to well effectively; Treat after 1～2 month sign and experiments index and stabilize to survival; Experimental index and sign normal basically or normal more than 6 months for rehabilitation, the symptom and sign of preserving every day with the record patient therapeutic process changes, and comprises body temperature, blood pressure, pulse condition, defecation, xanthochromia, ascites, abdominal distention degree, singultus etc. and hepatic encephalopathy, hemorrhage, hepatorenal syndrome, concurrent infection etc. and omnidistance the video recording.5, randomly drawed by problem cooperation unit, the patient who treats with Western medicine colligation sets up matched group.
Technology path
1, differential diagnosis of diseases is executed and controlled: adopt modern Western medicine diagnose means and Chinese Medical Association in 2006 to infect and hepatology branch liver the decline standard of phase morning, noon and afternoon of its liver of diagnosis guide that declines, the patient that declines treats the liver that is diagnosed as early metaphase.2, with the foundation of laboratory inspection index as change of illness state.3, on the plantation basis that enlarges bright native Radix Scrophulariae, consider booth or off-season cultivation.
Therapeutic Method: adopt the traditional decoction method of Chinese medicine; It is oral to adopt Chinese prescription (the liver heat removing toxin expelling returns contrary soup) to fry in shallow oil into extract, and 1 to 2 dose of every day, 5～7 days is a course of treatment; General 1 to 2 course of treatment; The doctor trained in Western medicine auxiliary treatment keeps water-electrolyte balance, prevents secondary infection etc., and indivedual state of an illness complicacy persons are extended the period of treatment.
The Administration of Traditional Chinese Medicine evaluation through Zhejiang, 1, " the liver heat removing toxin expelling soup " of having confirmed this Project Study in viral hepatitis gravis treatment, have definite and curative effect rapidly.2, the medicine output in existing Chinese medicine base can satisfy the clinical needs of project basically and enlarge the needed medicament sources in planting base.3, through secular clinical observation to severe hepatopath, therapeutic scheme is complete day by day, and management is constantly strengthened, and has had more complete working condition and sophisticated research team.
Claims (6)
1. Chinese medicine preparation of treating hepatopathy, prescription is formed as follows:
Rhizoma Smilacis Glabrae 180～250g, native Radix Scrophulariae 100～150g, water 1400～1600g, and through mixing the Chinese medicine preparation that decocting forms, it is characterized in that: described Rhizoma Smilacis Glabrae is fresh Rhizoma Smilacis Glabrae, described native Radix Scrophulariae is fresh native Radix Scrophulariae.
2. Chinese medicine preparation of treating hepatopathy, prescription is formed as follows:
Rhizoma Smilacis Glabrae 180～250g, native Radix Scrophulariae 100～150g, water 1400～1600g, Rhizoma Imperatae 20～40g, and through mixing the Chinese medicine preparation that decocting forms, it is characterized in that: described Rhizoma Smilacis Glabrae is fresh Rhizoma Smilacis Glabrae, described native Radix Scrophulariae is fresh native Radix Scrophulariae.
3. Chinese medicine preparation of treating hepatopathy, prescription is formed as follows:
Rhizoma Smilacis Glabrae 180～250g, native Radix Scrophulariae 100～150g, water 1400～1600g; Rhizoma Imperatae 20～40g, Herba Lysimachiae 20～40g, and through mixing the Chinese medicine preparation that decocting forms; It is characterized in that: described Rhizoma Smilacis Glabrae is fresh Rhizoma Smilacis Glabrae, and described native Radix Scrophulariae is fresh native Radix Scrophulariae.
4. the Chinese medicine preparation of treatment hepatopathy according to claim 3 is characterized in that: said fresh Rhizoma Smilacis Glabrae 200g, fresh native Radix Scrophulariae 120g, water 1500g, Rhizoma Imperatae 30g, Herba Lysimachiae 30g.
5. according to the method for preparing of claim 1 or 2 or 3 said treatment hepatopathy Chinese medicine preparation, it is characterized in that: this method for preparing may further comprise the steps as follows:
Fresh Rhizoma Smilacis Glabrae 180～250g and fresh native Radix Scrophulariae 100～150g are cleaned up with clear water respectively; The fresh Rhizoma Smilacis Glabrae that to clean then and fresh native Radix Scrophulariae are cut into slices respectively; It is that 100 ℃ capacity is that the water of 1400～1600g carried out decocting 50～70 minutes that above-mentioned fresh Rhizoma Smilacis Glabrae and bright native Radix Scrophulariae after the section are put into temperature; Gross weight to fresh Rhizoma Smilacis Glabrae, fresh native Radix Scrophulariae and water is 250g, then Chinese medicine preparation is isolated, and this isolated Chinese medicine preparation is finished product; Or/and during Herba Lysimachiae, to carry out the decocting ad pond om be 250g or/and Herba Lysimachiae 20～40g mixes with above-mentioned prescription with Rhizoma Imperatae 20～40g, then Chinese medicine preparation isolated when being added with Rhizoma Imperatae in the above-mentioned prescription, and this isolated Chinese medicine preparation is finished product.
6. method for preparing according to claim 5 is characterized in that: with Chinese medicine preparation be packaged into the bag or be packaged in the bottle.
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| CN104127763A (en) * | 2014-06-27 | 2014-11-05 | 桂林浩新科技服务有限公司 | Traditional Chinese medicine preparation for treatment of hepatopathy |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1385205A (en) * | 2002-06-04 | 2002-12-18 | 孟昭强 | Soft-extract for treating hepatitis B and preparation process thereof |
| CN1927374A (en) * | 2006-09-04 | 2007-03-14 | 郭占林 | Traditional Chinese medicine for treating hepatitis B and its preparing process |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1385205A (en) * | 2002-06-04 | 2002-12-18 | 孟昭强 | Soft-extract for treating hepatitis B and preparation process thereof |
| CN1927374A (en) * | 2006-09-04 | 2007-03-14 | 郭占林 | Traditional Chinese medicine for treating hepatitis B and its preparing process |
Non-Patent Citations (1)
| Title |
|---|
| 刘昌尧.乙肝防治 重在脾胃.《湖北中医杂志》.2009,第31卷(第3期),48-49. * |
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| CN102068588A (en) | 2011-05-25 |
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