CN102058869B - Costus qi-regulating gastric-floating preparation and preparation method thereof - Google Patents
Costus qi-regulating gastric-floating preparation and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a costus qi-regulating gastric-floating preparation and a preparation method thereof. Costus, amomum fruit, rhizoma cyperi processed with rice vinegar, areca nut, liquorice, dried tangerine or orange peel, prepared mangnolia officinalis, fried fructus aurantii, fried rhizoma atractylodis, fried green tangerine peel and ginger are prepared into costus qi-regulating medication extract according to the traditional ratio, and 5-50 parts of the costus qi-regulating medication extract, 40-80 parts of floating agent, 7-10 parts of gel, 10-70 parts of filler, 0-100 parts of disintegrating agent, 0-10 parts of lubricating agent, 0-10 parts of flow aid and 10-100 parts of effervescing agent are processed and prepared into the costus qi-regulating gastric floating preparation by adopting a conventional preparation process or a hot melting extrusion preparation process. By applying the costus qi-regulating gastric floating preparation in the invention, the problem of oral targeting delivery of the costus qi-regulating preparation is solved, release time for regulating qi by costus is increased, and pharmaceutical effect is improved.
Description
Technical field
The invention belongs to the Chinese medicine preparation technical field, relate to novel form of Chinese medicine aplotaxis carminative pill and preparation method thereof, particularly relate to pleasant stomach floating preparation of a kind of Radix Aucklandiae and preparation method thereof.
Background technology
Functional dyspepsia is more common disease, and how slow onset is, and the course of disease is very long, normal persistence or outbreak repeatedly.The conventional formulation aplotaxis carminative pill is made up of ten Herba indigoferae Pseudotinctoriae such as the Radix Aucklandiae, Fructus Amomi, Rhizoma Cyperi (vinegar system), Semen Arecae, Radix Glycyrrhizae, Pericarpium Citri Reticulatae, Cortex Magnoliae Officinalis (system), Fructus Aurantii (parched), Rhizoma Atractylodis (stir-fry), Pericarpium Citri Reticulatae Viride (stir-fry), Rhizoma Zingiberiss; Has the circulation of qi promoting removing dampness; The effect of invigorating the spleen and regulating the stomach; Be used for clinically that chest and diaphragm painful abdominal mass due to the turbid damp retardance mechanism of qi is vexed, abdominal distention, vomiting are felt sick, belch is indigestion and loss of appetite, and be better for the functional dyspepsia therapeutic effect.
The pleasant patent medicine of the present Radix Aucklandiae mainly is honeyed pill, the watered pill or granule, and there is certain defective in such preparation: the pill taking dose is big, and the patient is difficult for swallowing; And the molten speed of loosing of disintegrate is slow; The evenly stripping of the active component of various character, short at gastric transit time, can't be directly in the diseased region release; Thereby cause its bioavailability low, influence curative effect of medication; The granule sugar content is higher, is prone to moisture absorption caking, influences product quality, and is not suitable for middle-aged and elderly people and diabetics is taken.
Therefore active component evenly discharges in the pleasant patent medicine of the Radix Aucklandiae to develop a kind of new can making, and directly acts on diseased region for a long time, improves the high novel formulation of bioavailability and is very important.The stomach floating preparation just in time can reach above specification requirement.
Summary of the invention
The purpose of this invention is to provide pleasant stomach floating preparation of a kind of Radix Aucklandiae and preparation method thereof, to solve the problem that exists in the existing pleasant conventional formulation of the Radix Aucklandiae.
Technical scheme of the present invention is: in the pleasant prescription medicine extract of traditional Radix Aucklandiae, add low-density pharmaceutic adjuvant and other necessary pharmaceutic adjuvants; Adopt conventional formulation technology or hot melt to extrude preparation process and be processed into the pleasant stomach floating preparation of the Radix Aucklandiae, described stomach floating preparation is tablet, capsule, pilule, micropill or granule.
The pleasant stomach floating preparation of the Radix Aucklandiae of the present invention is to be prepared from pleasant prescription medicine extract of the Radix Aucklandiae of following weight proportioning and adjuvant:
5～50 parts of the pleasant prescription medicine extracts of the Radix Aucklandiae, 40～80 parts of leafing agents, 7～70 parts of gels, 10～70 parts of filleies, 0～100 part of disintegrating agent, 0～10 part of lubricant, 0～10 part of fluidizer, 10～100 parts of effervescents.
Wherein, The pleasant prescription medicine extract of the described Radix Aucklandiae is to be constituent with the Radix Aucklandiae, Fructus Amomi, Rhizoma Cyperi (processed with vinegar), Semen Arecae, Radix Glycyrrhizae, Pericarpium Citri Reticulatae, Sichuan Cortex Magnoliae Officinalis (processed), Fructus Aurantii (parched), Rhizoma Atractylodis (parched), parch skin, Rhizoma Zingiberis Recens, the water extract of the prescription medicine of forming according to traditional ratio.
Described leafing agent is one or more in macromolecular material, polymer resin, tristerin, polyacrylic acid crosslinked polymer, fatty acid and the carbon fibre; Described gel is one or more in macromolecular material, carbomer, gelatin, arabic gum, carrageenan, tragacanth gum, the polyacrylic acid crosslinked polymer; Described filler is one or more in polyvinylpyrrolidone, microcrystalline Cellulose, mannitol, lactose, the amylum pregelatinisatum; Described disintegrating agent is one or more in crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose, carboxymethyl starch sodium, microcrystalline Cellulose, the sodium alginate; Described lubricant, fluidizer are one or more in Pulvis Talci, micropowder silica gel, hydrogenated vegetable oil, Polyethylene Glycol, stearic acid, magnesium stearate, the dicalcium phosphate dihydrate; Described coating materials is one or more mixing in acrylic resin, hydroxypropyl emthylcellulose, the Polyethylene Glycol.
The weight proportion of pleasant prescription medicine extract of the comparatively ideal Radix Aucklandiae of the present invention and adjuvant is:
5～50 parts of the pleasant prescription medicine extracts of the Radix Aucklandiae, 5～10 parts of carbomers, 15～30 parts of tristerins, 10～20 parts in polyacrylic acid crosslinked polymer, 7～70 parts of polyvinylpyrrolidones, 7～70 parts of hexadecanol, 10～70 parts of amylum pregelatinisatums, 20～100 parts of crospolyvinylpyrrolidone, 2～10 parts of micropowder silica gels, 2～10 parts of magnesium stearate, 10～100 parts of effervescents.
Further, the optimum weight proportioning of pleasant prescription medicine extract of the Radix Aucklandiae of the present invention and adjuvant is:
20 parts of the pleasant prescription medicine extracts of the Radix Aucklandiae, 10 parts of carbomers, 30 parts of tristerins, 10 parts in polyacrylic acid crosslinked polymer, 70 parts of hexadecanol, 20 parts of crospolyvinylpyrrolidone, 10 parts of micropowder silica gels, 10 parts of magnesium stearate.
Or
20 parts of the pleasant prescription medicine extracts of the Radix Aucklandiae, 30 parts of tristerins, 10～20 parts in polyacrylic acid crosslinked polymer, 70 parts of hexadecanol, 10 parts of micropowder silica gels, 10 parts of magnesium stearate.
Or
20 parts of the pleasant prescription medicine extracts of the Radix Aucklandiae, 30 parts of tristerins, 10～20 parts in polyacrylic acid crosslinked polymer, 70 parts of amylum pregelatinisatums, 10 parts of micropowder silica gels, 10 parts of magnesium stearate.
Or
20 parts of the pleasant prescription medicine extracts of the Radix Aucklandiae, 30 parts of tristerins, 10～20 parts in polyacrylic acid crosslinked polymer, 70 parts of hexadecanol, 10 parts of sodium bicarbonate, 10 parts of magnesium stearate.
Or
20 parts of the pleasant prescription medicine extracts of the Radix Aucklandiae, 30 parts of tristerins, 10～20 parts in polyacrylic acid crosslinked polymer, 70 parts of amylum pregelatinisatums, 10 parts of sodium bicarbonate, 10 parts of magnesium stearate.
Or
20 parts of the pleasant prescription medicine extracts of the Radix Aucklandiae, 70 parts of hexadecanol, 10 parts of magnesium stearate.
Or
20 parts of the pleasant prescription medicine extracts of the Radix Aucklandiae, 70 parts of polyvinylpyrrolidones, 10 parts of magnesium stearate.
Or
20 parts of the pleasant prescription medicine extracts of the Radix Aucklandiae, 70 parts of hexadecanol, 10 parts of magnesium stearate, 10 parts of sodium bicarbonate.
Or
20 parts of the pleasant prescription medicine extracts of the Radix Aucklandiae, 70 parts of polyvinylpyrrolidones, 10 parts of magnesium stearate, 10 parts of sodium bicarbonate.
The concrete method for preparing of the pleasant stomach floating preparation of the Radix Aucklandiae of the present invention is:
1), the pleasant prescription medicine extract of the preparation Radix Aucklandiae: get 100 parts of the Radix Aucklandiae, 100 parts of Fructus Amomis, 100 parts of Rhizoma Cyperi (processed with vinegar), 100 parts of Semen Arecaes, 100 parts of Pericarpium Citri Reticulataes, 100 parts of Sichuan Cortex Magnoliae Officinalis (processed), 100 parts of Fructus Aurantii (parched), 100 parts of Rhizoma Atractylodis (parched), 100 parts of parch skins, 200 parts of merging of Rhizoma Zingiberis Recens; The water that adds 10 times of weight of medicine; Distillating extracting oil 5 hours, it is subsequent use to collect volatile oil; Extracting liquid filtering, the A that must filtrate is subsequent use; Medicinal residues merge with 50 portions of Radix Glycyrrhizaes again, add 80%～85% ethanol of 8 times of weight, and reflux, extract, 2 hours filters, and it is subsequent use that filtrating is concentrated into fluid extract A; The decocting that medicinal residues add 10 times of weight again boils once, filters, and it is subsequent use to get liquor B; Merging filtrate A, liquor B are condensed into fluid extract B, and with after above-mentioned fluid extract A mixes, drying under reduced pressure becomes dry extract, sprays into above-mentioned volatile oil and obtains the pleasant prescription medicine extract of the Radix Aucklandiae again.
2), the pleasant stomach floating preparation of the preparation Radix Aucklandiae: get 5～50 parts of the pleasant prescription medicine extracts of the above-mentioned Radix Aucklandiae, 40～80 parts of leafing agents, 7～70 parts of gels, 10～70 parts of filleies, 0～100 part of disintegrating agent, 0～10 part of lubricant, 0～10 part of fluidizer, 10～100 parts of effervescents; After crossing No. 3 pharmacopeia sieve respectively; With extract and each adjuvant by the recipe quantity equivalent mix homogeneously that progressively increases; Survey intermediate content, adopt the conventional formulation method to be prepared into tablet, capsule, pilule, pellet or granule again;
Perhaps:
Get 5～50 parts of the pleasant prescription medicine extracts of the above-mentioned Radix Aucklandiae, 40～80 parts of leafing agents, 0～10 part of lubricant, 0～10 part of fluidizer, 10～100 parts of effervescents; After crossing No. 3 pharmacopeia sieve respectively; With extract and each adjuvant by the recipe quantity equivalent mix homogeneously that progressively increases; Be prepared into intermediate through the hot melt extruding technology, survey intermediate content, adopt the conventional formulation method to be prepared into tablet, capsule, pilule, pellet or granule again;
Compare with prior art; The present invention is on the prescription basis of original aplotaxis carminative pill; Through testing repeatedly, contrast, conclude, screening, to sum up and obtained the pleasant stomach floating preparation of a kind of brand-new Radix Aucklandiae, this stomach floating preparation has well solved the problem of the pleasant oral target administration of the Radix Aucklandiae; Increase release time for the Radix Aucklandiae is pleasant, improved drug effect.It still to existing dosage form do not carried out replenishing, perfect, and enriched the kind of dosage form, for the utilization of clinical Banksia rose preparation for lowering adverse Qi flow provides a kind of new selection.
Description of drawings
Fig. 1 is the release in vitro of the pleasant stomach floating preparation of the Radix Aucklandiae of the present invention line of writing music.
The specific embodiment
Prescription: 20 parts of the pleasant prescription medicine extracts of the Radix Aucklandiae, 10 parts of carbomers, 30 parts of tristerins, 10 parts in polyacrylic acid crosslinked polymer, 70 parts of hexadecanol, 20 parts of crospolyvinylpyrrolidone, 10 parts of micropowder silica gels, 10 parts of magnesium stearate.
Technology: get whole prescribed doses, cross the pharmacopeia sieve respectively No. 3, subsequent use; With extract and each the adjuvant equivalent mix homogeneously that progressively increases, survey intermediate content, it is heavy to calculate sheet, and (hardness of control strip is 3～9Kg) during tabletting for dry powder direct tabletting.
Prescription: 20 parts of the pleasant prescription medicine extracts of the Radix Aucklandiae, 30 parts of tristerins, 10～20 parts in polyacrylic acid crosslinked polymer, 70 parts of hexadecanol, 10 parts of micropowder silica gels, 10 parts of magnesium stearate.
Technology: get whole prescribed doses, cross the pharmacopeia sieve respectively No. 3, subsequent use; With extract and each the adjuvant equivalent mix homogeneously that progressively increases, survey intermediate content, it is heavy to calculate sheet, and (hardness of control strip is 3～5Kg) during tabletting for dry powder direct tabletting.
Prescription: 20 parts of the pleasant prescription medicine extracts of the Radix Aucklandiae, 30 parts of tristerins, 10～20 parts in polyacrylic acid crosslinked polymer, 70 parts of amylum pregelatinisatums, 10 parts of micropowder silica gels, 10 parts of magnesium stearate.
Technology: get whole prescribed doses, cross the pharmacopeia sieve respectively No. 3, subsequent use; With extract and each the adjuvant equivalent mix homogeneously that progressively increases, survey intermediate content, it is heavy to calculate sheet, and (hardness of control strip is 3～5Kg) during tabletting for dry powder direct tabletting.
Prescription: 20 parts of the pleasant prescription medicine extracts of the Radix Aucklandiae, 30 parts of tristerins, 10～20 parts in polyacrylic acid crosslinked polymer, 70 parts of hexadecanol, 10 parts of sodium bicarbonate, 10 parts of magnesium stearate.
Technology: get whole prescribed doses, cross the pharmacopeia sieve respectively No. 3, subsequent use; With extract and each the adjuvant equivalent mix homogeneously that progressively increases, survey intermediate content, it is heavy to calculate sheet, and (hardness of control strip is 3～5Kg) during tabletting for dry powder direct tabletting.
Prescription: 20 parts of the pleasant prescription medicine extracts of the Radix Aucklandiae, 20 parts of carbomers, 30 parts of tristerins, 10 parts in polyacrylic acid crosslinked polymer, 20 parts of hexadecanol, 5 parts of hydroxypropyl emthylcelluloses, coating materials (20 parts of antiplastering aids; 20 parts of plasticizers, 60 parts of acrylic resins), blank microsphere is an amount of.
Technology: get whole prescribed doses, with suitable quantity of water or the dissolving of certain density ethanol water, subsequent use; The blank pill heart is put in the fluid bed, the blank pill heart is carried out the medicine layer coating; Detect the medicament contg that has wrapped medicine layer piller (micropill), in fluid bed, above-mentioned piller is carried out the floating coating of stomach, promptly obtain the pleasant stomach Pellets Floating of the Radix Aucklandiae (micropill).
Get the pleasant stomach Pellets Floating of the Radix Aucklandiae (micropill) of embodiment 5 preparations, need filled capsules, promptly obtain the pleasant gastric floating capsule of the Radix Aucklandiae according to dosage.
Get the pleasant stomach Pellets Floating of the Radix Aucklandiae (micropill) of embodiment 5 preparations, need carry out tabletting, promptly obtain the pleasant intra-gastric floating tablet of the Radix Aucklandiae according to dosage.
Prescription: 20 parts of the pleasant prescription medicine extracts of the Radix Aucklandiae, 20 parts of carbomers, 30 parts of tristerins, 10 parts in polyacrylic acid crosslinked polymer, 20 parts of hexadecanol, 10 parts of micropowder silica gels, 700 parts of starch, 10～20 parts of binding agents.Coating materials prescription (20 parts of antiplastering aids, 20 parts of plasticizers, 60 parts of acrylic resins).
Technology: measure extract, carbomer, tristerin, polyacrylic acid crosslinked polymer, hexadecanol, micropowder silica gel, the starch equivalent mix homogeneously that progressively increases by prescription; Add binding agent and process soft material; Process granule through 20～24 mesh standard sieves, oven dry, granulate.Granule is carried out coating, and the coating weightening finish is 5～15mg/cm
2, survey intermediate content.Pack according to taking dose and promptly to obtain the agent of the pleasant stomach floating particle of the Radix Aucklandiae.
Embodiment 9
A, get the pleasant prescription medicine extract of the Radix Aucklandiae and the adjuvant of following weight proportion: 20 parts of the pleasant prescription medicine extracts of the Radix Aucklandiae, 70 parts of hexadecanol, 10 parts of magnesium stearate.
B, extract and each the adjuvant equivalent mix homogeneously that progressively increases is crossed 100 mesh sieves, is prepared into intermediate through the hot melt extrusion method, detects intermediate content, and is subsequent use.
C, intermediate is pulverized, be prepared into tablet, capsule or granule according to conventional method and promptly get.
Embodiment 10
A, get the pleasant prescription medicine extract of the Radix Aucklandiae and the adjuvant of following weight proportion: 20 parts of the pleasant prescription medicine extracts of the Radix Aucklandiae, 70 parts of polyvinylpyrrolidones, 10 parts of magnesium stearate.
B, extract and each the adjuvant equivalent mix homogeneously that progressively increases is crossed 100 mesh sieves, is prepared into intermediate through the hot melt extrusion method, detects intermediate content, and is subsequent use.
C, intermediate is pulverized, be prepared into tablet, capsule or granule according to conventional method and promptly get.
Embodiment 11
A, get the pleasant prescription medicine extract of the Radix Aucklandiae and the adjuvant of following weight proportion: 20 parts of the pleasant prescription medicine extracts of the Radix Aucklandiae, 70 parts of hexadecanol, 10 parts of magnesium stearate, 10 parts of sodium bicarbonate.
B, extract and each the adjuvant equivalent mix homogeneously that progressively increases is crossed 100 mesh sieves, is prepared into intermediate through the hot melt extrusion method, detects intermediate content, and is subsequent use.
C, intermediate is pulverized, be prepared into tablet, capsule or granule according to conventional method and promptly get.
Embodiment 12
A, get the pleasant prescription medicine extract of the Radix Aucklandiae and the adjuvant of following weight proportion: 20 parts of the pleasant prescription medicine extracts of the Radix Aucklandiae, 70 parts of polyvinylpyrrolidones, 10 parts of magnesium stearate, 10 parts of sodium bicarbonate.
B, extract and each the adjuvant equivalent mix homogeneously that progressively increases is crossed 100 mesh sieves, is prepared into intermediate through the hot melt extrusion method, detects intermediate content, and is subsequent use.
C, intermediate is pulverized, be prepared into tablet, capsule or granule according to conventional method and promptly get.
Application examples
Medicine of the present invention is through release in vitro degree verification experimental verification, and its result of the test can reach the regulation of 2010 editions stomach floating preparations of Chinese Pharmacopoeia.
The pleasant stomach floating preparation of table 1 Radix Aucklandiae release in vitro degree result of the test
Can find out that by table 1 data these article are stable lasting release in 8 hours in the 0.1mol/L hydrochloric acid solution, in 8 hours, discharges basically fully.
Medicine of the present invention and ordinary preparation are carried out release in vitro degree contrast test, its result such as table 2 and Fig. 1:
The pleasant stomach floating preparation of table 2 Radix Aucklandiae release in vitro degree comparative test result
| 0h | 0.5h | 1h | 2h | 4h | 6h | 8h | |
| Aplotaxis carminative pill | 0.00％ | 64.00％ | 98.50％ | --- | --- | ||
| |
0.00％ | 3.80％ | 11.78％ | 18.50％ | 43.20％ | 70.60％ | 93.20 |
| Embodiment | |||||||
| 2 | 0.00％ | 3.60％ | 12.94％ | 19.30％ | 42.10％ | 72.50％ | 94.30 |
| Embodiment | |||||||
| 3 | 0.00％ | 4.50％ | 12.71％ | 20.00％ | 41.00％ | 73.30％ | 92.60 |
| Embodiment | |||||||
| 4 | 0.00％ | 89.60％ | 96.70％ | --- | --- | --- | --- |
| |
0.00％ | 4.00％ | 10.90％ | 16.80％ | 39.90％ | 71.20％ | 95.10 |
| Embodiment | |||||||
| 6 | 0.00％ | 3.70％ | 9.60％ | 15.40％ | 40.10％ | 75.30％ | 94.00 |
| Embodiment | |||||||
| 7 | 0.00％ | 5.10％ | 11.20％ | 17.30％ | 38.70％ | 71.90％ | 92.80 |
| Embodiment | |||||||
| 8 | 0.00％ | 4.80％ | 10.60％ | 16.20％ | 42.30％ | 72.80％ | 95.60％ |
| Embodiment 9 | 0.00％ | 3.20％ | 9.80％ | 14.90％ | 40.20％ | 70.60％ | 94.80％ |
| Embodiment 10 | 0.00％ | 5.10％ | 13.50％ | 19.50％ | 41.60％ | 73.50％ | 95.70％ |
| Embodiment 11 | 0.00％ | 92.10％ | 97.50％ | --- | --- | --- | --- |
| Embodiment 12 | 0.00％ | 93.50％ | 98.10％ | --- | --- | --- | --- |
Experimental result by table 2 and Fig. 1 can be found out; The pleasant stomach floating preparation of the Radix Aucklandiae is compared with ordinary preparation; Release rapidly in vivo after effervescence type stomach floating preparation (embodiment 4,11,12) is taken medicine; Thereby shortened the action time of medicine, can bring into play therapeutical effect rapidly after making medicine get in the body; Stomach float type stomach floating preparation can be stablized lasting release in vivo; Thereby prolonged the action time of medicine, and reduced blood concentration fluctuation, improved curative effect because of frequently taking medicine and causing; Increased the safety of medicine; And can be positioned at stomach release, to the target organ effect, thereby improved the purposiveness of treating.Can stablize in vivo and continue release, thereby prolong the action time of medicine, and reduce blood concentration fluctuation, improve curative effect, increase the safety of medicine because of frequently taking medicine and causing.
Certainly, according to foregoing of the present invention,,, can also make modification, replacement or the change of other various ways not breaking away under the above-mentioned basic fundamental thought of the present invention prerequisite according to the ordinary skill and the customary means of this area.
More than be content of the present invention to be done further to specify through the form of embodiment; But should this be interpreted as that the scope of the above-mentioned theme of the present invention only limits to above specific embodiment, all technology that realizes based on foregoing of the present invention all belong to scope of the present invention.
Claims (2)
1. pleasant stomach floating preparation of the Radix Aucklandiae is to be prepared from pleasant prescription medicine extract of the Radix Aucklandiae of following weight proportioning and adjuvant:
5～50 parts of the pleasant prescription medicine extracts of the Radix Aucklandiae, 40～80 parts of leafing agents, 7～70 parts of gels, 10～70 parts of filleies, 0～100 part of disintegrating agent, 0～10 part of lubricant, 0～10 part of fluidizer, 10～100 parts of effervescents;
Wherein, The pleasant prescription medicine extract of the described Radix Aucklandiae is to be constituent with the Radix Aucklandiae, Fructus Amomi, Rhizoma Cyperi (processed with vinegar), Semen Arecae, Radix Glycyrrhizae, Pericarpium Citri Reticulatae, Sichuan Cortex Magnoliae Officinalis (processed), Fructus Aurantii (parched), Rhizoma Atractylodis (parched), parch skin, Rhizoma Zingiberis Recens; Get 100 parts of the Radix Aucklandiae, 100 parts of Fructus Amomis, 100 parts of Rhizoma Cyperi (processed with vinegar), 100 parts of Semen Arecaes, 100 parts of Pericarpium Citri Reticulataes, 100 parts of Sichuan Cortex Magnoliae Officinalis (processed), 100 parts of Fructus Aurantii (parched), 100 parts of Rhizoma Atractylodis (parched), 100 parts of parch skins, 200 parts of merging of Rhizoma Zingiberis Recens; The water that adds 10 times of weight of medicine; Distillating extracting oil 5 hours, it is subsequent use to collect volatile oil; Extracting liquid filtering, the A that must filtrate is subsequent use; Medicinal residues merge with 50 portions of Radix Glycyrrhizaes again, add 80%～85% ethanol of 8 times of weight, and reflux, extract, 2 hours filters, and it is subsequent use that filtrating is concentrated into fluid extract A; The decocting that medicinal residues add 10 times of weight again boils once, filters, and it is subsequent use to get liquor B; Merging filtrate A, liquor B are condensed into fluid extract B, and with after above-mentioned fluid extract A mixes, drying under reduced pressure becomes dry extract, sprays into the pleasant prescription medicine extract of the Radix Aucklandiae that above-mentioned volatile oil obtains again;
Described leafing agent is one or more in polymer resin, tristerin, polyacrylic acid crosslinked polymer, fatty acid and the carbon fibre; Described gel is one or more in carbomer, gelatin, arabic gum, carrageenan, tragacanth gum, the polyacrylic acid crosslinked polymer; Described filler is one or more in polyvinylpyrrolidone, microcrystalline Cellulose, mannitol, lactose, the amylum pregelatinisatum; Described disintegrating agent is one or more in crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose, carboxymethyl starch sodium, microcrystalline Cellulose, the sodium alginate; Described lubricant, fluidizer are one or more in Pulvis Talci, micropowder silica gel, hydrogenated vegetable oil, Polyethylene Glycol, stearic acid, magnesium stearate, the dicalcium phosphate dihydrate; Described effervescent is one or more mixing in acrylic resin, hydroxypropyl emthylcellulose, the Polyethylene Glycol.
2. the method for preparing of the pleasant stomach floating preparation of the said Radix Aucklandiae of claim 1 may further comprise the steps:
1), the pleasant prescription medicine extract of the preparation Radix Aucklandiae: get 100 parts of the Radix Aucklandiae, 100 parts of Fructus Amomis, 100 parts of Rhizoma Cyperi (processed with vinegar), 100 parts of Semen Arecaes, 100 parts of Pericarpium Citri Reticulataes, 100 parts of Sichuan Cortex Magnoliae Officinalis (processed), 100 parts of Fructus Aurantii (parched), 100 parts of Rhizoma Atractylodis (parched), 100 parts of parch skins, 200 parts of merging of Rhizoma Zingiberis Recens; The water that adds 10 times of weight of medicine; Distillating extracting oil 5 hours, it is subsequent use to collect volatile oil; Extracting liquid filtering, the A that must filtrate is subsequent use; Medicinal residues merge with 50 portions of Radix Glycyrrhizaes again, add 80%～85% ethanol of 8 times of weight, and reflux, extract, 2 hours filters, and it is subsequent use that filtrating is concentrated into fluid extract A; The decocting that medicinal residues add 10 times of weight again boils once, filters, and it is subsequent use to get liquor B; Merging filtrate A, liquor B are condensed into fluid extract B, and with after above-mentioned fluid extract A mixes, drying under reduced pressure becomes dry extract, sprays into above-mentioned volatile oil and obtains the pleasant prescription medicine extract of the Radix Aucklandiae again;
2), the pleasant stomach floating preparation of the preparation Radix Aucklandiae: get 5～50 parts of the pleasant prescription medicine extracts of the above-mentioned Radix Aucklandiae, 40～80 parts of leafing agents, 7～70 parts of gels, 10～70 parts of filleies, 0～100 part of disintegrating agent, 0～10 part of lubricant, 0～10 part of fluidizer, 10～100 parts of effervescents; After crossing No. 3 pharmacopeia sieve respectively; With extract and each adjuvant by the recipe quantity equivalent mix homogeneously that progressively increases; Survey intermediate content, adopt the conventional formulation method to be prepared into tablet, capsule, pellet or granule again;
Perhaps:
Get 5～50 parts of the pleasant prescription medicine extracts of the above-mentioned Radix Aucklandiae, 40～80 parts of leafing agents, 0～10 part of lubricant, 0～10 part of fluidizer, 10～100 parts of effervescents; After crossing No. 3 pharmacopeia sieve respectively; With extract and each adjuvant by the recipe quantity equivalent mix homogeneously that progressively increases; Be prepared into intermediate through the hot melt extruding technology, survey intermediate content, adopt the conventional formulation method to be prepared into tablet, capsule, pellet or granule again.
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2010
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1638741A (en) * | 2002-01-03 | 2005-07-13 | 史密丝克莱恩比彻姆公司 | Novel pharmaceutical dosage forms and method for producing same |
Non-Patent Citations (4)
| Title |
|---|
| Shreeraj H.SHAH等.胃内滞留漂浮给药系统中使用草药根除幽门螺旋杆菌的研究进展(英文).《中西医结合学报》.2009,(第10期), * |
| 中华人民共和国卫生部药典委员会.《木香顺气丸》.《中华人民共和国卫生部药品标准 中药成方制剂》.1995,第1卷 * |
| 姚静等.窄吸收窗药物缓释制剂的研发进展.《中国医药技术经济与管理》.2007,(第01期), * |
| 张梅君等.《胃滞留型给药系统研究概况》.《医药导报》.2009,第28卷(第8期), * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102058869A (en) | 2011-05-18 |
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