CN102058671A - Traditional Chinese medicine for expelling wind, removing dampness, dredging channel and stopping pain and preparation method thereof - Google Patents
Traditional Chinese medicine for expelling wind, removing dampness, dredging channel and stopping pain and preparation method thereof Download PDFInfo
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- CN102058671A CN102058671A CN 201010142586 CN201010142586A CN102058671A CN 102058671 A CN102058671 A CN 102058671A CN 201010142586 CN201010142586 CN 201010142586 CN 201010142586 A CN201010142586 A CN 201010142586A CN 102058671 A CN102058671 A CN 102058671A
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- 208000002193 Pain Diseases 0.000 title claims abstract description 21
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- 239000000243 solution Substances 0.000 claims description 16
- 241000612166 Lysimachia Species 0.000 claims description 15
- 239000013558 reference substance Substances 0.000 claims description 9
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- 229920002472 Starch Polymers 0.000 claims description 7
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims description 7
- 239000000706 filtrate Substances 0.000 claims description 7
- 239000000047 product Substances 0.000 claims description 7
- 229910052708 sodium Inorganic materials 0.000 claims description 7
- 239000011734 sodium Substances 0.000 claims description 7
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- INYYVPJSBIVGPH-UHFFFAOYSA-N 14-episinomenine Natural products C1CN(C)C2CC3=CC=C(OC)C(O)=C3C31C2C=C(OC)C(=O)C3 INYYVPJSBIVGPH-UHFFFAOYSA-N 0.000 claims description 6
- INYYVPJSBIVGPH-QHRIQVFBSA-N Sinomenine Chemical compound C([C@@H]1N(CC2)C)C3=CC=C(OC)C(O)=C3[C@@]32[C@@H]1C=C(OC)C(=O)C3 INYYVPJSBIVGPH-QHRIQVFBSA-N 0.000 claims description 6
- RARWEROUOQPTCJ-RBUKOAKNSA-N cepharamine Natural products C1CC2=CC=C(OC)C(O)=C2[C@@]2(CCN3C)[C@]13C=C(OC)C(=O)C2 RARWEROUOQPTCJ-RBUKOAKNSA-N 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 6
- 229930002966 sinomenine Natural products 0.000 claims description 6
- HBNIZFCGAXVRDO-UHFFFAOYSA-N C(C)NCC.C(C)(=O)OCC.C1=CC=CC=C1 Chemical compound C(C)NCC.C(C)(=O)OCC.C1=CC=CC=C1 HBNIZFCGAXVRDO-UHFFFAOYSA-N 0.000 claims description 5
- 239000008187 granular material Substances 0.000 claims description 5
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonium chloride Substances [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 claims description 4
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 claims description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 4
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 4
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- ONBIUAZBGHXJDM-UHFFFAOYSA-J bismuth;potassium;tetraiodide Chemical compound [K+].[I-].[I-].[I-].[I-].[Bi+3] ONBIUAZBGHXJDM-UHFFFAOYSA-J 0.000 claims description 4
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 4
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- 239000004375 Dextrin Substances 0.000 claims description 3
- 235000019425 dextrin Nutrition 0.000 claims description 3
- 238000007598 dipping method Methods 0.000 claims description 3
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Abstract
The invention discloses a traditional Chinese medicine for expelling wind, removing dampness, dredging channels and stopping pain. The traditional Chinese medicine is prepared from the following raw materials in parts by weight: 1,600-2,000 parts of ovientvine, 1,000-1,400 parts of periploca forrestii schltr and 920-1,120 parts of starflowerlike loosestrife root or herb. The invention also provides a particle preparation formulation of the traditional Chinese medicine, a simpler preparation method and an accurate identifying method of the traditional Chinese medicine. The traditional Chinese medicine provided by the invention has the advantages of high adsorbing speed, convenience for carrying and taking, better taste, unlimited drying temperature, more water addition amount in the process and more full extracted effective component, replaces reduced pressure drying with normal pressure drying in the process, overcomes the technical prejudice, and generates an unexpected effect; the test group display efficiency of the medicament provided by the invention is 71 percent, and the total efficiency is 93.9 percent.
Description
Technical field
The invention belongs to the field of Chinese medicines, relate to a kind of Chinese medicine preparation that is used for expelling wind and removing dampness, removing obstruction in the collateral to relieve pain.
Background technology
Arthromyodynia (Bi syndrome) be by wind, cold, wet, heat etc. cause with limbs joint and muscular soreness, numbness, weighing, joint stuffiness, even the scorching hot grade of arthroncus is a class disease of primary symptom.The heresy that primary disease and affection of exogenous wind-cold are damp and hot is relevant with human righteousness's deficiency.Pathogens such as wind and cold is wet are invaded human body easily in the time of a little less than the human body deficiency of defensive qi and are caused a disease.Exposure to wind when sweating, the wetland that sit to crouch, paddle in spite of the rain etc., all can make pathogens such as wind and cold is wet invade the body meridians, stay, cause passages through which vital energy circulates QI and blood impatency difference in the joint, stagnation of QI and blood may bring about pain, said as " element is asked the numbness opinion ": " wet three gas of wind and cold are assorted extremely, close and are numbness." according to the relative weight of experiencing pathogen, often be divided into migratory arthralgia (migratory arthralgia), arthralgia aggravated by cold (arthralgia due to cold), damp arthralgia (arthralgia chiefly caused by damp pathogen).If innate excess of YANG in the body or hyperactivity of fire caused by deficiency of YIN are felt wind-cold damp pathogen again, evil in transconversion into heat, or catching pathogenic heat, stay and annotate the joint, then be pyretic arthralgia.In a word, the heresy that wind and cold is damp and hot is invaded body, and numbness resistance articular muscle grain causes the QI and blood impatency obstructed, produces primary disease.Though the medicine of treatment arthromyodynia is various, still has deficiency.
Summary of the invention
The invention provides a kind of Chinese medicine preparation that is used for expelling wind and removing dampness, removing obstruction in the collateral to relieve pain simple, that curative effect is high, discriminating is prepared for preparing.
Expelling wind and removing dampness, the removing obstruction in the collateral to relieve pain Chinese medicine of being used for of the present invention is to be formed by the feedstock production by following weight portion:
Caulis Sinomenii 1600-2000 part Heiguteng exract 1000-1400 part Lysimachia trientaloides Hemsl. 920-1120 part.
Expelling wind and removing dampness, the removing obstruction in the collateral to relieve pain Chinese medicine of being used for of the present invention, wherein the weight portion proportioning of raw material is:
1020 parts of 1200 parts of Lysimachia trientaloides Hemsl.s of 1800 parts of Heiguteng exracts of Caulis Sinomenii.
Expelling wind and removing dampness, the removing obstruction in the collateral to relieve pain Chinese medicine of being used for of the present invention, wherein the weight portion proportioning of raw material is:
1020 parts of 1400 parts of Lysimachia trientaloides Hemsl.s of 1600 parts of Heiguteng exracts of Caulis Sinomenii.
Expelling wind and removing dampness, the removing obstruction in the collateral to relieve pain Chinese medicine of being used for of the present invention, wherein the weight portion proportioning of raw material is:
920 parts of 1000 parts of Lysimachia trientaloides Hemsl.s of 2000 parts of Heiguteng exracts of Caulis Sinomenii.
Expelling wind and removing dampness, the removing obstruction in the collateral to relieve pain Chinese medicine granules of being used for of the present invention also comprises 450 parts of carboxymethyl starch sodium, 30 parts of Aspartane.
Expelling wind and removing dampness, the removing obstruction in the collateral to relieve pain preparation method of Chinese medicine of being used for of the present invention comprises the steps:
Get Caulis Sinomenii and be ground into fine powder, standby; Remaining Caulis Sinomenii and Heiguteng exract, Lysimachia trientaloides Hemsl. decoct with water three times, add 8 times of amount dippings of water 2 hours for the first time, decoct 2.5 hours, adding for the second time 6 times of amounts of water decocted 2 hours, add 6 times of amounts of water for the third time and decocted 1.5 hours, collecting decoction filters, it is 1.25～1.30 clear paste that filtrate is condensed into 80 ℃ of following relative densities, add above-mentioned fine powder, an amount of dextrin and carboxymethyl starch sodium, Aspartane, mixing is granulated, drying is made 1000 bags.
The discrimination method that is used for expelling wind and removing dampness, removing obstruction in the collateral to relieve pain Chinese medicine of the present invention comprises the steps: to get 5.6 parts of this product contents, porphyrize, add ammonia solution 1ml and chloroform 20ml, reflux 1 hour filters, filtrate evaporate to dryness, residue add ethanol 1ml makes dissolving, as need testing solution; Other gets the sinomenine reference substance, adds ethanol and makes the solution that every 1ml contains 1mg, in contrast product solution; According to Chinese Pharmacopoeia version thin layer chromatography test in 2005, draw each 5～10 μ l of above-mentioned two kinds of solution, put respectively in same be on the silica gel g thin-layer plate of adhesive with the sodium carboxymethyl cellulose, with proportioning is that benzene-ethyl acetate-diethylamine of 7: 2: 1 is developing solvent, launches, and takes out, dry, 105 ℃ the heating 20 minutes, put cold, the spray with bismuth potassium iodide test solution; In the test sample chromatograph, with the corresponding position of reference substance chromatograph on, show the speckle of same color.
Crude drug source of the present invention:
The dry root or the Herb of Heiguteng exract (Periploca forrestii Schlechter) have the meridian dredging, and wind-damp dispelling is invigorated blood circulation, the effect of antiinflammatory.
Caulis Sinomenii (Caulis Sinomenii) is the dry rattan of menispermaceous plants Sinomenium acutum and hair Sinomenium acutum, has the function of wind-damp dispelling, the meridian dredging.
The herb of Chinese medicine Zhuifengsan (Lysimachia trientaloides Hemsl.), perennial herb has the function of dispelling wind and removing obstruction in the collateral, promoting blood circulation and stopping pain.
The advantage of Chinese medicine of the present invention is as follows:
1, infiltration rate: carry and taking convenience, mouthfeel is better, conveniently takes;
2, constant pressure and dry replaces drying under reduced pressure in the technology, baking temperature scope height, and amount of water is more in the technology, and the effective ingredient of extraction is more abundant, has overcome the low more good more and unsuitable too many technology prejudice of amount of water of baking temperature, has produced unexpected clinical effectiveness; Take the test group obvious effective rate 71% of medicine of the present invention, total effective rate is 93.9%.
3, discrimination test is more accurate.
Test example 1, add the selection test of the multiple of water
According to the parallel test method, be divided into 9 groups of tests, every group of medical material amount is for to feed intake according to 100 preparation units.
Table 1 adds the selection test of the multiple of water
| Test | Decocting for the first time | Decocting for the second time | Decocting for the third time | Extractum g | Sinomenine mg |
| 1 | 10 | 6 | 6 | 27.1 | 653 |
| 2 | 10 | 5 | 4 | 25.2 | 649 |
| 3 | 10 | 4 | 5 | 28.8 | 696 |
| 4 | 8 | 6 | 6 | 37.3 | 789 |
| 5 | 8 | 5 | 4 | 34.6 | 746 |
| 6 | 8 | 4 | 5 | 31.5 | 738 |
| 7 | 4 | 6 | 6 | 29.5 | 697 |
| 8 | 4 | 5 | 4 | 24.6 | 706 |
| 9 | 4 | 4 | 5 | 21.7 | 711 |
The result shows, for the first time decocting 8 hours, decocting 6 hours, 6 hours effect optimums of decocting for the third time for the second time.
Test example 2, clinical comparison test
1, experimental condition
Experimental group MethodsThe cases enrolled 49 examples, patient age is between 18～64 years old.
Matched group MethodsThe cases enrolled 50 examples, patient age is between 18～64 years old.
2, include in the case standard meet in, rheumatoid arthritis, the rheumatic arthritis person of Western medicine diagnose standard, can include the test case in.
3, get rid of the case rated age under-18s or over-65s person, gestation or women breast-feeding their children are to this medicine allergy sufferers; Be associated with liver, kidney, cardiovascular disease, the psychotic; Late deformity, maimed person, disability person.
4, test specimen
4.1 the test group embodiment of the invention 2 makes sample, the 5g/ bag.
4.2 the matched group Heiguteng exract chases after the wind collaterals-activating capsule, the 0.3g/ grain.
4.3 the administrated method and the course of treatment: Heiguteng exract chases after the each 0.9g of wind collaterals-activating capsule, 3 times on the 1st; Sample of the present invention, warm boiled water, 1 time 1 bag, 3 times on the 1st.2 weeks were a course of treatment, other similar medicines of stopping using during the treatment.
5, result of the test
Test group obvious effective rate 71%, total effective rate are 93.9%; Matched group obvious effective rate 65%, total effective rate are 88.9%, and the result shows that the test group curative effect obviously is better than matched group, sees Table 2.
Table 2 clinical test results
| Group | Sum | Cure | Produce effects | Effectively | Invalid | Obvious effective rate (%) | Total effective rate (%) |
| Test group | 49 | 13 | 22 | 11 | 3 | 77.8 | 93.9 |
| Matched group | 50 | 11 | 22 | 12 | 5 | 66.0 | 90.0 |
Model case: patient's money, the man, the peasant 47 years old, suffered from rheumatic arthritis 6 years.Disease is seen muscular soreness, numbness, is being weighed, joint stuffiness, takes course of treatment of the embodiment of the invention 2 Drug therapys, and symptom disappears substantially.
Test example 3 discrimination tests relatively
Developing solvent condition 1 is got embodiment 2 sample contents 5.6 grams, and porphyrize adds ammonia solution 1ml and chloroform 20ml, and reflux 1 hour filters, and filtrate evaporate to dryness, residue add ethanol 1ml makes dissolving, as need testing solution; Other gets the sinomenine reference substance, adds ethanol and makes the solution that every 1ml contains 1mg, in contrast product solution; According to Chinese Pharmacopoeia version thin layer chromatography test in 2005, draw each 5～10 μ l of above-mentioned two kinds of solution, put respectively in same be on the silica gel g thin-layer plate of adhesive with the sodium carboxymethyl cellulose, with proportioning is that benzene-ethyl acetate-diethylamine of 7: 2: 1 is developing solvent, launches, and takes out, dry, 105 ℃ the heating 20 minutes, put cold, the spray with bismuth potassium iodide test solution; In the test sample chromatograph, with the corresponding position of reference substance chromatograph on, show the speckle of same color.
Developing solvent condition 2 other conditions are constant, and developing solvent changes benzene-ethyl acetate-diethylamine (7: 2: 1) into.
As a result, developing solvent condition 2 can't normally detect the sinomenine in the trial target, and unfolding condition 1 with the corresponding position of reference substance chromatograph on, show the clear speckle of same color.
The specific embodiment
Embodiment 1:
Caulis Sinomenii 1800g Heiguteng exract 1200g Lysimachia trientaloides Hemsl. 1020g
Carboxymethyl starch sodium 450g, Aspartane 30g make granule.
Get Caulis Sinomenii and be ground into fine powder, standby; Remaining Caulis Sinomenii and Heiguteng exract, Lysimachia trientaloides Hemsl. decoct with water three times, add 8 times of amount dippings of water 2 hours for the first time, decoct 2.5 hours, add for the second time 6 times of amounts of water and decocted 2 hours, add 6 times of amounts of water for the third time and decocted collecting decoction 1.5 hours, filter, it is 1.25～1.30 clear paste that filtrate is condensed into 80 ℃ of following relative densities, adds above-mentioned fine powder, an amount of dextrin and carboxymethyl starch sodium, Aspartane, mixing, granulate, under the normal pressure, 105 ℃ of dryings are made 1000 bags.
Embodiment 2:
Recipe quantity Caulis Sinomenii 160kg Heiguteng exract 140kg Lysimachia trientaloides Hemsl. 102kg carboxymethyl starch sodium 45kg, Aspartane 3kg make granule.Preparation method is with embodiment 1.
Embodiment 3:
Caulis Sinomenii 2000g Heiguteng exract 1000g Lysimachia trientaloides Hemsl. 920g.Supplementary product consumption and preparation method are with embodiment 1.
Embodiment 4: discrimination test
Get embodiment 2 sample contents 5.6 grams, porphyrize adds ammonia solution 1ml and chloroform 20ml, and reflux 1 hour filters, and filtrate evaporate to dryness, residue add ethanol 1ml makes dissolving, as need testing solution; Other gets the sinomenine reference substance, adds ethanol and makes the solution that every 1ml contains 1mg, in contrast product solution; According to Chinese Pharmacopoeia version thin layer chromatography test in 2005, draw each 5～10 μ l of above-mentioned two kinds of solution, put respectively in same be on the silica gel g thin-layer plate of adhesive with the sodium carboxymethyl cellulose, with proportioning is that benzene-ethyl acetate-diethylamine of 7: 2: 1 is developing solvent, launches, and takes out, dry, 105 ℃ the heating 20 minutes, put cold, the spray with bismuth potassium iodide test solution; In the test sample chromatograph, with the corresponding position of reference substance chromatograph on, show the speckle of same color.
The above embodiment only is that preferred implementation of the present invention is described; be not that scope of the present invention is limited; design under the prerequisite of spirit not breaking away from the present invention; various distortion and improvement that the ability those of ordinary skill is made technical scheme of the present invention all should fall in the definite protection domain of claims of the present invention.
Claims (7)
1. one kind is used for expelling wind and removing dampness, removing obstruction in the collateral to relieve pain Chinese medicine, it is characterized in that, be to form by the feedstock production by following weight portion:
Caulis Sinomenii 1600-2000 part Heiguteng exract 1000-1400 part Lysimachia trientaloides Hemsl. 920-1120 part.
2. expelling wind and removing dampness, the removing obstruction in the collateral to relieve pain Chinese medicine of being used for as claimed in claim 1 is characterized in that the weight portion proportioning of described raw material is:
1020 parts of 1200 parts of Lysimachia trientaloides Hemsl.s of 1800 parts of Heiguteng exracts of Caulis Sinomenii.
3. expelling wind and removing dampness, the removing obstruction in the collateral to relieve pain Chinese medicine of being used for as claimed in claim 1 is characterized in that the weight portion proportioning of described raw material is:
1020 parts of 1400 parts of Lysimachia trientaloides Hemsl.s of 1600 parts of Heiguteng exracts of Caulis Sinomenii.
4. expelling wind and removing dampness, the removing obstruction in the collateral to relieve pain Chinese medicine of being used for as claimed in claim 1 is characterized in that the weight portion proportioning of described raw material is:
920 parts of 1000 parts of Lysimachia trientaloides Hemsl.s of 2000 parts of Heiguteng exracts of Caulis Sinomenii.
5. as described expelling wind and removing dampness, the removing obstruction in the collateral to relieve pain Chinese medicine of being used for of above-mentioned each claim, it is characterized in that, also comprise 450 parts of carboxymethyl starch sodium, 30 parts of Aspartane, make granule.
6. expelling wind and removing dampness, the removing obstruction in the collateral to relieve pain preparation method of Chinese medicine of being used for as claimed in claim 5 comprises the steps:
Get Caulis Sinomenii and be ground into fine powder, standby; Remaining Caulis Sinomenii and Heiguteng exract, Lysimachia trientaloides Hemsl. decoct with water three times, add 8 times of amount dippings of water 2 hours for the first time, decoct 2.5 hours, adding for the second time 6 times of amounts of water decocted 2 hours, add 6 times of amounts of water for the third time and decocted 1.5 hours, collecting decoction filters, it is 1.25～1.30 clear paste that filtrate is condensed into 80 ℃ of following relative densities, add above-mentioned fine powder, an amount of dextrin and carboxymethyl starch sodium, Aspartane, mixing is granulated, drying is made 1000 bags.
7. the discrimination method that is used for expelling wind and removing dampness, removing obstruction in the collateral to relieve pain Chinese medicine as claimed in claim 5 comprises the steps:
Get 5.6 parts of this product contents, porphyrize adds ammonia solution 1ml and chloroform 20ml, and reflux 1 hour filters, and filtrate evaporate to dryness, residue add ethanol 1ml makes dissolving, as need testing solution; Other gets the sinomenine reference substance, adds ethanol and makes the solution that every 1ml contains 1mg, in contrast product solution; According to Chinese Pharmacopoeia version thin layer chromatography test in 2005, draw each 5～10 μ l of above-mentioned two kinds of solution, put respectively in same be on the silica gel g thin-layer plate of adhesive with the sodium carboxymethyl cellulose, with proportioning is that benzene-ethyl acetate-diethylamine of 7: 2: 1 is developing solvent, launches, and takes out, dry, 105 ℃ the heating 20 minutes, put cold, the spray with bismuth potassium iodide test solution; In the test sample chromatograph, with the corresponding position of reference substance chromatograph on, show the speckle of same color.
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| CN102552463A (en) * | 2012-02-21 | 2012-07-11 | 简福川 | Chinese medicine for treating cervical bone hyperplasia |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1429599A (en) * | 2002-12-02 | 2003-07-16 | 贵州老来福药业有限公司 | Medicine for treating damp arthralgia |
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| CN1429599A (en) * | 2002-12-02 | 2003-07-16 | 贵州老来福药业有限公司 | Medicine for treating damp arthralgia |
Non-Patent Citations (1)
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| 《国家中成药标准汇编 中成药地方标准上升国家标准部分 经络肢体分册》 20021231 国家药品监督管理局 黑骨藤追风活络胶囊 437 1-7 , 1 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102552463A (en) * | 2012-02-21 | 2012-07-11 | 简福川 | Chinese medicine for treating cervical bone hyperplasia |
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| CN102058671B (en) | 2012-07-04 |
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