CN102050880B - Method for preparing soluble starch - Google Patents

Abstract

The invention relates to the field of starch production, in particular to a method for preparing soluble starch. The method is characterized in that a bio-enzyme enzymolysis secondary acidification technical route is adopted to produce the soluble starch and comprises the following steps of: adding alpha-amylase to 40 percent corn starch milk; degrading with bio-enzyme and then removing liquid; then dispersing chain scission corn starch into an aqueous solution; carrying out secondary acid denaturation; and neutralizing, removing liquid and dynamically drying to obtain a finished product.

Description

A kind of method of manufacture of Zulkovsky starch

Technical field

The present invention relates to the starch production field, specifically a kind of method of manufacture of Zulkovsky starch.

Background technology

Zulkovsky starch is white or off-white powder, is that the W-Gum modification forms.Nontoxic, solvability is good in hot water, chemical property is stable, reductibility is little, adsorptive power is strong, good mobility is arranged, and is nonhygroscopic.

Abroad; The water-soluble matchmaker's method acid of enzyme enzymolysis sex change technology is that the U.S. at first develops state-of-the-art Zulkovsky starch production technology the beginning of this century; This technology is the essence challenge to traditional hypo acid sex change technology; Be accompanied by the develop rapidly of W-Gum deep processing industries and the technology competition that is growing more intense, this technology has become in the world popular, the most promising Zulkovsky starch production technology.As the carrier and the pharmaceutical diluents of drug main composition, its product is widely used in sugar-free type granular formulation, tablet, the capsule.

In China; Because modified starch industry is started late compared with developed countries; Receive the restriction of aspects such as state of the art, range of product, the development of Zulkovsky starch starts from the beginning of this century, but the THE REDUCTIBILITY ON THE DISSOLUBLE AMYLUM of most of research institute development is high; Bury the performance of drug main composition, satisfied not user's demand.Though each producer's technology is being improved year by year,, do not form stable operational path so far and produce qualified product because of each technical parameter control is unreasonable.Therefore, existing market adopts the import Zulkovsky starch mostly, and in light of this situation, we place on the agenda with the W-Gum development for the main material production Zulkovsky starch.My unit is digesting and assimilating on the basis of advanced foreign technology, maintains the leading position with production technique in conjunction with the biological enzymolysis quadratic acid sex change of present status in China research and development is technological always.The Along with people's growth in the living standard, and people are to the concern of health, the sugar-free type medicine gains great popularity, so each big pharmacy corporation is fallen over each other development and production sugar-free type medicine, to meet the need of market.In addition, Zulkovsky starch also can be used as the medicine weighting agent, and disintegrating agent and tackiness agent use.

China needs 20,000 tons of Zulkovsky starches in present sugar-free type granular formulation year; Year is produced 2,280 hundred million in various tablets, needs 30,000 tons of Zulkovsky starches, 50,000 tons of aggregate demands.According to investigation, 2-3 family of the medicinal Zulkovsky starch of domestic development enterprise, the client is badly in need of this product.

Summary of the invention

The objective of the invention is to provide a kind of overcome acidification technique route of tradition produce Zulkovsky starch shortcoming and defect; Adopt after-souring; And increase the stabilization process route of enzyme enzymolysis, technical parameter control rationally, have a method of manufacture of the Zulkovsky starch of lower reductibility, higher solvability, good mobility, adsorptivity.

The objective of the invention is to realize like this, the process step of this method comprises an acidifying, neutralization, spinning, drying, pulverizing, it is characterized in that: it also comprises enzymolysis and after-souring step; Described enzymolysis step is before an acidification step, to carry out; The after-souring step is after an acidification step, to carry out, and specifically is to add AMS in 40% W-Gum Ruzhong, behind bio-enzyme degradation; Take off liquid; W-Gum with chain rupture is distributed in the aqueous solution then, through the quadratic acid sex change, neutralizes, takes off liquid, the dynamic dry finished product that gets.

The concrete process step that Zulkovsky starch is made is following:

1. the preparation of milk of starch: take by weighing 100 parts starch, be dissolved in 120 parts the water, start the reaction kettle whisking appliance, it is made into 40% milk of starch;

2. the preparation of denaturing agent: in stainless steel preparation still, at first add the hydrochloric acid of 30 parts of concentration 31%, add 170 parts of water, open and stir, be made into concentration and be 5.96% hydrochloric acid soln;

3. enzyme enzymolysis: 40% milk of starch in stainless steel cauldron, adding 1., open and stir, add 3 parts of AMSs, be warming up to 50 ℃, stopped reaction after 30 minutes, centrifugal dewatering is for use;

4. acidification hydrolization: in stainless steel cauldron, add 120 parts of water, open and stir; Add above-mentioned 3. in starch behind the enzymolysis, add 2. then in half denaturing agent carry out the acidifying first time, be warming up to 40 ℃, 2 hours after; Second half denaturing agent carries out the acidifying second time in adding 2. again; Be warming up to 50 ℃, after 2 hours, reaction finishes;

5. product neutralization: after the reaction, add 10% liquid caustic soda and be neutralized to neutrality 4.;

6. spinning: the material after will neutralizing separates with whizzer;

6. washing: in stainless steel cauldron, add 200 parts of water, add the material after the spinning again, stirs and take off liquid after 30 minutes, wash secondary like this after, the material that washing is got well takes off liquid with the explosion-proof centrifugal machine;

7. dry: the material after centrifugal is delivered to the vacuum drier drying, and material moisture to 13% stops drying, discharging;

8. pulverize: the material that drying is good is pulverized and is reached 80 orders, and finished product is through pack after the assay was approved.

The present invention has the following advantages and positively effect:

1, the present invention's present situation of basing on our country, the Zulkovsky starch of being produced is best in quality, makes domestic medicine to economical, the health type development, and reach advanced world standards.The Zulkovsky starch of my company's development is risen through Tonghua, and already units such as group, Siping City benefit people hall Pharmacy stock Co., Ltd are on probation for medicine company group, east, Tonghua panacea; Consistently think; This product reduces medicine with sugar for improving preparation process, improves drug quality; All obtain better effects, and form bigger economic benefit.

2, the present invention adopts enzyme enzymolysis after-souring technology to produce, and domestic literature does not appear in the newspapers.The relevant expert thinks that this technology has higher technology content, and novelty is stronger.

3, the present invention compares with original medical starch, dextrin, sucrose, lactose, has following characteristics:

1. solvability is good.Medical starch is an ative starch, and no solvability can only be made tablet.And Zulkovsky starch has solvability, is suitable for preparing electuary, instant tea and lozenge especially.

2. considerably less reduzate, chemical stabilization, suction and adsorptive power are strong, good fluidity.Dextrin has special uncomfortable flavor.When making thinner, drug effect there is the embedding effect with dextrin, the extraction of main ingredient when often influencing assay, tablet small to drug content and that particle is hard is particularly remarkable.Dextrin has reductibility, and meeting and some effective constituent generation chemical transformation of medicine reduce drug quality and drug effect.When making electuary,, be not easy to granulate because of its viscosity is big with dextrin.Prepare electuary with Zulkovsky starch, overcome above-mentioned shortcoming, granulating process is oversimplified, the electuary mouthfeel is good, and drug effect also is improved.

3. nonhygroscopic.Sucrose, dextrin all are prone to moisture absorption caking, can make medicine generation denaturalization phenomenon.Use Zulkovsky starch, nonhygroscopic because of it, both reduced medicine with sugar, make medicine be easy to save and not degenerate again, prolong medicine and kept the phase.

4. reasonable price.Lactose is an auxiliary material preferably, but price is high, and the Zulkovsky starch price is significantly less than lactose, replaces it as sugar-free type granular formulation, electuary etc.

5. sliding is good.During the preparation capsule,, make medicine be easy to incapsulate because Zulkovsky starch has sliding.Because of Zulkovsky starch has above-mentioned advantage, so can be widely used as thinner, absorption agent, disintegrating agent and the tackiness agent of tablet, electuary, capsule.

Description of drawings

Fig. 1 is the manufacturing process flow diagram of Zulkovsky starch.

Embodiment

In stainless steel enzymolysis still, add 100 kilograms of starch, 120 kg is made into 40% milk of starch, opens and stirs, and adds 3 kilograms of AMSs, is warming up to 50 ℃, reacts centrifugal dewatering 30 minutes.And then it is made into 40% milk of starch, and add again in the stainless steel cauldron, add 15 liter 31% hydrochloric acid soln (it is mixed with the hydrochloric acid soln of concentration 5.96%), 40 ℃ of acidifyings 2 hours; Be warming up to 50 ℃, drip remaining 15 liters of hydrochloric acid solns (it is mixed with the hydrochloric acid soln of concentration 5.96%) and carry out acidifying, chuck feeds hot water heating; The material temperature maintains 50 ℃, is incubated 2 hours, adds in 10% sodium hydroxide then and remaining acid; Add 200 kg of water washing 2 times, centrifugal dewatering is delivered to the vacuum drier drying with the material after centrifugal; Make material moisture to 13%, be crushed to 80 orders again, finished product is through pack after the assay was approved.

Claims (1)

1. the method for manufacture of a Zulkovsky starch, the process step of this method comprises an acidifying, neutralization, spinning, drying, pulverizing, it is characterized in that: it also comprises enzymolysis and after-souring step; Described enzymolysis step is before an acidification step, to carry out; The after-souring step is after an acidification step, to carry out, and specifically is to add AMS in 40% W-Gum Ruzhong, behind bio-enzyme degradation; Take off liquid; W-Gum with chain rupture is distributed in the aqueous solution then, through the quadratic acid sex change, neutralizes, takes off liquid, the dynamic dry finished product that gets;

The concrete process step that Zulkovsky starch is made is following:

1. the preparation of milk of starch: take by weighing 100 parts starch, be dissolved in 120 parts the water, start the reaction kettle whisking appliance, it is made into 40% milk of starch;

2. the preparation of denaturing agent: in stainless steel preparation still, at first add the hydrochloric acid of 30 parts of concentration 31%, adds 170 parts of water, open stirring, be made into concentration and be 5.96% hydrochloric acid soln;

3. enzyme enzymolysis: 40% milk of starch in stainless steel cauldron, adding 1., open and stir, add 3 parts of AMSs, be warming up to 50 ℃, stopped reaction after 30 minutes, centrifugal dewatering is for use;

4. acidification hydrolization: in stainless steel cauldron, add 120 parts of water, open and stir; Add above-mentioned 3. in starch behind the enzymolysis, add 2. then in half denaturing agent carry out the acidifying first time, be warming up to 40 ℃, 2 hours after; Second half denaturing agent carries out the acidifying second time in adding 2. again; Be warming up to 50 ℃, after 2 hours, reaction finishes;

5. product neutralization: after the reaction, add 10% liquid caustic soda and be neutralized to neutrality 4.;

6. spinning: the material after will neutralizing separates with whizzer;

6. washing: in stainless steel cauldron, add 200 parts of water, add the material after the spinning again, stirs and take off liquid after 30 minutes, wash secondary like this after, the material that washing is got well takes off liquid with the explosion-proof centrifugal machine;

7. dry: the material after centrifugal is delivered to the vacuum drier drying, and material moisture to 13% stops drying, discharging;

8. pulverize: the material that drying is good is pulverized and is reached 80 orders, and finished product is through pack after the assay was approved.

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