CN102038867A - Antialcoholismic composition and preparation method thereof - Google Patents
Antialcoholismic composition and preparation method thereof Download PDFInfo
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- CN102038867A CN102038867A CN2010106208448A CN201010620844A CN102038867A CN 102038867 A CN102038867 A CN 102038867A CN 2010106208448 A CN2010106208448 A CN 2010106208448A CN 201010620844 A CN201010620844 A CN 201010620844A CN 102038867 A CN102038867 A CN 102038867A
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Abstract
The invention relates to the field of medicaments and discloses an antialcoholismic composition. The raw materials of the antialcoholismic composition comprise: one or a mixture of more than two of S-adenosyl methionine, cysteine and methionine, one of a mixture of D-glyceric acid and D-glycerate, one or a mixture of more than two of succinic acid, fumaric acid, citric acid, oxaloacetic acid and malic acid, one or a mixture of more than two of vitamin B1, vitamin B6 and vitamin B2, one or a mixture of coenzyme Q10 or coenzyme I, L-glutamine, fortune eupatorium herb, artemisia capillaries, white paeony root and root of tall monkshood. The invention also provides a preparation method of the antialcoholismic composition. The antialcoholismic composition disclosed by the invention is taken after wine drinking for reducing absorption of alcohol, accelerating alcohol metabolism, as well as tonifying stomach and spleen and preventing drunkenness and alcoholism. The antialcoholismic composition is quick in effectiveness and has a bright application prospect.
Description
Technical field
The present invention relates to field of medicaments, particularly a kind of sobering-up composition and preparation method thereof.
Background technology
There are wine brewing and history of drinking history in several thousand in China, and wine becomes the part of " Chinese culture ".But the excessive consumption of alcohol health risk drunkly also may cause vehicle accident or influence public security, therefore develops alcohol-neutralize healthy product, has important value.
Ethanol is the main component of wine, the ethanol taken in 5% excretes without metabolism, 95% is absorbed and enters blood circulation, through liver metabolism, (alcohol dehydrogenase ADH) is converted into acetaldehyde by the alcoholdehydrogenase in the cytoplasm of liver earlier, the per molecule alcohol metabolism needs 1 molecule nadide (nicotinamide-adenine dinucleotide, NAD), NAD is converted into DPNH (NADH) after the dehydrogenation reaction, and its reaction equation is as follows:
Acetaldehyde is transferred in the liver cell mitochondria, by Intramitochondrial aldehyde dehydrogenase (aldehyde dehydrogenase, ALDH) be converted into acetic acid, this reaction needs nadide to participate in equally, NAD also is converted into DADH, acetic acid finally is converted into carbon dioxide and water is discharged or utilized, and its reaction equation is as follows:
The NADH that above-mentioned two step dehydrogenation reactions generate needs to reoxidize generation NAD through the mitochondrion respiratory chain.And reoxidize the ability that generates NAD in the normal cell is limited, and is not subjected to the adjusting of ethanol in blood concentration.The alcoholic acid speed of normal liver metabolism is 8g/h.In addition, too much NADH will suppress the core tricarboxylic acid cycle of liver cell mitochondria respiratory chain (citric acid cycle, CAC), this will be the main cause that ethanol brings out fatty liver.
The alcohol metabolism rate dependent in the hepatocyte metabolic enzyme (ADH, activity ALDH), enzymatic activity have individual and interracial difference, making ethanol conversion is that acetaldehyde speed is fast, and acetaldehyde is converted into acetic acid and slows down, the accumulation of acetaldehyde in blood easily causes alcoholism.Acetaldehyde is the arch-criminal of ethanol acute poisoning, can cause the forfeiture of enzymatic activity and DNA repair function, and can make fatty over oxidation, causes pathological changes such as fatty liver and hepatic fibrosis.Acetaldehyde also changes the brain neurotransmitter molecular structure, and synthetic relevant enzymes of Profilin and histogenic immunity function cause brain injury and mandatory drinking behavior.
The NADH/NAD proportional imbalance, acetaldehyde concentration is too high and reducing substances exhausts it being the dominant mechanism that causes the ethanol related damage.Still there is not antialcoholic medicine fast at present.
Summary of the invention
The purpose of this invention is to provide the bonded sobering-up composition of a kind of Chinese medicine and western medicine.
Sobering-up composition provided by the invention, its raw material comprises:
The mixture of one or more in S-ademetionine or cysteine or the methionine,
A kind of or the mixture of D-glyceric acid or D-glycerate,
The mixture of one or more of succinic acid, fumarate, citric acid, oxaloacetic acid or malic acid,
Vitamin B
1Or vitamin B
6Or vitamin B
2In one or more mixture, coenzyme Q10 or nadide in a kind of or mixture,
L-glutaminate, Herba Eupatorii, Herba Artemisiae Scopariae, the Radix Paeoniae Alba and Folium Microcoris paniculatae.
The present application people is according to ethanol absorption, metabolic biochemical process and cause crapulent mechanism, in conjunction with traditional medicine, is aided with the Chinese medicine of refreshment, sedative action, makes the sobering-up composition with the refreshment of relieving the effect of alcohol.Sobering-up composition of the present invention absorbs to reduce ethanol, and acceleration of alcohol metabolism and detoxifcation are main, be aided be good for the stomach, the natural nutrition thing of spleen invigorating, with pre-preventing drunkenness and acute alcoholism.
Wherein, cysteine, methionine all can reduce acetaldehyde and discharge to blood circulation by combining with acetaldehyde, alleviate its toxicity.Cysteine can be a mercaptoethylmaine through 4 '-phosphoric acid Pantethien-L-cysteine, Pantethien metabolism in the body.U.S. Pat 2005/0148-674A1 once disclosed employing mercaptamine compounds (cysteamine hydrochloride) and had promoted alcohol metabolism, increased ADH and ALDH enzymatic activity, reduced blood alcohol concentration.
(S-adenosyl-methioninede SAM) is the precursor of cysteine to SAM, replenishes SAM by promoting cysteine synthetic, and metabolism is the mercaptamine compounds, reaches the promotion alcohol metabolism, increases ADH and the effect of ALDH enzymatic activity; Or combine with acetaldehyde by cysteine, reduce acetaldehyde and discharge to blood circulation, alleviate its toxicity.In addition, SAM is the intermediate product of sulfur-bearing amino acid metabolism in the body, topmost methyl donor in the body, and the methylation reaction of more than 50 kind of material in the participation body, SAM has multiple function in alcohol metabolism and relevant hepatic injury protection.Be converted into cysteine in the SAM body, the latter is the constituent of most important anti-oxidative defense system-glutathion in the body, and is the synthetic speed limit link of glutathion.Additional SAM can increase glutathion and generate, and is more effective than directly replenishing methionine and cysteine, and can prevent the mobile increase of alcohol induced mitochondrial membrane.Therefore, additional SAM can prevent the glutathion exhaustion of alcohol-induced, reduces the blood plasma transaminase, reduces the liver athero that ethanol causes, alleviates Pruritus, cholestasis, associated conditions such as hemobilirubin rising.
D-glyceric acid (D-ghyceric acid, D-GLAC) be one of carbohydrate metabolism intermedium in the human body, can transform preparation by glyceric acid calcium, glycerol is generated glyceraldehyde (glyceraldehyde by ADH catalysis in the internal metabolism process, GA), GA generates glyceric acid under ALDH catalysis, metabolic process also needs NAD to be converted into NADH, and the metabolism of this and ethanol and acetaldehyde has similarity.But the glycerol metabolic response is reversible, generates GA and glycerol by GLAC, utilizes NADH to generate NAD, just in time intercouples with the acetaldehyde dehydrogenation reaction, promotes the acetaldehyde metabolism, and its reaction equation is as follows:
And D-glyceric acid and acetaldehyde do not exist the ALDH enzyme and vies each other, and when ALDH and coenzyme NAD H formed the ALDH-NADH complex, catalysis D-GLAC generated D-GA.Catalysis acetaldehyde generates acetic acid when forming the ALDH-NAD complex equally.Catalytic reaction is subjected to the influence of NADH/NAD ratio, and exogenous additional D-GLAC will produce more NAD, provides the aldehyde dehydrogenation reaction required coenzyme, quickens its metabolism and detoxifcation.
D-glyceraldehyde in like manner also can generate glycerol through reversible reaction, and NAD is provided, and promotes the alcohol dehydrogenase reaction, and its reaction equation is as follows:
But different is, D-GLAC and salt thereof generate D-GA only a path, and D-GA is except being generated the glycerol by ADH catalysis, also can generate glyceraldehyde 3-phosphate by triokinase (Triokinase) catalysis, entering the carbohydrate metabolism approach is consumed, therefore it promotes the ethanol dehydrogenase respond to be weaker than the reaction of promotion aldehyde dehydrogenase slightly, is beneficial to removing acetaldehyde.Harmful material is acetaldehyde exactly, and this kind effect is particularly useful for and prevents that acetaldehyde from causing alcoholism and injury.
Tricarboxylic acid cycle (tricarboxylic acid cycle) is a ubiquitous metabolic pathway in the aerobe object, is the main process of saccharide, fat or aminoacid aerobic oxidation.Begin by S-acetyl-coenzyme-A and the oxaloacetic acid condensation generation citric acid that generates, produce CO by a series of oxidation steps again
2, NADH and FADH
2, still generate oxaloacetic acid at last, carry out recirculation, thereby provide energy-producing basis for cell provides the degraded acetyl group.The main mechanism of alcoholism is that respiratory chain inhibition and ADH and ALDH distribute in hepatocyte unbalance, adopts the chemical compound of following promotion tricarboxylic acid cycle and respiratory chain can help detoxifcation:
Ubiquinone
10, nadide, vitamin B
1Or vitamin B
6Or vitamin B
2All can in mitochondrion, quicken NADH and be converted into NAD, promote acetaldehyde to be converted into the acetic acid detoxifcation.
Succinic acid, fumarate, citric acid, oxaloacetic acid and malic acid are the tricarboxylic acid cycle metabolic intermediate, can activate tricarboxylic acid cycle, promote the aerobic oxidation process.
L-glutaminate promotes that by the process of shuttling back and forth of the malic acid Aspartic Acid between acceleration line plastochondria endochylema acetaldehyde enters mitochondrion, removes oxalic acid and acetic acid simultaneously the feedback of succinate dehydrogenase is suppressed, and quickens succinate oxidation, thereby promotes the acetaldehyde metabolism.
Herba Eupatorii is the aerial parts of feverfew Herba Chlorophyti Eupatorium fortunei Turcz., has another name called Radix Crotonis Crassifolii, with all herbal medicine, the effect of analgesic clearing away summer-heat, dispelling dampness to invigorate the stomach, preventing or arresting vomiting is arranged.
Herba Artemisiae Scopariae Artemisia capillaries, belong to the Compositae mugwort, it is about 0.27% that the effective ingredient escoparone and chlorogenic acid and the caffeic acid that contain the tool choleretic effect, herb contain quintessence oil, and its composition has nopinene, capillin, capillon, capillene, capillarin, has clearing away heat-damp and promoting diuresis, the hepatoprotective choleretic effect.
The Radix Paeoniae Alba, Paeonia sterniana Fletcher in Journ. also claim Paeonia sterniana Fletcher in Journ., is Ranunculaceae Paeonia plant.Perennial herb or undershrub, its root also is used as medicine, and root contains paeoniflorin, paeonol, paeoniflorin, and benzoic acid is about 1.07%, volatile oil, fatty oil, resin, tannin, sugar, starch, phlegmatic temperament, protein, cupreol and triterpenes, the spleen invigorating easing the affected liver is arranged, effect during stomach function regulating is transferred.
Folium Microcoris paniculatae, Microcos paniculata Linn. another name straw rain cape, Folium Microcoris paniculatae, burlap leaf have the removing food stagnancy stomach function regulating, the clearing away heat and eliminating dampness effect.
The present invention also provides a kind of preparation method of sobering-up composition, with etc. Herba Eupatorii, Herba Artemisiae Scopariae, the Radix Paeoniae Alba and the Folium Microcoris paniculatae of weight add 15-18 times of weight water logging bubble 8-12 hour, put into extraction pot 65-70 ℃ heating extraction 60-90 minute, collect extracting solution, via hole diameter is ultrafiltration of 100-200nm ultrafilter membrane and the 1/3-1/5 that is concentrated into Herba Eupatorii, Herba Artemisiae Scopariae, the Radix Paeoniae Alba and Folium Microcoris paniculatae cumulative volume, obtains water extract;
Mixture, the vitamin B of one or more of a kind of or mixture, succinic acid, fumarate, citric acid, oxaloacetic acid or the malic acid of mixture, D-glyceric acid or the D-glycerate of one or more in described water extract in adding S-ademetionine or cysteine or the methionine
1Or vitamin B
6Or vitamin B
2In one or more mixture, coenzyme Q10 or nadide in a kind of or mixture, L-glutaminate, mix homogeneously is promptly.
As preferably, the mixture of one or more in S-ademetionine or cysteine or the methionine and the mass volume ratio of described water extract are 10-20% in g/ml, are preferably 15%.
As preferably, a kind of or mixture of D-glyceric acid or D-glycerate and the mass volume ratio of described water extract are 0.25-1.125% in g/ml, are preferably 0.75%.
As preferably, the mixture of one or more of succinic acid, fumarate, citric acid, oxaloacetic acid or malic acid and the mass volume ratio of described water extract are counted 1.2-1.6% with g/ml, are preferably 1.4%.
As preferably, vitamin B
1Or vitamin B
6Or vitamin B
2The mass volume ratio of one or more mixture and described water extract is 0.2-0.4% in g/ml, is preferably 0.3%.
As preferably, a kind of or mixture in ubiquinone 10 or the nadide and the mass volume ratio of described water extract are 0.3-0.5% in g/ml, are preferably 0.45%.
As preferably, the mass volume ratio of L-glutaminate and described water extract is counted 10-12% with g/ml, is preferably 11%.
The present invention also provides the sobering-up composition that makes according to above-mentioned preparation method.
The present invention also provides a kind of pharmaceutical preparation, comprises sobering-up composition provided by the invention and acceptable accessories.As preferably, pharmaceutical preparation provided by the invention is specially oral liquid, capsule, electuary, tablet, teabag, injection.
Verify through animal experiment, take the mice 1 hour after drinking and the 2 little back rat blood alcohol contents of sobering-up composition of the present invention and hang down 23% and 32% than matched group respectively, and difference has statistical significance, shows that sobering-up composition of the present invention has the effect that promotes alcohol metabolism.
Sobering-up composition of the present invention is being taken after drinking, can reduce ethanol and absorb, and acceleration of alcohol metabolism is aided with the spleen-invigorating function that is good for the stomach, preventing drunkenness and alcoholism in advance, and instant effect is with a wide range of applications.
Description of drawings:
Fig. 1 shows that sobering-up composition of the present invention is to the influence of the alcohol concentration in 1 hour, 2 hours bleeding from anus of mice alcoholism;
Fig. 2 shows the statistical result of sobering-up composition of the present invention to the influence of alcoholism mice blood-alcohol concentration.
The specific embodiment
The invention discloses a kind of sobering-up composition and preparation method, those skilled in the art can use for reference this paper content, suitably improve technological parameter and realize.Special needs to be pointed out is that all similarly replace and change apparent to those skilled in the art, they all are regarded as being included in the present invention.Method of the present invention and application are described by preferred embodiment, the related personnel obviously can change or suitably change and combination methods and applications as herein described in not breaking away from content of the present invention, spirit and scope, realizes and use the technology of the present invention.
The present invention is described in further detail below in conjunction with specific embodiment.
Embodiment 1: the preparation of sobering-up composition
Adopt water extraction method to prepare extract: 10 parts of weighing Herba Eupatoriis, 10 parts of Herba Artemisiae Scopariae, 10 parts of the Radix Paeoniae Albas, 10 parts of Folium Microcoris paniculatae, the deionized water that adds 15 times of volumes, soaking at room temperature 8-12 hour, put into extraction pot in 65-70 ℃ of heating 60-90 minute, collect extracting solution, via hole diameter is through the ultrafiltration of 200nm ultrafilter membrane, gets the ultrafiltrate of removing residue and bulky grain composition and carries out vacuum concentration to 1/5 of raw material of Chinese medicine cumulative volume and promptly get water extract.
Adding quality and described water extract volume ratio are counted 10% S-ademetionine, 0.75% D-glyceric acid, 0.7% succinic acid, 0.7% Fumaric acid, 11% L-glutaminate, 0.3% vitamin B with g/ml in described water extract
2, 0.45% coenzyme Q10, stirring and evenly mixing is promptly.
Embodiment 2: the preparation of sobering-up composition
Adopt water extraction method to prepare drug extract: 10 parts of weighing Herba Eupatoriis, 10 parts of Herba Artemisiae Scopariae, 10 parts of the Radix Paeoniae Albas, 10 parts of Folium Microcoris paniculatae, the deionized water that adds 18 times of volumes, soaking at room temperature 8-12 hour, put into extraction pot in 65-70 ℃ of heating 60-90 minute, collect extracting solution, through the ultrafiltration of 150nm ultrafilter membrane, get the ultrafiltrate of removing residue and bulky grain composition, vacuum concentration to 1/4 of 10 parts of Herba Eupatoriis, 10 parts of Herba Artemisiae Scopariae, 10 parts of the Radix Paeoniae Albas, 10 parts of cumulative volumes of Folium Microcoris paniculatae promptly get water extract.
Adding quality and described water extract volume ratio are counted 15% S-ademetionine, 1.125% D-glyceric acid, 0.7% citric acid, 0.7% malic acid, 12% L-glutaminate with g/ml in described water extract, 0.4% vitamin B 6,0.3% nadide, stirring and evenly mixing promptly.
Embodiment 3: the preparation of sobering-up composition
Adopt water extraction method to prepare drug extract: 20 parts of weighing Herba Eupatoriis, 20 parts of Herba Artemisiae Scopariae, 20 parts of the Radix Paeoniae Albas, 20 parts of Folium Microcoris paniculatae, the deionized water that adds 15 times of volumes, soaking at room temperature 8-12 hour, put into extraction pot in 65-70 ℃ of heating 60-90 minute, collect extracting solution, through the ultrafiltration of 100nm ultrafilter membrane, get the ultrafiltrate of removing residue and bulky grain composition, vacuum concentration to 1/3 of 20 parts of raw material of Chinese medicine Herba Eupatoriis, 20 parts of Herba Artemisiae Scopariae, 20 parts of the Radix Paeoniae Albas, 20 parts of cumulative volumes of Folium Microcoris paniculatae promptly get water extract.
In described water extract, add quality and described water extract volume ratio and count 20% cysteine or methionine, 0.25% D-glyceric acid, 0.5% oxaloacetic acid, 0.7% Fumaric acid, 10%L-glutamine with g/ml, 0.2% vitamin B1,0.5% coenzyme Q10, stirring and evenly mixing promptly.
Embodiment 4: the preparation oral liquor for sobering from wine
Get the sobering-up composition of embodiment 1-3 preparation, add an amount of glucose and correctives respectively, heat 70-80 ℃ of sterilization, the sterile vacuum branch is filled in the peace bottle 10m/ and props up and promptly get oral liquor for sobering from wine.
Embodiment 5: the alcohol metabolism experiment
Experiment material:
1) laboratory animal: the male Wistar rat in 30 10 ages in week, body weight 300-400g.
2) edible ethanol is formulated as 10% concentration (w/v).
3) sobering-up composition: embodiment 1-3 preparation.
Experimental technique:
1) laboratory animal is divided into experimental group and matched group, each 15 rat.Rat is put into laboratory fed 7 days, to adapt to experimental situation.Experiment begins to begin the previous day fasting (12-16 hour), 10 experiments in morning next day.
2) give experimental group rats gavaged sobering-up composition (5ml/kg body weight), control rats gavages the normal saline of same dose.Experimental group and control rats distribute and gavage ethanol (1.2g/kg body weight) after 1 hour.
3) take before the ethanol, take back 1 hour and 2 hours venous blood samples respectively.
4) adopt gas chromatography to detect alcohol content in the blood.
Laboratory animal BAC measurement result as depicted in figs. 1 and 2, result's demonstration is compared with matched group, sobering-up composition of the present invention 1 hour and 2 little back rat blood alcohol contents are respectively than matched group low 23% and 32% after taking, and difference has statistical significance, shows that sobering-up composition of the present invention has the effect that promotes alcohol metabolism.
The above only is a preferred implementation of the present invention; should be pointed out that for those skilled in the art, under the prerequisite that does not break away from the principle of the invention; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (10)
1. sobering-up composition, its raw material comprises:
The mixture of one or more in S-ademetionine or cysteine or the methionine,
A kind of or the mixture of D-glyceric acid or D-glycerate,
The mixture of one or more of succinic acid, fumarate, citric acid, oxaloacetic acid or malic acid,
Vitamin B
1Or vitamin B
6Or vitamin B
2In one or more mixture,
A kind of or mixture in coenzyme Q10 or the nadide,
L-glutaminate,
Herba Eupatorii,
Herba Artemisiae Scopariae,
The Radix Paeoniae Alba and Folium Microcoris paniculatae.
2. the preparation method of a sobering-up composition, it is characterized in that, with etc. Herba Eupatorii, Herba Artemisiae Scopariae, the Radix Paeoniae Alba, the Folium Microcoris paniculatae of weight add 15-18 times of weight water logging bubble 8-12 hour, put into extraction pot 65-70 ℃ heating extraction 60-90 minute, collect extracting solution, via hole diameter is ultrafiltration of 100-200nm ultrafilter membrane and the 1/3-1/5 that is concentrated into described Herba Eupatorii, Herba Artemisiae Scopariae, the Radix Paeoniae Alba and Folium Microcoris paniculatae cumulative volume, obtains water extract;
Mixture, the vitamin B of one or more of a kind of or mixture, succinic acid or the fumarate of mixture, D-glyceric acid or the D-glycerate of one or more in described water extract in adding S-ademetionine or cysteine or the methionine or citric acid or oxaloacetic acid or malic acid
1Or vitamin B
6Or vitamin B
2In one or more mixture, coenzyme Q10 or nadide in a kind of or mixture, L-glutaminate, mix homogeneously is promptly.
3. preparation method according to claim 2 is characterized in that, the mixture of one or more in S-ademetionine or cysteine or the methionine and the mass volume ratio of described water extract are 10-20% in g/ml, are preferably 15%.
4. preparation method according to claim 2 is characterized in that, a kind of or mixture of D-glyceric acid or D-glycerate and the mass volume ratio of described water extract are 0.25-1.125% in g/ml, are preferably 0.75%.
5. preparation method according to claim 2, it is characterized in that, the mixture of one or more of succinic acid or fumarate or citric acid or oxaloacetic acid or malic acid and the mass volume ratio of described water extract are counted 1.2-1.6% with g/ml, are preferably 1.4%.
6. preparation method according to claim 2 is characterized in that vitamin B
1Or vitamin B
6Or vitamin B
2The mass volume ratio of one or more mixture and described water extract is 0.2-0.4% in g/ml, is preferably 0.3%.
7. preparation method according to claim 2 is characterized in that, a kind of or mixture in ubiquinone 10 or the nadide and the mass volume ratio of described water extract are 0.3-0.5% in g/ml, are preferably 0.45%.
8. preparation method according to claim 2 is characterized in that the mass volume ratio of L-glutaminate and described water extract is counted 10-12% with g/ml, is preferably 11%.
9. according to the sobering-up composition of each described preparation method preparation of claim 2-8.
10. pharmaceutical preparation is made up of claim 1 or 9 described sobering-up compositions and acceptable accessories, and described pharmaceutical preparation is preferably oral liquid, capsule, electuary, tablet, teabag, injection.
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103404934A (en) * | 2013-08-24 | 2013-11-27 | 江苏神华药业有限公司 | Hang-over solid beverage containing glutamine and preparation method thereof |
| CN103750344A (en) * | 2014-01-25 | 2014-04-30 | 北京凯因科技股份有限公司 | Yeast glutathione nutrition preparation |
| CN104053368A (en) * | 2011-11-15 | 2014-09-17 | 蒂马基金会 | Composition For Protection Against Cell-damaging Effects |
| WO2015036656A3 (en) * | 2013-09-13 | 2015-05-14 | Replicon Health Oy | Method for enhancing energy production and metabolism in cells |
| CN109453267A (en) * | 2018-12-19 | 2019-03-12 | 泓博元生命科技（深圳）有限公司 | Sobering-up composition and the preparation method and application thereof |
| CN109567181A (en) * | 2018-10-15 | 2019-04-05 | 河南省锐达医药科技有限公司 | The application of a kind of raw-food material composition on the aspect of dispelling the effects of alcohol |
| CN109602756A (en) * | 2018-12-19 | 2019-04-12 | 泓博元生命科技（深圳）有限公司 | A kind of sobering-up composition and the preparation method and application thereof |
| EP3766500A1 (en) | 2019-07-18 | 2021-01-20 | Global University Support GmbH | Pharmaceutical kit for enhanced regeneration of the human body |
| WO2024164494A1 (en) * | 2023-02-08 | 2024-08-15 | Inner Mongolia Kingdomway Pharmaceutical Co., Ltd. | Glyceric acid, glycerate, and composition thereof |
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| CN1413606A (en) * | 2001-10-24 | 2003-04-30 | 邓大勇 | Medicine for treatment of hepatitis |
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| CN104053368A (en) * | 2011-11-15 | 2014-09-17 | 蒂马基金会 | Composition For Protection Against Cell-damaging Effects |
| CN103404934A (en) * | 2013-08-24 | 2013-11-27 | 江苏神华药业有限公司 | Hang-over solid beverage containing glutamine and preparation method thereof |
| US10500176B2 (en) | 2013-09-13 | 2019-12-10 | Replicon Health Oy | Method for enhancing energy production and metabolism in cells |
| WO2015036656A3 (en) * | 2013-09-13 | 2015-05-14 | Replicon Health Oy | Method for enhancing energy production and metabolism in cells |
| US12083084B2 (en) | 2013-09-13 | 2024-09-10 | Replicon Health Oy | Method for enhancing energy production and metabolism in cells |
| US11357746B2 (en) | 2013-09-13 | 2022-06-14 | Replicon Health Oy | Method for enhancing energy production and metabolism in cells |
| CN103750344A (en) * | 2014-01-25 | 2014-04-30 | 北京凯因科技股份有限公司 | Yeast glutathione nutrition preparation |
| CN103750344B (en) * | 2014-01-25 | 2015-11-04 | 北京凯因科技股份有限公司 | A kind of yeast glutathione nutrition preparation |
| CN109567181A (en) * | 2018-10-15 | 2019-04-05 | 河南省锐达医药科技有限公司 | The application of a kind of raw-food material composition on the aspect of dispelling the effects of alcohol |
| CN109602756A (en) * | 2018-12-19 | 2019-04-12 | 泓博元生命科技（深圳）有限公司 | A kind of sobering-up composition and the preparation method and application thereof |
| CN109453267A (en) * | 2018-12-19 | 2019-03-12 | 泓博元生命科技（深圳）有限公司 | Sobering-up composition and the preparation method and application thereof |
| EP3766500A1 (en) | 2019-07-18 | 2021-01-20 | Global University Support GmbH | Pharmaceutical kit for enhanced regeneration of the human body |
| WO2024164494A1 (en) * | 2023-02-08 | 2024-08-15 | Inner Mongolia Kingdomway Pharmaceutical Co., Ltd. | Glyceric acid, glycerate, and composition thereof |
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