CN102037015B - 对血管生成的抑制 - Google Patents

对血管生成的抑制 Download PDF

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Publication number
CN102037015B
CN102037015B CN200880117292.XA CN200880117292A CN102037015B CN 102037015 B CN102037015 B CN 102037015B CN 200880117292 A CN200880117292 A CN 200880117292A CN 102037015 B CN102037015 B CN 102037015B
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China
Prior art keywords
antibody
cells
vegf
antibodies
tumor
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Expired - Fee Related
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CN200880117292.XA
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English (en)
Chinese (zh)
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CN102037015A (zh
Inventor
拿破仑·费拉拉
法波·沙吉
秀敏·吴
钟翠玲
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Genentech Inc
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Genentech Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/243—Colony Stimulating Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Urology & Nephrology (AREA)
CN200880117292.XA 2007-09-21 2008-09-19 对血管生成的抑制 Expired - Fee Related CN102037015B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US97438207P 2007-09-21 2007-09-21
US60/974,382 2007-09-21
US8307108P 2008-07-23 2008-07-23
US61/083,071 2008-07-23
PCT/US2008/076954 WO2009039337A2 (en) 2007-09-21 2008-09-19 Inhibition of angiogenesis

Publications (2)

Publication Number Publication Date
CN102037015A CN102037015A (zh) 2011-04-27
CN102037015B true CN102037015B (zh) 2016-02-03

Family

ID=40030248

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200880117292.XA Expired - Fee Related CN102037015B (zh) 2007-09-21 2008-09-19 对血管生成的抑制

Country Status (19)

Country Link
US (1) US9284369B2 (cg-RX-API-DMAC10.html)
EP (1) EP2203479B1 (cg-RX-API-DMAC10.html)
JP (1) JP5615709B2 (cg-RX-API-DMAC10.html)
KR (1) KR101578945B1 (cg-RX-API-DMAC10.html)
CN (1) CN102037015B (cg-RX-API-DMAC10.html)
AR (1) AR068532A1 (cg-RX-API-DMAC10.html)
AU (1) AU2008302214B2 (cg-RX-API-DMAC10.html)
CA (1) CA2700276A1 (cg-RX-API-DMAC10.html)
CL (1) CL2008002782A1 (cg-RX-API-DMAC10.html)
CO (1) CO6270370A2 (cg-RX-API-DMAC10.html)
ES (1) ES2568881T3 (cg-RX-API-DMAC10.html)
IL (1) IL204502A (cg-RX-API-DMAC10.html)
MX (1) MX2010003013A (cg-RX-API-DMAC10.html)
NZ (1) NZ584787A (cg-RX-API-DMAC10.html)
PE (1) PE20091197A1 (cg-RX-API-DMAC10.html)
RU (2) RU2471498C2 (cg-RX-API-DMAC10.html)
TW (1) TWI457349B (cg-RX-API-DMAC10.html)
WO (1) WO2009039337A2 (cg-RX-API-DMAC10.html)
ZA (1) ZA201001868B (cg-RX-API-DMAC10.html)

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KR100942880B1 (ko) * 2001-08-29 2010-02-17 제넨테크, 인크. 유사분열촉진 활성을 가진 Ｂｖ８ 핵산 및 폴리펩티드
CN102225194B (zh) 2003-03-12 2014-07-16 健泰科生物技术公司 Bv8和/或EG-VEGF促进造血的用途
JP2010519907A (ja) * 2007-03-02 2010-06-10 エムディーアールエヌエー，インコーポレイテッド Ｖｅｇｆファミリー遺伝子の発現を抑制するための核酸化合物およびその使用
ES2513292T3 (es) 2009-07-31 2014-10-24 Genentech, Inc. Inhibición de metástasis tumoral usando anticuerpos anti-G-CSF
AU2010313621C1 (en) 2009-10-14 2015-11-26 Humanigen, Inc. Antibodies to EphA3
MX2012007379A (es) * 2009-12-23 2012-08-31 Genentech Inc Anticuerpos anti-bv8 y usos de los mismos.
WO2011103389A1 (en) * 2010-02-19 2011-08-25 Cornell University Method to treat autoimmune demyelinating diseases and other autoimmune or inflammatory diseases
RU2605595C2 (ru) 2011-06-13 2016-12-20 СиЭсЭл Лимитид Антитела против g-csfr и их применение
JP2014525412A (ja) * 2011-08-17 2014-09-29 ジェネンテック， インコーポレイテッド 難治性腫瘍における血管新生の阻害
WO2013082511A1 (en) 2011-12-02 2013-06-06 Genentech, Inc. Methods for overcoming tumor resistance to vegf antagonists
US20150118215A1 (en) * 2012-03-30 2015-04-30 The General Hospital Corporation Methods of Inhibiting Cell Proliferation
TWI498425B (zh) * 2013-01-08 2015-09-01 Nat Univ Tsing Hua 層析濾紙型酵素連結免疫吸附分析法
US20160030558A1 (en) * 2013-03-13 2016-02-04 Health Research, Inc. Enhancement of vaccines
KR102359396B1 (ko) * 2013-11-22 2022-02-08 주식회사 젬백스앤카엘 혈관 신생 억제 활성을 가지는 펩티드 및 이를 포함하는 조성물
CN104237223B (zh) * 2014-10-08 2017-04-12 江苏奥赛康药业股份有限公司 测定铁‑碳水化合物络合物中不稳定铁含量的方法
CN104587469A (zh) * 2015-01-19 2015-05-06 马洁 G-csf拮抗剂在治疗慢性炎症、预防炎症相关肿瘤中的应用
WO2017096124A1 (en) * 2015-12-03 2017-06-08 National Health Research Institutes Heterodimeric vascular endothelial growth factor and use thereof
WO2018108862A1 (en) * 2016-12-12 2018-06-21 INSERM (Institut National de la Santé et de la Recherche Médicale) Antagonist of prokineticin receptor 2 for use as a medicament for treating an eg-vegf-related cancer
US20210179721A1 (en) * 2017-11-29 2021-06-17 Csl Limited Method of treating or preventing ischemia-reperfusion injury
US11524053B2 (en) 2018-01-26 2022-12-13 The Regents Of The University Of California Methods and compositions for treatment of angiogenic disorders using anti-VEGF agents
US12281160B2 (en) 2018-03-23 2025-04-22 Csl Limited Method of treating asthma
PE20240329A1 (es) 2019-06-05 2024-02-27 Regeneron Pharma Dispositivos y metodos para administracion de dosis de precision
CN114867487A (zh) 2019-11-25 2022-08-05 加利福尼亚大学董事会 用于眼内新生血管的长效vegf抑制剂
CN115768475A (zh) 2020-06-04 2023-03-07 Csl创新私人有限公司 治疗或预防急性呼吸窘迫综合征的方法
US12649031B2 (en) 2021-09-08 2026-06-09 Regeneron Pharmaceuticals, Inc. Methods for delivering agents with pre-filled syringes to minimize intraocular inflammation
USD1120314S1 (en) 2022-11-30 2026-03-24 Regeneron Pharmaceuticals, Inc. Dose delivery device
EP4739706A1 (en) 2023-07-05 2026-05-13 CSL Innovation Pty Ltd Methods of treating or preventing a complication of sickle cell disease
CN117054649A (zh) * 2023-08-04 2023-11-14 广州中医药大学第一附属医院 一种慢性萎缩性胃炎向胃癌转化标志物及其应用

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CN1575338A (zh) * 2001-08-29 2005-02-02 杰南技术公司 具有促细胞分裂活性的Bv8的核酸和多肽
CN1802169A (zh) * 2003-03-12 2006-07-12 健泰科生物技术公司 Bv8和/或EG－VEGF促进造血的用途

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CA2622575A1 (en) * 2005-09-13 2007-03-22 Zymogenetics, Inc. Prok2 antagonists and methods of use
ITRM20070182A1 (it) 2007-04-03 2008-10-04 Univ Roma Antagonisti dei recettori delle prochineticine derivati di essi e loro uso

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
CN1575338A (zh) * 2001-08-29 2005-02-02 杰南技术公司 具有促细胞分裂活性的Bv8的核酸和多肽
CN1802169A (zh) * 2003-03-12 2006-07-12 健泰科生物技术公司 Bv8和/或EG－VEGF促进造血的用途

Non-Patent Citations (1)

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The endocrine-gland-derived VEGF homologue Bv8 promotes angiogenesis in the testis: localization of Bv8 receptors to endothelial cells;LECOUTER J et al;《PNAS》;20030301;第100卷(第5期);2685－2690 *

Also Published As

Publication number Publication date
EP2203479A2 (en) 2010-07-07
CO6270370A2 (es) 2011-04-20
RU2010115755A (ru) 2011-10-27
US20100316633A1 (en) 2010-12-16
EP2203479B1 (en) 2016-01-27
KR101578945B1 (ko) 2015-12-21
TWI457349B (zh) 2014-10-21
IL204502A (en) 2015-05-31
CA2700276A1 (en) 2009-03-26
TW200920750A (en) 2009-05-16
RU2471498C2 (ru) 2013-01-10
CL2008002782A1 (es) 2009-07-31
AR068532A1 (es) 2009-11-18
RU2012140185A (ru) 2014-03-27
WO2009039337A3 (en) 2009-05-14
HK1141538A1 (zh) 2010-11-12
CN102037015A (zh) 2011-04-27
ES2568881T3 (es) 2016-05-05
JP5615709B2 (ja) 2014-10-29
ZA201001868B (en) 2011-06-29
JP2010540449A (ja) 2010-12-24
PE20091197A1 (es) 2009-08-14
NZ584787A (en) 2012-12-21
AU2008302214B2 (en) 2012-10-25
MX2010003013A (es) 2010-08-02
AU2008302214A1 (en) 2009-03-26
WO2009039337A2 (en) 2009-03-26
KR20100075513A (ko) 2010-07-02
US9284369B2 (en) 2016-03-15

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