CN102030836A - Method for dehydrating sodium hyaluronate - Google Patents
Method for dehydrating sodium hyaluronate Download PDFInfo
- Publication number
- CN102030836A CN102030836A CN2009102047266A CN200910204726A CN102030836A CN 102030836 A CN102030836 A CN 102030836A CN 2009102047266 A CN2009102047266 A CN 2009102047266A CN 200910204726 A CN200910204726 A CN 200910204726A CN 102030836 A CN102030836 A CN 102030836A
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- China
- Prior art keywords
- ethanol
- hyaluronate sodium
- dewatering
- jar
- sodium hyaluronate
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Abstract
The invention discloses a method for dehydrating sodium hyaluronate. The whole dehydration process is completed in a tank; protein, colloids, nucleic acids and impurities are removed at the same time; and finally, the water content of the sodium hyaluronate is reduced to less than 4%. Thus, the invention thoroughly avoids artificial and environmental secondary pollution caused by manual operation when the traditional sodium hyaluronate production process is carried out outside the tank, and can save the consumption of ethanol by 50%, thereby greatly lowering the cost and enhancing the product quality.
Description
Affiliated technical field
The present invention relates to a kind of hyaluronate sodium dewatering, belong to technical field of bioengineering.
Background technology:
The dehydration in China's fermentative production hyaluronate sodium process at present, centrifugal, drying process are all manually finished outside jar, influence the quality of product like this with regard to being easy to cause artificial and second environmental pollution.The present invention just provides a kind of hyaluronate sodium dewatering, uses the present invention and can thoroughly solve the secondary pollution problem that causes because of artificial operation and environment outside jar, can save 50% ethanol consumption simultaneously, reduces cost greatly, and improves the quality of product.
Summary of the invention
The present invention provides a kind of hyaluronate sodium dewatering, it is characterized in that device to major general's hyaluronate sodium fermented liquid after filtration post precipitation with toothed gear pump throw out is squeezed in the retort, pass through dewatering of ethanol, simultaneously wherein protein, colloid, nucleic acid, impurity are removed, the hyaluronate sodium water content is dropped to less than about 4%.
Hyaluronate sodium liquid after the present invention can filter the hyaluronate sodium fermentation is finished dehydration, is removed deproteinize, colloid, nucleic acid and impurity simultaneously in a jar, the hyaluronate sodium water content is dropped to less than about 4%.Thereby thoroughly avoided traditional mode of production hyaluronate sodium process outside jar, to carry out,, influenced the quality of product because of the artificial and second environmental pollution that manual operation causes.
Technical scheme:
A kind of hyaluronate sodium dewatering, it is characterized in that to major general's hyaluronate sodium fermented liquid after filtration post precipitation with toothed gear pump throw out is squeezed in the retort, add dewatering of ethanol by secondary, simultaneously wherein protein, colloid, nucleic acid, impurity are dissolved in the ethanol; Discharge ethanol, remove wherein protein, colloid, nucleic acid, impurity simultaneously; To be evacuated in the jar with vacuum pump again, the hyaluronate sodium water content is dropped to less than 4%.
The invention has the advantages that:
Hyaluronate sodium liquid after the present invention can filter the hyaluronate sodium fermentation is finished dehydration in a jar, remove deproteinize, colloid, nucleic acid and impurity simultaneously, and the hyaluronate sodium water content is dropped to less than 4%.Thereby thoroughly avoided traditional mode of production hyaluronate sodium process outside jar, to carry out, the artificial and second environmental pollution that causes because of manual operation; Simultaneously can save 50% ethanol consumption, reduce cost greatly, and improve the quality of product.
Embodiment:
Enforcement of the present invention is like this: with the hyaluronate sodium fermented liquid after filtration post precipitation with toothed gear pump throw out is squeezed in the retort, inject 95% ethanol suitable by the ethanol opening for feed with reaction mass, carry out dehydration in 1 hour, wherein protein, colloid, nucleic acid, impurity is dissolved in the ethanol; Waste ethanol is discharged by the ethanol discharge port, removes wherein protein, colloid, nucleic acid, impurity and water simultaneously; For the second time inject 95% fresh ethanol, dewatered again 1 hour; Discharge ethanol, and close all valves; To be evacuated in the jar with vacuum pump, temperature keeps 50 ℃ in jar; So dry 20 hours, the hyaluronate sodium water content is dropped to less than 4%, from discharge hole for discharge, pack the back after testing.
Claims (4)
1. hyaluronate sodium dewatering, it is characterized in that at least its with the hyaluronate sodium fermented liquid after filtration post precipitation with toothed gear pump throw out is squeezed in the retort, add dewatering of ethanol by secondary, simultaneously wherein protein, colloid, nucleic acid, impurity are dissolved in the ethanol; Discharge ethanol, remove wherein protein, colloid, nucleic acid, impurity simultaneously; To be evacuated in the jar with vacuum pump again, the hyaluronate sodium water content is dropped to less than 4%.
2. a kind of hyaluronate sodium dewatering as claimed in claim 1 is characterized in that the concentration of ethanol that secondary adds is 95%; The amount and the reaction mass that add are suitable.
3. a kind of hyaluronate sodium dewatering as claimed in claim 1 is characterized in that dewatering time was discharged waste ethanol at 1 hour for the first time; Ethanol is discharged in ethanol dehydration for the second time 1 hour.
4. a kind of hyaluronate sodium dewatering as claimed in claim 1 is characterized in that will being evacuated in the jar with vacuum pump, and temperature keeps 50 ℃ in jar, dry 20 hours, the hyaluronate sodium water content is dropped to less than 4%.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009102047266A CN102030836A (en) | 2009-09-27 | 2009-09-27 | Method for dehydrating sodium hyaluronate |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009102047266A CN102030836A (en) | 2009-09-27 | 2009-09-27 | Method for dehydrating sodium hyaluronate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102030836A true CN102030836A (en) | 2011-04-27 |
Family
ID=43884339
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009102047266A Pending CN102030836A (en) | 2009-09-27 | 2009-09-27 | Method for dehydrating sodium hyaluronate |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102030836A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103819579A (en) * | 2013-12-10 | 2014-05-28 | 上海景峰制药股份有限公司 | Drying method of sodium hyaluronate |
-
2009
- 2009-09-27 CN CN2009102047266A patent/CN102030836A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103819579A (en) * | 2013-12-10 | 2014-05-28 | 上海景峰制药股份有限公司 | Drying method of sodium hyaluronate |
| CN103819579B (en) * | 2013-12-10 | 2017-01-04 | 上海景峰制药股份有限公司 | A kind of drying means of hyaluronic acid sodium |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20110427 |