CN103819579B - A kind of drying means of hyaluronic acid sodium - Google Patents
A kind of drying means of hyaluronic acid sodium Download PDFInfo
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- CN103819579B CN103819579B CN201310671652.3A CN201310671652A CN103819579B CN 103819579 B CN103819579 B CN 103819579B CN 201310671652 A CN201310671652 A CN 201310671652A CN 103819579 B CN103819579 B CN 103819579B
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Abstract
The drying means of a kind of hyaluronic acid sodium disclosed by the invention, it is characterised in that when being dried, in leading portion chuck, the water temperature of logical hot water controls at 80 DEG C, continues evacuation；When temperature of charge rises to 45 DEG C, the water temperature of hot water logical in chuck is reduced to 55 DEG C, and every 15 minutes filtrated airs of logical 5s time in tank, until being dried.The present invention controls to adjust by the temperature of different phase when hyaluronic acid sodium is dried, and assist certain physical means, while ensureing that hyaluronic acid sodium loss on drying is qualified, make hyaluronic acid sodium shortening drying time, reach to save the production time, control the purpose of production cost products quality guarantee.
Description
Technical field:
The present invention relates to hyaluronic acid sodium preparing technical field, the special standby drying means referring to a kind of hyaluronic acid sodium.
Background technology:
Hyaluronic acid sodium is by (1 → 3)-2-acetylaminohydroxyphenylarsonic acid 2-deoxidation-β-D-Glucose-(1 → 4)-O-
The straight-chained polysaccharide that β-D glucuronic acid disaccharidase recurring unit is formed.The structure of HA is fairly regular,
Identical dissacharide units is the basic structural unit of HA, and the HA of different animals tissue and bacterial origin is without kind
Difference.To the mankind and animal no antigen.
HA divides in the length of chain and is inhomogenous point in amount, point in weight range be 2 × lO5-7×106, double
Sugar unit length is 300-11000 pair, belongs to biomacromolecule.
Commodity HA is generally sodium-salt form, for white fibrous or pulverulent solids, has stronger hygroscopicity,
Being dissolved in water, insoluble in organic reagent, medical fraction is 1 × 10 in amount6-2.5×106。
Current hyaluronic acid sodium drying process carries out filtration washing for entrance filtration washing drying machine and is dried, and is dried
Temperature constant, keeps vacuum-0.09～-0.1Mpa.But this drying means hyaluronic acid sodium is aqueous
Rate is the most higher.
Hyaluronic acid sodium crude drug in crude drug Workshop Production heats with chuck at present, and evacuation is dried,
Owing to hyaluronic acid sodium is sensitive for temperature as a kind of polysaccharide, in dry run, the temperature of material not can exceed that
60 DEG C, simultaneously because the character of hyaluronic acid sodium itself has hygroscopicity, the moisture in that material is by free state
Can more be difficult to be dried when being converted into combined state,
Summary of the invention:
Technical problem solved by the invention is for the problem existing for existing hyaluronic acid sodium drying means
And provide the drying means of a kind of hyaluronic acid sodium, to reduce the moisture content of hyaluronic acid sodium.
Technical problem solved by the invention can be to realize by the following technical programs:
The drying means of a kind of hyaluronic acid sodium, it is when being dried, the water temperature of logical hot water in leading portion chuck
Control at 80 DEG C, continue evacuation；When temperature of charge rises to 45 DEG C, by the water temperature of hot water logical in chuck
It is reduced to 55 DEG C, and every 15 minutes filtrated airs of logical 5s time in tank, until being dried.
In a preferred embodiment of the invention, be dried time strength imparting material above air velocity, make material faster be dried,
Stop when material upper and lower temperature difference is less than 1 DEG C being dried.
In a preferred embodiment of the invention, control at 10h whole drying time.
Owing to have employed technique scheme, use the moisture content of hyaluronic acid sodium that the drying means of the present invention is dried 14% with
Under.
Accompanying drawing explanation
Fig. 1 is the drying curve schematic diagram of former drying process.Its material starts to be dried from 15:00, to temperature
About at about 6-7 hour during balance, drying time is the longest, unfavorable to being dried
Fig. 2 is the drying curve schematic diagram of drying means of the present invention.
Detailed description of the invention:
The drying means of a kind of hyaluronic acid sodium, it is when dry, and in leading portion chuck, the water temperature of logical hot water controls, at 80 DEG C, to hold
Continuous evacuation, when dry temperature of charge rises to 45 DEG C, is reduced to 55 DEG C by the water temperature of hot water logical in chuck, and every
15 minutes, in tank, logical 5s time filtrated air, the air velocity above strength imparting material, made material faster be dried, work as thing
Stop being dried when material upper and lower temperature difference is less than 1 DEG C.
Seeing Fig. 2, material starts to be dried from 15:00, to temperature equilibrium time about 3-4 hour, during balance
Between shorten 3 hours, (differing 1 DEG C at temperature upper and lower temperature difference, material stirs for volume drying saving of time 4 hours
Observe its aliquation information summary after mixing to determine to be dried terminal)
When the hyaluronic acid sodium product of fermentative Production is produced as a trial, have employed its moisture after drying means of the present invention
Result is as follows:
| Lot number | 20130401 | 20130402 | 20130403 | 20130701 | 20130702 | 20130703 |
| Moisture | 11.2% | 12.6% | 11.5% | 10.4% | 12.3% | 12.5% |
To use the batch average moisture that is dried of old technology be 14.6%, and adopt new technology and be dried
Batch shortens 4h not only drying time, and average moisture only has 11.6% to have dropped 20%, shortens man-hour,
Save cost, and exception has not occurred in the indices of hyaluronic acid sodium finished product.
Although the present invention has been described in detail and has quoted some specific embodiments as proof, but to this area
For those of skill in the art, as long as can make various changes without departing from the spirit and scope of the present invention and correction is
Obvious.
Claims (1)
1. the drying means of a hyaluronic acid sodium, it is characterised in that when being dried, in leading portion chuck
The water temperature of logical hot water controls at 80 DEG C, continues evacuation；When temperature of charge rises to 45 DEG C, by chuck
The water temperature of logical hot water is reduced to 55 DEG C, and every 15 minutes filtrated airs of logical 5s time in tank, until
It has been dried；Be dried time strength imparting material above air velocity, make material faster be dried, when material is upper and lower
Stop when the temperature difference is less than 1 DEG C being dried；Whole drying time controls at 10h.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310671652.3A CN103819579B (en) | 2013-12-10 | 2013-12-10 | A kind of drying means of hyaluronic acid sodium |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310671652.3A CN103819579B (en) | 2013-12-10 | 2013-12-10 | A kind of drying means of hyaluronic acid sodium |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103819579A CN103819579A (en) | 2014-05-28 |
| CN103819579B true CN103819579B (en) | 2017-01-04 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201310671652.3A Active CN103819579B (en) | 2013-12-10 | 2013-12-10 | A kind of drying means of hyaluronic acid sodium |
Country Status (1)
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105564682B (en) * | 2015-12-24 | 2018-02-02 | 浙江景嘉医疗科技有限公司 | A kind of method for reducing Medical sodium hyaluronate gel bubble |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1432422A (en) * | 2002-01-14 | 2003-07-30 | 江苏省溧阳市云龙化工设备集团有限公司 | Mixing, washing, filtering and drying machine |
| CN201517078U (en) * | 2009-03-28 | 2010-06-30 | 桐乡市恒基生物科技有限公司 | Sodium hyaluronate dehydration drying device |
| CN101993503A (en) * | 2009-08-27 | 2011-03-30 | 上海佰加壹医药有限公司 | Method for preparing powdered sodium hyaluronate |
| CN102030836A (en) * | 2009-09-27 | 2011-04-27 | 桐乡市恒基生物科技有限公司 | Method for dehydrating sodium hyaluronate |
| CN102516408A (en) * | 2011-11-29 | 2012-06-27 | 上海景峰制药有限公司 | Purification method for sodium hyaluronate |
-
2013
- 2013-12-10 CN CN201310671652.3A patent/CN103819579B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1432422A (en) * | 2002-01-14 | 2003-07-30 | 江苏省溧阳市云龙化工设备集团有限公司 | Mixing, washing, filtering and drying machine |
| CN201517078U (en) * | 2009-03-28 | 2010-06-30 | 桐乡市恒基生物科技有限公司 | Sodium hyaluronate dehydration drying device |
| CN101993503A (en) * | 2009-08-27 | 2011-03-30 | 上海佰加壹医药有限公司 | Method for preparing powdered sodium hyaluronate |
| CN102030836A (en) * | 2009-09-27 | 2011-04-27 | 桐乡市恒基生物科技有限公司 | Method for dehydrating sodium hyaluronate |
| CN102516408A (en) * | 2011-11-29 | 2012-06-27 | 上海景峰制药有限公司 | Purification method for sodium hyaluronate |
Non-Patent Citations (1)
| Title |
|---|
| 过滤洗涤干燥多功能设备的开发与应用;陈国桓等;《现代化工》;19950930(第9期);第14-17页 * |
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| CN103819579A (en) | 2014-05-28 |
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Address after: No. 50, Roxin Road, Baoshan District, Shanghai Patentee after: Shanghai Jingfeng Pharmaceutical Co., Ltd. Address before: No. 50, Roxin Road, Baoshan District, Shanghai Patentee before: Shanghai Jingfeng Pharmaceutical Co., Ltd. |
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