CN103819579A - Drying method of sodium hyaluronate - Google Patents
Drying method of sodium hyaluronate Download PDFInfo
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- CN103819579A CN103819579A CN201310671652.3A CN201310671652A CN103819579A CN 103819579 A CN103819579 A CN 103819579A CN 201310671652 A CN201310671652 A CN 201310671652A CN 103819579 A CN103819579 A CN 103819579A
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- sodium hyaluronate
- hyaluronic acid
- acid sodium
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Abstract
The invention discloses a drying method of sodium hyaluronate, which is characterized by comprising the steps of controlling the water temperature of hot water in a front section jacket to be 80 DEG C during drying, continuously vacuumizing, when the temperature of a material rises to 45 DEG C, reducing the water temperature of the hot water in the jacket to be 55 DEG C, and charging sterile air into a tank for 5s every other 15min till the drying is accomplished. According to the method, when sodium hyaluronate is dried, the temperatures at different stages are controlled and adjusted; a certain physical means is aided; the qualified drying loss of sodium hyaluronate is ensured; the drying time of sodium hyaluronate is shortened; and the purposes of saving production time, controlling production cost and guaranteeing product quality are achieved.
Description
Technical field:
The present invention relates to hyaluronic acid sodium preparing technical field, the special standby drying means that refers to a kind of hyaluronic acid sodium.
Background technology:
The straight chain saccharan that hyaluronic acid sodium is made up of (1 → 3)-2-acetylaminohydroxyphenylarsonic acid 2-deoxidation-β-D-Glucose-(1 → 4)-O-β-D glucuronic acid disaccharide repeating unit.The structure of HA is fairly regular, the basic structural unit that identical disaccharide unit is HA, and the HA of different animals tissue and bacterial origin is without species variation.To the mankind and animal no antigen.
HA divides in the length of chain and point is inhomogenous in amount, point is 2 × lO in weight range
5-7 × 10
6, disaccharide unit length is 300-11000 couple, belongs to biomacromolecule.
Commodity HA is generally sodium-salt form, is white fiber shape or pulverulent solids, has stronger water absorbability, water-soluble, is insoluble to organic reagent, and medical fraction is 1 × 10 in amount
6-2.5 × 10
6.
At present to carry out filtration washing dry in order to enter filtration washing drying machine for hyaluronic acid sodium drying process, and drying temperature is constant, and maintenance vacuum tightness is at-0.09～-0.1Mpa.But the water ratio of this drying means hyaluronic acid sodium is still higher.
Hyaluronic acid sodium bulk drug in bulk drug Workshop Production heats with chuck at present, vacuumize and be dried, due to hyaluronic acid sodium as a kind of polysaccharide for temperature sensitive, in drying process, the temperature of material can not exceed 60 ℃, simultaneously because the character of hyaluronic acid sodium itself has water absorbability, when being converted into combined by free state, moisture in that material can more be difficult to be dried
Summary of the invention:
Technical problem solved by the invention is to provide for the existing problem of existing hyaluronic acid sodium drying means a kind of drying means of hyaluronic acid sodium, to reduce the water ratio of hyaluronic acid sodium.
Technical problem solved by the invention can be to realize by the following technical programs:
A drying means for hyaluronic acid sodium, it is in the time being dried, and in leading portion chuck, the water temperature of logical hot water is controlled at 80 ℃, continues to vacuumize; In the time that temperature of charge rises to 45 ℃, the water temperature of logical hot water in chuck is reduced to 55 ℃, and in 15 points of clockwise tanks, leads to the sterile air of 5s time, until be dried.
In a preferred embodiment of the invention, the air velocity of strength imparting material top when dry, makes material drier, in the time that material upper and lower temperature difference is less than 1 ℃, stops being dried.
In a preferred embodiment of the invention, be controlled at 10h whole time of drying.
Owing to having adopted technique scheme, adopt the water ratio of the dry hyaluronic acid sodium of drying means of the present invention below 14%.
Accompanying drawing explanation
Fig. 1 is the drying curve schematic diagram of former drying process.Its material starts to be dried from 15:00, and greatly about about 6-7 hour, time of drying is partially long, to dry unfavorable when the temperature equilibrium
Fig. 2 is the drying curve schematic diagram of drying means of the present invention.
Embodiment:
A kind of drying means of hyaluronic acid sodium, it is when dry, in leading portion chuck, the water temperature of logical hot water is controlled at 80 ℃, continues to vacuumize, in the time that dry temperature of charge rises to 45 ℃, the water temperature of logical hot water in chuck is reduced to 55 ℃, and every 15 minutes, in tank, lead to 5s time sterile air, the air velocity of strength imparting material top, make material drier, in the time that material upper and lower temperature difference is less than 1 ℃, stop being dried.
Referring to Fig. 2, material starts to be dried from 15:00, and to the about 3-4 hour of temperature equilibrium time, starting time shortens 3 hours, volume drying saving of time 4 hours (differ 1 ℃ at temperature upper and lower temperature difference, observe its aliquation information summary and determine dry terminal after material stirring)
Hyaluronic acid sodium product when trial production of fermentative Production, adopted drying means of the present invention after its moisture result as follows:
| Lot number | 20130401 | 20130402 | 20130403 | 20130701 | 20130702 | 20130703 |
| Moisture | 11.2% | 12.6% | 11.5% | 10.4% | 12.3% | 12.5% |
Batch average moisture that adopts old technology to be dried is 14.6%, and adopt new technology be dried batch not only shortened 4h time of drying, average moisture only has 11.6% to decline 20%, has shortened man-hour, saved cost, and the indices of hyaluronic acid sodium finished product does not occur abnormal.
Although the present invention has been described in detail and has quoted as proof some specific embodiments, to those skilled in the art, only otherwise it is obvious leaving that the spirit and scope of the present invention can make various changes and revise.
Claims (3)
1. a drying means for hyaluronic acid sodium, is characterized in that, in the time being dried, in leading portion chuck, the water temperature of logical hot water is controlled at 80 ℃, continues to vacuumize; In the time that temperature of charge rises to 45 ℃, the water temperature of logical hot water in chuck is reduced to 55 ℃, and in 15 points of clockwise tanks, leads to the sterile air of 5s time, until be dried.
2. the drying means of hyaluronic acid sodium as claimed in claim 1, is characterized in that, the air velocity of strength imparting material top when dry makes material drier, in the time that material upper and lower temperature difference is less than 1 ℃, stops being dried.
3. the drying means of hyaluronic acid sodium as claimed in claim 1, is characterized in that, is controlled at 10h whole time of drying.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310671652.3A CN103819579B (en) | 2013-12-10 | 2013-12-10 | A kind of drying means of hyaluronic acid sodium |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310671652.3A CN103819579B (en) | 2013-12-10 | 2013-12-10 | A kind of drying means of hyaluronic acid sodium |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103819579A true CN103819579A (en) | 2014-05-28 |
| CN103819579B CN103819579B (en) | 2017-01-04 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310671652.3A Active CN103819579B (en) | 2013-12-10 | 2013-12-10 | A kind of drying means of hyaluronic acid sodium |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105564682A (en) * | 2015-12-24 | 2016-05-11 | 杭州嘉伟生物制品有限公司 | Method for reducing medical sodium hyaluronate gel bubbles |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1432422A (en) * | 2002-01-14 | 2003-07-30 | 江苏省溧阳市云龙化工设备集团有限公司 | Mixing, washing, filtering and drying machine |
| CN201517078U (en) * | 2009-03-28 | 2010-06-30 | 桐乡市恒基生物科技有限公司 | Sodium hyaluronate dehydration drying device |
| CN101993503A (en) * | 2009-08-27 | 2011-03-30 | 上海佰加壹医药有限公司 | Method for preparing powdered sodium hyaluronate |
| CN102030836A (en) * | 2009-09-27 | 2011-04-27 | 桐乡市恒基生物科技有限公司 | Method for dehydrating sodium hyaluronate |
| CN102516408A (en) * | 2011-11-29 | 2012-06-27 | 上海景峰制药有限公司 | Purification method for sodium hyaluronate |
-
2013
- 2013-12-10 CN CN201310671652.3A patent/CN103819579B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1432422A (en) * | 2002-01-14 | 2003-07-30 | 江苏省溧阳市云龙化工设备集团有限公司 | Mixing, washing, filtering and drying machine |
| CN201517078U (en) * | 2009-03-28 | 2010-06-30 | 桐乡市恒基生物科技有限公司 | Sodium hyaluronate dehydration drying device |
| CN101993503A (en) * | 2009-08-27 | 2011-03-30 | 上海佰加壹医药有限公司 | Method for preparing powdered sodium hyaluronate |
| CN102030836A (en) * | 2009-09-27 | 2011-04-27 | 桐乡市恒基生物科技有限公司 | Method for dehydrating sodium hyaluronate |
| CN102516408A (en) * | 2011-11-29 | 2012-06-27 | 上海景峰制药有限公司 | Purification method for sodium hyaluronate |
Non-Patent Citations (1)
| Title |
|---|
| 陈国桓等: "过滤洗涤干燥多功能设备的开发与应用", 《现代化工》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105564682A (en) * | 2015-12-24 | 2016-05-11 | 杭州嘉伟生物制品有限公司 | Method for reducing medical sodium hyaluronate gel bubbles |
| CN105564682B (en) * | 2015-12-24 | 2018-02-02 | 浙江景嘉医疗科技有限公司 | A kind of method for reducing Medical sodium hyaluronate gel bubble |
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| Publication number | Publication date |
|---|---|
| CN103819579B (en) | 2017-01-04 |
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Address after: No. 50, Roxin Road, Baoshan District, Shanghai Patentee after: Shanghai Jingfeng Pharmaceutical Co., Ltd. Address before: No. 50, Roxin Road, Baoshan District, Shanghai Patentee before: Shanghai Jingfeng Pharmaceutical Co., Ltd. |
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