CN102028895A - Medicinal composition with antioxidant activity and blood vessel and blood cleaning antioxidant and/or protective agent - Google Patents
Medicinal composition with antioxidant activity and blood vessel and blood cleaning antioxidant and/or protective agent Download PDFInfo
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- CN102028895A CN102028895A CN2010105805672A CN201010580567A CN102028895A CN 102028895 A CN102028895 A CN 102028895A CN 2010105805672 A CN2010105805672 A CN 2010105805672A CN 201010580567 A CN201010580567 A CN 201010580567A CN 102028895 A CN102028895 A CN 102028895A
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Abstract
The invention discloses a medicinal composition with antioxidant activity and a blood vessel and blood cleaning antioxidant and/or protective agent. The medicinal composition comprises the following raw materials in part by weight: 1 to 60 parts of grape seed, 10 to 200 parts of fresh apple, 5 to 80 parts of blueberry, 10 to 200 parts of piny flower, 5 to 60 parts of lemon, 20 to 80 parts of hawthorn, 5 to 50 parts of purple salvia miltiorrhiza, 5 to 50 parts of mulberry, 10 to 50 parts of Chinese wolfberry, 10 to 50 parts of codonopsis pilosula, 10 to 50 parts of rhodiola, 50 to 200 parts of glutinous rice bran; 5 to 50 parts of epimedium herb and 1 to 10 parts of zinc gluconate or ferrous gluconate or a mixture of the zinc gluconate and the ferrous gluconate. The invention has high bioavailability, is easily digested and absorbed, has no pessimal stimulation to gastrointestinal tracts, and can exert the effect of primary anthocyanidin extracted from different plants and plant seeds to the greatest degree.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition with antioxidant activity and this pharmaceutical composition blood vessel and blood clean antioxidant and/or protective agent as effective ingredient.
Background technology
More and more many free radicals (Free Radicals) that studies have shown that are the arch-criminals who promotes human senility.Modern medicine study shows that free radical can directly cause the healthy disease of the common harm of kind more than 100, comprises heart disease, cancer and arthritis etc.The procyanidin that extracts from plant and plant seed has extremely strong non-oxidizability, can remove the intravital free radical of people rapidly.As the procyanidin (OPC) that from fruit, plants such as Fructus Vitis viniferae, Flos pini, Fructus Citri Limoniae, extracts, its ability of removing free radical is ascorbic 20 times, this procyanidin (OPC) is a kind of unique biological flavone, easily dissolving in water, but orally touch the OPC powder with gastric juice and Digestive system in the stomach and can form gel, indissoluble is untied, and has only small part to dissolve, be unfavorable for digesting and assimilating, thereby bioavailability is low.
Summary of the invention
Technical problem to be solved by this invention is the clothes the deficiencies in the prior art, provides a kind of pharmaceutical composition with antioxidant activity, its bioavailability height.
For solving above technical problem, the present invention takes following technical scheme:
A kind of pharmaceutical composition with antioxidant activity, in weight portion, the composition of raw materials of described pharmaceutical composition is as follows: 1～60 part of Semen Vitis viniferae; 10～200 parts of fresh apple; 5～80 parts of Pericarpium Citri tangerinaes; 10～200 parts of Flos pinis; 5～60 parts in Fructus Citri Limoniae; 20～80 parts of Fructus Crataegis, 5～50 parts of Radix Salviae Miltiorrhizae; 5～50 parts in Fructus Mori; 10～50 parts of Fructus Lyciis; 10～50 parts of Radix Codonopsis; 10～50 parts of Radix Rhodiolaes; 50～200 parts of Oryza glutinosa brans; 5～50 parts of Herba Epimedii; 1～10 part in zinc gluconate or Ferrous gluconate or the mixture of the two.
According to pharmaceutical composition of the present invention, can prepare as follows:
(1), takes by weighing Semen Vitis viniferae, fresh apple, Pericarpium Citri tangerinae, Fructus Citri Limoniae, Fructus Mori and Fructus Lycii in proportion, pulverize, the water that adds 20～80 times, stirring obtains aqueous dispersions, at room temperature concentrates with the membrance concentration system, film selects the control molecular weight below 10,000, to the concentrated solution volume be 5%～10% of aqueous dispersions volume, adopt spray drying method to make granule, be lower than 3% in vacuum drying to moisture below 65 ℃, be defined as component (a), stand-by;
(2), take by weighing Radix Salviae Miltiorrhizae, Radix Rhodiolae, Flos pini, Radix Codonopsis, Oryza glutinosa bran, Fructus Crataegi and Herba Epimedii in proportion, be ground into granule, put in the ultrasonic extraction jar, add 15～40 times water, ultrasonic extraction 1～2 hour, centrifugalize also keeps medicinal liquid, medicinal liquid is become syrupy shape at 50 ℃～70 ℃ following vacuum concentration, change the vacuum drying oven drying over to, the control temperature is dried to below 70 ℃ and obtains moisture and be lower than 3%, be defined as component (b), stand-by;
(3), the component (a) of step (1) preparation and the component (b) of step (2) preparation are ground into powder, the zinc gluconate or the Ferrous gluconate of adding formula ratio, mix homogeneously promptly obtains described pharmaceutical composition.
The invention still further relates to a kind of blood vessel and blood clean antioxidant and/or protective agent, it is for being effective ingredient with pharmaceutical composition of the present invention, routinely the capsule made of technology of preparing.
Because the utilization of technique scheme, the present invention compared with prior art has following advantage:
In the present invention's prescription, the apple polyphenol that contains in the extract of Fructus Mali pumilae has the enhancing muscle strength, reduces interior fat, keeps breathing smooth and easy (being included in responsive season), thereby reduces melanic formation skin whitening, helps skin to prevent functions such as ultraviolet; Radix Rhodiolae extract has anti-aging effects, oxygen lack resistant function, anti-pessimal stimulation effect, to body dual regulation, antifatigue effect, the effect of inhibition blood sugar increasing, to the influence of learning and memory.The procyanidin that Semen Vitis viniferae extracts (OPC), the most potent free radical scavenger that is so far to be found has very strong activity in vivo, strengthens the blood vessel wall resistance; Reduce capillary fragility, keep the suitable permeability of blood capillary, bruise is had mitigation, strengthen the function of blood capillary, vein, tremulous pulse; Alleviate the seriousness of athletic injury; Prevention is also alleviated varicosis; Alleviate edema and shank swelling; Treat chronic venous afunction; Reduce the initiation potential of diabetes; Improve the pliability of blood rbc film; Strengthen skin elasticity and soft and smooth property; The prevention sunray is to the radiation damage of skin; Irritated aspect: very effective to pollinosis (pollen hypersensitivity).
The present invention uses the traditional Chinese medical science five colors and joins five fortune, the five internal organs theory is organized prescription, the fever and chills and warm and cool property of medicine according to each different components has added adjuvant Testa oryzae extract simultaneously, Radix Codonopsis reaches a coordinative role, increased the bioavailability of these different procyanidins effectively, make whole Fang Yi digest and assimilate, gastrointestinal tract is not had bad irritant reaction, the effect of the procyanidin that extracts from different plants and plant seed is brought into play to greatest extent.
The specific embodiment
Be respectively the fruit of correspondence or the fruit of plant as the Semen Vitis viniferae in the raw material of pharmaceutical composition of the present invention, fresh apple, Pericarpium Citri tangerinae, Fructus Citri Limoniae, Fructus Mori, Fructus Lycii; Radix Salviae Miltiorrhizae in the raw material, Radix Rhodiolae, Flos pini, Radix Codonopsis, Fructus Crataegi and celestial being's spleen are the medical material of commercially available acquisition; The Oryza glutinosa bran is shell or the skin that the Oryza glutinosa from Oryza glutinosa comes off, can adopt conventional separate preparation or buy obtain; Zinc gluconate or Ferrous gluconate are the commercial goods.
Below in conjunction with specific embodiment the present invention is further described, but the invention is not restricted to these embodiment.
Embodiment 1
Present embodiment provides a kind of pharmaceutical composition with antioxidant activity, and its composition of raw materials is composed as follows: 10 parts of Semen Vitis viniferae; 80 parts of fresh apple; 40 parts of Pericarpium Citri tangerinaes; 90 parts of Flos pinis; 20 parts in Fructus Citri Limoniae; 30 parts of Fructus Crataegis, 25 parts of Radix Salviae Miltiorrhizae; 25 parts in Fructus Mori; 30 parts of Fructus Lyciis; 15 parts of Radix Codonopsis; 30 parts of Radix Rhodiolaes; 90 parts of Oryza glutinosa brans; 10 parts of Herba Epimedii; 5 parts of zinc gluconate.
Described preparation of drug combination method is as follows:
(1), takes by weighing Semen Vitis viniferae, fresh apple, Pericarpium Citri tangerinae, Fructus Citri Limoniae, Fructus Mori and Fructus Lycii in proportion, pulverize, the water that adds 30 times, stirring obtains aqueous dispersions, at room temperature concentrates with the membrance concentration system, film selects the control molecular weight below 10,000, to the concentrated solution volume be about 5% of aqueous dispersions volume, adopt spray drying method to make granule, be lower than 3% in vacuum drying to moisture below 65 ℃, be defined as component (a), stand-by;
(2), take by weighing Radix Salviae Miltiorrhizae, Radix Rhodiolae, Flos pini, Radix Codonopsis, Oryza glutinosa bran, Fructus Crataegi and Herba Epimedii in proportion, be ground into granule, put in the ultrasonic extraction jar, add 20 times water, ultrasonic extraction 1～2 hour, centrifugalize also keeps medicinal liquid, medicinal liquid is become syrupy shape at 65 ℃ of following vacuum concentration, change the vacuum drying oven drying over to, the control temperature is dried to below 70 ℃ and obtains moisture and be lower than 3%, be defined as component (b), stand-by;
(3), the component (a) of step (1) preparation and the component (b) of step (2) preparation are ground into powder, the zinc gluconate of adding formula ratio, mix homogeneously promptly obtains described pharmaceutical composition.
Embodiment 2
Present embodiment provides a kind of pharmaceutical composition with antioxidant activity, and its composition of raw materials is composed as follows: 40 parts of Semen Vitis viniferae; 60 parts of fresh apple; 60 parts of Pericarpium Citri tangerinaes; 90 parts of Flos pinis; 20 parts in Fructus Citri Limoniae; 30 parts of Fructus Crataegis, 25 parts of Radix Salviae Miltiorrhizae; 10 parts in Fructus Mori; 15 parts of Fructus Lyciis; 15 parts of Radix Codonopsis; 30 parts of Radix Rhodiolaes; 90 parts of Oryza glutinosa brans; 10 parts of Herba Epimedii; 5 parts of zinc gluconate.
Described preparation of drug combination method is as follows:
(1), takes by weighing Semen Vitis viniferae, fresh apple, Pericarpium Citri tangerinae, Fructus Citri Limoniae, Fructus Mori and Fructus Lycii in proportion, pulverize, the water that adds 20 times, stirring obtains aqueous dispersions, at room temperature concentrates with the membrance concentration system, film selects the control molecular weight below 10,000, to the concentrated solution volume be about 5% of aqueous dispersions volume, adopt spray drying method to make granule, be lower than 3% in vacuum drying to moisture below 65 ℃, be defined as component (a), stand-by;
(2), take by weighing Radix Salviae Miltiorrhizae, Radix Rhodiolae, Flos pini, Radix Codonopsis, Oryza glutinosa bran, Fructus Crataegi and Herba Epimedii in proportion, be ground into granule, put in the ultrasonic extraction jar, add 20 times water, ultrasonic extraction 1～2 hour, centrifugalize also keeps medicinal liquid, medicinal liquid is become syrupy shape at 65 ℃ of following vacuum concentration, change the vacuum drying oven drying over to, the control temperature is dried to below 70 ℃ and obtains moisture and be lower than 3%, be defined as component (b), stand-by;
(3), the component (a) of step (1) preparation and the component (b) of step (2) preparation are ground into powder, the zinc gluconate of adding formula ratio, mix homogeneously promptly obtains described pharmaceutical composition.
Embodiment 3
Present embodiment provides a kind of pharmaceutical composition with antioxidant activity, and its composition of raw materials is composed as follows: 40 parts of Semen Vitis viniferae; 60 parts of fresh apple; 60 parts of Pericarpium Citri tangerinaes; 100 parts of Flos pinis; 20 parts in Fructus Citri Limoniae; 30 parts of Fructus Crataegis, 5 parts of Radix Salviae Miltiorrhizae; 10 parts in Fructus Mori; 15 parts of Fructus Lyciis; 15 parts of Radix Codonopsis; 40 parts of Radix Rhodiolaes; 90 parts of Oryza glutinosa brans; 10 parts of Herba Epimedii; 5 parts of zinc gluconate.
Described preparation of drug combination method is with embodiment 2.
Embodiment 4
Present embodiment provides a kind of pharmaceutical composition with antioxidant activity, and its composition of raw materials is composed as follows: 10 parts of Semen Vitis viniferae; 80 parts of fresh apple; 40 parts of Pericarpium Citri tangerinaes; 90 parts of Flos pinis; 20 parts in Fructus Citri Limoniae; 20 parts of Fructus Crataegis, 25 parts of Radix Salviae Miltiorrhizae; 25 parts in Fructus Mori; 30 parts of Fructus Lyciis; 20 parts of Radix Codonopsis; 30 parts of Radix Rhodiolaes; 85 parts of Oryza glutinosa brans; 20 parts of Herba Epimedii; 5 parts of zinc gluconate.
Described preparation of drug combination method is with embodiment 1.
The aforementioned pharmaceutical compositions of embodiment 1-4 is made capsule according to conventional technology of preparing, called after " blood (snow) Hai Qing " capsule, every 0.5g, the content of every capsules Chinese medicine compositions is 80%.
Through the clinical practice in 4 years by a definite date, 50 elder's long-term observation of 50～88 years old are found, prescription of the present invention can effectively be removed the rubbish in the blood, stop bad cholesterol on ductus arteriosus wall, to be hoarded, reduce arteriosclerotic degree effectively, allow blood vessel possess the vigor of elasticity and young healthy, and most of hyperpietics' blood pressure has fallen, there is 40% hyperpietic's blood pressure to recover normal, and the hypertension agents of having stopped using.And use single variety OPC composition far not reach effect like this.Typical case is as follows.
Case 1: Chen Yuanlei, the man, 82 years old, economize machine-operated retired veteran cadre, suffer from cerebral arteriosclerosis, often fall in a swoon because of cerebral blood supply insufficiency.Will arrive the province the People's Hospital and do the carotid artery reopening operation twice every year.In July, 2005-JIUYUE is obeyed the sea of blood clearing capsule of embodiment 1 under our guidance, each two sooner or later.Do angiography October and show that the cerebral atherosclerosis complete obiteration has recovered elasticity.Removed logical blood vessel till now never again from 2006,88 years old now, healthy.
Case 2: Wu Ximei, the woman, 73 years old, suffered from hypertension 12 years, blood pressure 110-170mmHg keeps by eating depressor always.Eat sea of blood clearing capsule in April, 2007, each two sooner or later, depressor does not stop simultaneously.Blood pressure recovers normal after three months, withdraws depressor.And the complexion wrinkle disappeared manyly, and spirit is also fine, relaxation and happiness.So far do not obey depressor.Outdoor activities at ordinary times are how many, and people's indefatigability.
Case 3: Zhao Yi, the woman, 45 years old, 2004 because of chronic fatigue added the pain of losing one's husband again, one of serious disease, spirit is tired, and complexion is pitch-black.Amenorrhea.Obey sea of blood clearing capsule in May, 2005, each two sooner or later.Clothes are three months continuously.Recover menstruation, the people also recovers, and it is white touched with red that complexion becomes, and whole people has changed apperance fully, and juvenescence 10 years old is up to the present healthy, will seem young 5-8 year that than the age cohorts complexion is white touched with red, is full of youthful vigor.
As mentioned above, we are illustrated according to aim of the present invention fully, but the present invention is not limited to the foregoing description and implementation method.The practitioner of correlative technology field can carry out different variations and implement the foregoing description only being explanation technical conceive of the present invention and characteristics in the scope of technological thought permission of the present invention; its purpose is to allow the personage who is familiar with this technology can understand content of the present invention and enforcement according to this, can not limit protection scope of the present invention with this.All equivalences that spirit is done according to the present invention change or modify, and all should be encompassed within protection scope of the present invention.
Claims (3)
1. pharmaceutical composition with antioxidant activity, it is characterized in that: in weight portion, the composition of raw materials of described pharmaceutical composition is as follows: 1～60 part of Semen Vitis viniferae; 10～200 parts of fresh apple; 5～80 parts of Pericarpium Citri tangerinaes; 10～200 parts of Flos pinis; 5～60 parts in Fructus Citri Limoniae; 20～80 parts of Fructus Crataegis, 5～50 parts of Radix Salviae Miltiorrhizae; 5～50 parts in Fructus Mori; 10～50 parts of Fructus Lyciis; 10～50 parts of Radix Codonopsis; 10～50 parts of Radix Rhodiolaes; 50～200 parts of Oryza glutinosa brans; 5～50 parts of Herba Epimedii; 1～10 part in zinc gluconate or Ferrous gluconate or the mixture of the two.
2. the described preparation of drug combination method of claim 1 is characterized in that: comprise the steps:
(1), takes by weighing Semen Vitis viniferae, fresh apple, Pericarpium Citri tangerinae, Fructus Citri Limoniae, Fructus Mori and Fructus Lycii in proportion, pulverize, the water that adds 20～80 times, stirring obtains aqueous dispersions, at room temperature concentrates with the membrance concentration system, film selects the control molecular weight below 10,000, to the concentrated solution volume be 5%～10% of aqueous dispersions volume, adopt spray drying method to make granule, be lower than 3% in vacuum drying to moisture below 65 ℃, be defined as component (a), stand-by;
(2), take by weighing Radix Salviae Miltiorrhizae, Radix Rhodiolae, Flos pini, Radix Codonopsis, Oryza glutinosa bran, Fructus Crataegi and Herba Epimedii in proportion, be ground into granule, put in the ultrasonic extraction jar, add 15～40 times water, ultrasonic extraction 1～2 hour, centrifugalize also keeps medicinal liquid, medicinal liquid is become syrupy shape at 50 ℃～70 ℃ following vacuum concentration, change the vacuum drying oven drying over to, the control temperature is dried to below 70 ℃ and obtains moisture and be lower than 3%, be defined as component (b), stand-by;
(3), the component (a) of step (1) preparation and the component (b) of step (2) preparation are ground into powder, the zinc gluconate or the Ferrous gluconate of adding formula ratio, mix homogeneously promptly obtains described pharmaceutical composition.
3. a blood vessel and blood clean antioxidant and/or protective agent, it is characterized in that: described antioxidant and/or protective agent are effective ingredient for the pharmaceutical composition with claim 2 gained, routinely the capsule made of technology of preparing.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2010105805672A CN102028895A (en) | 2010-12-09 | 2010-12-09 | Medicinal composition with antioxidant activity and blood vessel and blood cleaning antioxidant and/or protective agent |
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| CN2010105805672A CN102028895A (en) | 2010-12-09 | 2010-12-09 | Medicinal composition with antioxidant activity and blood vessel and blood cleaning antioxidant and/or protective agent |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102430064A (en) * | 2011-12-05 | 2012-05-02 | 张家港天乙传统医药研究院有限公司 | Composition for tonifying primordial qi and removing meridian obstruction and regulating blood and preparation method thereof |
| CN105998525A (en) * | 2016-06-07 | 2016-10-12 | 华北理工大学 | Health-care drink capable of improving cerebral circulation insufficiency and preparation method thereof |
-
2010
- 2010-12-09 CN CN2010105805672A patent/CN102028895A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102430064A (en) * | 2011-12-05 | 2012-05-02 | 张家港天乙传统医药研究院有限公司 | Composition for tonifying primordial qi and removing meridian obstruction and regulating blood and preparation method thereof |
| CN105998525A (en) * | 2016-06-07 | 2016-10-12 | 华北理工大学 | Health-care drink capable of improving cerebral circulation insufficiency and preparation method thereof |
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Application publication date: 20110427 |