CN102028683A - Compound closantel sodium injection and preparation method thereof - Google Patents
Compound closantel sodium injection and preparation method thereof Download PDFInfo
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- CN102028683A CN102028683A CN2010105783601A CN201010578360A CN102028683A CN 102028683 A CN102028683 A CN 102028683A CN 2010105783601 A CN2010105783601 A CN 2010105783601A CN 201010578360 A CN201010578360 A CN 201010578360A CN 102028683 A CN102028683 A CN 102028683A
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- closantel
- injection
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- sodium
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Abstract
The invention relates to a compound closantel sodium injection and a preparation method thereof. The compound closantel sodium injection is prepared from components in the following steps: (1) putting closantel sodium into propanediol, heating to 50-60 DEG C, and stirring for 10-20 min until solution is clarified; (2) taking partial glycerol acetal and adding levamisole hydrochloride to stir and dissolve; and (3) mixing the solutions prepared in the step (1) and the step (2), adding the rest glycerol acetal until the solution reaches 1,000 L, uniformly stirring, keeping for 15-20 min and clarifying the liquid medicine to obtain a finished product. The invention complements the defects of narrow anti-parasite range by adopting the compound preparation of the closantel sodium and the levamisole hydrochloride, is effective and efficient on killing cow and sheep parasites, expands the anti-parasite range, reduces the cow and sheep illness and is favorable to the cow and sheep growth.
Description
Technical field
The present invention relates to poultry medicine field, especially a kind of compound sodium closantel injection and preparation method thereof.
Background technology
It is the disease that cattle, sheep very easily infect that cattle, sheep parasite infect, and can cause degradation problem under cattle, sheep undergrowth, the increase of food consumption rate, the resistance.Cattle, sheep parasite by endoparasites such as trematodiasis, ascarid, ancylostome, cestode and some vermins as: louse, torsalo maggot, acarid etc. are formed, traditional parasite medicine such as sodium closantel injection and levamisole hydrochloride injection killed, kill parasite certain limitation is arranged, as the closantel sodium anthelmintic, effectively sick to cattle and sheep distoma hepaticum, gastrointestinal tract nematicide and Oestrus ovis, invalid to acarid; Levamisole hydrochloride is killed effect to gastrointestinal tract nematicide (except the cestode), external arthropod (as louse, acarid etc.), and is invalid to cestode and trematodiasis and protozoacide.Above medicine need meet use could with in the body, vermin kills, repeated drug taking is not only wasted resource, and increase keeper's the amount of labour, and the ectoparasite insects medicine of antibody is generally with organophosphor or other insecticides, dosage is grasped and is not with great difficulty caused poisoning, animal licks health also can cause poisoning, and the antibody endoparasite insecticide also can cause poisoning, also can cause the phenomenon of organophosphate poisoning in much carrying out with antibody endoparasite treatment ill domestic animal.
According to the retrieval, find following patent, CN101693009A discloses a kind of cattle and sheep with sick closantel sodium transdermal solution of parasiticide and preparation method thereof, constitutes component and volume parts thereof and is respectively: ethyl acetate 5-15 part; Dimethyl sulfoxide 20-30 part; Azone 2-6 part; Isopropyl alcohol 1-3 part; Propylene glycol or ethanol 50-70 part; The closantel sodium content is that every 100ml solution contains 2.5-5g, through making finished product after dissolving, mixing, filtration, the fill.
This patent is compared with above-mentioned patent, is all inequality from composition or proportioning, and effect is significantly different with this patent with purposes.
Summary of the invention
The objective of the invention is to overcome the deficiencies in the prior art part, provide a kind of parasiticide scope wide, can alleviate compound sodium closantel injection of suffering from poultry health stress and preparation method thereof effectively.
The present invention is achieved by the following technical solutions:
A kind of compound sodium closantel injection, constituent is as follows:
Closantel sodium 30-100kg, levamisole hydrochloride 1-20kg, glycerin methylal 800-950L, propylene glycol 50-200L.
A kind of preparation method of compound sodium closantel injection, step is as follows:
(1) closantel sodium is put into propylene glycol, be heated to 50-60 ℃ and stir 10-20 minute to clarification;
(2) get the partial glycerol dimethoxym ethane, add the levamisole hydrochloride stirring and dissolving;
(3) merge the solution that " (1) " " (2) " make, add remaining glycerin methylal again, stir, kept 15-20 minute, treat that medicinal liquid promptly gets compound sodium closantel injection after clear and bright to 1000L.
Advantage of the present invention and good effect are:
1, the present invention adopts the compound preparation of closantel sodium and levamisole hydrochloride to come the deficiency of complementary pest-resistant scope, to killing cattle, sheep parasite effectively and efficient, has increased the parasiticide scope, reduce cattle, sheep ill probability, be beneficial to growth.
2, the present invention is with the uniting use and can enlarge pest-resistant scope of closantel sodium and levamisole hydrochloride, and practical application is extensive, can be widely used in cattle, sheep parasite, reduces the medication number of times, reduces the poisoning odds, and is easy to use.
The specific embodiment
Below in conjunction with embodiment, the present invention is further described, and following embodiment is illustrative, is not determinate, can not limit protection scope of the present invention with following embodiment.
Embodiment 1
A kind of compound sodium closantel injection, every 1000L injection is made by following raw material:
Closantel sodium 30kg, levamisole hydrochloride 1kg, glycerin methylal 800L, propylene glycol 200L.
A kind of preparation method of compound sodium closantel injection, step is as follows:
(1) closantel sodium is put into propylene glycol, be heated to 50-60 ℃ and stir 10-20 minute to clarification;
(2) get glycerin methylal 200L, add the levamisole hydrochloride stirring and dissolving;
(3) merge the solution that " (1) " " (2) " make, the glycerol adding dimethoxym ethane stirs to 1000L again, keeps 15-20 minute, treats that medicinal liquid promptly gets compound sodium closantel injection after clear and bright.
Embodiment 2
A kind of compound sodium closantel injection, every 1000L injection is made by following raw material:
Closantel sodium 100kg, levamisole hydrochloride 20kg, glycerin methylal 950L, propylene glycol 50L.
A kind of preparation method of compound sodium closantel injection, step is as follows:
(1) closantel sodium is put into propylene glycol, be heated to 50-60 ℃ and stir 10-20 minute to clarification;
(2) get glycerin methylal 200L, add the levamisole hydrochloride stirring and dissolving;
(3) merge the solution that " (1) " " (2) " make, the glycerol adding dimethoxym ethane stirs to 1000L again, keeps 15-20 minute, treats that medicinal liquid promptly gets compound sodium closantel injection after clear and bright.
Embodiment 3
A kind of compound sodium closantel injection, every 1000L injection is made by following raw material:
Closantel sodium 80kg, levamisole hydrochloride 15kg, glycerin methylal 900L, propylene glycol 100L.
A kind of preparation method of compound sodium closantel injection, step is as follows:
(1) closantel sodium is put into propylene glycol, be heated to 50-60 ℃ and stir 10-20 minute to clarification;
(2) get glycerin methylal 200L, add the levamisole hydrochloride stirring and dissolving;
(3) merge the solution that " (1) " " (2) " make, the glycerol adding dimethoxym ethane stirs to 1000L again, keeps 15-20 minute, treats that medicinal liquid promptly gets compound sodium closantel injection after clear and bright.
Clinical trial:
1, laboratory animal:
100 of the ill one-tenth of picked at random cattle, body weight is at 250-500kg.
2, trial drug:
The development of compound sodium closantel injection our unit
Sodium closantel injection our unit prepared in laboratory
Levamisole hydrochloride injection our unit prepared in laboratory
3, test method
Suffer from cattle with 100 and be divided into four groups at random by body weight.Wherein one group is the blank group, does not give the medicine treatment; One group for to treat with No. 6 prescriptions of compound sodium closantel injection of the present invention; Usage: intramuscular injection: every 1kg body weight is with 0.01～0.015ml, and repeated drug taking once after 7 days.Treat with existing medicine for other two groups, treat with sodium closantel injection for one group, intramuscular injection: every 1kg body weight 5mg, repeated drug taking once after 7 days, another group is treated intramuscular injection with the levamisole hydrochloride injection: every 1kg body weight 0.2mg, and repeated drug taking is once after 7 days, treat and add up therapeutic effect after 10 days, wherein
Invalid: after referring to 10 days, suffer from the poultry symptom and do not have obvious change, number of parasites and faecal egg are counted no change or are increased.
Effectively: after referring to 10 days, suffer from the poultry symptom and do not have obvious change, number of parasites and faecal egg number reduce or disappear.
Cure: after referring to 10 days, number of parasites and faecal egg number disappear.
Symptom is arranged during end: after referring to 10 days, number of parasites and faecal egg number reduce or no change.Suffering from poultry does not cure.Its numeral has been included in the numeral of invalid number and effective number.
The relative weight gain rate: refer to use behind the medicine rate of body weight gain with respect to matched group.
4, conclusion
This result of the test is analyzed by statistics, and compound sodium closantel injection treatment group, sodium closantel injection treatment group and levamisole hydrochloride injection for treating group and matched group difference is (P＜0.01) extremely significantly.Compound sodium closantel injection curative effect of the present invention is better than existing two kinds of medicines.
Claims (2)
1. compound sodium closantel injection, it is characterized in that: constituent is as follows:
Closantel sodium 30-100kg, levamisole hydrochloride 1-20kg, glycerin methylal 800-950L, propylene glycol 50-200L.
2. the preparation method of a compound sodium closantel injection as claimed in claim 1, it is characterized in that: step is as follows:
(1) closantel sodium is put into propylene glycol, be heated to 50-60 ℃ and stir 10-20 minute to clarification;
(2) get the partial glycerol dimethoxym ethane, add the levamisole hydrochloride stirring and dissolving;
(3) merge the solution that " (1) " " (2) " make, add remaining glycerin methylal again, stir, kept 15-20 minute, treat that medicinal liquid promptly gets compound sodium closantel injection after clear and bright to 1000L.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010105783601A CN102028683A (en) | 2010-12-08 | 2010-12-08 | Compound closantel sodium injection and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010105783601A CN102028683A (en) | 2010-12-08 | 2010-12-08 | Compound closantel sodium injection and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102028683A true CN102028683A (en) | 2011-04-27 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010105783601A Pending CN102028683A (en) | 2010-12-08 | 2010-12-08 | Compound closantel sodium injection and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102028683A (en) |
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2010
- 2010-12-08 CN CN2010105783601A patent/CN102028683A/en active Pending
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| PB01 | Publication | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20110427 |