CN102028654A - Long-acting tylosin injection - Google Patents
Long-acting tylosin injection Download PDFInfo
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- CN102028654A CN102028654A CN2010105790361A CN201010579036A CN102028654A CN 102028654 A CN102028654 A CN 102028654A CN 2010105790361 A CN2010105790361 A CN 2010105790361A CN 201010579036 A CN201010579036 A CN 201010579036A CN 102028654 A CN102028654 A CN 102028654A
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- tylosin
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- propylene glycol
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Abstract
The invention relates to long-acting tylosin injection. Every 10000ml of propylene glycol contains the following components by weight portion: 1000-2000g of tylosin antibiotic, 85-100g of benzyl alcohol, 450g-500g of polyvinyl pyrrolidone and 10-20g of 2,6-bi-tert-butyl-4-methylphenol. The injection has long drug-effect duration and low cost, is particularly suitable for curing respiratory diseases for livestock and poultry, and has small dosage. The injection is administrated onto animals in a hypodermic injection mode, and the drug-effect duration can reach more than 3days after the injection is administrated once. The injection has obvious prevention and cure effect for mycoplasma infectious diseases of animals such as chickens, piglets, lambs, calves and the like, and has the advantages of fewer injection times, good curative effect, and wide market prospect.
Description
Technical field
The present invention relates to field of veterinary, relate to the medicine for the treatment of respiratory tract disease, especially a kind of long-acting tylosin injection.
Background technology
The choice drug of the livestock and birds respiratory disease of China's treatment at present is a macrolide antibiotics, and the dosage form of tylosin has only a kind of normal injection, this injection administration number of times is many, to inject one every day 2 times, need to cure in 3-4 days, increase raiser's drug cost, and it is time-consuming, when especially injecting to pig, need could inject behind the binding pig, administration is pretty troublesome.
According to the retrieval, find the two piece patent documentations relevant with this patent, wherein CN101423826 discloses a kind of method of utilizing tylosin herb residue to produce complex enzyme preparation for feeding, this method comprises the steps: 1) prepare the aspergillus niger seed of producing complex enzyme preparation for feeding: aspergillus niger is inserted aspergillus niger rejuvenation culture medium, after the activated and amplification culture of bacterial strain, inoculum concentration with 5～10% is inoculated in the aspergillus niger seed culture medium, behind 28～32 ℃ of cultivation 72～120h, can make the aspergillus niger seed of producing complex enzyme preparation for feeding; 2) the degradation bacteria seed of preparation degraded medicinal residues tylosin: the degradation bacteria of the medicinal residues tylosin of will degrading, insert degradation bacteria rejuvenation culture medium, after the activated and amplification culture of degradation bacteria, be inoculated in one-level degradation bacteria seed culture medium with 5～10% inoculum concentrations, cultivate behind 18～24h switching again for 28～32 ℃ and go into secondary degradation bacteria seed culture medium, cultivate behind 26～30h switching again for 28～32 ℃ and go into the sub-culture medium of multi-stage degradation strain, behind 28～32 ℃ of cultivation 34～38h, can make the degradation bacteria seed of degraded medicinal residues tylosin; 3) with above-mentioned 1) the aspergillus niger seed and above-mentioned 2 of production complex enzyme preparation for feeding of preparation) the degradation bacteria seed of degraded medicinal residues tylosin of preparation press respectively in 5～10% inoculum concentrations access solid medicinal residues culture medium of fermentation substrate gross mass, 48～72h is cultivated in 28～32 ℃ of circulating ventilations, turn over Qu Yici during this time, promptly microbial solid fermentation is produced the complex enzyme preparation for feeding end; 4) with above-mentioned 3) tunning drying under 50～70 ℃, be complex enzyme preparation for feeding after the pulverizing.CN1572301 discloses a kind of antibiotic injection of tylosin class that contains and has formed and preparation method, tylosin class antibiotic is tylosin alkali, phosphoric acid or tylosin tartrate, tilmicosin and the salt that forms with acid thereof, acetyl-isovaleryl base tylosin and the salt that forms with acid thereof; Disperse medium is glycerol triacetate, benzyl benzoate, also can add formal glycerine, dimethyl acetylamide or N-methyl-ketopyrrolidine or non-ionic surface active agent in the preparation, also can add suspending agent during the preparation suspensoid.
Summary of the invention
The objective of the invention is to overcome the deficiencies in the prior art part, provide that a kind of injection volume is few, long action time, long-acting tylosin injection that therapeutic effect is good.
The present invention is achieved by the following technical solutions:
A kind of long-acting tylosin injection is characterized in that: component and weight are as follows: every 10000ml propylene glycol contains following composition and parts by weight are:
Tylosin class antibiotic 1000-2000g, benzyl alcohol 85-100g, polyvinylpyrrolidone 450-500g, 2,6-di-tert-butyl-4-methy phenol 10-20g.
And described tylosin class antibiotic is tylosin alkali, tylosin phosphonate or tylosin tartrate.
And, the preparation method of described long-acting tylosin injection is: with benzyl alcohol, polyvinylpyrrolidone, 2,6-di-tert-butyl-4-methy phenol (BHT) is dissolved in the propylene glycol of 6-8000ml successively, again tylosin is added above-mentioned solution dissolving, add propylene glycol at last to 10000ml, promptly get long-acting tylosin injection.
Advantage of the present invention and good effect are:
What 1, the tylosin class antibiotic in the raw material of the present invention used is the special-purpose antibiotic of poultry, can not bring the cross resistance problem to the mankind, it is the choice drug of livestock and poultry mycoplasma disease, except that mycoplasma is had the specially good effect, staphylococcus, streptococcus, corynebacterium, mycobacterium, pasteurellosis bacillus, spirillum etc. are also had pretend usefulness, it also has certain effect to coccidiosis simultaneously.
2, tylosin class Antibiotic Additive amount is little among the present invention, and in skin was injected into the pig body, clothes absorbed fast, can reach the highest blood drug level in a stock-traders' know-how 2-3 hour, and it is wide to distribute in the tissue, and the Mlc time of remaining valid is long, drains also thorough.
3, it is long that injection of the present invention has duration of efficacy, cost is low, especially be fit to the treatment livestock and birds respiratory disease, consumption is little, gives the animal subcutaneous injection, a drug, duration of efficacy can reach more than 3 days, and the prevention effect that is used for animal mycoplasma infection diseases such as chicken, piglet, lamb, calf is remarkable, used frequency injection few, good effect has vast market prospect.
The specific embodiment
Below in conjunction with embodiment, the present invention is further described, and following embodiment is illustrative, is not determinate, can not limit protection scope of the present invention with following embodiment.
Embodiment 1
A kind of long-acting tylosin injection, component and weight are as follows:
Tylosin 2000g, benzyl alcohol 100g, polyvinylpyrrolidone 500g, 2,6-di-tert-butyl-4-methy phenol 20g, propylene glycol add to 10000ml.
Preparation method is: with benzyl alcohol, polyvinylpyrrolidone, 2,6-di-tert-butyl-4-methy phenol (BHT) is dissolved in the propylene glycol of 7000ml successively, again tylosin is added above-mentioned solution dissolving, add propylene glycol at last, promptly get long-acting tylosin injection to 10000ml.
Embodiment 2
A kind of long-acting tylosin injection, component and weight are as follows:
Tylosin tartrate 1000, benzyl alcohol 85, polyvinylpyrrolidone 450g, 2,6-di-tert-butyl-4-methy phenol 10g, propylene glycol add to 10000ml.
Preparation method is: with benzyl alcohol, polyvinylpyrrolidone, 2,6-di-tert-butyl-4-methy phenol (BHT) is dissolved in the propylene glycol of 7000ml successively, again tylosin is added above-mentioned solution dissolving, add propylene glycol at last, promptly get long-acting tylosin injection to 10000ml.
Embodiment 3
A kind of long-acting tylosin injection, component and weight are as follows:
Tylosin phosphonate 1500g, benzyl alcohol 90g, polyvinylpyrrolidone 470g, 2,6-di-tert-butyl-4-methy phenol 15g, propylene glycol add to 10000ml.
Preparation method is: with benzyl alcohol, polyvinylpyrrolidone, 2,6-di-tert-butyl-4-methy phenol (BHT) is dissolved in the propylene glycol of 7000ml successively, again tylosin is added above-mentioned solution dissolving, add propylene glycol at last, promptly get long-acting tylosin injection to 10000ml.
Embodiment 4
A kind of long-acting tylosin injection, component and weight are as follows:
Tylosin 2000g, benzyl alcohol 100g, polyvinylpyrrolidone 500g, 2,6-di-tert-butyl-4-methy phenol 20g, propylene glycol add to 10000ml.
Preparation method is: with benzyl alcohol, polyvinylpyrrolidone, 2,6-di-tert-butyl-4-methy phenol (BHT) is dissolved in the propylene glycol of 7000ml successively, again tylosin is added above-mentioned solution dissolving, add propylene glycol at last, promptly get long-acting tylosin injection to 10000ml.
Clinical trial:
1, trial drug
The development of long-acting tylosin injection our unit
Tylosin (897IU/mg wet product) Xi'an Hengtongguanghua Pharmaceutical Co., Ltd produces
2, test period, place, select animal for use
August in 2009,31 days-JIUYUE 10 days was on the pig farm, Tianjin, prerun 7 days, formal 3 days phases, select long white and big York two-way cross pig for use, the second parity body weight 23-31kg, healthy, active, 17 of the pigs that stress is little are divided into 9 of test group, 3 of matched groups, 3 of blank groups, 2 of reserve groups, all anthelmintics before the test, the earmarking number record.
3, test pig grouping
Weigh morning on an empty stomach before the test, be divided into 5 groups at random by body weight, every group 3, I, II, III group are experimental group, by per kilogram of body weight 50mg, 100mg, 200mg dosage, injection back leg muscle, IV are organized and are matched group respectively, by the oral 20mg tylosin of per kilogram of body weight raw material, the V group is organized not administration for blank.
4, blood sampling test
Medicine inject time is 0 o'clock, blood sampling at set intervals later on once, the about 5ml of each blood sampling, put centrifugal 5min taking-up under the 4000r/min rotating speed in the centrifuge tube, get serum 0.3ml, add dehydrated alcohol 2ml, 15% trichloroacetic acid 5ml shakes up, and adds dehydrated alcohol 10ml again and shakes up, and adds developer 2ml, hydrochloric acid 3ml, glacial acetic acid 3ml shakes up, and places 10 minutes, uses membrane filtration, with 753 spectrophotometers at 486 ± 1mm place, carry out colorimetric determination.Developer be glacial acetic acid configuration 0.5% to the dimethylamine benzaldehyde solution.
5, experimental result
Half-life test data in the long-acting tylosin injection blood (mg/100ml serum)
Claims (3)
1. long-acting tylosin injection, it is characterized in that: component and weight are as follows: every 10000ml propylene glycol contains following composition and parts by weight are:
Tylosin class antibiotic 1000-2000g, benzyl alcohol 85-100g, polyvinylpyrrolidone 450-500g, 2,6-di-tert-butyl-4-methy phenol 10-20g.
2. a kind of long-acting tylosin injection according to claim 1 is characterized in that: described tylosin class antibiotic is tylosin alkali, tylosin phosphonate or tylosin tartrate.
3. a kind of long-acting tylosin injection according to claim 1, it is characterized in that: the preparation method of described long-acting tylosin injection is: with benzyl alcohol, polyvinylpyrrolidone, 2,6-di-tert-butyl-4-methy phenol (BHT) is dissolved in the propylene glycol of 6-8000ml successively, again tylosin is added above-mentioned solution dissolving, add propylene glycol at last to 10000ml, promptly get long-acting tylosin injection.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010105790361A CN102028654A (en) | 2010-12-08 | 2010-12-08 | Long-acting tylosin injection |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010105790361A CN102028654A (en) | 2010-12-08 | 2010-12-08 | Long-acting tylosin injection |
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| CN102028654A true CN102028654A (en) | 2011-04-27 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2486906C2 (en) * | 2009-11-11 | 2013-07-10 | Государственное научное учреждение Всероссийский научно-исследовательский ветеринарный институт патологии, фармакологии и терапии Российской академии сельскохозяйственных наук (ГНУ ВНИВИПФиТ Россельхозакадемии) | Method of treating respiratory diseases in young farm animals |
| CN108524443A (en) * | 2017-03-31 | 2018-09-14 | 佛山市南海东方澳龙制药有限公司 | A kind of tylosin injection and preparation method thereof, application |
| CN114425036A (en) * | 2022-01-11 | 2022-05-03 | 佛山市南海东方澳龙制药有限公司 | Basic tylosin injection and preparation method thereof |
-
2010
- 2010-12-08 CN CN2010105790361A patent/CN102028654A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2486906C2 (en) * | 2009-11-11 | 2013-07-10 | Государственное научное учреждение Всероссийский научно-исследовательский ветеринарный институт патологии, фармакологии и терапии Российской академии сельскохозяйственных наук (ГНУ ВНИВИПФиТ Россельхозакадемии) | Method of treating respiratory diseases in young farm animals |
| CN108524443A (en) * | 2017-03-31 | 2018-09-14 | 佛山市南海东方澳龙制药有限公司 | A kind of tylosin injection and preparation method thereof, application |
| CN114425036A (en) * | 2022-01-11 | 2022-05-03 | 佛山市南海东方澳龙制药有限公司 | Basic tylosin injection and preparation method thereof |
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Application publication date: 20110427 |