CN102027114A - 使用编码bmp-7的重组载体的关节软骨基因疗法 - Google Patents

使用编码bmp-7的重组载体的关节软骨基因疗法 Download PDF

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Publication number
CN102027114A
CN102027114A CN2008801158299A CN200880115829A CN102027114A CN 102027114 A CN102027114 A CN 102027114A CN 2008801158299 A CN2008801158299 A CN 2008801158299A CN 200880115829 A CN200880115829 A CN 200880115829A CN 102027114 A CN102027114 A CN 102027114A
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bmp
polypeptide
seq
leu
ser
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CN2008801158299A
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Chinese (zh)
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L·B·菲舍
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Merial Ltd
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Merial Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0075—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the delivery route, e.g. oral, subcutaneous
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/10—Animals modified by protein administration, for non-therapeutic purpose
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/102—Caprine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Virology (AREA)
  • Plant Pathology (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
CN2008801158299A 2007-10-05 2008-10-07 使用编码bmp-7的重组载体的关节软骨基因疗法 Pending CN102027114A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/867,919 US7846428B2 (en) 2007-10-05 2007-10-05 Articular cartilage gene therapy with recombinant vector encoding BMP-7
PCT/US2008/079090 WO2009046464A1 (en) 2007-10-05 2008-10-07 Articular cartilage gene therapy with recombinant vector encoding bmp-7

Publications (1)

Publication Number Publication Date
CN102027114A true CN102027114A (zh) 2011-04-20

Family

ID=40276182

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2008801158299A Pending CN102027114A (zh) 2007-10-05 2008-10-07 使用编码bmp-7的重组载体的关节软骨基因疗法

Country Status (7)

Country Link
US (1) US7846428B2 (https=)
EP (1) EP2205743B1 (https=)
JP (1) JP2012505151A (https=)
CN (1) CN102027114A (https=)
BR (1) BRPI0817753A8 (https=)
CA (1) CA2701215C (https=)
WO (1) WO2009046464A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109310734A (zh) * 2016-04-13 2019-02-05 马斯特里赫特大学 骨关节炎的治疗或预防方法
CN109496152A (zh) * 2018-05-17 2019-03-19 广州蓝亮医药科技有限公司 癸氧喹酯组合物的肌肉内库存及其预防和治疗的方法
CN112168793A (zh) * 2020-10-26 2021-01-05 辰欣药业股份有限公司 一种盐酸氨溴索口腔崩解片及其制备方法

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2784861A1 (en) * 2009-12-21 2011-07-14 Pharmathene, Inc. Recombinant butyrylcholinesterases and truncates thereof
RU2516951C1 (ru) * 2013-03-01 2014-05-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Мордовский государственный университет им. Н.П. Огарёва" Способ профилактики посттравматического артроза коленного сустава
PL3369435T3 (pl) 2013-07-18 2020-04-30 Xalud Therapeutics, Inc. Kompozycja do leczenia choroby zapalnej stawów
EP3043825A4 (en) * 2013-09-09 2017-05-03 Figene, LLC Gene therapy for the regeneration of chondrocytes or cartilage type cells
RU2771490C2 (ru) 2016-01-13 2022-05-05 Мериал, Инк. Рекомбинантные aav векторы, экспрессирующие остеопротективные гены, включая has2 и лубрицин, пригодные при лечении остеоартрита и сходных заболеваний суставов у млекопитающих
JP7308151B2 (ja) * 2017-04-27 2023-07-13 イーライ リリー アンド カンパニー ヒトｂｍｐ７タンパク質のバリアント
US20240316219A1 (en) * 2021-05-03 2024-09-26 North Carolina State University Compositions and methods related to the treatment of ocular diseases in equines

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5266683A (en) * 1988-04-08 1993-11-30 Stryker Corporation Osteogenic proteins
US6159464A (en) * 1990-12-20 2000-12-12 University Of Pittsburgh Of The Commonwealth System Of Higher Education Viral vectors to inhibit leukocyte infiltration or cartilage degradation of joints
AU2002311777A1 (en) * 2001-04-17 2002-10-28 Genetix Pharmaceuticals, Inc. Method of treating arthritis using lentiviral vectors in gene therapy
US20040167088A1 (en) * 2003-02-25 2004-08-26 Genvec, Inc. Method of using adenoviral vectors with increased persistence in vivo
US20040223953A1 (en) * 2003-03-17 2004-11-11 Hsiang-Fu Kung Combined adeno-associated virus and adenovirus cocktail gene delivery system for high efficiency gene expression without eliciting immune response in immuno-competent subjects
WO2005007098A2 (en) * 2003-07-08 2005-01-27 New York University Nucleic acid therapy to enhance cartilage repair
EP1660663A4 (en) * 2003-08-12 2007-07-11 Brigham & Womens Hospital METHOD AND COMPOSITIONS FOR TISSUE REPAIR
EP3147296A1 (en) * 2005-11-14 2017-03-29 Merial, Inc. Gene therapy for renal failure
WO2007087053A2 (en) * 2005-12-22 2007-08-02 Centocor, Inc Bmp-7 variant compositions, methods and uses

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109310734A (zh) * 2016-04-13 2019-02-05 马斯特里赫特大学 骨关节炎的治疗或预防方法
CN109310734B (zh) * 2016-04-13 2022-06-24 马斯特里赫特大学 骨关节炎的治疗或预防方法
CN109496152A (zh) * 2018-05-17 2019-03-19 广州蓝亮医药科技有限公司 癸氧喹酯组合物的肌肉内库存及其预防和治疗的方法
CN112168793A (zh) * 2020-10-26 2021-01-05 辰欣药业股份有限公司 一种盐酸氨溴索口腔崩解片及其制备方法

Also Published As

Publication number Publication date
WO2009046464A1 (en) 2009-04-09
CA2701215C (en) 2016-05-17
EP2205743B1 (en) 2017-07-19
JP2012505151A (ja) 2012-03-01
BRPI0817753A2 (pt) 2015-03-24
EP2205743A1 (en) 2010-07-14
WO2009046464A8 (en) 2012-04-26
BRPI0817753A8 (pt) 2017-09-26
US20090093427A1 (en) 2009-04-09
CA2701215A1 (en) 2009-04-09
US7846428B2 (en) 2010-12-07

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Application publication date: 20110420