CN102026652B - 凝血酶抑制剂 - Google Patents

凝血酶抑制剂 Download PDF

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Publication number
CN102026652B
CN102026652B CN200880102585.0A CN200880102585A CN102026652B CN 102026652 B CN102026652 B CN 102026652B CN 200880102585 A CN200880102585 A CN 200880102585A CN 102026652 B CN102026652 B CN 102026652B
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thrombin
variegin
seq
inhibitor
exosite
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CN102026652A (zh
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玛丽亚·卡济米罗娃
R·曼朱纳塔·基尼
许祖尧
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National University of Singapore
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Natural Environment Research Council
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Optics & Photonics (AREA)
  • Neurosurgery (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN200880102585.0A 2007-06-18 2008-06-18 凝血酶抑制剂 Active CN102026652B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0711779.9 2007-06-18
GBGB0711779.9A GB0711779D0 (en) 2007-06-18 2007-06-18 Thrombin inhibitor
PCT/IB2008/002109 WO2008155658A2 (en) 2007-06-18 2008-06-18 Thrombin inhibitor

Publications (2)

Publication Number Publication Date
CN102026652A CN102026652A (zh) 2011-04-20
CN102026652B true CN102026652B (zh) 2014-06-04

Family

ID=38332312

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200880102585.0A Active CN102026652B (zh) 2007-06-18 2008-06-18 凝血酶抑制剂

Country Status (8)

Country Link
US (1) US9217027B2 (enExample)
EP (1) EP2185185B1 (enExample)
JP (1) JP5699393B2 (enExample)
CN (1) CN102026652B (enExample)
AU (1) AU2008264890A1 (enExample)
CA (1) CA2691243A1 (enExample)
GB (1) GB0711779D0 (enExample)
WO (1) WO2008155658A2 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102225966B (zh) 2004-10-19 2012-12-26 隆萨股份公司 用于固相肽合成的方法
GB0711779D0 (en) 2007-06-18 2007-07-25 Univ Singapore Thrombin inhibitor
GB0907698D0 (en) * 2009-05-05 2009-06-10 Univ Singapore Method of modifying serine protease inhibitors
AU2011336345B2 (en) * 2010-12-02 2016-07-07 Becton, Dickinson And Company Blood collection devices containing blood stabilization agent
GB201121513D0 (en) 2011-12-14 2012-01-25 Cambridge Entpr Ltd Thrombin-binding antibody molecules and uses thereof
US9518128B2 (en) 2011-12-14 2016-12-13 Janssen Pharmaceuticals, Inc. Thrombin-binding antibody molecules
US20140220552A1 (en) * 2013-02-01 2014-08-07 Becton, Dickinson And Company Blood collection devices containing contact pathway inhibition additives
GB201310948D0 (en) * 2013-06-19 2013-07-31 Cambridge Entpr Ltd Screening methods
GB201406863D0 (en) * 2014-04-16 2014-05-28 Univ Leeds Compositions comprising variegin
EP3942931A1 (en) 2014-06-10 2022-01-26 Biomatrica, INC. Stabilization of thrombocytes at ambient temperatures
SG10201911414SA (en) * 2015-06-18 2020-02-27 Nat Univ Singapore Novel thrombin inhibitors
KR20250047404A (ko) 2015-12-08 2025-04-03 바이오매트리카 인코포레이티드 적혈구 침강 속도의 감소
NZ754781A (en) * 2016-12-16 2021-12-24 Univ Sydney Thrombin inhibitors for treatment of stroke and related coagulative disorders
BR102017005783A2 (pt) * 2017-03-21 2018-10-02 Fund Butantan processo de obtenção de esculptina e seus fragmentos, esculptina recombinante e seus usos
WO2019030706A1 (en) 2017-08-10 2019-02-14 Janssen Pharmaceutica Nv ANTI-THROMBIN ANTIBODY MOLECULES AND METHODS OF USE IN ORTHOPEDIC SURGERY
WO2019035055A1 (en) 2017-08-16 2019-02-21 Janssen Pharmaceutica Nv ANTI-THROMBIN ANTIBODY MOLECULES AND METHODS OF USE WITH PLATELET ANTI-AGGREGATE AGENTS
ES3020087T3 (en) * 2020-09-21 2025-05-21 Instr Laboratory Co Detecting and monitoring oral anticoagulants or intravenous direct thrombin inhibitors in a blood sample

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1341032C (en) 1987-01-23 2000-06-20 John L. Krstenansky Anticoagulant peptides
US5196404B1 (en) 1989-08-18 1996-09-10 Biogen Inc Inhibitors of thrombin
US6060451A (en) 1990-06-15 2000-05-09 The National Research Council Of Canada Thrombin inhibitors based on the amino acid sequence of hirudin
ATE198603T1 (de) 1993-10-25 2001-01-15 Ca Nat Research Council Bivalente thrombininhibitore
WO1996010638A1 (en) 1994-09-30 1996-04-11 Ppl Therapeutics (Scotland) Ltd. Alpha-1-antitrypsin and antithrombine-iii variants
GB9506212D0 (en) 1995-03-27 1995-05-17 Iaf Biochem Int Bifunctional thrombin inhibitors bearing highly truncated fibrinogen recognition exosite binding component
GB9613718D0 (en) 1996-06-29 1996-08-28 Thrombosis Res Inst Thrombin inhibitors
US5985833A (en) 1996-09-17 1999-11-16 Wisconsin Alumni Research Foundation Thrombin inhibitor
GB0209249D0 (en) * 2002-04-23 2002-06-05 Evolutec Ltd Anticoagulants
WO2004076484A1 (en) 2003-02-27 2004-09-10 National Research Council Of Canada Peptide inhibitors of thrombin as potent anticoagulants
GB0711779D0 (en) 2007-06-18 2007-07-25 Univ Singapore Thrombin inhibitor

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
An inhibitor of thrombin-stimulated blood platelet aggregation from the salivary glands of the hard tick Amblyomma variegatum;MÁRIA KAZIMÍROVÁ, VIERA JANˇ CINOVÁ, et al.;《Experimental and Applied Acarology》;20021231 *
Variegin, a Novel Fast and Tight Binding Thrombin Inhibitor from the Tropical Bont Tick;Cho Yeow Koh,Maria Kazimirova, Adama Trimnell, et al.;《THE JOURNAL OF BIOLOGICAL CHEMISTRY》;20071005;第282卷(第40期) *
新型凝血酶抑制剂阿加曲班;袁莉娟等;《中国新药杂志》;20051231(第02期) *
直接凝血酶抑制剂在心血管疾病中的应用;李琳等;《中国医药导刊》;20060528(第03期) *

Also Published As

Publication number Publication date
AU2008264890A1 (en) 2008-12-24
US9217027B2 (en) 2015-12-22
WO2008155658A3 (en) 2010-03-04
US20130183237A1 (en) 2013-07-18
WO2008155658A2 (en) 2008-12-24
EP2185185B1 (en) 2016-05-04
GB0711779D0 (en) 2007-07-25
CN102026652A (zh) 2011-04-20
JP2010530238A (ja) 2010-09-09
CA2691243A1 (en) 2008-12-24
EP2185185A2 (en) 2010-05-19
WO2008155658A8 (en) 2009-09-03
JP5699393B2 (ja) 2015-04-08

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Patentee after: The National University of Singapore

Address before: England, Wiltshire, England

Patentee before: Natural Environment Research Council